New research at the 2018 ACR/ARHP Annual Meeting builds on current evidence that hematopoietic stem cell transplantation can significantly improve long-term outcomes for patients with severe scleroderma when compared to use of conventional treatment with cyclophosphamide.
Hematopoietic stem cell transplantation showed benefit in a subset of patients with systemic sclerosis who tend not to improve on immunosuppressive therapies like mycophenolate mofetil, according to new research findings presented this week at the 2018 ACR/ARHP Annual Meeting.
Vascular ultrasound is sensitive enough to use as a first-line imaging test in patients suspect to have giant cell arteritis, according to new research findings presented this week at the 2018 ACR/ARHP Annual Meeting.
Scientists at the UCLA Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research and the Stein Eye Institute have been awarded a $5.1 million grant from the California Institute for Regenerative Medicine to advance the development of a novel therapy for blinding retinal conditions.
A team of Tufts University-led researchers has developed three-dimensional (3D) human tissue culture models for the central nervous system that mimic structural and functional features of the brain and demonstrate neural activity sustained over a period of many months.
Using a combination of computational modeling and experimental techniques, a research team has developed new information about how intercellular communication affects the differentiation of an embryonic stem cell colony over time.
UT Southwestern Professor Dr. Sean Morrison, Director of the Children’s Medical Center Research Institute (CRI) at UT Southwestern, has been elected to the National Academy of Medicine (NAM), one of the highest honors in the fields of health and medicine.
Led by Andreas H. Gomoll, MD, sports medicine surgeon at Hospital for Special Surgery (HSS), the study is looking at the effects on knee function of ReNu, an allograft product composed of human amniotic membrane and cells from the amniotic fluid.
University of Colorado Cancer Center study shows that "normal" gene CDK1 interacts with "abnormal" gene Sox2 to keep cancer stem cells "stemmy."
UT Southwestern researchers attempting to transform supporting brain cells into neurons instead reprogrammed mature inhibitory neurons into a different type of neuron that creates the neurotransmitter lost in Parkinson’s disease.
A randomized clinical trial at Memorial Sloan Kettering Cancer Center (MSK) has shown that fecal microbiota transplants (FMTs)
Researchers at the University of Illinois at Chicago have received a four-year, $5.25 million grant from the U.S. Department of Defense to lead a multi-site clinical trial to test the efficacy of a stem cell-based treatment for eye injuries.The treatment uses mesenchymal stem cells — cells that can differentiate into fat, bone or cartilage, but which also produce an abundance of anti-inflammatory factors that have been shown to speed healing and reduce scaring in experimental models of eye injury.
A technique using umbilical cord blood stem cells could be a promising new approach for repair of cleft palate in infants, reports a paper in The Journal of Craniofacial Surgery, published in the Lippincott portfolio by Wolters Kluwer.
Splitting up and getting back together is always hard to do, but for proteins, it's almost impossible. However, a computer-guided algorithm may help scientists find just the right spot to split a protein and then reassemble it to functionality.
روتشستر، مينيسوتا – طوّر الباحثون لدى Mayo Clinic أداة تكهنية جديدة تعتمد على الجينات للتكهن بمتلازمات خلل التنسج النقوي (MDS). ومن المقرر أن تنشر نتائج اكتشافهم في عدد أكتوبر المطبوع من مجلة أحداث Mayo Clinic.
Pesquisadores da Mayo Clinic desenvolveram uma nova ferramenta de prognóstico com base em genética para a síndrome mielodisplástica (MDS). As descobertas da equipe foram publicadas na edição de outubro da Mayo Clinic Proceedings.
In two newly published papers, a scientific team at Case Western Reserve University School of Medicine reports on the discovery and implementation of a new, more efficient method for generating an important brain stem cell in the laboratory. The findings pave the way for greater understanding of the underlying mechanisms of neurological disorders of myelin and ultimately, possible new treatment and prevention options. The studies were published in the September issues of Nature Communications and Stem Cell Reports.
