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Medicine

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Cancer, Therapy, Prostate Cancer, Stem Cells

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Analysis of Metastatic Prostate Cancers Suggests Treatment Options

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Study maps out abnormal signaling pathways in prostate cancer cells and provides computational approaches to identify individualized targets for therapy

Medicine

Channels:

Neuroscience, Genetics, Psychiatry, Stem Cells, Behavioral Psychology, Cognitive Science Society, Williams Syndrome

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Neurodevelopmental Model of Williams Syndrome Offers Insight Into Human Social Brain

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In a study spanning molecular genetics, stem cells and the sciences of both brain and behavior, researchers at University of California San Diego, with colleagues at the Salk Institute for Biological Studies and elsewhere, have created a neurodevelopmental model of a rare genetic disorder that may provide new insights into the underlying neurobiology of the human social brain.

Medicine

Channels:

Chromosome, Stem Cell, Gene

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Reawakening a Sleeping Giant

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Most molecular biologists look at how to switch on and regulate single genes. Scientists at the MRC Clinical Sciences Centre (CSC) have gone further, and have explored how to reawaken an entire set of inactive genes, a chromosome, that is present in every female human cell.

Medicine

Channels:

facial reconstruction, Stem Cell, Tissue Engineering

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Bioengineers Grow Living Bone for Facial Reconstruction

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Researchers have engineered living bone tissue to repair bone loss in the jaw, a structure that is typically difficult to restore. They grafted customized implants into pig jaws that resulted in integration and function of the engineered graft into the recipient’s own tissue.

Medicine

Channels:

Icahn School of Medicine at Mount Sinai, Mount Sinai Health System, Mammalian Cells, Stem Cell, Cell Cycle

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New Tool Enables Researchers to Rapidly Manipulate Protein Levels in Mammalian Cells

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Advance will make complex gene studies quicker and easier

Medicine

Science

Channels:

Stem Cell, Pluripotency, Differentiation, Developmental Biology, Cell Therapy

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Breakthrough in Understanding How Stem Cells Become Specialized

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Scientists at Sanford Burnham Prebys Medical Discovery Institute (SBP) have made a major advance in understanding how the cells of an organism, which all contain the same genetic information, come to be so diverse. A study published today in Molecular Cell shows that a protein called OCT4 narrows down the range of cell types that stem cells can become. The findings could impact efforts to produce specific types of cells for future therapies to treat a broad range of diseases.

Medicine

Channels:

Eric Raabe, Stem Cell, Medulloblastoma, Palbociclib , Cancer, Tumor

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Stem Cells May Speed Up Screening of Drugs for Rare Cancers

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Researchers at the Johns Hopkins Kimmel Cancer Center say they have developed a system that uses transformed human stem cells to speed up screening of existing drugs that might work against rare brain and other cancers.

Science

Channels:

University, College, Research, stem, Microfluidics, Chemistry, Biology, Science, Keck Foundation, Los Angeles, Education

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Cal State LA Receives Grant to Develop Future Leaders in the Field of Paper Microfluidics

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Cal State LA has been awarded a grant to educate tomorrow’s leaders in the interdisciplinary field of paper microfluidics. The $375,000 grant from the W.M. Keck Foundation aims to engage more than 1,500 undergraduate students annually in the research of paper microfluidics to contribute to solving real-world scientific problems.

Medicine

Science

Channels:

Cell Biology, Biotechnology, Medicine & Health, ophtahlmology, Rehabilitation, Prosthetic, Transplant

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Study in Mice Suggests Stem Cells Could Ward Off Glaucoma

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An infusion of stem cells could help restore proper drainage for fluid-clogged eyes at risk for glaucoma. That's the upshot of a study led by a Veterans Affairs and University of Iowa team.

Medicine

Channels:

Aging, Alzheimer's, Artherosclerosis, Botox, Osteoporosis, Genetics, Stem Cells, Embryonic Stem Cells, Premature Aging, Bioinformatic

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Embryonic Gene Nanog Reverses Aging in Adult Stem Cells

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In a series of experiments at the University at Buffalo, the embryonic stem cell gene Nanog kicked into action dormant cellular processes that are key to preventing weak bones, clogged arteries and other telltale signs of growing old.

