Feature Channels: Stem Cells

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Released: 6-Apr-2023 5:00 AM EDT
Cynomolgus monkey embryo model captures gastrulation and early pregnancy
Cell Stem Cell

Stem cell-based embryo models provide a useful system for studying early embryonic development. Li and colleagues reported the generation of cynomolgus monkey blastoids with similar characteristics to natural blastocysts. These blastoids possess the

Released: 6-Apr-2023 5:00 AM EDT
Response to Magenheim et al.: Ductal Ngn3-expressing progenitors contribute to adult beta cell neogenesis in the pancreas
Cell Stem Cell

The existence of adult beta cell neogenesis has been controversial, with numerous papers published arguing for and against over the years, and many conclusions in the field are thus based on studies that were performed years and sometimes decades ago

Released: 6-Apr-2023 5:00 AM EDT
When gene editing turns a nasty goddess into a friendly MEDUSA
Cell Stem Cell

Marchiano and colleagues interrogate the underlying causes of ventricular arrhythmias occurring after human pluripotent stem cell-cardiomyocyte transplantation. Through stepwise analysis and gene editing of ion channel expression, they mitigate pace-

Released: 6-Apr-2023 5:00 AM EDT
Gene editing to prevent ventricular arrhythmias associated with cardiomyocyte cell therapy
Cell Stem Cell

Engraftment arrhythmia (EA) compromises the safety of hPSC-CM cell therapy. We hypothesized that spontaneous graft depolarizations are the source of EAs. We used a CRISPR screen to demonstrate that targeting excitatory channels HCN4, CACNA1H, and SLC

Released: 6-Apr-2023 5:00 AM EDT
It takes two to untangle: Combined stimulation of adult neurogenesis reverts AD symptoms
Cell Stem Cell

Alzheimer’s disease (AD) is associated with reduced adult hippocampal neurogenesis and impaired hippocampal-dependent behaviors. Li et al. report that stimulating adult neurogenesis combined with new-born neuron activation ameliorates behavioral s

Released: 6-Apr-2023 5:00 AM EDT
Activation of hypothalamic-enhanced adult-born neurons restores cognitive and affective function in Alzheimer’s disease
Cell Stem Cell

The process of generating adult-born neurons (ABNs) in the hippocampus is impaired in AD. Song and colleagues report a circuit-based strategy by stimulating SuM to enhance hippocampal neurogenesis in AD mice. Activation of SuM-modified ABNs restores

Released: 6-Apr-2023 5:00 AM EDT
Human hematopoietic stem cells expand beyond cytokines
Cell Stem Cell

The paucity of hematopoietic stem cells (HSCs) presents a challenge for both transplantation and the study of HSCs.1 Sakurai et al.2 now present a cytokine-free culture system for robust ex vivo expansion of functional human HSCs that may lead to e

Released: 6-Apr-2023 5:00 AM EDT
Matters arising: Insufficient evidence that pancreatic β cells are derived from adult ductal Neurog3-expressing progenitors
Cell Stem Cell

Magenheim et al. challenge a recent study claiming that pancreatic beta cells are generated at a physiologically important rate from progenitor cells within ducts. They show that the lineage-tracing systems used in that study do in fact pulse label

Released: 6-Apr-2023 5:00 AM EDT
Harnessing matrix stiffness to engineer a bone marrow niche for hematopoietic stem cell rejuvenation
Cell Stem Cell

Yue and colleagues demonstrate that matrix stiffness negatively regulates the HSC niche factor expression by BMSCs. They successfully engineer a soft bone marrow niche that not only promotes HSC maintenance and lymphopoiesis but also rejuvenates midd

Released: 6-Apr-2023 5:00 AM EDT
Chemical reprogramming takes the fast lane
Cell Stem Cell

Small molecule-induced cell fate transitions are characterized by low efficiency and slow kinetics. An optimized chemical reprogramming approach now facilitates the robust and rapid conversion of somatic cells to pluripotent stem cells, unlocking exc

Released: 6-Apr-2023 5:00 AM EDT
Maintenance of high-turnover tissues during and beyond homeostasis
Cell Stem Cell

