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Released: 30-May-2017 5:30 PM EDT
Small Molecule Prevents Blood Clots Without Increasing Bleeding Risk
Case Western Reserve University

It may be possible to disrupt harmful blood clots in people at risk for heart attack or stroke without increasing their risk of bleeding, according to a new study published in Nature Communications.

Released: 29-May-2017 9:05 PM EDT
NUS Researchers Make Inroads Into Finding Out How T-cell Acute Lymphoblastic Leukaemia Develops
National University of Singapore (NUS)

A research team from the National University of Singapore led by Assistant Professor Takaomi Sanda, Principal Investigator from the Cancer Science Institute of Singapore and Department of Medicine at NUS Yong Loo Lin School of Medicine, has provided new insights into the molecular mechanism affecting how genes are produced during normal T-cell development, and contributing to leukaemia formation.

   
Released: 24-May-2017 2:05 PM EDT
Jefferson Researcher Identifies Targets for Better Anti-Thrombotic Medicine
Thomas Jefferson University

Blood thinners, such as aspirin, reduce the risk of thrombus formation but also interfere with the initial clot formation that is essential for preventing blood loss from the wounds. Now researchers have discovered that a molecule plays a role in thrombus development, but not the initial clot formation, suggesting a new avenue for developing more specific and protective blood thinners.

Released: 24-May-2017 1:05 PM EDT
Penn’s Garret FitzGerald Receives American Heart Association Merit Award to Enhance Blood Pressure Control
Perelman School of Medicine at the University of Pennsylvania

Garret FitzGerald, MD, FRS, director of the Institute for Translational Medicine and Therapeutics in the Perelman School of Medicine at the University of Pennsylvania, has received a $1 million Merit Award from the American Heart Association (AHA) to help the millions of patients with high blood pressure improve their condition.

Released: 22-May-2017 12:05 PM EDT
New Heart Disease Risk Genes Point to Flaws in Blood Vessel Walls
Perelman School of Medicine at the University of Pennsylvania

Coronary artery disease (CAD) is a leading cause of death worldwide. Despite dozens of regions in the genome associated with CAD, most of the genetic components of heart diseases are not fully understood, suggesting that more genes are out there to be found. A team found 15 new risk genes for coronary artery disease.

Released: 19-May-2017 3:05 PM EDT
Circadian Fluctuations in Glaucoma
University of Alabama at Birmingham

Brian Samuels, M.D., says there is an increase of eye pressure throughout the morning, and that pressure comes and goes throughout the day. This fluctuation is a known risk factor for the progression of glaucoma.

Released: 19-May-2017 9:15 AM EDT
Blood Discovery Could Benefit Preemies, Help End Platelet Shortages
University of Virginia Health System

A new discovery may be the key to stopping shortages of vital blood-clotting cells that can represent the difference between life and death. The finding also could offer big benefits for premature babies.

Released: 17-May-2017 3:05 PM EDT
Hospital-Acquired Anemia More Common, Increases Risks
UT Southwestern Medical Center

One in three patients hospitalized for medical problems experienced a drop in their red blood cell count due to the hospitalization – a concept called hospital-acquired anemia, new research showed.

3-May-2017 8:55 AM EDT
New Blood Test Technology Reduces False Readings, Saves Costs, and Improves Care - Live Virtual Press Briefing with Researcher May 16
Newswise

Research findings to be published about new blood test technology that will greatly reduce errors in labwork and improve care in public health and infectious disease. Press briefing scheduled for May 16, reserve press access to live virtual event now.

Released: 17-May-2017 9:00 AM EDT
Study Shows Novel Device Significantly Reduces Blood Draw Contamination, Reduces Risks to Patients
University of Nebraska Medical Center (UNMC)

A study at the University of Nebraska Medical Center (UNMC) found that a novel device can significantly reduce contamination of blood cultures, potentially reducing risky overtreatment and unnecessary use of antibiotics for many patients. This approach could also substantially reduce healthcare costs, according to the study. Thousands of U.S. patients get their blood drawn every day for blood cultures in order to diagnose serious infections such as sepsis, which can be a deadly condition. A small but significant percentage of the blood cultures are contaminated, due in part to skin fragments containing bacteria that are dislodged during a blood draw. This leads to false results that can mislead clinicians into thinking a patient has a potentially serious bloodstream infection. The consequences are costly and put patients at risk.

