Feature Channels: Regenerative Medicine

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Released: 3-Mar-2021 4:40 PM EST
Pericardial Injection Effective, Less Invasive Way to Get Regenerative Therapies to Heart
North Carolina State University

Injecting hydrogels containing stem cell or exosome therapeutics directly into the pericardial cavity could be a less invasive, less costly, and more effective means of treating cardiac injury.

23-Feb-2021 2:00 PM EST
Scientists Identify Cells Responsible For Liver Tissue Maintenance And Regeneration
UT Southwestern Medical Center

While the amazing regenerative power of the liver has been known since ancient times, the cells responsible for maintaining and replenishing the liver have remained a mystery. Now, research from the Children’s Medical Center Research Institute at UT Southwestern (CRI) has identified the cells responsible for liver maintenance and regeneration while also pinpointing where they reside in the liver.

Released: 24-Feb-2021 10:55 AM EST
David Kaplan Elected to National Academy of Engineering
Tufts University

David Kaplan, the Stern Family Professor of Engineering at Tufts University School of Engineering, has been elected to the National Academy of Engineering in recognition of his contributions to silk-based materials for tissue engineering and regenerative medicine.

Released: 23-Feb-2021 8:00 AM EST
Evan Snyder named Fellow of the American Institute for Medical and Biological Engineering
Sanford Burnham Prebys

The American Institute for Medical and Biological Engineering (AIMBE) has elected to its College of Fellows Evan Y. Snyder, M.D., Ph.D., professor and founding director of the Center for Stem Cells and Regenerative Medicine at Sanford Burnham Prebys Medical Discovery Institute. Snyder was nominated, reviewed, and elected by his peers and members of the College of Fellows for his seminal contributions to regenerative medicine.

18-Feb-2021 6:05 PM EST
Brain organoids grown in lab mature much like infant brains
University of California, Los Angeles (UCLA), Health Sciences

A new study from UCLA and Stanford University researchers finds that three-dimensional human stem cell-derived brain organoids can mature in a manner that is strikingly similar to human brain development.

Released: 16-Feb-2021 8:05 AM EST
Recent FDA Designation Puts Promising Engineered Cellular Therapy that Reduces Complications of Lymphoma Treatment on Accelerated Path to Market Approval
Hackensack Meridian Health

In November 2020, the U.S. Food and Drug Administration (FDA) granted Regenerative Medicine Advanced Therapy (RMAT) designation for a promising engineered cellular therapy called AB-205. AB-205 acts promptly to repair injured vascular niches of organs to prevent or reduce severe toxicities in patients who have Hodgkin lymphoma (HL) or non-Hodgkin lymphoma (NHL) undergoing high dose chemotherapy and autologous stem cell transplantion.

Released: 12-Feb-2021 8:45 AM EST
Lin Han, PhD, receives 2021 Kappa Delta Young Investigator Award for the study of cartilage function, regeneration and disease intervention in osteoarthritis
American Academy of Orthopaedic Surgeons (AAOS)

The 2021 Kappa Delta Young Investigator Award was presented to Lin Han, PhD, for research on the structure and function of cartilage extracellular matrix (ECM) and its impact on tissue regeneration and disease evolution in osteoarthritis (OA).

Released: 12-Feb-2021 8:30 AM EST
Kappa Delta Ann Doner Vaughn Award Presented to Cato T. Laurencin, MD, PhD, FAAOSfor pioneering research in bone regenerative engineering
American Academy of Orthopaedic Surgeons (AAOS)

Cato T. Laurencin, MD, PhD, was named the 2021 Kappa Delta Ann Doner Vaughn Award recipient for his 30 years of scientific research in musculoskeletal regenerative engineering, the field which he founded and brought to the forefront of translational medicine.

