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Medicine

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Drug Trial for Solid Cancer Tumors, Lynch Syndrome Awareness, Side Effects for Prostate Cancer Treatments, and More in the Cancer News Source

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Medicine

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Memorial Sloan Kettering Cancer Center, Memorial Sloan Kettering, Breast Cancer, Epigenetic, Epigenetics, José Baselga, Pik3 Ca, PI3K, PI3K inhibitors , ER+, ER+ breast cancer, Science, Research

Researchers Identify First Evidence of Epigenetic Role in Breast Cancer

Researchers from Memorial Sloan Kettering Cancer Center (MSK) have identified, for the first time, an epigenetic mechanism promoting breast cancer. The team found that inhibition of the PI3K pathway leads to activation of ER-dependent transcription through the epigenetic regulator KMT2D. These findings provide a rationale for epigenetic therapy in patients with PIK3CA-mutant, ER-positive breast cancer. While epigenetic factors have been known to play an important role in various cancers such as leukemia and lymphoma, this is the first evidence found in breast cancer.

Medicine

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Kimmel Cancer Center, Cristian Tomasetti, Bert Vogelstein, Cancer, DNA, mutatuons

New Study Finds That Most Cancer Mutations are Due to Random DNA Copying ‘Mistakes’

Johns Hopkins Kimmel Cancer Center scientists report data from a new study providing evidence that random, unpredictable DNA copying “mistakes” account for nearly two-thirds of the mutations that cause cancer. Their research is grounded on a novel mathematical model based on DNA sequencing and epidemiologic data from around the world.

Medicine

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Suburban Hospital, Wade Chien, Gene Therapy, Hearing Loss, DEAF, Deafness, Dizziness

Novel Gene Therapy Experiment Offers Hope for People with Certain Hearing Loss and Dizziness Disorder

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In a first-of-its-kind study published in the March 1, 2017 edition of Molecular Therapy, researchers from the National Institute on Deafness and Other Communication Disorders (NIDCD) and Johns Hopkins University School of Medicine showed that gene therapy was able to restore balance and hearing in genetically modified mice that mimic Usher Syndrome, a genetic condition in humans characterized by partial or total hearing loss, dizziness, and vision loss that worsens over time. The hearing loss and dizziness is caused by abnormalities of the inner ear.

Medicine

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Cystic Fibrosis, Mucus

The Mechanism of Mucus: Discovery Could Lead to Better Cystic Fibrosis Treatments

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University of North Carolina scientists found that mucin proteins, which make mucus thick and sticky, fail to unfold properly in the airways of people with cystic fibrosis. And they found the lack of water in the lung can trigger the misfolding mucins.

Medicine

Life

Social and Behavioral Sciences

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Developmental Disabilities, Genetics, History Of Science, History of genetics

History Professor Earns NSF Grant to Look at Evolution of Attitudes Toward People with Developmental Disabilities

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Andrew Hogan, PhD, an assistant professor in the Creighton University Department of History, has earned a grant from the NSF’s Science, Technology and Society program to study the evolution of attitudes and narratives about people with developmental disabilities.

Science

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Metals, DNA, metal-containing drugs , Drugs, Cancer, Molecular Mechanisms, chemotherapeutic, Agents, Leticia González , University of Vienna, Jacinto Sá, Uppsala University , Interact

How Do Metals Interact with DNA?

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Since a couple of decades, metal-containing drugs have been successfully used to fight against certain types of cancer. The lack of knowledge about the underlying molecular mechanisms slows down the search for new and more efficient chemotherapeutic agents. An international team of scientists, led by Leticia González from the University of Vienna and Jacinto Sá from the Uppsala University, have developed a protocol that is able to detect how metal-based drugs interact with DNA.

Medicine

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Infectious Diseases, zika virus, Pregnancy, Obstetrics, Autism, Neurology, Virology

How Prenatal Maternal Infections May Affect Genetic Factors in Autism Spectrum Disorder

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In a new study, researchers at the University of California San Diego School of Medicine, University of Cyprus and Stanford University map the complex biological cascade caused by MIA: the expression of multiple genes involved in autism are turned up or down by MIA, affecting key aspects of prenatal brain development that may increase risk for atypical development later in life.

Medicine

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Alzheimber's Disease, Genetics, Neurology, Epidemiology, genetic assessment, polygenic hazard score

Genetic Assessment Developed to Determine Risk for Age-Associated Alzheimer’s Disease

An international team of scientists, led by researchers at University of California San Diego School of Medicine and University of California San Francisco, has developed a novel genetic score that allows individuals to calculate their age-specific risk of developing Alzheimer’s disease (AD), based upon genetic information.

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New Software Tool Powers Up Genomic Research

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A group of computational biological researchers, led by Stony Brook University’s Rob Patro, an Assistant Professor in the Department of Computer Science in the College of Engineering and Applied Sciences, has developed a new software tool, Salmon — a lightweight method to provide fast and bias-aware quantification from RNA-sequencing reads. The research was published in the March 6 edition of Nature Methods. .







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