11-May-2017 4:50 PM EDT
Media Briefing: Blood Test Device Improves Sepsis Detection and Antimicrobial Stewardship
Dowling & Dennis Public Relations

In a virtual media briefing next Tuesday, May 16, at 11:30 a.m. EDT, noted infectious disease expert Mark Rupp, M.D. will detail the results of a forthcoming journal publication on a new device.

Released: 16-May-2017 5:05 PM EDT
Autoimmune Vasculitis Specialists Presenting at the2017 International Vasculitis Symposium June 23-25 in Chicago
Vasculitis Foundation

Some of the world's leading experts in the field of autoimmune vasculitis research will present at the 2017 International Vasculitis Symposium in Chicago. Sessions will include information about the latest vasculitis research, and treatment and management of autoimmune vasculitis.

Released: 16-May-2017 2:05 PM EDT
Sick Kids Live Longer, but Brain Function May Suffer
Vanderbilt University

Hundreds of thousands of children with chronic illnesses who used to die are now surviving their disease and treatment—which is amazing. But their brains are being damaged in the process of keeping them alive. This first ever research quantifies the IQ impact of six main illnesses and looks and the common threads that connect them. It also takes next steps on how psychologists can team up with surgeons/oncologists, etc. to help treat kids and their parents, so they can thrive in school and life.

Released: 10-May-2017 10:30 AM EDT
Beetroot Juice May Provide Benefits to Heart Disease Patients
American Physiological Society (APS)

A new study finds that dietary nitrate—a compound that dilates blood vessels to decrease blood pressure—may reduce overstimulation of the sympathetic nervous system that occurs with heart disease. The research team looked specifically at beetroot juice, a source of dietary nitrate, to explore its use as a future targeted treatment option for people with cardiovascular disease.

Released: 9-May-2017 11:05 AM EDT
Research Elucidates Ghrelin’s Role in Blood Glucose Regulation, a Finding with Implications for Treating Diabetes
UT Southwestern Medical Center

UT Southwestern research investigating the blood glucose-regulatory actions of the hormone ghrelin may have implications for development of new treatments for diabetes.

3-May-2017 9:05 AM EDT
Researchers Uncover Key Role for MicroRNA in Inflammatory Bowel Disease
The Rockefeller University Press

An international team of researchers has discovered that a microRNA produced by certain white blood cells can prevent excessive inflammation in the intestine. The study, “Myeloid-derived miR-223 regulates intestinal inflammation via repression of the NLRP3 inflammasome,” which will be published May 9 in The Journal of Experimental Medicine, shows that synthetic versions of this microRNA can reduce intestinal inflammation in mice and suggests a new therapeutic approach to treating patients with Crohn’s disease or ulcerative colitis.

Released: 8-May-2017 10:05 AM EDT
Researchers Use Modified Insulin and Red Blood Cells to Regulate Blood Sugar
North Carolina State University

Researchers have developed a new technique that uses modified insulin and red blood cells to create a glucose-responsive “smart” insulin delivery system. In an animal model study, the new technique effectively reduced blood sugar levels for 48 hours in a strain of mice that had Type 1 diabetes.

Released: 5-May-2017 12:05 PM EDT
Backed by Dana-Farber Research, FDA Approves New AML Drug
Dana-Farber Cancer Institute

A targeted drug whose clinical testing was led by Richard Stone, MD, of Dana-Farber Cancer Institute, has become the first new treatment for newly diagnosed acute myeloid leukemia (AML) in more than 25 years.

