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Stem Cells

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Medicine

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Chromosome, Stem Cell, Gene

Reawakening a Sleeping Giant

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Most molecular biologists look at how to switch on and regulate single genes. Scientists at the MRC Clinical Sciences Centre (CSC) have gone further, and have explored how to reawaken an entire set of inactive genes, a chromosome, that is present in every female human cell.

Medicine

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facial reconstruction, Stem Cell, Tissue Engineering

Bioengineers Grow Living Bone for Facial Reconstruction

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Researchers have engineered living bone tissue to repair bone loss in the jaw, a structure that is typically difficult to restore. They grafted customized implants into pig jaws that resulted in integration and function of the engineered graft into the recipient’s own tissue.

Medicine

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Icahn School of Medicine at Mount Sinai, Mount Sinai Health System, Mammalian Cells, Stem Cell, Cell Cycle

New Tool Enables Researchers to Rapidly Manipulate Protein Levels in Mammalian Cells

Advance will make complex gene studies quicker and easier

Medicine

Science

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Stem Cell, Pluripotency, Differentiation, Developmental Biology, Cell Therapy

Breakthrough in Understanding How Stem Cells Become Specialized

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Scientists at Sanford Burnham Prebys Medical Discovery Institute (SBP) have made a major advance in understanding how the cells of an organism, which all contain the same genetic information, come to be so diverse. A study published today in Molecular Cell shows that a protein called OCT4 narrows down the range of cell types that stem cells can become. The findings could impact efforts to produce specific types of cells for future therapies to treat a broad range of diseases.

Medicine

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Eric Raabe, Stem Cell, Medulloblastoma, Palbociclib , Cancer, Tumor

Stem Cells May Speed Up Screening of Drugs for Rare Cancers

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Researchers at the Johns Hopkins Kimmel Cancer Center say they have developed a system that uses transformed human stem cells to speed up screening of existing drugs that might work against rare brain and other cancers.

Science

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University, College, Research, stem, Microfluidics, Chemistry, Biology, Science, Keck Foundation, Los Angeles, Education

Cal State LA Receives Grant to Develop Future Leaders in the Field of Paper Microfluidics

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Cal State LA has been awarded a grant to educate tomorrow’s leaders in the interdisciplinary field of paper microfluidics. The $375,000 grant from the W.M. Keck Foundation aims to engage more than 1,500 undergraduate students annually in the research of paper microfluidics to contribute to solving real-world scientific problems.

Medicine

Science

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Cell Biology, Biotechnology, Medicine & Health, ophtahlmology, Rehabilitation, Prosthetic, Transplant

Study in Mice Suggests Stem Cells Could Ward Off Glaucoma

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An infusion of stem cells could help restore proper drainage for fluid-clogged eyes at risk for glaucoma. That's the upshot of a study led by a Veterans Affairs and University of Iowa team.

Medicine

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Aging, Alzheimer's, Artherosclerosis, Botox, Osteoporosis, Genetics, Stem Cells, Embryonic Stem Cells, Premature Aging, Bioinformatic

Embryonic Gene Nanog Reverses Aging in Adult Stem Cells

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In a series of experiments at the University at Buffalo, the embryonic stem cell gene Nanog kicked into action dormant cellular processes that are key to preventing weak bones, clogged arteries and other telltale signs of growing old.

Medicine

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Stem Cells, Regenerative Medicine, Cirm, Parkinson Disease

TSRI Scientists Receive Funding to Advance Stem Cell-Based Parkinson’s Therapy

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Scientists at The Scripps Research Institute (TSRI) and Scripps Clinic have received a grant of nearly $2.4 million from the California Institute for Regenerative Medicine (CIRM) to support safety and quality tests of a potential stem cell therapy for Parkinson’s disease.

Medicine

Science

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Biology, Cell Biology

Cerebrospinal Fluid Signals Control the Behavior of Stem Cells in the Brain

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Prof. Fiona Doetsch's research team at the Biozentrum, University of Basel, has discovered that the choroid plexus, a largely ignored structure in the brain that produces the cerebrospinal fluid, is an important regulator of adult neural stem cells. The study recently published in "Cell Stem Cell" also shows that signals secreted by the choroid plexus dynamically change during aging which affects aged stem cell behavior.

