Pesquisadores da Mayo Clinic descobriram um padrão distinto em um conjunto específico de 17 genes que pode estar associado com a remissão após o tratamento para câncer de mama triplo negativo.
Los investigadores de Mayo Clinic han descubierto un patrón característico en un conjunto de 17 genes que podrían asociarse con la remisión después del tratamiento para el cáncer de mama triple negativo.
By monitoring changes in circulating tumor DNA (ctDNA) among 30 patients treated with immunotherapies for metastatic non-small cell lung cancers, researchers were able to determine molecular response — the clearance of tumor genetic material in the bloodstream.
Living through a historic pandemic while handling the stress of the first year of college sent one-third of students in a new study into clinical depression. That’s double the percentage seen in previous years of the same study.
New research conducted by investigators at Sylvester Comprehensive Cancer Center and collaborating cancer centers indicates that a new type of targeted therapy may offer new treatment options for patients living with advanced myelofibrosis, a bone marrow disorder. Study results will be shared at ASH 2023 in San Diego, Dec. 9-12.
It only takes holding your breath for slightly too long to understand that too little oxygen is bad for you.
It's the moooost wonderful time...of the year! Are you looking for new story ideas that are focused on the winter holiday season? Perhaps you're working on a story on on managing stress and anxiety? Perhaps you're working on a story on seasonal affective disorder? Or perhaps your editor asked you to write a story on tracking Santa? Look no further. Check out the Winter Holidays channel.
The lab of Yongchao C. Ma, PhD, at Stanley Manne Children’s Research Institute at Ann & Robert H. Lurie Children’s Hospital of Chicago uncovered a novel mechanism that leads to motor neuron degeneration in spinal muscular atrophy (SMA).
The targeted therapy trastuzumab deruxtecan (T-Dxd), an antibody drug conjugate, is now an approved treatment of HER2-low advanced breast cancers. In a new study led by Yale Cancer Center researchers at Yale School of Medicine, their findings revealed important differences in the genetic makeup of HER2-low advanced breast cancers — a discovery that could lead to better treatment options for patients.
Researchers who have studied malaria for decades, hoping to find a cure, long thought they’d identified a type of blood that seemed to defend against the disease. But a new study published Dec. 5 in Cell Host & Microbe concludes that even some people with the protective blood type became infected. The question now is, “how?”
Patients with sickle cell disease (SCD) often face a reduced quality of life and a lower life expectancy. Allotransplantation, the first treatment for SCD with curative potential, comes with risks, including transplant-related mortality. Gene therapy, once approved for SCD, could also offer a lifelong cure without the risk associated with allotransplantation.
St. Jude researchers will participate in multiple oral and poster presentations and education sessions as well as moderate panels during the ASH conference.
A partnership between ARUP Laboratories and Medicover has made a new companion diagnostic, and thereby a new gene therapy, more accessible to patients in the European Union.
The electric eel is the biggest power-making creature on Earth. It can release up to 860 volts, which is enough to run a machine. In a recent study, a research group from Nagoya University in Japan found electric eels can release enough electricity to genetically modify small fish larvae. They published their findings in PeerJ - Life and Environment.
A new study led by UT Southwestern Medical Center molecular biologists presents a novel culture system to grow both embryonic and extraembryonic stem cells, potentially providing important insights into the genesis of congenital malformations and early developmental disorders.
Scientists attacking the problem of high miscarriage rates have long wondered if there is a way to tell whether an egg cell will successfully develop into an embryo and grow or if there is a marker indicating when it is destined to fail. Two Rutgers-led research teams have found strong clues in two separate studies using both human and mouse data that will allow them to begin to answer “yes” to both questions.
Researchers from at University of California San Diego, West Health, and the University of Washington have found evidence that the private insurers that sponsor Medicare Part D are artificially inflating the costs of certain generic drugs by overpaying pharmacies.
In a recent study, scientists led by Professor Stefan Müller from Goethe University’s Institute of Biochemistry II investigated a specific form of blood cancer known as acute myeloid leukemia, or AML. The disease mainly occurs in adulthood and often ends up being fatal for older patients.
Many of the most potent human oncoproteins belong to a class of proteins called transcription factors, but designing small molecule drugs that target transcription factors is a major challenge.
Gene expression is often regulated by chemical modifications, a process known as epigenetics for DNA and epitranscriptomics for RNA. Among these, N6-methyladenosine (m6A) is a significant internal modification of mRNA that plays crucial roles in gene expression and various biological and pathological processes, including cancer development.
A comprehensive analysis of the soybean genome can help develop improved varieties of soybean by identifying crucial genes linked to desirable traits.
A roundup of the latest medical discoveries and faculty news at Cedars-Sinai.
A massive genetic study involving almost 800,000 participants has uncovered genetic factors that contribute to the use of sleep medications, shedding new light on the intricate relationship between sleep problems and psychiatric conditions.