Released: 5-May-2017 8:05 AM EDT
Unlocking the Barrier
Harvard Medical School

At a glance: · New study reveals that blood-brain barrier function relies on the balance between omega-3 fatty acids and other lipids in cells that line blood vessels in the central nervous system. · This lipid make-up keeps the barrier closed by inhibiting the formation of vesicles that shuttle molecules across cells, a process known as transcytosis. · Low levels of vesicles are maintained by the lipid transport protein Mfsd2a. · Disrupting Mfsd2a may be a strategy for opening the blood-brain barrier to deliver drugs into the brain.

1-May-2017 4:05 PM EDT
Surprising Link Between Blood Sugar and Brain Cancer Found
Ohio State University

New research further illuminates the surprising relationship between blood sugar and brain tumors and could begin to shed light on how certain cancers develop.

Released: 28-Apr-2017 8:05 AM EDT
Artificial Pancreas Benefits Young Children, Trial Shows
University of Virginia Health System

A pilot study among young children with Type 1 diabetes found that a University of Virginia-developed artificial pancreas helped study participants better control their condition.

17-Apr-2017 8:00 AM EDT
Low-Sodium Diet Might Not Lower Blood Pressure
Federation of American Societies for Experimental Biology (FASEB)

A new study that followed more than 2,600 men and women for 16 years found that consuming less sodium wasn’t associated with lower blood pressure. The study adds to growing evidence that current recommendations for sodium intake may be misguided.

21-Apr-2017 12:05 PM EDT
White Blood Cell Count and Neutrophil‑lymphocyte Ratio Improve Prediction of Delayed Cerebral Ischemia in Good‑grade Subarachnoid Hemorrhage
American Association of Neurological Surgeons (AANS)

Winner of the DePuy Synthes Cerebrovascular Award, Fawaz Al-Mufti, MD, presented his research, White Blood Cell Count and Neutrophil‑lymphocyte Ratio Improve Prediction of Delayed Cerebral Ischemia in Good‑grade Subarachnoid Hemorrhage, during the 2017 American Association of Neurological Surgeons (AANS) Annual Scientific Meeting.

   
Released: 24-Apr-2017 10:05 AM EDT
LJI Professor Klaus Ley Wins Prestigious National Award
La Jolla Institute for Immunology

Professor Klaus Ley, M.D., has been selected as this year’s winner of the Eugene M. Landis Award, the Microcirculatory Society’s top honor, in recognition of his pioneering work in vascular biology and microcirculation. The microcirculation comprises all the small blood vessels in all tissues and organs and their contents (blood plasma and blood cells).

17-Apr-2017 8:00 AM EDT
Altered Immune Cells May Both Contribute to Preeclampsia and Offer New Hope for Treatment
Federation of American Societies for Experimental Biology (FASEB)

In a new study presented today at the APS annual meeting at Experimental Biology 2017, researchers have found that the immune system’s natural killer (NK) cells activate and change in response to placental ischemia. Disrupting these altered cells seems to blunt some of the dangerous complications of the condition, including high blood pressure (hypertension) and inflammation in the mother and growth restriction in the fetus.

   
17-Apr-2017 8:00 AM EDT
4 Exciting Advances in Food and Nutrition Research
Federation of American Societies for Experimental Biology (FASEB)

New discoveries tied to how food affects our body and why we make certain food choices could help inform nutrition plans and policies that encourage healthy food choices. The Experimental Biology 2017 meeting will showcase groundbreaking research in food policy, nutrition and the biochemistry of food.

Released: 20-Apr-2017 10:30 AM EDT
Sensor-Filled Glove Could Help Doctors Take Guesswork Out of Physical Exams
University of California San Diego

Researchers have developed a sensor-filled glove that doctors could wear to accurately measure muscle stiffness, known as spasticity, in patients suffering from stroke, cerebral palsy, multiple sclerosis and other muscle control disorders.

   
Released: 13-Apr-2017 2:05 PM EDT
Epidemiological Analysis Shows Unexpected Benefit Related to High Blood Pressure for Many with Ovarian Cancer
Roswell Park Comprehensive Cancer Center

An international team of collaborators retroactively examined the associations between survival among patients diagnosed with invasive epithelial ovarian cancer and those patients’ history of hypertension, heart disease, diabetes, and medications taken for those conditions. They found that while hypertension was linked to better outcomes, diabetes was associated with decreased survival.

