Researchers at The Wistar Institute have developed novel synthetic DNA-encoded monoclonal antibodies (DMAbs) directed against PCSK9, a protein key to regulating cholesterol levels in the bloodstream.
The WHO considers Rift Valley fever a potential public health emergency. This study shows just how damaging the virus is during pregnancy and sets the stage for vaccine development.
The gift of promoting a healthy lifestyle is probably the most valuable thing you could give to someone you care about this holiday season, yet it can also turn into a potential landmine of gift-giving disasters.
Over the years, the Centers for Disease Control (CDC) and its partners have made major progress towards reducing lead exposure in the United States. But more work remains in preventing lead poisoning in US children and adults, according to a special supplement to the Journal of Public Health Management and Practice. The journal is published in the Lippincott portfolio by Wolters Kluwer.
Conrad Tucker, associate professor of engineering design and industrial engineering, demonstrates how a mobile-based application will use a cellphone camera and computer vision techniques to capture pulse rate. Tucker and his team use a Masimo Rad-97, a compact, portable patient monitoring device which measures pulse rate, respiratory rate, oxygen saturation, perfusion index, total hemoglobin and pleth variability index, as a ground to compare the application's captured data.
Investigations of lead poisoning cases in New York City (NYC) have found high levels of lead in certain spices purchased abroad, reports a study in the Journal of Public Health Management and Practice, part of a special supplement devoted to Lead Poisoning Prevention. The journal is published in the Lippincott portfolio by Wolters Kluwer.
Physician-scientists from Children’s Hospital of Philadelphia presented updated efficacy and safety data on Kymriah (tisagenlecleucel) --the first-ever FDA-approved personalized CAR T-cell gene immunotherapy for aggressive blood cancers, at the American Society of Hematology annual meeting, as well as first-of-its-kind research on overcoming CAR T-cell resistance.
The Basser Center for BRCA at Penn Medicine’s Abramson Cancer Center, the world’s first comprehensive center aimed at advancing research, treatment, and prevention of BRCA-related cancers, has announced Maria Jasin, PhD, as the recipient of the sixth annual Basser Global Prize. Jasin is a member of the Developmental Biology Program at Memorial Sloan Kettering Cancer Center and a professor at the Weill Graduate School of Medical Sciences at Cornell University.
NCCN Oncology Research Program Awarded $2 Million from Lilly to Study Mechanisms of Resistance to CDK4 & 6 Inhibitors in Breast Cancer Treatment
A new study from the University of Pennsylvania School of Nursing (Penn Nursing) suggests that alcohol consumption may attenuate long-term weight loss in adults with Type 2 diabetes.
With $1.2 million in funding from the National Science Foundation, the Penn State Center for Nanotechnology Education and Utilization, along with Norfolk State University and Tidewater Community College, will form the Southeastern Coalition for Engagement and Exchange in Nanotechnology Education to broaden participation of underrepresented minority students in STEM.
In an update to a global clinical trial stretching from Philadelphia to four continents, the chimeric antigen receptor (CAR) T cell therapy Kymriah® (tisagenlecleucel, formerly CTL019) led to long-lasting remissions in patients with relapsed/refractory (r/r) diffuse large B-cell lymphoma (DLBCL).
Using a larger dataset than all previous studies on the subject combined, researchers found a small but significant connection between brain size and cognitive performance
Chronic myelomonocytic leukemia (CMML) is a rare disease with overlapping features of two categories of bone marrow and blood cell disorders that poses challenges in clinical management. Joint recommendations on diagnosis and treatment of CMML from two European specialty societies were published today in HemaSphere, the official journal of the European Hematology Association (EHA). The journal is published in the Lippincott portfolio by Wolters Kluwer.
Hospitalization rates among homeless adults have increased sharply in recent years, with a very different set of causes from those in non-homeless individuals, reports a study in the January issue of Medical Care. The journal is published in the Lippincott portfolio by Wolters Kluwer.
Scoring models used to predict 30-day readmission risk in the general hospital population may not accurately predict readmissions for patients in the neurocritical care unit, reports a study in the Journal of Neuroscience Nursing, official journal of the American Association of Neuroscience Nurses. The journal is published in the Lippincott portfolio by Wolters Kluwer.