Medicine

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Arthritis, Osteoarthritis, osteoarthritis knee, Knee Arthritis, Stem Cell, Stem Cells

Study Launched to Determine if Stem Cell Treatment Could Give Patients a Leg Up on Knee Arthritis

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Researchers at Hospital for Special Surgery have launched a study to determine if a treatment using stem cells could help people with painful knee arthritis. To evaluate safety and efficacy, investigators are currently recruiting patients with osteoarthritis, which comes from wear and tear on a joint.

Medicine

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Biology, Stem Cell, Integrins, Muscular Dystrophy, muscle degeneration

Protein Found to Bolster Growth of Damaged Muscle Tissue

Biologists have found that a protein that plays a key role in the lives of stem cells can bolster the growth of damaged muscle tissue, a step that could potentially contribute to treatments for muscle degeneration caused by old age and diseases such as muscular dystrophy.

Medicine

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ALS, Lou Gehrig disease, Lou Gehrig's Disease, pluripotent stem (iPS) cells , Clive Svendsen

ALS Research Suggests Stem Cells for Studies Should Be ‘Aged’ to Speed Progress Toward Finding Potential Treatments

Cedars-Sinai scientists are seeking to build an improved stem-cell model of amyotrophic lateral sclerosis (ALS) to accelerate progress toward a cure for the devastating neurological disorder. Their findings demonstrate that current models can be enhanced by the aging of motor neurons to show how ALS damages cells later in life.

Medicine

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Osteoarthritis, Hip Replacement, Knee Replacement, Orthopaedic Surgery, Stem Cell Biology

Stem Cells Engineered to Grow Cartilage, Fight Inflammation

With a goal of treating worn, arthritic hips without extensive surgery to replace them, scientists at Washington University School of Medicine in St. Louis have programmed stem cells to grow new cartilage on a 3-D template shaped like the ball of a hip joint. What’s more, using gene therapy, they have activated the new cartilage to release anti-inflammatory molecules to fend off a return of arthritis.

Science

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Whitehead Institute, Rudolf Jaenisch, Human Embryonic Stem Cells, Naive, Stem Cells Development Regeneration, Criteria

Defining What It Means to Be a Naive Stem Cell

Whitehead Institute scientists have created a checklist that defines the “naive” state of cultured human embryonic stem cells (ESCs). Such cells provide a better model of early human embryogenesis than conventional ESCs in later stages of development.

Medicine

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Stem Cells, Cancer, Cord Blood, genetic, princess margaret cancer centre, University Health Network, Stem Cell Treatment

Stem Cell Scientists Discover Genetic Switch to Increase Supply of Stem Cells From Cord Blood for Future Clinical Use

International stem cell scientists, co-led in Canada by Dr. John Dick and in the Netherlands by Dr. Gerald de Haan, have discovered the switch to harness the power of cord blood and potentially increase the supply of stem cells for cancer patients needing transplantation therapy to fight their disease.

Medicine

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Cancer, Immunotheapy, hematologic malignancies

Immunotherapy Benefits Relapsed Stem Cell Transplant Recipients

Dana-Farber Cancer Institute study published in the New England Journal of Medicine suggests that using repeated doses of an immunotherapy drug can restore a complete remission for some relapsed stem cell transplant recipients.

Science

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Breakthrough in Scaling Up Life-Changing Stem Cell Production

Scientists have discovered a new method of creating human stem cells which could solve the big problem of the large-scale production needed to fully realise the potential of these remarkable cells for understanding and treating disease.

Science

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B-complex vitamins , Folate, stem cell proliferation , Stem Cell, B Vitamins, Developmental Cell, University of Georgia

Study Shows New Role for B-Complex Vitamins in Promoting Stem Cell Proliferation

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Folates can stimulate stem cell proliferation independently of their role as vitamins, according to a collaborative study from the University of Georgia and Tufts University, which used an in vitro culture and animal model system in their findings.

Medicine

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Stem Cells, ALS, Lou Gehrig disease, Amyothrophic Lateral Sclerosis, Stem Cell Treatment, American Academy Of Neurology, Journal Neurology, Neurology, Brain, Spine

Stem Cell Treatment for Lou Gehrig’s Disease May Be Safe

A phase II clinical trial in people with amyotrophic lateral sclerosis (ALS), or Lou Gehrig’s disease, suggests that transplanting human stem cells into the spinal cord may be done safely. The research is published in the June 29, 2016, online issue of Neurology®, the medical journal of the American Academy of Neurology. While the study was not designed to determine whether the treatment was effective, researchers noted that it did not slow down the progression of the disease.







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