Released: 12-Apr-2017 8:00 AM EDT
First-of-Its-Kind App Offers Personalized Rehab Therapy for Stroke Patients
University Health Network (UHN)

A new, first-of-its-kind app is now available to support clinicians with decisions on best practice rehabilitation strategies for patients with arm impairment due to stroke.

Released: 11-Apr-2017 7:05 AM EDT
New Study Offers Hope for More Effective Treatment of Leukemia
University of Vermont

The discovery of a protein signature that is highly predictive of leukemia could lead to novel treatments of the leading childhood cancer, according to new study showing that competition among certain proteins causes an imbalance that leads to leukemia.

3-Apr-2017 10:05 AM EDT
Seemingly Innocuous Virus Can Trigger Celiac Disease
University of Chicago Medical Center

Infection with reovirus, a common but otherwise harmless virus, can trigger the immune system response to gluten that leads to celiac disease, according to new research from the University of Chicago and the University of Pittsburgh School of Medicine.

Released: 6-Apr-2017 9:05 AM EDT
Tumor Necrosis Factor Found to Directly Regulate Blood Pressure
University Health Network (UHN)

Ted Rogers Centre for Heart Research study is first to show TNF operating beyond immune system, Caution needed when administering anti-TNF medications

3-Apr-2017 1:00 PM EDT
X-Ray Study Reveals Long-Sought Insights Into Potential Drug Target
Arizona State University (ASU)

Many hypertension medications currently on the market target the AT1 receptor because of its well-understood role in blood pressure regulation; they block AT1 in order to reduce blood pressure. The AT2 receptor, on the other hand, is still an elusive drug target despite multiple studies of its function. Now, researchers have solved its structure to hone in on its function. The results of the experiments were surprising in several ways. First, although both compounds were designed to block and deactivate the receptors, they left AT2 in a state that appeared to be active. In addition, although AT1 and AT2 were thought to be very similar, the pockets where the receptors bind to the compounds exhibited marked differences.

Released: 5-Apr-2017 9:00 AM EDT
Fruits and Vegetables’ Latest Superpower? Lowering Blood Pressure
Keck Medicine of USC

A new study from the Keck School of Medicine of USC links increased dietary potassium with lower blood pressure.

Released: 5-Apr-2017 9:00 AM EDT
First U.S. Patient Treated in Landmark Vascular Study of Lithoplasty® Technology
UPMC Pinnacle

PinnacleHealth CardioVascular Institute enrolled the first patient in the United States in a trial assessing the safety and effectiveness of a new type of approach for blockages in the leg artery. DISRUPT PAD III is the largest ever multi-center randomized study to exclusively enroll patients with calcified peripheral artery disease (PAD).

1-Apr-2017 3:05 PM EDT
Artificial Pancreas Improves Blood Sugar Control in Young Kids
Endocrine Society

An artificial pancreas, which delivers insulin in an automated way to individuals with type 1 diabetes, appears to be safe and effective for use in children ages 5 to 8 years, a new study finds. Results will be presented Tuesday at the Endocrine Society’s 99th annual meeting in Orlando, Fla.

Released: 30-Mar-2017 5:05 PM EDT
These 5 Tests Better Predict Heart Disease Risk
UT Southwestern Medical Center

Five simple medical tests together provide a broader and more accurate assessment of heart-disease risk than currently used methods, cardiologists at UT Southwestern Medical Center found.

Released: 30-Mar-2017 9:00 AM EDT
Endocrine Society Joins March for Science
Endocrine Society

The Endocrine Society is proudly partnering with the March for Science, which will bring together more than 100 scientific organizations on Saturday, April 22 to celebrate science and rally public support for publicly funded research.