Scientists have long argued over which cells enable salamanders to grow back lost limbs. By tracking lineages and characterising individual cells, researchers could now show that connective tissue cells develop stem-cell-like properties and underlie the regeneration of legs. The findings were published in the journal “Science”.
For many cancer patients, high-intensity treatments such as intubation and ICU admission are administered during their end-of-life care, but little is known about whether that care is in line with a patient’s wishes and treatment goals.
Scientists working to bioengineer the entire human gastrointestinal system in a laboratory now report using pluripotent stem cells to grow human esophageal organoids. The newly published research in the journal Cell Stem Cell is the first time scientists have been able to grow human esophageal tissue entirely from pluripotent stem cells (PSCs), which can form any tissue type in the body.
Researchers generated stable lines of spinal cord neural stem cells in culture. Transplanted into a rat model of spinal cord injury, the cells enabled robust regeneration of functional neurons along the length of the spine.
Omacetaxine (to block protein synthesis) with venetoclax (to block oxidative phosphorylation), was highly effective against CD123+ leukemia stem cells.
Scientists with the Virginia Tech Carilion Research Institute say a gene involved in the body’s sleep cycle is a potential target for therapies to help patients with a deadly form of brain cancer known as glioblastoma. This discovery, to be published in the journal Scientific Reports on Tuesday, Sept. 11, points to a subtype of a particular gene that apparently is enabling the survival of cancer cells, although it is more commonly associated with circadian rhythms — the body’s 24-hour biological clock.
Anyone with arthritis can appreciate how useful it would be if scientists could grow cartilage in the lab. To this end, Keck School of Medicine of USC scientists in the USC Stem Cell laboratory of Denis Evseenko, MD, PhD, collaborated with colleagues at several institutions to provide new insights into how gene activity drives the development of cartilage. Their findings appear today in Nature Communications.
Writing in the current online issue of the journal Stem Cells and Development, researchers at University of California San Diego School of Medicine describe development of a rapid, cost-effective method to create human cortical organoids directly from primary cells.
Researchers from the University of California, Irvine have identified intrinsic cell properties that influence the fate of neural stem cells, affecting what type of brain cell they will form: neurons, astrocytes, or oligodendrocytes. This discovery could give scientists a new way to predict or control the fate of stem cells, improving their use in transplantation therapies.
Papers on stem cell methods and models in toxicology; comparative toxicogenomics and AOPs; machine vs. animal models; pesticides and asthma; and estimating risk without animals featured in latest issue of Toxicological Sciences.
UNC Lineberger Comprehensive Cancer Center researchers showed they could shrink tumors in laboratory models of medulloblastoma. The study, published in PLOS ONE, is a necessary step toward developing clinical trials that would see if the approach works for children.
Researchers at University of California San Diego School of Medicine have launched a phase Ib clinical trial to assess the safety and tolerability of cirmtuzumab, in combination with standard chemotherapy, to treat metastatic or locally advanced breast cancer that cannot be surgically removed.
Muscles of the elderly and of patients with Duchene muscular dystrophy have trouble regenerating. A new nanohydrogel with muscle stem cells has boosted muscle growth in mouse models while protecting the stem cells from immune reactions that usually weaken or destroy them.
New research from Wake Forest Institute for Regenerative Medicine (WFIRM) scientists into the health risks of space radiation exposure shows a potential greater risk than previously thought.
It’s a longstanding mystery why salamanders can perfectly regenerate their tails whereas lizard tails grow back all wrong. By transplanting neural stem cells between species, Pitt researchers have discovered that the lizard’s native stem cells are the primary factor hampering tail regeneration.
Engineers and medical researchers at the University of Minnesota have teamed up to create a groundbreaking 3D-printed device that could someday help patients with long-term spinal cord injuries regain some function.
