Feature Channels: Immunology

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5-Sep-2018 10:25 AM EDT
What is Shared Decision-Making and How Does It Work for Allergists?
American College of Allergy, Asthma and Immunology (ACAAI)

A new article published in Annals of Allergy, Asthma and Immunology, walks allergists and other health care providers through the steps involved in shared decision-making (SDM). It also details what is, and what is not, SDM.

Released: 6-Sep-2018 12:05 PM EDT
Mayo Clinic physicians receive Stand up to Cancer Catalyst Award for melanoma research
Mayo Clinic

Mayo Clinic physicians Matthew Block, M.D., Ph.D. and Tina Hieken, M.D., have received a Stand up to Cancer (SU2C) Catalyst Award to fund melanoma research and a neoadjuvant clinical trial.

Released: 6-Sep-2018 11:05 AM EDT
Immune System Emerges as Potential Partner in Opioid Addiction Fight
Vanderbilt University

There’s promise in specific immune system peptides – amino acid compounds that signal cells how to function – affecting brain activity.

Released: 5-Sep-2018 11:40 AM EDT
GW Researcher Investigating Link between Parasitic Infection and Bile Duct Cancer
George Washington University

Paul Brindley, PhD, at the GW School of Medicine and Health Sciences, has received more than $1.7 million from the National Cancer Institute at the National Institutes of Health to investigate the cellular and molecular links between liver fluke infection and bile duct cancer.

Released: 5-Sep-2018 11:40 AM EDT
Enhancing the Efficacy of Immune Checkpoint Inhibitor Therapy Using a Novel Treatment Combination
Wistar Institute

A combination of a novel inhibitor of the protein CK2 (Casein kinase 2) and an immune checkpoint inhibitor has dramatically greater antitumor activity than either inhibitor alone, according to research from The Wistar Institute that was published online in Cancer Research.

Released: 4-Sep-2018 7:05 PM EDT
Fred Hutch Tip Sheet: Next-generation CAR T-cell immunotherapies; rural-urban cancer care disparities; organizing chromosomes in egg and sperm cells
Fred Hutchinson Cancer Center

The August tip sheet from Fred Hutch includes story ideas about next-gen CAR T-cell immunotherapies, cancer care disparities in rural and urban settings, organizing chromosomes in egg and sperm cells, decoding our immune system's memories and more.

4-Sep-2018 12:05 PM EDT
Clinical Trial Shows Best Outcomes to Date for Older Hodgkin Lymphoma Patients
Rutgers Cancer Institute of New Jersey

Recently published results of a phase 2 clinical trial have shown the best outcomes to date for newly diagnosed older Hodgkin lymphoma patients treated with brentuximab vedotin given before and after doxorubicin, vinblastine and dacarbazine (AVD) chemotherapy, which is the standard of care.

Released: 4-Sep-2018 1:05 PM EDT
Synthetic DNA Technology Provides a Novel Strategy for Effective Delivery of a Complex Anti-HIV Agent
Wistar Institute

Wistar scientists have applied their synthetic DNA technology to engineer a novel eCD4-Ig anti-HIV agent and to enhance its potency in vivo, providing a new simple strategy for constructing complex therapeutics for infectious agents as well as for diverse implications in therapeutic delivery.

28-Aug-2018 9:30 AM EDT
New Program Boosts Use of HIV Medications in Injection-Drug Users
Ohio State University

A relatively simple effort to provide counseling and connect injection-drug users with resources could prove powerful against the spread of HIV in a notoriously hard-to-reach population, new research suggests.

30-Aug-2018 8:05 AM EDT
Insulin Gives an Extra Boost to the Immune System
University Health Network (UHN)

The role of insulin as a boost to the immune system to improve its ability to fight infection has been detailed for the first time by Toronto General Hospital Research Institute (TGHRI) scientists.

Released: 30-Aug-2018 8:05 AM EDT
The Medical Minute: Immunization the Best Defense Against Measles
Penn State Health

High fever. Cough. Runny nose. Red, watery eyes. It may not be the flu. It could be measles.

Released: 30-Aug-2018 8:05 AM EDT
Stigmatizing Views and Myths about Psoriasis Are Pervasive in the United States
Perelman School of Medicine at the University of Pennsylvania

The stigma associated with the autoimmune disease psoriasis may lead people to avoid patients who show signs of the condition, including not wanting to date, shake hands, or have people in their homes if they suffer from the disease. New multidisciplinary research involving both psychologists and dermatologists from the Perelman School of Medicine at the University of Pennsylvania is the first to examine how common this stigma may be among the general population of the United States as well as among medical students.

Released: 29-Aug-2018 10:00 AM EDT
Failing Immune System ‘Brakes’ Help Explain Type 1 Diabetes in Mice
Johns Hopkins Medicine

Immune reactions are usually a good thing--the body's way of eliminating harmful bacteria and other pathogens.