Breast reconstruction using a "free flap" from the patient's abdomen is a safe procedure with a high success rate in older women opting for reconstruction after mastectomy, reports a study in the December issue of Plastic and Reconstructive Surgery®, the official medical journal of the American Society of Plastic Surgeons (ASPS).
Nasal surgery to relieve obstructed breathing can reduce or eliminate chronic headaches in selected patients, reports a paper in the December issue of Plastic and Reconstructive Surgery®, the official medical journal of the American Society of Plastic Surgeons (ASPS).
The U.S. Food and Drug Administration (FDA) has approved the first ever inhibitor drug specifically approved for treating patients with relapsed or refractory acute myeloid leukemia (AML) with a mutation in the Fms-like tyrosine kinase 3 (FLT3) gene.
Fetal alcohol spectrum disorder (FASD) is a common condition with a high economic impact in both children and adults, concludes an updated review in the Journal of Addiction Medicine, the official journal of the American Society of Addiction Medicine (ASAM). The journal is published in the Lippincott portfolio by Wolters Kluwer.
Existing methods for recording and modulating neurons in the brain are either highly invasive or yield results with low spatiotemporal resolution. Mehdi Kiani, Dorothy Quiggle Assistant Professor of Electrical Engineering, is working to change that.
Youth winter sports are underway, and with a recent increase in national attention on the possible dangers of head trauma for athletes, it is important for coaches, parents and players to recognize symptoms of a concussion and also help lessen their likelihood of occurring.
Why do humans have hair on our arms and legs but not on the palms of our hands and the soles of our feet? It’s a fundamental question in human evolution that researchers at the Perelman School of Medicine at the University of Pennsylvania say they’ve found clues to in a new study.
Black patients with atrial fibrillation are significantly less likely to receive oral anticoagulants--particularly newer, more effective versions-- than white and Hispanic patients.
ASRA has awarded the 2018 Chronic Pain Medicine Research Grant to Eellan Sivanesan, MD, for a project looking at the effectiveness of spinal cord stimulation (SCS) for the treatment of chemotherapy-induced painful neuropathy (CIPN). Sivanesan is an assistant professor in the department of anesthesiology and critical care medicine at Johns Hopkins University School of Medicine in Baltimore, MD.
To combat "fake news" that undermines health information, a pair of health scientists explain what to think about when trying to break through people's spheres of influence when it comes to research.
Some patients with coronary artery disease have inadequate blood flow to the heart muscle during periods of mental/emotional stress. This condition – called "mental stress-induced myocardial ischemia" (MSIMI) – is related to the severity of plaque buildup in the coronary arteries in men but not women, reports a study in Psychosomatic Medicine: Journal of Biobehavioral Medicine, the official journal of the American Psychosomatic Society. The journal is published in the Lippincott Portfolio by Wolters Kluwer.
A material based on a natural product of bones and citrus fruits, called citrate, provides the extra energy stem cells need to form new bone tissue, according to a team of Penn State bioengineers.
For patients undergoing orthopaedic surgery, the use of "overlapping" procedures – where the attending surgeon is simultaneously involved in two different surgeries in different operating rooms – does not lead to an increased risk of complications, reports a study in the November 21, 2018 issue of The Journal of Bone & Joint Surgery. The journal is published in the Lippincott portfolio in partnership with Wolters Kluwer.
Penn researchers will present findings at the 60th American Society of Hematology Annual Meeting and Exposition in San Diego, including studies that evaluate CAR T combinations, how the timing of CAR T therapy may impact its effectiveness, and which patients who currently aren’t eligible for CAR T therapy should have greater access.
For the first time, bioengineered spinal discs were successfully implanted and provided long-term function in the largest animal model ever evaluated for tissue-engineered disc replacement. A new Penn Medicine study published in Science Translational Medicine provides compelling translational evidence that the cells of patients suffering from neck and back pain could be used to build a new spinal disc in the lab to replace a deteriorated one. The study, which was performed using goats, was conducted by a multidisciplinary team in the University of Pennsylvania’s Perelman School of Medicine, School of Engineering and Applied Science, and School of Veterinary Medicine.
A protein found in healing muscles of younger mice helps older animals bounce back from injury.