- Scientists at Huntsman Cancer Institute (HCI) at the University of Utah (U of U), in collaboration with the Salk Institute for Biological Studies, have generated the first single cell resolution atlas of genes that control the formation of breast tissue. The atlas provides a comprehensive molecular map that will be used to help researchers understand how breast cancers form and to pinpoint new ways to prevent, diagnose, and treat the disease.
Researchers at University of California San Diego School of Medicine report that they have successfully created spinal cord neural stem cells (NSCs) from human pluripotent stem cells (hPSCs) that differentiate into a diverse population of cells capable of dispersing throughout the spinal cord and can be maintained for long periods of time.
Researchers from the Stowers Institute for Medical Research and collaborators have identified a way to expand blood-forming, adult stem cells from human umbilical cord blood (hUCB).
The fight against cystic fibrosis (CF) has taken a major step forward, with pioneering research by University of Adelaide scientists showing that cells causing the debilitating genetic disorder could be successfully replaced with healthy ones.
Scientists at Sanford Burnham Prebys Medical Discovery Institute (SBP), in collaboration with the Fondazione Santa Lucia IRCCS in Rome, have discovered a new disease-specific role of FAP cells in muscle wasting and scarring, indicating a potential new avenue for treating motor neuron diseases.
In a new study, published in this week’s issue of Cell Reports, researchers at the University of California San Diego School of Medicine scrutinized the whole genome sequences of 18 induced pluripotent stem cell lines derived from skin cells that they had reprogrammed to identify and characterize somatic mutations.
The governing board of the California Institute for Regenerative Medicine (CIRM) unanimously approved this week two grants worth more than $2.2 million to University of California San Diego School of Medicine researchers investigating stem cell-based therapies for a rare genetic disorder that affects the heart and a chronic, progressive affliction of the lungs.
The latest research and feature news on vision in the Vision News Source
Research led by Professor G.V. Shivashankar of the Mechanobiology Institute, Singapore and Italy’s IFOM has revealed that mature cells can be reprogrammed into redeployable stem cells without direct genetic modification – by confining them to a defined geometric space for an extended period of time.
The Coriell Institute for Medical Research's quality managment system has been certified to the updated ISO 9001:2015 standards.
A drug used in stem cell therapy to treat certain cancers may also protect against cigarette smoke-induced lung injury. The study, published ahead of print in the American Journal of Physiology—Lung Cellular and Molecular Physiology, was chosen as an APSselect article for July.
Researchers have found that cancer stem cells exist in more than one state and can change form, sliding back and forth between a dormant state and a rapidly growing state. The cell's metabolism controls this change, suggesting a possible way in to attack the stem cells.
Researchers develop a simple and efficient method to induce human pluripotent stem cells to become blood, which could be key in future treatments for blood disorders, immune deficiencies and cancer
Emerging CAR-T immunotherapies leverage modified versions of patient’s T-cells to target and kill cancer cells. In a new study, published June 28 online in Cell Stem Cell, researchers at University of California San Diego School of Medicine and University of Minnesota report that similarly modified natural killer (NK) cells derived from human induced pluripotent stem cells (iPSCs) also displayed heightened activity against a mouse model of ovarian cancer.
Mesenchymal stem cells exist in the outer layer of arteries in adult humans, and appear to play a key role in mediating vascular diseases, including coronary artery disease.
The Monell Center, in partnership with the University of Florida Center for Smell and Taste and the Rocky Mountain Taste and Smell Center at the University of Colorado School of Medicine, will host an interdisciplinary two-day conference in November 2018 to establish a roadmap for treatment-focused research on smell and taste disorders. The “Identifying Treatments for Taste and Smell Disorders” meeting will include sessions focused on the science of sensory disorders and their treatment and also on patient education.
Researchers at the University of Virginia School of Medicine have discovered that microglia, specialized immune cells in the brain, play a key role in clearing dead material after brain injury. The study, which will be published June 25 in the Journal of Experimental Medicine, reveals that microglia gobble up the remnants of injured neurons, which could prevent the damage from spreading to neighboring neurons and causing more extensive neurodegeneration.
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