Released: 29-Aug-2018 8:00 AM EDT
Using Gene Therapy to Build an Immune System in Newborns Without One
Seattle Children's Hospital

Gene therapy holds promise of a potentially safer, more effective path to a cure in infants born without the critical infection-fighting cells of the immune system.Out of every 60,000 births, a baby arrives to face the world without a fully functioning immune system leaving them unequipped to fight even the most common infections.

24-Aug-2018 2:05 PM EDT
Discovery Could Lead to Higher Response Rates for Bladder Cancer Patients Treated with Immunotherapy
Mount Sinai Health System

Mount Sinai researchers have discovered that a particular type of cell present in bladder cancer may be the reason why so many patients do not respond to the groundbreaking class of drugs known as PD-1 and PD-L1 immune checkpoint inhibitors, which enable the immune system to attack tumors.

Released: 28-Aug-2018 2:00 PM EDT
Crowdsourcing Campaigns Increase HIV Testing Among At-Risk Men in China
University of North Carolina Health Care System

Researchers at the University of North Carolina at Chapel Hill have found that crowdsourced campaigns can motivated men at-risk of HIV infection in China to get tested.

24-Aug-2018 2:05 PM EDT
Immune System Prioritizes Distinct Immune Responses in Infants with Flu
St. Jude Children's Research Hospital

The immune system appears to put a premium on maintaining lung function in infants infected with the influenza virus by mounting a rapid response to repair damaged cells, according to research led by St. Jude Children’s Research Hospital.

27-Aug-2018 3:05 PM EDT
A Non-Canonical Strategy May Improve Cancer Radiotherapy
University of Chicago Medical Center

Interactions between radiation therapy and the immune system can improve cancer treatment. The cellular carnage caused by radiation attracts scavengers, such as dendritic cells, that present cancer cell fragments to T cells. This study suggests novel ways to improve treatment by using radiation to boost immunotherapy.

Released: 28-Aug-2018 8:45 AM EDT
Scientists Sweep Cellular Neighborhoods Where Zika Hides Out
American Society for Biochemistry and Molecular Biology (ASBMB)

Researchers are reporting the protein/protein interactome of Zika virus and its human host cells with a proteomic approach that gives unprecedented insight into membrane-bound protein interactions. The data reveal a new role for a familiar organelle in viral replication.

   
Released: 28-Aug-2018 7:05 AM EDT
Combination Approach Shows Promise for Beating Advanced Melanoma
University of California, Los Angeles (UCLA), Health Sciences

A UCLA-led study has found that a treatment that uses a bacteria-like agent in combination with an immunotherapy drug could help some people with advanced melanoma, an aggressive form of skin cancer, live longer.

Released: 27-Aug-2018 1:05 PM EDT
New Urine Dipstick Test Detects Cause of Disease That Blinds Millions
Scripps Research Institute

Scientists at Scripps Research have developed a urine diagnostic to detect the parasitic worms that cause river blindness, also called onchocerciasis, a tropical disease that afflicts 18 to 120 million people worldwide.

   
Released: 27-Aug-2018 11:05 AM EDT
How Malaria Parasites Take Over Human Red Blood Cells, According to Newly Published Research
Iowa State University

The parasites that cause malaria make themselves at home inside a host’s red blood cells. An Iowa State University scientist has shown in a pair of newly published articles just how that process works. This new understanding could help to identify new ways to treat malaria.

Released: 27-Aug-2018 8:05 AM EDT
CAR T Cell Therapy Receives Approval for Use Across European Union
Perelman School of Medicine at the University of Pennsylvania

The European Commission (EC) has approved a personalized cellular therapy developed at the University of Pennsylvania’s Abramson Cancer Center, making it the first chimeric antigen receptor (CAR) T cell therapy permitted for use in the European Union in two distinct indications.

Released: 23-Aug-2018 2:05 PM EDT
The Unexpected Upside of E. coli
University of Colorado Boulder

Best known as a pathogen that causes food poisoning or steals nutrients away from its host, the E. coli bacterium actually plays a critical role in promoting health by producing a compound that helps cells take up iron.

Released: 21-Aug-2018 2:00 PM EDT
First in-Depth Profile of CAR T-Cell Signals Suggests How to Improve Immunotherapy
Fred Hutchinson Cancer Center

CAR T-cell therapy, which reprograms immune cells to fight cancer, has shown great promise in people with some blood cancers who have not responded to other treatments. But until now, the underlying biological pathways enabling anti-cancer responses have not been thoroughly examined.

Released: 16-Aug-2018 10:05 AM EDT
Transgenic Rice Plants Could Help to Neutralize HIV Transmission
Iowa State University

An international research group, which included an ISU scientist, has proven that three proteins that can help prevent the spread of HIV can be expressed in transgenic rice plants. Using plants as a production platform could provide a cost-effective means of producing prophylactics, particularly in the developing world.