Venoms have developed in many animal groups independently of each other. One group that has many venomous species is Hymenoptera, an insect order that also includes aculeates (stinging insects) such as bees, wasps and ants. Hymenoptera is very species-rich, with over 6,000 species of bees alone.
The largest review of papers for brain cancer that has spread from the lungs has found abnormalities in the brain cancer and for which licensed drugs could be clinically trialled to find out if they could treat the disease.
The method identified promising targets for precision oncology in two types of cancer
Far too many antibiotics are used around the world. As a result, bacteria are becoming resistant. Curing bacterial diseases is becoming more difficult than before, because antibiotics are perhaps our foremost weapons in the fight against them.
Research on fruit flies has implications for this poorly understood process in humans
In a new Cell study, scientists at La Jolla Institute for Immunology (LJI) and Massachusetts General Hospital, Harvard Medical School, show how a protein called IKAROS helps "weave" the genome.
Cedars-Sinai investigators found no established link between the use of assisted reproductive technologies and potential problems in DNA methylation that might impact genetic expression or embryonic development.
A gene previously linked to autism spectrum disorder (ASD) by UT Southwestern Medical Center researchers appears to play an important role in steering cells in the brain’s hippocampus toward their ultimate identities, the same team reported in a new study.
The Wnt signaling pathway, a system present in living organisms, plays a pivotal role in cell growth, differentiation, and migration. It has a long history dating back to 1982 when the first Wnt gene, which is essential for cellular growth, was discovered.
Stay informed! Keep up with the latest research on the COVID-19 virus in the Coronavirus channel on Newswise.
Bladder cancer, notorious for being one of the most costly malignancies to manage, often results in patient discomfort and frequent, invasive, and expensive procedures.
A Yale-led analysis of the genomes of more than 1 million people has shed light on the underlying biology of cannabis use disorder and its links to psychiatric disorders, abuse of other substances such as tobacco, and possibly even an elevated risk of developing lung cancer.
Scientists at St. Jude Children’s Research Hospital mapped the difference in chromatin accessibility and regulation in different pediatric acute lymphoblastic leukemia subtypes.
Feeding dogs raw (uncooked) meat increases their risk of excreting E. coli that cannot be killed by a widely used antibiotic - ciprofloxacin - researchers at the University of Bristol have found from a study of 600 healthy pet dogs.
Researchers at the University of Pittsburgh and KU Leuven have discovered a suite of genes that influence head shape in humans.
For over 20 years, a research team at Lund University in Sweden has studied the common bluetail damselfly. Females occur in three different colour forms – one with a male-like appearance, something that protects them from mating harassment. In a new study, an international research team found that this genetic colour variation that is shared between several species arose through changes in a specific genomic region at least five million years ago.
Every cell in the human body contains the same genetic instructions, encoded in its DNA. However, out of about 30,000 genes, each cell expresses only those genes that it needs to become a nerve cell, immune cell, or any of the other hundreds of cell types in the body.
In a new study, researchers at the Georgia Institute of Technology investigated whether 25 rare gene variants known to be associated with inflammatory bowel disease (IBD) play a role in risk for African Americans.
US and IRB Barcelona researchers have shown for the first time that these hybrids are clearly a source of cancer-associated mutations
A new study involving University of Portsmouth researchers has uncovered key molecular defects underlying a rare developmental brain condition in children.
Patients with advanced prostate cancer with tumors harboring RB1 gene loss or neuroendocrine features often have a poor prognosis and limited treatment options.
The world’s total population is expected to reach 9.9 billion by 2050. This rapid increase in population is boosting the demand for agriculture to cater for the increased demand. Below are some of the latest research and features on agriculture and farming in the Agriculture channel on Newswise.
With today’s fast and automated analysis tools, the field of biology is bursting at the seams with datasets about gene sequences and expression in the microbiomes around us – and inside us.
St. Jude scientists mapped the gene regulatory networks responsible for progressive differentiation states of tumor-infiltrating T cells, using a technology known as single-cell CRISPR screening to knock out or genetically perturb multiple genes potentially involved.
To help mitigate the world’s biodiversity crisis, Arizona State University’s Julie Ann Wrigley Global Futures Laboratory has recruited Harris Lewin, a prominent genome scientist currently spearheading one of biology’s most ambitious ‘moonshot’ goals, a complete DNA catalog of the genetic code for life on Earth by the end of this decade.
The Department of Immunology and Immunotherapy and the Icahn Genomics Institute (IGI) at the Icahn School of Medicine at Mount Sinai have been awarded a $5 million grant from the National Cancer Institute (NCI) of the National Institutes of Health to establish a state-of-the-art center dedicated to the discovery and development of cutting-edge targets for cancer therapy.
A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 20, entitled, “Alcohol consumption and epigenetic age acceleration across human adulthood.”
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