Released: 11-Feb-2021 1:45 PM EST
Johns Hopkins Scientists Find Mammals Share Gene Pathways That Allow Zebrafish To Grow New Eyes
Johns Hopkins Medicine

Working with fish, birds and mice, Johns Hopkins Medicine researchers report new evidence that some animals’ natural capacity to regrow neurons is not missing, but is instead inactivated in mammals. Specifically, the researchers found that some genetic pathways that allow many fish and other cold-blooded animals to repair specialized eye neurons after injury remain present in mammals as well, but are turned off, blocking regeneration and healing.

   
Released: 10-Feb-2021 2:25 PM EST
A recipe for regenerating bioengineered hair
RIKEN

Researchers at the RIKEN Center for Biosystems Dynamics Research in Japan have discovered a recipe for continuous cyclical regeneration of cultured hair follicles from hair follicle stem cells.

Released: 9-Feb-2021 12:05 PM EST
Promising Approach to Urinary Bladder Tissue Regeneration
Ann and Robert H. Lurie Children's Hospital of Chicago

Scientists from Stanley Manne Children’s Research Institute at Ann & Robert H. Lurie Children’s Hospital of Chicago were able to regenerate functional urinary bladder tissue in a rodent model using human bone marrow derived stem and progenitor cells. Their findings, published in Scientific Reports, offer great promise to children suffering from end stage bladder dysfunction, for whom surgery carries significant risks.

Released: 5-Jan-2021 2:40 PM EST
LA based company donates masks to science institute in NC
Atrium Health Wake Forest Baptist

LA based company Harmony Farms Inc. donates masks to the Wake Forest Institute for Regenerative Medicine in NC.

Released: 22-Dec-2020 10:15 AM EST
Cormac the Llama Yields Antibodies that may Prove Effective Against COVID-19 Infection
Uniformed Services University of the Health Sciences (USU)

Researchers from the Uniformed Services University (USU) recently identified pint-sized antibodies, or “nanobodies,” that could protect against COVID-19. At least one of these nanobodies – produced by a llama named Cormac – also appears to work well in either liquid or aerosol form, suggesting it could also help protect a person’s lungs from infections.

Released: 14-Dec-2020 7:00 AM EST
Leaders in stem cell science, regenerative medicine combine efforts in 2021
Atrium Health Wake Forest Baptist

Leaders in stem cell science and regenerative medicine will combine two separate courses into one in June 2021.

   
7-Dec-2020 9:00 AM EST
Gene therapy injection in one eye surprises scientists by improving vision in both
University of Cambridge

Injecting a gene therapy vector into one eye of someone suffering from LHON, the most common cause of mitochondrial blindness, significantly improves vision in both eyes, scientists have found.

Released: 7-Dec-2020 4:30 PM EST
Scientists discover how COVID-19 virus causes multiple organ failure in mice
University of California, Los Angeles (UCLA), Health Sciences

UCLA researchers are the first to create a version of COVID-19 in mice that shows how the disease damages organs other than the lungs. Using their model, the scientists discovered that the SARS-CoV-2 virus can shut down energy production in cells of the heart, kidneys, spleen and other organs.

1-Dec-2020 11:20 AM EST
Synthetic Biology and Machine Learning Speed the Creation of Lab-Grown Livers
Health Sciences at the University of Pittsburgh

Researchers at the University of Pittsburgh School of Medicine have combined synthetic biology with a machine learning algorithm to create human liver organoids with blood and bile handling systems. When implanted into mice with failing livers, the lab-grown replacement livers extended life.

   
Released: 3-Dec-2020 11:00 AM EST
Development of New Stem Cell Type May Lead to Advances In Regenerative Medicine
UT Southwestern Medical Center

DALLAS – Dec. 3, 2020 – A team led by UT Southwestern has derived a new “intermediate” embryonic stem cell type from multiple species that can contribute to chimeras and create precursors to sperm and eggs in a culture dish.

