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Medicine

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Cancer Research, Leukemia, Stem Cell Transplant, Umbilical Cord Blood Transplant, Cord Blood

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For High-Risk Leukemia Patients, Umbilical Cord Blood Transplant Associated with Lower Risk of Relapse

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Umbilical cord blood transplants may have advantages beyond offering an alternative stem cell source for leukemia patients without a traditional donor match, according to a study published today in The New England Journal of Medicine.

Medicine

Channels:

Stem Cell, Neurorestoration, Regeneration, Regenerative Medicine, clinicial trials, Neurology, Movement, AST-OPC1, Spinal Cord Injury

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Paralyzed Man Regains Use of Arms and Hands After Experimental Stem Cell Therapy at Keck Hospital of USC

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After receiving a stem cell injection into his spine, Kris Boesen, who was paralyzed from his neck to his toes after a car accident, is regaining movement in his extremities and hope for increased independence.

Medicine

Channels:

Embryology, Chimera, Embryo Donation

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Case Western Reserve Researcher Outlines Road Map for Addressing Ethical Concerns Tied to Research on Combination Human-Animal Embryos

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Insoo Hyun has proposed a framework for addressing ethical questions surrounding potentially revolutionary research on part-human, part-animal embryos, which can be produced when human stem cells are transplanted into animal embryos.

Science

Channels:

Cirm, California Institute For Regenerative Medicine, Asteroid, Stem Cells, Embryonic Stem Cell, Spinal Cord Injury, Clincal Trial, Dr. Edith Perez, C. Randal Mills, Dr. Randy Mills, Jake Javier

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Stem Cell Agency Spinal Cord Injury Clinical Trial Passes Safety Hurdles

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A clinical trial using stem cells to treat people with recent spinal cord injuries has cleared two key safety hurdles, and been given approval to expand the therapy to a larger group of patients with a much higher dose of cells.

Medicine

Channels:

Drug Discovery, Mood Disorder, Schizophrenia, Bipolar Disorder, induced pluripotent stem (iPS) cells

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Sanford Burnham Prebys Medical Discovery Institute Included in Consortium Awarded $15 Million to Unravel Bipolar Disorder and Schizophrenia

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Sanford Burnham Prebys Medical Discovery Institute (SBP), the Johns Hopkins University School of Medicine, the Salk Institute for Biological Studies, and the University of Michigan will embark on a $15.4 million effort to develop new systems for quickly screening libraries of drugs for potential effectiveness against schizophrenia and bipolar disorder, the National Institute of Mental Health (NIMH) has announced.

Medicine

Channels:

Mount Sinai Health System, Icahn School of Medicine at Mount Sinai

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Stem Cell Breakthrough Unlocks Mysteries Associated with Inherited and Sometimes Lethal Heart Conditions

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Scientists have created a model of a heart condition called hypertrophic cardiomyopathy (HCM).

Medicine

Channels:

tissue-engineered liver, Progenitor Cells

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Functional Human Tissue-Engineered Liver Generated From Stem and Progenitor Cells

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A research team at Children’s Hospital Los Angeles has generated functional human and mouse tissue-engineered liver from adult stem and progenitor cells. Tissue-engineered Liver (TELi) was found to contain normal structural components such as hepatocytes, bile ducts and blood vessels.

Medicine

Channels:

Cancer, Leukemia, Stem Cells, Hematology, Aging, Secondary Acute Myeloid Leukemia, sAML

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Researchers Find a New Way to Identify and Target Malignant Aging in Leukemia

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Researchers at University of California San Diego School of Medicine and Moores Cancer Center have identified RNA-based biomarkers that distinguish between normal, aging hematopoietic stem cells and leukemia stem cells associated with secondary acute myeloid leukemia (sAML), a particularly problematic disease that typically afflicts older patients who have often already experienced a bout with cancer.

Medicine

Channels:

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Altering Stem Cell Perception of Tissue Stiffness May Help Treat Musculoskeletal Disorders

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A new biomaterial can be used to study how and when stem cells sense the mechanics of their surrounding environment. With further development, this biomaterial could be used to control when immature stem cells differentiate into more specialized cells for regenerative and tissue-engineering-based therapies.

Medicine

Channels:

Cancer, Cell Biology

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New Research Reveals Cancers Need a 'Perfect Storm' of Conditions to Develop

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SCIENTISTS have demonstrated for the first time the 'perfect storm' of conditions that cells need to start forming cancer, helping to explain why some organs are more susceptible to developing the disease, according to a new study published in Cell today (Thursday).