Released: 28-Mar-2017 3:05 PM EDT
Tiny Bioengineered Blood Vessel Grafts Aid Delicate Microsurgeries
National Institute of Biomedical Imaging and Bioengineering

Scientists have been working diligently to create engineered tissue implants to repair or replace damaged or diseased tissue and organs; but their success hinges on the ability to build a sturdy connection linking the implant’s blood vessels and the patient’s existing vasculature. National Institute of Biomedical Imaging and Bioengineering (NIBIB)-funded researchers have created segments of engineered blood vessels to address this critical issue.

   
Released: 27-Mar-2017 1:05 PM EDT
Scientists Discover New Class of Anti-Diabetes Compounds That Reduce Liver Glucose Production
Scripps Research Institute

A team of scientists from the Florida campus of The Scripps Research Institute (TSRI), Dana-Farber Cancer Institute, Harvard Medical School and the Yale University School of Medicine, among others, have identified a new class of compounds that reduce production of glucose in the liver.

16-Mar-2017 8:05 AM EDT
Revised Understanding of Graft-Versus-Host Disease Origins Offers New Direction for Potential Therapies
University of Michigan

An international research team led by the University of Michigan Life Sciences Institute is changing the understanding of the key cellular and molecular events that trigger graft-versus-host disease, an often fatal complication of bone marrow transplants.

Released: 20-Mar-2017 1:05 PM EDT
First Patient Cured of Rare Blood Disorder
University of Illinois Chicago

Using a technique that avoids the use of high-dose chemotherapy and radiation in preparation for a stem cell transplant, physicians at the University of Illinois Hospital & Health Sciences System have documented the first cure of an adult patient with congenital dyserythropoietic anemia.

Released: 20-Mar-2017 10:05 AM EDT
New Research Shows Promise for the Production of Patient-Matched Blood Cells for Therapies, Disease Modeling and Drug Screening
Ann and Robert H. Lurie Children's Hospital of Chicago

The Galat laboratory at Stanley Manne Children’s Research Institute, Ann & Robert H. Lurie Children’s Hospital of Chicago, has developed an elegant system to derive blood cell precursors from human pluripotent stem cells (hPSC). This type of stem cell has the potential to develop into many different kinds of cells in the body, and is capable of participating in organ repair and function. These qualities have prompted scientists to test the use of hPSC to treat some diseases. However, the development of a fully defined system to generate functional blood cell precursors has proven to be a significant challenge. The Galat lab’s findings hold promise to overcome this challenge.

16-Mar-2017 3:05 PM EDT
New Blood Thinner Better at Preventing Recurrent Blood Clots Than Aspirin
McMaster University

Venous thromboembolism is a chronic disease, with risks of additional blood clots over a patient’s lifetime. However, many physicians and patients are deciding against long-term treatment with blood thinners because of concern about the risk of bleeding. Some are choosing aspirin instead because they consider it to be safer. This study has shown that the blood thinner rivaroxaban is as safe as aspirin, and more effective at preventing recurrence of life-threatening blood clots in the legs and lungs.

8-Mar-2017 7:05 AM EST
Rapid Blood Pressure Drops in Middle Age Linked to Dementia in Old Age
Johns Hopkins Bloomberg School of Public Health

Middle-aged people who experience temporary blood pressure drops that often cause dizziness upon standing up may be at an increased risk of developing cognitive decline and dementia 20 years later, new Johns Hopkins Bloomberg School of Public Health research suggests.

Released: 7-Mar-2017 10:00 AM EST
New Drug Combination Targets Aggressive Blood Cancer
Van Andel Institute

A pair of drugs that may be a one-two punch needed to help combat acute myeloid leukemia (AML), an aggressive blood cancer that kills nearly three-fourths of patients within five years of diagnosis, is the focus of a new multi-center clinical trial that will enroll patients at three sites across the U.S.

Released: 6-Mar-2017 5:05 PM EST
Tackling Lupus and Its Renal Complications with Novel Small Molecule Drug Candidate
RUSH

A new international study co-led by a Rush University Medical Center researcher suggests that a drug starting through the pipeline could ameliorate or even eliminate the symptoms in most sufferers.



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