Banjac et al. review the mechanisms behind homeostasis and regeneration in the epidermis, hematopoietic system, and intestinal epithelium with an emphasis on tissue stem cells. They highlight key challenges facing the field with reference to underst

Released: 6-Apr-2023 5:00 AM EDT
Highly efficient and rapid generation of human pluripotent stem cells by chemical reprogramming
Cell Stem Cell

Chemical reprogramming provides a robust approach for cell fate manipulation. Here, Deng and colleagues developed a highly reproducible and efficient chemical reprogramming method for the induction of human pluripotent stem cells and revealed increas

Newswise: Harvard University’s Paola Arlotta Receives FASEB Excellence in Science Award
Released: 5-Apr-2023 10:05 AM EDT
Harvard University’s Paola Arlotta Receives FASEB Excellence in Science Award
Federation of American Societies for Experimental Biology (FASEB)

The Federation of American Societies for Experimental Biology (FASEB) awarded Paola Arlotta, PhD, Professor of Stem Cell and Regenerative Biology at Harvard University, with its Excellence in Science Mid-career Investigator Award.

   
Newswise: FDA-approved drug shows promise in lab models for blinding childhood disease 
Released: 29-Mar-2023 12:05 PM EDT
FDA-approved drug shows promise in lab models for blinding childhood disease 
NIH, National Eye Institute (NEI)

A National Eye Institute-led team has identified a compound already approved by the U.S. Food and Drug Administration that keeps light-sensitive photoreceptors alive in three models of Leber congenital amaurosis type 10 (LCA 10), an inherited retinal ciliopathy disease that often results in severe visual impairment or blindness in early childhood.

Newswise: Neuro Annual Report 2023: A Year of Patients, Progress
Released: 27-Mar-2023 12:35 PM EDT
Neuro Annual Report 2023: A Year of Patients, Progress
Cedars-Sinai

The Departments of Neurology and Neurosurgery at Cedars-Sinai highlighted progress against Alzheimer’s disease, Parkinson’s disease, ALS, multiple sclerosis, brain cancer and stroke in their 2023 Annual Report, which also details advancements in spine surgery.

Released: 26-Mar-2023 12:00 PM EDT
Disease modeling of desmosome-related cardiomyopathy using induced pluripotent stem cell-derived cardiomyocytes
World Journal of Stem Cells

Cardiomyopathy is a pathological condition characterized by cardiac pump failure due to myocardial dysfunction and the major cause of advanced heart failure requiring heart transplantation. Although optimized medical therapies have been develop

Released: 26-Mar-2023 12:00 PM EDT
Immunomodulation: The next target of mesenchymal stem cell-derived exosomes in the context of ischemic stroke
World Journal of Stem Cells

Ischemic stroke (IS) is the most prevalent form of brain disease, characterized by high morbidity, disability, and mortality. However, there is still a lack of ideal prevention and treatment measures in clinical practice. Notably, the transplan

Released: 26-Mar-2023 12:00 PM EDT
Mesenchymal stem/stromal cells-derived exosomes for osteoporosis treatment
World Journal of Stem Cells

Osteoporosis is a systemic bone disease, which leads to decreased bone mass and an increased risk of fragility fractures. Currently, there are many anti-resorption drugs and osteosynthesis drugs, which are effective in the treatment of osteopor

Released: 26-Mar-2023 12:00 PM EDT
Mammalian Ste20-like kinase 1 inhibition as a cellular mediator of anoikis in mouse bone marrow mesenchymal stem cells
World Journal of Stem Cells

BACKGROUNDThe low survival rate of mesenchymal stem cells (MSCs) caused by anoikis, a form of apoptosis, limits the therapeutic efficacy of MSCs. As a proapoptotic molecule, mammalian Ste20-like kinase 1 (Mst1) can increase the production of re

Released: 26-Mar-2023 12:00 PM EDT
Clinical trials using dental stem cells: 2022 update
World Journal of Stem Cells

For nearly 20 years, dental stem cells (DSCs) have been successfully isolated from mature/immature teeth and surrounding tissue, including dental pulp of permanent teeth and exfoliated deciduous teeth, periodontal ligaments, dental follicles, a

Released: 24-Mar-2023 10:20 AM EDT
Important step towards accurate use of stem cell-based disease models
University of Helsinki

During the past ten years, scientists have learned to create induced pluripotent stem cells (iPSC) from ordinary cells by genetic reprogramming.