Released: 24-Nov-2020 7:25 AM EST
World’s first: Drug guides stem cells to desired location, improving their ability to heal
Sanford Burnham Prebys

Scientists at Sanford Burnham Prebys Medical Discovery Institute have created a drug that can lure stem cells to damaged tissue and improve treatment efficacy—a scientific first and major advance for the field of regenerative medicine. The discovery, published in the Proceedings of the National Academy of Sciences (PNAS), could improve current stem cell therapies designed to treat such neurological disorders as spinal cord injury, stroke, amyotrophic lateral sclerosis (ALS) and other neurodegenerative disorders; and expand their use to new conditions, such as heart disease or arthritis.

   
Released: 19-Nov-2020 3:30 PM EST
Cato T. Laurencin Awarded the Materials Research Society's Highest Honor
Materials Research Society (MRS)

Laurencin will accept the honor during the 2020 Virtual MRS Spring/Fall Meeting, where at 4:00 pm (ET), Wednesday, December 2, he will present his award lecture, Regenerative Engineering: Materials and Convergence.

   
Released: 10-Nov-2020 9:30 AM EST
Scientists use bacteria as micro-3D printers
Aalto University

A team at Aalto University has used bacteria to produce intricately designed three-dimensional objects made of nanocellulose. With their technique, the researchers are able to guide the growth of bacterial colonies through the use of strongly water repellent – or superhydrophobic – surfaces.

Released: 9-Nov-2020 12:10 PM EST
Wound-Healing Biomaterials Activate the Immune System to Create Stronger Skin
University of California, Los Angeles (UCLA), Health Sciences

A new hydrogel can trigger the body’s adaptive immune system, leading to improved tissue repair abilities

20-Oct-2020 8:30 AM EDT
Scientists use gene therapy and a novel light-sensing protein to restore vision in mice
NIH, National Eye Institute (NEI)

A newly developed light-sensing protein called the MCO1 opsin restores vision in blind mice when attached to retina bipolar cells using gene therapy. The National Eye Institute, part of the National Institutes of Health, provided a Small Business Innovation Research grant to Nanoscope, LLC for development of MCO1. The company is planning a U.S. clinical trial for later this year.

Released: 14-Oct-2020 12:55 PM EDT
AAOS Advances Biologics Initiative with Innovative Dashboard
American Academy of Orthopaedic Surgeons (AAOS)

The American Academy of Orthopaedic Surgeons (AAOS) continues to demonstrate its commitment to advancing the quality of musculoskeletal care in a fully transparent and scientific way. Debuting today as a new member benefit, the AAOS Biologics Dashboard is a dynamic online tool designed to help orthopaedic surgeons navigate the approval status of biologic-based interventions. The development of the AAOS Biologics Dashboard is just one of several efforts within the Academy’s Biologics Initiative that offers evidence-based guidance to the musculoskeletal health community. An additional effort is the revision of two biologics-related position statements, recently approved by the AAOS Board of Directors.

Released: 12-Oct-2020 11:10 AM EDT
NuShores Biosciences receives $2.8 million contract for intelligent manufacturing automation of bone regeneration technology
University of Arkansas at Little Rock

NuShores Biosciences, a spin-off company of the University of Arkansas at Little Rock, has received a three-year, $2.8 million contract from the Medical Technology Enterprise Consortium, a biomedical technology consortium associated with the U.S. Army Medical Research and Development Command. The contract will enable NuShores to develop intelligent automated production of its NuCress™ bone void filler scaffold products using its factory-in-a-box concept. Key collaborators on the project include UA Little Rock and MiQ Partners of Cincinnati.

   
Released: 9-Oct-2020 8:55 AM EDT
Hackensack University Medical Center Urologists Offer Pioneering Clinical Trial to Study Nerve Recovery after Robotic Prostatectomy for Prostate Cancer
Hackensack Meridian Health

Department of Urology uses bioregenerative medicine to improve erectile function and continence after robotic radical prostatectomy

Released: 29-Sep-2020 3:05 PM EDT
Exosome treatment improves recovery from heart attacks in a preclinical study
University of Alabama at Birmingham

Research in pigs shows that using the exosomes naturally produced from a mix of heart muscle, endothelial and smooth muscle cells — all derived from human induced pluripotent stem cells — yields regenerative benefits equivalent to the injected human induced pluripotent stem cell-cardiac cells.