Medicine

Channels:

Stem Cells, Regenerative Medicine, Cirm, Parkinson Disease

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TSRI Scientists Receive Funding to Advance Stem Cell-Based Parkinson’s Therapy

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Scientists at The Scripps Research Institute (TSRI) and Scripps Clinic have received a grant of nearly $2.4 million from the California Institute for Regenerative Medicine (CIRM) to support safety and quality tests of a potential stem cell therapy for Parkinson’s disease.

Medicine

Science

Channels:

Biology, Cell Biology

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Cerebrospinal Fluid Signals Control the Behavior of Stem Cells in the Brain

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Prof. Fiona Doetsch's research team at the Biozentrum, University of Basel, has discovered that the choroid plexus, a largely ignored structure in the brain that produces the cerebrospinal fluid, is an important regulator of adult neural stem cells. The study recently published in "Cell Stem Cell" also shows that signals secreted by the choroid plexus dynamically change during aging which affects aged stem cell behavior.

Medicine

Channels:

Arthritis, Osteoarthritis, osteoarthritis knee, Knee Arthritis, Stem Cell, Stem Cells

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Study Launched to Determine if Stem Cell Treatment Could Give Patients a Leg Up on Knee Arthritis

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Researchers at Hospital for Special Surgery have launched a study to determine if a treatment using stem cells could help people with painful knee arthritis. To evaluate safety and efficacy, investigators are currently recruiting patients with osteoarthritis, which comes from wear and tear on a joint.

Medicine

Channels:

Biology, Stem Cell, Integrins, Muscular Dystrophy, muscle degeneration

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Protein Found to Bolster Growth of Damaged Muscle Tissue

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Biologists have found that a protein that plays a key role in the lives of stem cells can bolster the growth of damaged muscle tissue, a step that could potentially contribute to treatments for muscle degeneration caused by old age and diseases such as muscular dystrophy.

Medicine

Channels:

ALS, Lou Gehrig disease, Lou Gehrig's Disease, pluripotent stem (iPS) cells , Clive Svendsen

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ALS Research Suggests Stem Cells for Studies Should Be ‘Aged’ to Speed Progress Toward Finding Potential Treatments

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Cedars-Sinai scientists are seeking to build an improved stem-cell model of amyotrophic lateral sclerosis (ALS) to accelerate progress toward a cure for the devastating neurological disorder. Their findings demonstrate that current models can be enhanced by the aging of motor neurons to show how ALS damages cells later in life.

Medicine

Channels:

Osteoarthritis, Hip Replacement, Knee Replacement, Orthopaedic Surgery, Stem Cell Biology

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Stem Cells Engineered to Grow Cartilage, Fight Inflammation

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With a goal of treating worn, arthritic hips without extensive surgery to replace them, scientists at Washington University School of Medicine in St. Louis have programmed stem cells to grow new cartilage on a 3-D template shaped like the ball of a hip joint. What’s more, using gene therapy, they have activated the new cartilage to release anti-inflammatory molecules to fend off a return of arthritis.

Science

Channels:

Whitehead Institute, Rudolf Jaenisch, Human Embryonic Stem Cells, Naive, Stem Cells Development Regeneration, Criteria

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Defining What It Means to Be a Naive Stem Cell

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Whitehead Institute scientists have created a checklist that defines the “naive” state of cultured human embryonic stem cells (ESCs). Such cells provide a better model of early human embryogenesis than conventional ESCs in later stages of development.

Medicine

Channels:

Stem Cells, Cancer, Cord Blood, genetic, princess margaret cancer centre, University Health Network, Stem Cell Treatment

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Stem Cell Scientists Discover Genetic Switch to Increase Supply of Stem Cells From Cord Blood for Future Clinical Use

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International stem cell scientists, co-led in Canada by Dr. John Dick and in the Netherlands by Dr. Gerald de Haan, have discovered the switch to harness the power of cord blood and potentially increase the supply of stem cells for cancer patients needing transplantation therapy to fight their disease.

Medicine

Channels:

Cancer, Immunotheapy, hematologic malignancies

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Immunotherapy Benefits Relapsed Stem Cell Transplant Recipients

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Dana-Farber Cancer Institute study published in the New England Journal of Medicine suggests that using repeated doses of an immunotherapy drug can restore a complete remission for some relapsed stem cell transplant recipients.

Science

Channels:

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Breakthrough in Scaling Up Life-Changing Stem Cell Production

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Scientists have discovered a new method of creating human stem cells which could solve the big problem of the large-scale production needed to fully realise the potential of these remarkable cells for understanding and treating disease.







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