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Science

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Biology, Medicine, Health, Bone Marrow Transplants, Graft Versus Host Disease

Revised Understanding of Graft-Versus-Host Disease Origins Offers New Direction for Potential Therapies

An international research team led by the University of Michigan Life Sciences Institute is changing the understanding of the key cellular and molecular events that trigger graft-versus-host disease, an often fatal complication of bone marrow transplants.

Medicine

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CDA, Anemia, Stem Cell Transplant, Hematology

First Patient Cured of Rare Blood Disorder

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Using a technique that avoids the use of high-dose chemotherapy and radiation in preparation for a stem cell transplant, physicians at the University of Illinois Hospital & Health Sciences System have documented the first cure of an adult patient with congenital dyserythropoietic anemia.

Medicine

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Stem Cell, human pluripotent stem cells, blood cell precursors, Blood Disorders

New Research Shows Promise for the Production of Patient-Matched Blood Cells for Therapies, Disease Modeling and Drug Screening

The Galat laboratory at Stanley Manne Children’s Research Institute, Ann & Robert H. Lurie Children’s Hospital of Chicago, has developed an elegant system to derive blood cell precursors from human pluripotent stem cells (hPSC). This type of stem cell has the potential to develop into many different kinds of cells in the body, and is capable of participating in organ repair and function. These qualities have prompted scientists to test the use of hPSC to treat some diseases. However, the development of a fully defined system to generate functional blood cell precursors has proven to be a significant challenge. The Galat lab’s findings hold promise to overcome this challenge.

Medicine

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Blood Clots, Blood Thinners, Rivaroxaban, Venous Thromboembolism

New Blood Thinner Better at Preventing Recurrent Blood Clots Than Aspirin

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Venous thromboembolism is a chronic disease, with risks of additional blood clots over a patient’s lifetime. However, many physicians and patients are deciding against long-term treatment with blood thinners because of concern about the risk of bleeding. Some are choosing aspirin instead because they consider it to be safer. This study has shown that the blood thinner rivaroxaban is as safe as aspirin, and more effective at preventing recurrence of life-threatening blood clots in the legs and lungs.

Medicine

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Cardiology, Cardiology and Heart Surgery, American College Of Cardiology, Cholesterol, Congenital Heart Disease, Hypertension, Interventional Cardiology, NewYork-Presbyterian Hospital

NewYork-Presbyterian’s World-Renowned Cardiology Experts Available for Comment at #ACC17

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Medicine

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Dementia, Orthostatic Hypotension, Dizziness

Rapid Blood Pressure Drops in Middle Age Linked to Dementia in Old Age

Middle-aged people who experience temporary blood pressure drops that often cause dizziness upon standing up may be at an increased risk of developing cognitive decline and dementia 20 years later, new Johns Hopkins Bloomberg School of Public Health research suggests.

Science

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Acute Myeloid Leukemia, AML

New Drug Combination Targets Aggressive Blood Cancer

A pair of drugs that may be a one-two punch needed to help combat acute myeloid leukemia (AML), an aggressive blood cancer that kills nearly three-fourths of patients within five years of diagnosis, is the focus of a new multi-center clinical trial that will enroll patients at three sites across the U.S.

Medicine

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lupus treatment, Lupus, Autoimmune Disease, Treatment Advances

Tackling Lupus and Its Renal Complications with Novel Small Molecule Drug Candidate

A new international study co-led by a Rush University Medical Center researcher suggests that a drug starting through the pipeline could ameliorate or even eliminate the symptoms in most sufferers.

Medicine

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Breast Cancer, triple negative breast cancer, Resistance, Chemotherapy, cobination therapy, Leflunomide

Newly Discovered Vulnerability in an Aggressive Breast Cancer Provides Therapeutic Target

• Triple-negative breast cancer quickly becomes resistant to current therapies, leaving patients no therapeutic options. • BIDMC researchers discovered that TNBC cells increase production of pyrimidine nucleotides in response to traditional chemotherapy. • Discovery represents a vulnerability that can be exploited by blocking pyrimidine using an existing inhibitor in combination with chemotherapy.

Medicine

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Liver, Liver Enzymes, Blood Test, Pathology, Hepatology, Gastroenterology, Electronic Health Record

Too Many Patients Get Liver Tests They Don’t Need, Which Can Raise Fears and Costs, Research Shows

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Doctors are ordering too many liver-related blood tests at the same time, new research shows, which may lead to unneeded worry, biopsies and costs. Instead of “overtesting”, the researchers say, doctors should exclude common liver issues before testing for the uncommon ones, and healthcare computer systems should help.







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