Released: 25-Sep-2020 6:05 PM EDT
Could a tiny fish hold the key to curing blindness?
NIH, National Eye Institute (NEI)

Imagine this: A patient learns that they are losing their sight because an eye disease has damaged crucial cells in their retina. Then, under the care of their doctor, they simply grow some new retinal cells, restoring their vision. Although science hasn’t yet delivered this happy ending, researchers are working on it – with help from the humble zebrafish. When a zebrafish loses its retinal cells, it grows new ones. This observation has encouraged scientists to try hacking the zebrafish’s innate regenerative capacity to learn how to treat human disease. That is why among the National Eye Institute’s 1,200 active research projects, nearly 80 incorporate zebrafish.

Released: 15-Sep-2020 8:00 AM EDT
Scientists uncover a novel approach to treating Duchenne muscular dystrophy
Sanford Burnham Prebys

Scientists at Sanford Burnham Prebys, Fondazione Santa Lucia IRCCS, and Università Cattolica del Sacro Cuore in Rome have shown that pharmacological (drug) correction of the content of extracellular vesicles released within dystrophic muscles can restore their ability to regenerate muscle and prevent muscle scarring. The study, published in EMBO Reports, reveals a promising new therapeutic approach for Duchenne muscular dystrophy (DMD), an incurable muscle-wasting condition.

Released: 31-Aug-2020 3:15 PM EDT
University of Miami Researchers Launch First U.S. Trial Testing Platelet-Rich Plasma as Peyronie’s Disease Treatment
University of Miami Health System, Miller School of Medicine

University of Miami Miller School of Medicine researchers are about to start recruiting for the first U.S. clinical trial looking at treating Peyronie’s disease, a painful and agonizing condition common in men, with platelet-rich plasma (PRP).

Released: 24-Aug-2020 9:30 AM EDT
Pigs Grow New Liver in Lymph Nodes, Study Shows
Health Sciences at the University of Pittsburgh

Hepatocytes – the chief functional cells of the liver – are natural regenerators, and the lymph nodes serve as a nurturing place where they can multiply. Researchers demonstrated that large animals with ailing livers can grow a new organ in their lymph nodes from their own hepatocytes.

   
Released: 27-Jul-2020 1:35 PM EDT
Researchers Identify MicroRNA That Shows Promise for Hair Regrowth
North Carolina State University

Researchers have identified a microRNA (miRNA) that could promote hair regeneration. This miRNA – miR-218-5p – plays an important role in regulating the pathway involved in follicle regeneration, and could be a candidate for future drug development.

   
Released: 21-Jul-2020 8:00 AM EDT
Sanford Burnham Prebys receives CIRM award for COVID-19 research
Sanford Burnham Prebys

Sanford Burnham Prebys Medical Discovery Institute has received an award from the California Institute for Regenerative Medicine (CIRM) to advance promising drug candidates for COVID-19. The research team will test two existing drugs against “mini lungs in a dish” that have been infected with SARS-CoV-2.

Released: 15-Jul-2020 4:25 PM EDT
New antiplatelet drug shows promise for treating heart attack
University of Illinois Chicago

Researchers have developed a new drug that prevents blood clots without causing an increased risk of bleeding, a common side effect of all antiplatelet medications currently available. A new study published in the journal Science Translational Medicine describes the drug and its delivery mechanisms and shows that the drug is also an effective treatment for heart attack in animal models.

Released: 13-Jul-2020 9:00 AM EDT
Alliance for Regenerative Rehabilitation and Training Receives $5 Million NIH Grant to Continue Innovative Work
Health Sciences at the University of Pittsburgh

The National Institutes of Health has renewed a five-year grant for $5 million for the Alliance for Regenerative Rehabilitation and Training (AR3T) to continue its work expanding scientific knowledge, expertise and methodologies focused on science and regenerative medicine.