Pharmacogenetic tests are marketed as an aid to psychiatrists in selecting the antidepressant or antipsychotic medication that will work best in individual patients, based on their genetic makeup. But for most patients, these pharmacogenetic tests don't provide much useful information, beyond a basic understanding of how antidepressant and antipsychotic drugs are metabolized, suggests a study in the Journal of Psychiatric Practice. The journal is published in the Lippincott portfolio by Wolters Kluwer.
Patients with stronger-pumping hearts have as many physical and cognitive impairments as those with weaker hearts, suggesting the need for better treatment.
The Abramson Cancer Center joins 27 other leading academic cancer centers from across the United States in creating the most frequently updated cancer care guidelines worldwide, as an NCCN Member Institution.
The Abramson Cancer Center at the University of Pennsylvania announced today that it is joining the National Comprehensive Cancer Network® as its 28th member institution.
Nearly one in five intensive care unit (ICU) survivors die within one year, and increased hospital use is among the factors associated with a higher risk of death, reports a UK population-based study in the January 2019 issue of Critical Care Medicine, the official journal of the Society of Critical Care Medicine (SCCM). Critical Care Medicine is published in the Lippincott portfolio by Wolters Kluwer.
NCCN Guidelines for Patients®: Oral Cancers provides information about mouth cancers for patients and caregivers.
Continuing its mission of high-quality patient care, cutting-edge research and innovation, and training the world’s doctors, Penn Medicine has announced it is expanding to the United Kingdom.
After the first year of an innovative, five-year contract between the University of Pennsylvania Health System (UPHS) and Independence Blue Cross (Independence), the health system is reporting a more than 25 percent cut in hospital readmissions – the largest readmission reduction in both organizations’ history. As part of the first collaboration of its kind in the United States between a health system and a health insurer, the two organizations have launched a new slate of innovations to reduce the number of patients who return to the hospital within a month of going home. The contract provided that Independence wouldn’t pay for the resulting hospitalization in those cases.
The Association of American Cancer Institutes is excited to announce the launch of its redesigned website (aaci-cancer.org). The revamped internet presence will enhance communication between AACI and its 98 cancer center members and within the cancer research and advocacy community.
Decades after two brothers died in childhood from a mitochondrial disease, scientists pinpointed the genetic cause as a founder mutation in an Ashkenazi Jewish ancestor. The discoverers say the causative gene should be included in prenatal genetic carrier screening tests.
Anti-malaria drugs known as chloroquines have been repurposed to treat cancer for decades, but until now no one knew exactly what the chloroquines were targeting when they attack a tumor. Now, researchers from the Abramson Cancer Center of the University of Pennsylvania say they have identified that target – an enzyme called PPT1.
Winners of Penn's Art in Science competition feature beautiful visual images produced using methods of scientific inquiry. And next month, a new medical student group will host its first-ever Penn Med art show to highlight the artistic talents of medical students, faculty, and staff.
New research published in JNCCN-Journal of the National Comprehensive Cancer Network found Latino men were 21% less likely to receive definitive treatment compared to non-Latino white men, with significant differences for younger patients, the uninsured, and those treated at NCI-designated centers.
A higher polygenic risk score—a genetic analysis computed from a combination of several of a person’s genes—is associated with more frequent and severe headaches. The findings support the idea that a propensity for headaches has a genetic basis.
Physician education and training about LGBTQ medical needs are much needed to improve their attitudes and skills in treating LGBTQ patients and increase patients’ satisfaction with their medical care.
Patients with fibromyalgia who use tobacco products are at greater risk for cognitive impairment and other symptoms that affect quality of life, according to the results of a study from the Mayo Clinic in Rochester, MI.
A minimal opiate supply, just a two-day course compared to a traditional two-week prescription, along with a scheduled-dose multimodal pain regimen after surgery limits the use of opiate medication by patients and, subsequently, opiate-related adverse effects while still providing effective pain control and high patient satisfaction.
RSS
Medicine keyboard_arrow_right
Sciencekeyboard_arrow_right
Life keyboard_arrow_right
Business keyboard_arrow_right
Journal News keyboard_arrow_right
By Location keyboard_arrow_right
Meetings, Grants, and Events keyboard_arrow_right