Scientists have captured the most information yet about proteins within a single human cell, giving scientists one of their clearest looks yet at the molecular happenings inside a human cell. The team detected on average more than 650 proteins in each cell – many times more than conventional techniques capture from single cells.
Stem cells that make blood cells in fish flourish in the shade provided by a newly discovered cellular “umbrella” that keeps them safe from UV damage.
Researchers at UC Davis have confirmed that autologous hematopoietic stem cell transplant improves survival for people suffering from multiple myeloma, yet many potentially eligible patients never undergo the procedure.
Research in mice shows that a protein made by the stem cells that give rise to neurons, but not by neurons themselves, is key to brain cells’ ability to migrate during development and assume their proper positions. This primordial protein acts by clinging onto thousands of sites in the genome, affecting the activity of multiple genes that regulate brain development. The findings could yield valuable clues for a variety of neurodevelopmental disorders.
Researchers share perspective about Clinical Trials in a Dish (CTiD), a novel strategy that bridges preclinical testing and clinical trials.
Reporting results from a first-in-human phase I clinical trial, researchers at University of California San Diego School of Medicine have found that treatment with cirmtuzumab, an experimental monoclonal antibody-based drug, measurably inhibited the “stemness” of chronic lymphocytic leukemia cancer (CLL) cells — their ability to self-renew and resist terminal differentiation and senescence.
The latest research, features, and experts on HIV and AIDS.
In a new paper, published in the May 23 online issue of Science Translational Medicine, researchers at University of California San Diego School of Medicine report that adult rat myelin actually stimulated axonal outgrowth in rat neural precursor cells (NPCs) and human induced pluripotent (iPSC)-derived neural stem cells (NSCs).
Researchers at University of California San Diego School of Medicine and their collaborators have developed a technique that allows them to speed up or slow down human heart cells growing in a dish on command — simply by shining a light on them and varying its intensity. The cells are grown on a material called graphene, which converts light into electricity, providing a more realistic environment than standard plastic or glass laboratory dishes.
Researchers from the Albert Einstein College of Medicine in New York have discovered that a signaling protein elevated in patients with acute myeloid leukemia (AML) plays a much wider role in the disease than previously thought. The study, which will be published May 17 in the Journal of Experimental Medicine, raises hopes that current efforts to target this signaling protein could be a successful strategy to treat AML and other blood cancers.
The University of Kansas Medical Center announced that the U.S. Food and Drug Administration (FDA) has cleared it to begin a first-in-human clinical trial of MSCTC-0010 in patients with de novo high-risk acute or steroid-refractory acute graft-versus-host disease (HR/SR aGvHD).
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In a new paper, publishing Mary 9 in Science Translational Medicine, an international team led by scientists at University of California San Diego School of Medicine describe successfully grafting induced pluripotent stem cell (iPSC)-derived neural precursor cells back into the spinal cords of genetically identical adult pigs with no immunosuppression efforts. The grafted cells survived long-term, displayed differentiated functionality and caused no tumors.
The new research opens the door to studying common brain conditions such as autism, schizophrenia, addiction and Alzheimer’s disease under reproducible conditions in a dish.
New research from the Stowers Institute for Medical Research reveals that a DNA regulatory element within the Hoxb cluster globally mediates signals to the majority of Hoxb genes to control their expression in blood-forming stem cells.
The FSMB has released best practices and recommendations for the regulation of stem cell and regenerative therapies
University of Illinois at Chicago researchers have discovered a way turn pluripotent stem cells into atrial cells. The discovery will enable them to better study atrial fibrillation, the most common heart rhythm disorder.
Harvard Medical School scientists developed a new technique to analyze, with unprecedented quantitative precision, how cells initiate the removal of defective mitochondria by the cell’s autophagy, or “self-eating,” system.
The U.S. Food and Drug Administration (FDA) has expanded approval for a personalized cellular therapy developed at the University of Pennsylvania’s Abramson Cancer Center, this time for the treatment of adult patients with relapsed or refractory large B-Cell lymphoma after two or more lines of systemic therapy. Today’s approval includes treatment of diffuse large B-cell lymphoma (DLBCL) – the most common form of non-Hodgkin’s lymphoma – as well as high grade B-cell lymphoma and DLBCL arising from follicular lymphoma.
A presentation at the 2018 American Association of Neurological Surgeons Annual Scientific Meeting
By treating living cells like tiny absorbent sponges, researchers have developed a potentially new way to introduce molecules and therapeutic genes into human cells.
A new study in the journal Nature Cell Biology has uncovered information about a key stage that human embryonic cells must pass through just before an embryo implants. The research, led by UCLA biologist Amander Clark, could help explain certain causes of infertility and spontaneous miscarriage. Infertility affects around 10 percent of the U.
Doctors at the University of Illinois Hospital have cured seven adult patients of sickle cell disease, an inherited blood disorder primarily affecting the black community, using stem cells from donors previously thought to be incompatible, thanks to a new transplant treatment protocol.
A new study at Washington University School of Medicine in St. Louis shows an investigational drug prevents graft-versus-host disease, a dangerous side effect of stem cell transplantation.