Released: 8-Jul-2020 3:50 PM EDT
University of Miami Miller School-led technology paves way for islet regeneration in human pancreas
University of Miami Health System, Miller School of Medicine

New research published in Nature Communications uses a technology first developed at the University of Miami Miller School of Medicine to enhance the oxygenation of cultured tissues that will likely be able to conduct real-time regeneration and development studies in the human pancreas.

   
Released: 3-Jul-2020 11:35 AM EDT
How the body regulates scar tissue growth after heart attacks
University of California, Los Angeles (UCLA), Health Sciences

New UCLA research conducted in mice could explain why some people suffer more extensive scarring than others after a heart attack. The study, published in the journal Cell, reveals that a protein known as type 5 collagen plays a critical role in regulating the size of scar tissue in the heart.

25-Jun-2020 1:00 PM EDT
WFIRM Scientists Prove Bioengineered Uteri Support Pregnancy
Atrium Health Wake Forest Baptist

WFIRM scientists were able to show that bioengineered uteri in an animal model developed the native tissue-like structures needed to support normal reproductive function.

   
Released: 18-Jun-2020 10:20 AM EDT
National Eye Institute establishes office of regenerative medicine
NIH, National Eye Institute (NEI)

The National Eye Institute (NEI) has established an office to accelerate progress in regenerative medicine for eye disease and vision disorders.

Released: 11-Jun-2020 1:20 PM EDT
Putting “Super” in Natural Killer Cells
UC San Diego Health

Using induced pluripotent stem cells (iPSCs) and deleting a key gene, researchers at University of California San Diego School of Medicine have created natural killer cells — a type of immune cell — with measurably stronger activity against a form of leukemia, both in vivo and in vitro.

28-May-2020 11:00 AM EDT
Lab-Grown Miniature Human Livers Successfully Transplanted in Rats
Health Sciences at the University of Pittsburgh

Using skin cells from human volunteers, researchers at the University of Pittsburgh School of Medicine have created fully functional mini livers, which they then transplanted into rats. In this proof-of-concept experiment, the lab-made organs survived for four days inside their animal hosts.

   
Released: 27-May-2020 4:05 PM EDT
Human Growth Hormone Treatment After ACL Injury May Prevent Loss of Muscle Strength
Michigan Medicine - University of Michigan

A new study finds the use of HGH treatment in patients that have undergone ACL reconstructive surgery may prevent the loss of muscle strength and weakness.

Released: 26-May-2020 9:00 AM EDT
Rejuvenated fibroblasts can recover the ability to contract
National University of Singapore (NUS)

A recent study from the Mechanobiology Institute at the National University of Singapore has shown that rejuvenated fibroblasts can recover their ability to self-contract. This encouraging discovery holds great potential for applications in regenerative medicine and stem cell engineering.

   
Released: 26-May-2020 8:55 AM EDT
Sexton Biotechnologies and Ikeda Scientific Provide Human Platelet Lysate to Japanese Regenerative Medicine Product Manufacturers
Sexton Biotechnologies

Sexton Biotechnologies pathogen reduced hPL confirmed by PMDA as human derived raw material for regen med products.

   
Released: 19-May-2020 10:50 AM EDT
Hackensack Meridian Health Invests in EpiBone, Inc., A Regenerative Medicine Company
Hackensack Meridian Health

EpiBone’s Craniomaxillofacial, or EB-CMF, product is a living, anatomically correct bone graft made from a patient’s own fat-derived stem cells.

   
11-May-2020 12:45 PM EDT
Scientists show MRI predicts the efficacy of a stem cell therapy for brain injury
Sanford Burnham Prebys

Scientists at Sanford Burnham Prebys Medical Discovery Institute and Loma Linda University Health have demonstrated the promise of applying magnetic resonance imaging (MRI) to predict the efficacy of using human neural stem cells to treat a brain injury—a first-ever “biomarker” for regenerative medicine that could help personalize stem cell treatments for neurological disorders and improve efficacy. The study was published in Cell Reports.



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