Released: 21-Mar-2023 2:25 PM EDT
What makes blood stem cells transform? Regulation of RNA splicing may be an answer
Lund University

Researchers at Lund University Faculty of Medicine have determined a novel mechanism linking the metabolism of ribonucleic acids, RNA, to the development of leukemia in myelodysplastic syndrome patients, MDS.

Newswise:Video Embedded to-ward-off-aging-stem-cells-must-take-out-the-trash
VIDEO
Released: 21-Mar-2023 11:30 AM EDT
To Ward Off Aging, Stem Cells Must Take Out the Trash
University of California San Diego

UC San Diego researchers find stem cells use a surprising system for discarding misfolded proteins. This unique pathway could be the key to maintaining long-term health and preventing age-related blood and immune disorders.

Released: 20-Mar-2023 2:05 PM EDT
Genes that form specific bones in the womb heal them later in life
NYU Langone Health

Genes long known to control the formation of bones before birth also control bone healing later in life, a new study found.

Released: 20-Mar-2023 9:00 AM EDT
Antibiotic resistance is an increasing problem. Learn all about it in the Drug Resistance channel.
Newswise

Staphylococcus aureus, Clostridioides difficile, Candida auris, Drug-resistant Shigella. These bacteria not only have difficult names to pronounce, but they are also difficult to fight off. These bacteria may infect humans and animals, and the infections they cause are harder to treat than those caused by non-resistant bacteria. Antimicrobial resistance is an urgent global public health threat.

     
Newswise: Discovery of an unexpected function of blood immune cells : Their ability to proliferate !
Released: 17-Mar-2023 1:00 PM EDT
Discovery of an unexpected function of blood immune cells : Their ability to proliferate !
University of Liege

The ability of a cell to divide, to proliferate, is essential for life and gives rise to the formation of complex organisms from a single cell.

Released: 14-Mar-2023 7:00 AM EDT
Pesquisa em fase inicial da Mayo Clinic encontra na terapia com células-tronco uma perspectiva para fístula perianal em pacientes com doença de Crohn
Mayo Clinic

Um plugue absorvível entregou terapia com células-tronco com poucos efeitos colaterais em pacientes com fístulas perianais de trato único, segundo descoberta de pesquisadores da Mayo Clinic.

Released: 14-Mar-2023 7:00 AM EDT
Las primeras investigaciones en Mayo Clinic encuentran esperanza en la terapia con células madres para las fístulas perianales en pacientes con la enfermedad de Crohn
Mayo Clinic

Los investigadores de Mayo Clinic descubrieron que un tapón soluble administró terapia con células madre ocasionando pocos efectos secundarios en pacientes con fístulas perianales de un solo trayecto.

Released: 14-Mar-2023 7:00 AM EDT
بحث في المراحل المبكرة لمايو كلينك يجد أملًا في الخلايا الجذعية لعلاج الناسور الشرجي لدى المرضى المصابين بداء كْرون
Mayo Clinic

توصّل باحثو مايو كلينك إلى إمكانية العلاج بالخلايا الجذعية عبر سدادة قابلة للذوبان لديها آثارٌ جانبية قليلة على المرضى المصابين بالناسور الشرجي أحادي السبيل. النواسير الشرجية هي ممرات مؤلمة بين الأمعاء والجلد، ولا تُشفى عادةً بالرعاية الطبية أو الجراحية القياسية. إن المصابين بداء كْرون أو غيره من حالات التهاب الأمعاء هم الأكثر عرضة لخطر الإصابة بهذه الحالة المرضية.

Released: 13-Mar-2023 12:35 PM EDT
Heart Tissue Heads to Space to Aid Research on Aging and Impact of Long Spaceflights
Johns Hopkins Medicine

Johns Hopkins Medicine researchers are collaborating with NASA to send human heart “tissue-on-a-chip” specimens into space as early as March. The project is designed to monitor the tissue for changes in heart muscle cells’ mitochondria (their power supply) and ability to contract in low-gravity conditions.