Released: 15-Aug-2018 5:05 PM EDT
Researchers Uncover Immune Cell Dysfunction Linked to Photosensitivity
Hospital for Special Surgery

Researchers at Hospital for Special Surgery (HSS) have discovered that a type of immune cell known as Langerhans appears to play an important role in photosensitivity, an immune system reaction to sunlight that can trigger severe skin rashes.

15-Aug-2018 10:05 AM EDT
This Matrix Delivers Healing Stem Cells to Injured Elderly Muscles
Georgia Institute of Technology

Muscles of the elderly and of patients with Duchene muscular dystrophy have trouble regenerating. A new nanohydrogel with muscle stem cells has boosted muscle growth in mouse models while protecting the stem cells from immune reactions that usually weaken or destroy them.

Released: 15-Aug-2018 9:20 AM EDT
Protein Droplets Keep Neurons at the Ready and Immune System in Balance
Howard Hughes Medical Institute (HHMI)

Discoveries by two HHMI investigators show how proteins that organize into liquid droplets inside cells make certain biological functions possible.

   
Released: 14-Aug-2018 2:05 PM EDT
Get Ready for Fall Allergies Because They’re Headed Your Way
American College of Allergy, Asthma and Immunology (ACAAI)

You may not want to think about fall allergies, but if you start planning now, your allergy symptoms will likely be much less severe, and you’ll be able to enjoy the beauty the fall season brings.

9-Aug-2018 12:05 PM EDT
Mount Sinai Researchers Artificially Generate Immune Cells Integral to Creating Cancer Vaccines
Mount Sinai Health System

For the first time, Mount Sinai researchers have identified a way to make large numbers of immune cells that can help prevent cancer reoccurrence, according to a study published in August in Cell Reports.

Released: 14-Aug-2018 10:20 AM EDT
Space Travel Carries Risks to Immune System Health
Atrium Health Wake Forest Baptist

New research from Wake Forest Institute for Regenerative Medicine (WFIRM) scientists into the health risks of space radiation exposure shows a potential greater risk than previously thought.

   
Released: 14-Aug-2018 10:00 AM EDT
Seattle Cancer Care Alliance again ranked in the Top 10 in the nation for adult cancer care
Seattle Cancer Care Alliance

Seattle Cancer Care Alliance (SCCA) / University of Washington Medical Center (UWMC) is ranked among the best in the nation for adult cancer care by U.S. News & World Report for 2018-2019.

Released: 14-Aug-2018 12:05 AM EDT
U.S. News & World Report ‘Best Hospitals Honor Roll’: Mayo Clinic No. 1 in Phoenix and Arizona
Mayo Clinic

PHOENIX ─ Mayo Clinic Hospital, Phoenix, Arizona is again ranked No. 1 in Arizona and the Phoenix metro area, and No. 11 nationally by U.S. News & World Report. This marks the second time Mayo Clinic has been recognized with two hospitals on U.S. News & World Report's "Best Hospitals Honor Roll," which includes the top 20 hospitals in the nation. Mayo Clinic’s campus in Rochester, Minnesota, ranked No. 1 nationally. The results were announced today on the U.S. News & World Report web site.

Released: 13-Aug-2018 10:05 AM EDT
Duke Team Finds Missing Immune Cells That Could Fight Lethal Brain Tumors
Duke Health

Researchers at Duke Cancer Institute have tracked the missing T-cells in glioblastoma patients. They found them in abundance in the bone marrow, locked away and unable to function because of a process the brain stimulates in response to glioblastoma, to other tumors that metastasize in the brain and even to injury.

Released: 13-Aug-2018 10:00 AM EDT
$1M Commitment from Embrace Kids Foundation Supports Recruitment of Pediatric Cancer Research Faculty at Rutgers Cancer Institute of New Jersey
Rutgers Cancer Institute of New Jersey

Rutgers Cancer Institute of New Jersey now has additional resources in the fight against pediatric cancers and blood disorders, thanks to a $1 million commitment from Embrace Kids Foundation that will support the recruitment of pediatric cancer research faculty.

Released: 9-Aug-2018 11:00 AM EDT
Scientists Identify Genetic Marker for Gastric Cancer Prognosis
Atrium Health Wake Forest Baptist

Although immunotherapy is seen as a very promising treatment for cancer, currently only 20 to 30 percent of patients respond positively. Being able to identify the people most likely to benefit from the costly therapy is a Holy Grail for oncologists.

6-Aug-2018 1:05 PM EDT
Cancer Cells Send Out “Drones” to Battle Immune System from Afar
Perelman School of Medicine at the University of Pennsylvania

Checkpoint inhibitor therapies have made metastatic melanoma and other cancers a survivable condition for 20 to 30 percent of treated patients, but clinicians have had very limited ways of knowing which patients will respond. Researchers have uncovered a novel mechanism by which tumors suppress the immune system. Their findings also usher in the possibility that a straightforward blood test could predict and monitor cancer patients’ response to immunotherapy.

