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Medicine

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Mount Sinai Health System, PTEN mutation, PTEN, Pten/P13 K Pathway, Gene, metabolic pathway, Breast Cancer, Prostate Cancer, Glioblastoma, Endometrial Cancer, triple negative breast cancer, Glutamine, Leflunomide, Rheumatoid Arthritis Drugs

Scientists Discover Metabolic Pathway That Drives Tumor Growth in Aggressive Cancers

Mount Sinai researchers have discovered that a rheumatoid arthritis drug can block a metabolic pathway that occurs in tumors with a common cancer-causing gene mutation, offering a new possible therapy for aggressive cancers with few therapeutic options, according to a study to be published in Cancer Discovery.

Medicine

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Gene Therapy, Leukemia and Lymphoma Society, AACR, Yale Cancer Center, Roy Herbst

Gene Therapy to Fight a Blood Cancer Succeeds in Major Study

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An experimental gene therapy that turns a patient's own blood cells into cancer killers worked in a major study. Article by the Associated Press.

Medicine

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Enzyme, Brain Lesions, Cholesterol

Cholesterol-Processing Enzyme Protects From Debilitating Brain Lesions

Researchers from Case Western Reserve University School of Medicine, the National Institute of Standards and Technology, and Karolinska Institute in Sweden discovered that a specific enzyme in the brain could reduce the formation of debilitating brain lesions in the two diseases.

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Research Shows Nature Can Beat Back Scientific Tinkering with Genes of Entire Species

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A University of Kansas researcher and colleagues from Cornell University have revealed daunting challenges to changing the DNA of entire populations of species via the most promising techniques available today to produce “gene drive.”

Medicine

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Rare Disease Day, Rare Diseases

University of Notre Dame's Richard Taylor Can Speak to Media About Rare Disease Day and Drug Development at the Warren Center

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Mayo Clinic Publishes Genetic Screen for Alzheimer’s in African-Americans

A Mayo Clinic research team has found a new gene mutation that may be a risk factor for late-onset Alzheimer’s disease in African-Americans.

Medicine

Science

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Cancer, drug resp

Genetic ‘Balance’ May Influence Response to Cancer Treatment

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Choosing among cancer treatments increasingly involves determining whether tumor cells harbor specific, mutated “oncogenes” that drive abnormal growth and that may also be especially vulnerable or resistant to particular drugs. But according to a new study led by UCSF researchers, in the case of the most commonly mutated cancer-driving oncogene, called KRAS (pronounced “kay-rass”), response to treatment can change as tumors evolve, either when a normal copy of the gene from the other member of the matched chromosome pair is lost, or when the cancers cells evolve to produce additional copies of the mutated form of the gene.

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Genetic Variant of the p53 Gene Linked to Breast Cancer Risk in Premenopausal African American Women

Scientists at The Wistar Institute in collaboration with Roswell Park Cancer Institute found a significant association between a rare genetic variant of the p53 gene present in African American women and their risk of developing breast cancer in premenopausal age.

Science

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doublesex, Genetics, sexual differentiation, evolutionary development, Evolution, sexual traits, Entomology, Insects, Beetles, Biology, evodevo, dsx, Sexual Development

IU Biologists Reveal Ways Powerful 'Master Gene' Regulates Physical Differences Between Sexes

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A study by scientists at Indiana University has found that the master gene that regulates differences between males and females plays a complex role in matching the right physical trait to the right sex. The research, published Feb. 27 in the journal Nature Communications, reveals new details about the behavior of the gene called "doublesex," or dsx.

Medicine

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Genetics, ophthalmolgy, coloboma, Blindness, Deafness, Waardenburg syndrome, Children, National Eye Institute (NEI), National Institutes Of Health (NIH), Albinism, Genetic Testing

Media Availability: NIH Scientists Identify Disorder Causing Blindness, Deafness, Albinism and Fragile Bones

Researchers at the National Eye Institute (NEI), part of the National Institutes of Health, have identified the genetic underpinnings of a rare disorder that causes children to be born with deafness, blindness, albinism and fragile bones.







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