   
Released: 9-Mar-2023 8:05 AM EST
Magrolimab Plus Azacitidine Results in Promising Activity in Higher-Risk MDS Patients
Moffitt Cancer Center

In a new article published today in the Journal of Clinical Oncology, Moffitt Cancer Center physician-scientists, in collaboration with institutions from across the United States and the United Kingdom, share promising phase 1b trial results of a new combination therapy — magrolimab + azacitidine — for patients with higher-risk MDS.

Released: 8-Mar-2023 12:00 PM EST
MD Anderson Research Highlights for March 8, 2023
University of Texas MD Anderson Cancer Center

The University of Texas MD Anderson Cancer Center’s Research Highlights showcases the latest breakthroughs in cancer care, research and prevention. These advances are made possible through seamless collaboration between MD Anderson’s world-leading clinicians and scientists, bringing discoveries from the lab to the clinic and back.

   
Newswise: Splicing Deregulation Detected and Targeted in Type of Childhood Leukemia
Released: 7-Mar-2023 12:30 PM EST
Splicing Deregulation Detected and Targeted in Type of Childhood Leukemia
University of California San Diego

UC San Diego researchers delve deep into the unknown cause of pediatric acute myeloid leukemia to identify a gene splicing dysregulation and potential target for treating the disease, which often becomes treatment-resistant.

Released: 7-Mar-2023 7:00 AM EST
Ingeniería de tejidos para fortalecer corazones con malformaciones
Mayo Clinic

¿Acaso sería posible extraer células de una pequeña porción de piel y transformarlas en tejido muscular para reparar un defecto cardíaco congénito? Esta es una pregunta científica que el Dr. Timothy Nelson, y sus colaboradores esperan responder para ayudar a quienes nazcan con una cavidad malformada en el hemisferio izquierdo del corazón, una afección compleja e infrecuente conocida como síndrome del corazón izquierdo hipoplásico (HLHS, por sus siglas en inglés).

Released: 7-Mar-2023 7:00 AM EST
هندسة الأنسجة لدعم القلوب غير مكتملة النمو
Mayo Clinic

هل يمكن لخلايا مأخوذة من رقعة جلدية صغيرة أن تتحول لتصبح عضلة قلبية وتصلح عيبًا خلقيًا نادرًا بالقلب؟ هذا هو السؤال العلمي الذي يأمل تيموثي نيلسون، دكتور في الطب وحاصل على دكتوراه، والمتعاونون معه في الإجابة عليه من أجل هؤلاء الذين يولدون بحجرة قلب يسرى غير مكتملة النمو، وهي حالة مرضية نادرة ومعقدة تعرف باسم متلازمة القلب الأيسر ناقص التنسُّج.

Released: 2-Mar-2023 2:35 PM EST
Early Mayo Clinic research finds hope in stem cell therapy for perianal fistulas in patients with Crohn’s disease
Mayo Clinic

A dissolvable plug delivered stem cell therapy with few side effects in patients with single tract perianal fistulas, Mayo Clinic researchers discovered. Perianal fistulas are painful tunnels between the intestine and the skin that often do not go away with standard medical or surgical care.

Newswise: Possible treatment strategy identified for bone marrow failure syndrome
28-Feb-2023 5:40 PM EST
Possible treatment strategy identified for bone marrow failure syndrome
Washington University in St. Louis

Research led by Washington University School of Medicine in St. Louis has identified a possible treatment strategy for a rare bone marrow failure syndrome that is named poikiloderma with neutropenia. The work also may have implications for treating other bone marrow failure syndromes with similar underlying dysfunctions.