A team led by Columbia University Biomedical Engineering Professor Gordana Vunjak-Novakovic has designed a creative new approach to help injured hearts regenerate by applying extracellular vesicles secreted by cardiomyocytes rather than implanting the cells. The study shows that the cardiomyocytes derived from human pluripotent stem cells (derived in turn from a small sample of blood) could be a powerful, untapped source of therapeutic microvesicles that could lead to safe and effective treatments of damaged hearts.
The University of Texas Health Science Center at Houston (UTHealth) has received funding through a public/private partnership for the first-ever clinical trial investigating a stem cell therapy for early treatment and prevention of complications after severe traumatic injury.
Scientists have re-created brain neurons of obese patients using "disease in a dish" technology, offering a new method to study the brain's role in obesity and possibly help tailor treatments to specific individuals.
Clinical trial planning is underway at MedStar Heart & Vascular Institute to determine whether a novel stem cell therapy will improve heart function for patients with heart failure.
Investigators at Cedars-Sinai are exploring a new way to treat amyotrophic lateral sclerosis (ALS) by transplanting specially engineered neural cells into the brain. Their new study shows the transplanted cells delayed disease progression and extended survival in animal models.
Cells acquire distinct fates and functions during development. A study from the IMBA reveals a new mechanism of cell fate specification involving the regulation of cell metabolism.
Physicians and researchers at the USC Roski Eye Institute have collaborated with other California institutions to show that a first-in-kind stem cell–based retinal implant is feasible for use in people with advanced dry age-related macular degeneration.
Researchers have developed a radically new approach to growing in the lab adult-like human heart muscle from human induced pluripotent stem cells in only four weeks. They compressed the development timeframe into a faster, more complete transition to cardiac maturity than any other team has done so far. They formed cardiac tissues from early-stage iPSC-derived cardiomyocytes, soon after the initiation of spontaneous contractions, by subjecting the cells encapsulated in hydrogel to increasingly intense physical conditioning.
Evan Y. Snyder, M.D., Ph.D., professor and founding director, Center for Stem Cells & Regenerative Medicine at Sanford Burnham Prebys Medical Discovery Institute (SBP) and professor at the University of California San Diego, has been elected to membership in the Association of American Physicians (AAP).
A team of computational biologists has developed an algorithm that can ‘align’ multiple sequencing datasets with single-cell resolution. The new method has implications for better understanding how different groups of cells change during disease progression, in response to drug treatment, or across evolution.
Researchers at Houston Methodist used computer modeling to find an existing investigational drug compound for leukemia patients to treat triple negative breast cancer once it spreads to the brain.
Three tumor samples collected over time from a single patient show how cancer evolves in response to treatment.
Young women with premature ovarian insufficiency (POI) may be able to use their own bone marrow stem cells to rejuvenate their ovaries and avoid the effects of premature menopause, new research suggests. The preliminary results from the ongoing ROSE clinical trial will be presented Tuesday at ENDO 2018, the 100th annual meeting of the Endocrine Society, in Chicago, Ill.
Cells made by fusing a normal human muscle cell with a muscle cell from a person with Duchenne muscular dystrophy —a rare but fatal form of muscular dystrophy — were able to significantly improve muscle function when implanted into the muscles of a mouse model of the disease. The findings are reported by researchers from the University of Illinois at Chicago in the Stem Cell Reviews and Reports.
Whether caused by an undetected birth defect or by a heart attack (myocardial infarction), when a heart sustains damage, it can be difficult to repair.
Researchers have identified a lung stem cell that repairs the organ’s gas exchange compartment. They isolated and characterized these progenitor cells from mouse and human lungs and demonstrated they are essential to repairing lung tissue damaged by severe influenza and other respiratory ailments.
Newly identified stem cells in the lung that multiply rapidly after a pulmonary injury may offer an opportunity for innovative future treatments that harness the body’s ability to regenerate. Scientists describe cells that could become a new tool to treat lung diseases across the lifespan, from premature infants to the elderly.
Led by researchers at University of California San Diego School of Medicine, a diverse team of neuroscientists and surgeons successfully grafted human neural progenitor cells into rhesus monkeys with spinal cord injuries. The grafts not only survived, but grew hundreds of thousands of human axons and synapses, resulting in improved forelimb function in the monkeys.
Researchers at The University of Texas at Dallas have devised a new technique to isolate aggressive cells thought to form the root of many hard-to-treat metastasized cancers, a significant step toward developing new drugs that might target these cells.
UCLA researchers used fluorescent colored proteins to trace how cardiomyocytes — cells in heart muscle that enable it to pump blood — are produced in mouse embryos. The findings could eventually lead to methods for regenerating heart tissue in human adults.
A team of researchers at the University of Georgia's Regenerative Bioscience Center and ArunA Biomedical, a UGA startup company, have developed a new treatment for stroke that reduces brain damage and accelerates the brain's natural healing tendencies in animal models.
People with a mutated ATF6 gene have a malformed or missing fovea, severely limiting vision. UC San Diego School of Medicine researchers first linked ATF6 to this type of vision impairment. Now the team discovered that a chemical that activates ATF6 converts patient stem cells into blood vessels.
Replenishing a naturally occurring heart protein could improve stem cell therapy after a heart attack
In fruit flies, repeating genetic elements shrink with age, but then expand in future generations, a resurgence that may help explain how some cells stay immortal.
Cleveland Clinic researchers have published findings in Nature Communications on a new stem cell pathway that allows a highly aggressive form of breast cancer - triple-negative breast cancer - to thrive.
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