Medicine

Channels:

Iannis Aifantis, Nyu Langone, Leukemia, Hematopoiesis, Hematopoietic Stem Cell, Bone Marrow, med12, mediator commplex, Howard Hughes

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Study Shows Protein Complex Essential to Creating Healthy Blood Cells

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A group of proteins best known for helping to activate all mammalian genes has been found to play a particularly commanding role in the natural development of specialized stem cells into healthy blood cells, a process known as hematopoiesis.

Medicine

Channels:

St. Jude Children's Research Hospital, Stem Cells, Oncology, Origins of Cancer, Prom1, cancer models, marker molecule, cancer proliferation

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Stem Cell Propagation Fuels Cancer Risk in Different Organs

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Experiments reveal the crucial contribution of stem cells to the origins of cancer in different organs.

Medicine

Channels:

microcephaly , zika, zika virus

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In Some Genetic Cases of Microcephaly, Stem Cells Fail to Launch

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In a very severe, genetic form of microcephaly, stem cells in the brain fail to divide, according to a new Columbia University Medical Center study that may provide important clues to understanding how the Zika virus affects the developing brain.

Medicine

Channels:

Stroke, neurological damage, Stem Cell, Biotechnology, Brain Damage, Disability After Stroke

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Hope for Reversing Stroke-Induced Long-Term Disability

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Permanent brain damage from a stroke may be reversible thanks to a developing therapeutic technique. The novel approach combines transplanted human stem cells with a special protein that the U.S. Food and Drug Administration already approved for clinical studies in new stroke patients.

Science

Channels:

Biochemistry, Biology, Neurochemistry

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Neural Stem Cells Control Their Own Fate

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To date, it has been assumed that the differentiation of stem cells depends on the environment they are embedded in. A research group at the University of Basel now describes for the first time a mechanism by which hippocampal neural stem cells regulate their own cell fate via the protein Drosha. The journal Cell Stem Cell has published their results.

Medicine

Channels:

Tulane Univeristy, Stem Cells, National Science Foundation, chemical and biomolecular engineering

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Tulane Professor Receives Grant to Improve Stem Cell Survival

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Kim O’Connor, a professor in Tulane University’s Department of Chemical and Biomolecular Engineering, received a three-year $599,638 grant from the National Science Foundation to study ways to improve the survival of mesenchymal stem cells once they are implanted in patients.

Science

Channels:

California Institute For Regenerative Medicine, Cirm, UC Riverside School of Medicine, UC Riverside , Deborah Deas, Jonathan Thomas, Donna Weston

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UC Riverside Dean Deborah Deas Joins Stem Cell Agency Board

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Deborah Deas, M.D., M.P.H, Dean and CEO for Clinical Affairs at the University of California, Riverside, has been appointed to the governing Board of the California Institute for Regenerative Medicine (CIRM), the state’s stem cell agency.

Medicine

Channels:

Leukemia, Lymphoma, hematopoietic stem cell transplantation, Bone Marrow Cell Therapy, TNF, Graft-versus-host disease, GVHD

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Researchers Develop New Strategy to Limit Side Effects of Stem Cell Transplants

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Scientists in Germany have developed a new approach that may prevent leukemia and lymphoma patients from developing graft-versus-host disease (GvHD) after therapeutic bone marrow transplants. The researchers describe the successful application of their strategy in mice in “Exogenous TNFR2 activation protects from acute GvHD via host T reg cell expansion,” which will be published online August 15 ahead of issue in The Journal of Experimental Medicine.

Science

Channels:

planaria regeneration, Stem Cell, neoblasts

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Researchers Discover a Key Molecular Signal That Shapes Regeneration in Planarian Stem Cells

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Researchers at the Stowers Institute have identified a key molecule that directs stem cells in the planarian flatworm to make copies of themselves.

Medicine

Channels:

zika, microcephaly , Mosquito, aedes aegypti, Pregnancy, Infectious Diseases, Microbiology, Akt-mTOR pathway, NS4A protein, NS4B protein, Brazil, zika prevention, causes of microcephaly

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Two Zika Proteins Responsible for Microcephaly Identified

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It’s the first study to examine Zika infection in human neural stem cells from second-trimester fetuses, USC researchers say.







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