Released: 2-Mar-2023 6:00 AM EST
Epitranscriptomic regulation of cortical neurogenesis via Mettl8-dependent mitochondrial tRNA m3C modification
Cell Stem Cell

Zhang et al. identified an epitranscriptomic mechanism regulating cortical neural stem cells in the embryonic mouse brain and human forebrain organoids. Specifically, Mettl8 installs m3C modification on mitochondrial tRNAThr/Ser(UNC), which regulate

Released: 2-Mar-2023 6:00 AM EST
Brain organoids restore cortical damage
Cell Stem Cell

Cortical damage is irreparable and poses a challenge to regenerative medicine. Whether brain organoids can compensate for injured brain regions remains unclear. In this issue of Cell Stem Cell, Jgamadze et al. report that human forebrain organoids t

Released: 2-Mar-2023 6:00 AM EST
Human stem cell models unravel mechanisms of somite segmentation
Cell Stem Cell

In vitro models to study human somitogenesis, the formation of the segmented body plan, have so far been limited.1 Two papers in Nature now report the creation of pluripotent stem cell (PSC)-derived 3D culture systems that recapitulate the formation

Released: 2-Mar-2023 6:00 AM EST
AMD recapitulated in a 3D biomimetic: A breakthrough in retina tissue engineering
Cell Stem Cell

Song et al. (Nature Methods, 2022) engineered a 3D model of the human outer blood-retina barrier (oBRB) that recapitulates key features of healthy and age-related macular degeneration (AMD)-affected eyes.1 We shine a spotlight on this tissue-enginee

Released: 2-Mar-2023 6:00 AM EST
Unraveling barriers to iPSC-derived CAR-T cell differentiation
Cell Stem Cell

The generation of off-the-shelf CAR-T cells from TiPSCs has been hindered by the difficulty to recapitulate adaptive T cell development and lower therapeutic efficacy compared to peripheral blood CAR-T cells. Ueda et al. address these issues in a t

Released: 2-Mar-2023 6:00 AM EST
Pandemic city: Village-in-a-dish unlocks dynamic genetic effects in the brain
Cell Stem Cell

In this issue, Wells et al. combine genetic multiplexing (“village-in-a-dish”) and Stem-cell-derived NGN2-accelerated Progenitors (SNaPs) to evaluate genotype-phenotype relationships across 100 donors in the context of Zika virus infection in th

Released: 1-Mar-2023 6:25 PM EST
Researchers uncover how gene that increases risk of genetic heart disease works, paving way for new treatments
Murdoch Childrens Research Institute

Researchers have discovered how a gene that increases the risk of developing genetic heart disease functions, paving the way for new treatments.

Newswise:Video Embedded real-ai-will-need-biology-computers-powered-by-human-brain-cells
VIDEO
Released: 1-Mar-2023 1:15 PM EST
Real AI will need biology: Computers powered by human brain cells
Cortical Labs

The time has come to create a new kind of computer, say researchers from John Hopkins University together with Dr Brett Kagan, chief scientist at Cortical Labs in Melbourne, who recently led development of the DishBrain project, in which human cells in a petri dish learnt to play Pong.

Released: 28-Feb-2023 12:45 PM EST
Clinical trial for patients with swallowing difficulties after cancer treatment
UC Davis Health (Defunct)

UC Davis Health researchers have begun a new stem cell clinical trial to treat patients with swallowing problems. The study takes stem cells and injects them into the patient’s tongue.

Newswise: UC San Diego's Astrobiotechnology Hub to Drive Drug Discovery in Space
Released: 28-Feb-2023 11:45 AM EST
UC San Diego's Astrobiotechnology Hub to Drive Drug Discovery in Space
University of California San Diego

UC San Diego’s new Astrobiotechnology Hub brings together leaders in academia, biotechnology and aerospace industries under a united mission to advance stem cell science and commercialization in space.

   
Released: 26-Feb-2023 12:00 PM EST
Mesenchymal stem cells in ischemic tissue regeneration
World Journal of Stem Cells

Diseases caused by ischemia are one of the leading causes of death in the world. Current therapies for treating acute myocardial infarction, ischemic stroke, and critical limb ischemia do not complete recovery. Regenerative therapies opens new

Newswise: Healing the brain: Hydrogels enable neuronal tissue growth
Released: 24-Feb-2023 11:45 AM EST
Healing the brain: Hydrogels enable neuronal tissue growth
Hokkaido University

Synthetic hydrogels were shown to provide an effective scaffold for neuronal tissue growth in areas of brain damage, providing a possible approach for brain tissue reconstruction.



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