6-Aug-2018 11:05 AM EDT
Innate Lymphoid Cells (ILCs) form an essential line of defense against enteric bacteria
La Jolla Institute for Immunology

Mice deficient in innate lymphoid cells are vulnerable to lethal infection by the bacterial pathogen Yersinia enterocolitica (YE), which causes some forms of food poisoning. Moreover, activation by a cytokine called LIGHT, which is a member of the tumor necrosis factor (TNF) superfamily, is necessary for ILCs to mount an anti-bacterial response.

Released: 8-Aug-2018 9:00 AM EDT
Johns Hopkins Kimmel Cancer Center Researchers Using Big Data to Predict Immunotherapy Responses
Johns Hopkins Medicine

In the age of Big Data, cancer researchers are discovering new ways to monitor the effectiveness of immunotherapy treatments.

Released: 7-Aug-2018 8:00 AM EDT
Researchers Uncover Potential New Drug Targets in the Fight Against HIV
Johns Hopkins Medicine

Johns Hopkins scientists report they have identified two potential new drug targets for the treatment of HIV. The finding is from results of a small, preliminary study of 19 people infected with both HIV—the virus that causes AIDS—and the hepatitis C virus. The study revealed that two genes—CMPK2 and BCLG, are selectively activated in the presence of type 1 interferon, a drug once used as the first line of treatment against hepatitis C.

Released: 6-Aug-2018 2:05 PM EDT
Doxorubicin disrupts the immune system to cause heart toxicity
University of Alabama at Birmingham

Researchers have found an important contributor to heart pathology caused by the cancer drug doxorubicin — disruption of metabolism that controls immune responses in the spleen and heart. This allows chronic, non-resolving inflammation that leads to advanced heart failure.

30-Jul-2018 1:15 PM EDT
Maternal Dengue Immunity Protects Against Fetal Damage in Mice Following Zika Virus Infection
La Jolla Institute for Immunology

A mouse mother's prior dengue immunity would protects her unborn pups from devastating brain defects such as microencephaly associated with ZIKV. These findings could guide development of more effective flavivirus vaccines and hint at what types of immune responses are maximally protective against fetal brain damage after Zika invasion.

Released: 31-Jul-2018 12:05 PM EDT
Vaccines: The must-have on your child’s back-to-school checklist
University of Alabama at Birmingham

With the start of the school year just around the corner, it is easy to overlook one of the most important things on any back-to-school checklist — making sure your child is vaccinated.

Released: 31-Jul-2018 10:00 AM EDT
Turning Off Protein Could Boost Immunotherapy Effectiveness on Cancer Tumors
Johns Hopkins Medicine

Researchers at the Bloomberg~Kimmel Institute for Cancer Immunotherapy in the Johns Hopkins Kimmel Cancer Center discovered inhibiting a previously known protein could reduce tumor burdens and enhance the effectiveness of immunotherapy treatments.

Released: 30-Jul-2018 5:05 PM EDT
FDA Approves Ortho Clinical Diagnostics VITROS® Immunodiagnostic Products HIV Combo Reagent Pack and Calibrator on the VITROS® 3600 Immunodiagnostic System
70th AACC Annual Scientific Meeting Press Program

Ortho Clinical Diagnostics, a global leader of in vitro diagnostics, announced that its VITROS Immunodiagnostic Products HIV Combo Reagent Pack and Calibrator (VITROS® HIV Combo test) received approval from the U.S. Food and Drug Administration for use on Ortho’s VITROS 3600 Immunodiagnostic System

Released: 30-Jul-2018 5:05 PM EDT
FDA Approves Two Ortho Clinical Diagnostics Specialty Hepatitis B Assays
70th AACC Annual Scientific Meeting Press Program

Ortho Clinical Diagnostics received approval from the U.S. Food and Drug Administration for Ortho’s VITROS® Immunodiagnostic Products HBeAg Assay and the VITROS® Immunodiagnostic Products Anti-HBe Assay for use on the VITROS® 3600 Immunodiagnostic System and VITROS® 5600 Integrated System

Released: 30-Jul-2018 4:05 PM EDT
Ortho Clinical Diagnostics and Thermo Fisher Scientific Agree to Deliver 14 Assays for Use on Ortho's VITROS® Systems
70th AACC Annual Scientific Meeting Press Program

Ortho Clinical Diagnostics, a global leader of in vitro diagnostics, announced an international distribution and co-promotion agreement with Thermo Fisher Scientific to provide 14 assays used to monitor therapeutic drugs, immunosuppressive drugs and drugs of abuse.



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