Feature Channels: Drug Resistance

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5-Aug-2022 2:35 PM EDT
New antibiotic resistance genes identified in tuberculosis
PLOS

An international consortium analyzed the genetic sequences and antibiotic susceptibility of more than 10,000 global Mycobacterium tuberculosis isolates.

5-Aug-2022 3:05 PM EDT
New drug candidate fights off more than 300 drug-resistant bacteria
American Chemical Society (ACS)

Urinary tract infections are common, yet can be tough to treat as the bacteria that cause them become resistant to many antibiotics. In ACS Central Science, researchers report a new molecule that inhibits drug-resistant bacteria in lab experiments, as well as in mice with pneumonia and UTIs.

   
Released: 3-Aug-2022 2:55 PM EDT
This is how highly resistant strains of fungi emerge
Ruhr-Universität Bochum

An international research team has deciphered the mechanism by which the fungus Cryptococcus neoformans is resistant to fungus-specific drugs.

Newswise: Giant Viruses Build a Cell Nucleus Surprisingly Like Our Own
Released: 3-Aug-2022 2:30 PM EDT
Giant Viruses Build a Cell Nucleus Surprisingly Like Our Own
University of California San Diego

Scientists are using new technologies to obtain unprecedented looks inside viruses and their unique abilities to infect and destroy bacteria. Using cryo-EM and other technologies, they found that jumbo phage cells feature a compartment that is surprisingly similar to the nucleus of human cells.

Released: 29-Jul-2022 2:05 PM EDT
Don't give up the fight. Read the latest news about drug and antibiotic resistance
Newswise

Here are some of the latest articles that have been added to the Drug Resistance channel on Newswise, a free source for journalists.

Newswise: One-two punch: Researchers discover sophisticated mechanism that bacteria use to resist antibiotics
26-Jul-2022 4:15 PM EDT
One-two punch: Researchers discover sophisticated mechanism that bacteria use to resist antibiotics
McMaster University

Researchers at Canada's McMaster University have discovered a significant and previously unknown mechanism that many bacteria use to resist antibiotics.

Released: 26-Jul-2022 1:15 PM EDT
Researchers Find Link Between Genetic Mutations and Cancer Treatment Resistance
Michigan Medicine - University of Michigan

Patients with relapsed multiple myeloma are resistant to commonly used treatments. Researchers are one step closer to understanding the genetic reason why.

Released: 22-Jul-2022 3:10 PM EDT
New findings may reduce the risk of infection for patients with urinary catheters
Karolinska Institute

Patients who have indwelling urinary catheters often suffer from urinary tract infections, which can be difficult to treat.

20-Jul-2022 1:00 AM EDT
Feeding Dogs Raw Meat Associated with Increased Presence of Antibiotic-Resistant Bacteria
University of Bristol

New research, led by a team a the University of Bristol, has revealed an association between the feeding of raw meat to pet dogs and the presence of bacteria resistant to critically important antibiotics.

Newswise: Evolve… Innovate… Repeat: Scientists Peel Back the Layers of Virus-Host Evolution and Innovation
Released: 12-Jul-2022 8:05 PM EDT
Evolve… Innovate… Repeat: Scientists Peel Back the Layers of Virus-Host Evolution and Innovation
University of California San Diego

Scientists have uncovered an intriguing new understanding of how viruses and the hosts they infect evolve new innovations to outcompete each other. Culminating a 10-year research effort, the researchers tracked the way fitness landscapes constantly change in the ongoing struggle for survival.

   
Newswise: Hidden Genes May Be Tapped for New Antibiotics
Released: 12-Jul-2022 2:05 AM EDT
Hidden Genes May Be Tapped for New Antibiotics
Rice University

Silents are potentially golden in the search for antibiotics to slow the ongoing crisis of resistance in the treatment of disease.

Newswise: Familiarity Breeds Exempt: Why Staph Vaccines Don’t Work in Humans
5-Jul-2022 4:05 PM EDT
Familiarity Breeds Exempt: Why Staph Vaccines Don’t Work in Humans
UC San Diego Health

UC San Diego researchers say they may have found the reason why multiple human clinical trials of staphylococcus vaccines have failed: the bacteria knows us too well.

Newswise: Female Urinary Tract Lactobaccilli Can Kill Pathogenic Bacteria, UAH Research Shows
Released: 6-Jul-2022 10:05 AM EDT
Female Urinary Tract Lactobaccilli Can Kill Pathogenic Bacteria, UAH Research Shows
University of Alabama Huntsville

Lactobacilli that live in the human female urinary tract’s microbiome are competitive and kill nearby pathogenic bacteria, says the first study of its kind done at The University of Alabama in Huntsville (UAH). Greater understanding of the processes involved could lead to new therapies.

Released: 6-Jul-2022 8:05 AM EDT
Researchers Discover Mechanisms of Drug-Resistant Fungal Infection in Transplant Patient
Mount Sinai Health System

Experts Encourage Rapid Genomic Screenings and Development of New Therapeutics for Drug-Resistant Pathogens to Address Emerging Global Health Concern

Released: 5-Jul-2022 1:25 PM EDT
Study Reveals Why Highly Infectious Cholera Variant Mysteriously Died Out
University of Cambridge

A new study reveals why a highly infectious variant of the cholera bug, which caused large disease outbreaks in the early 1990s, did not cause the eighth cholera pandemic as feared – but instead unexpectedly disappeared.

Newswise: Cleveland Clinic Researchers Shed New Light on Importance of Ecological Cellular Interactions in Targeted Therapy Resistance in Lung Cancer
30-Jun-2022 10:40 AM EDT
Cleveland Clinic Researchers Shed New Light on Importance of Ecological Cellular Interactions in Targeted Therapy Resistance in Lung Cancer
Cleveland Clinic

New Cleveland Clinic research has uncovered key information about cellular interaction between tumor cells and normal tissue, providing better understanding of how therapeutic resistance develops. Findings published in Science Advances.

Newswise: Highly Antibiotic-Resistant Strain of MRSA That Arose in Pigs Can Jump to Humans
Released: 28-Jun-2022 1:05 PM EDT
Highly Antibiotic-Resistant Strain of MRSA That Arose in Pigs Can Jump to Humans
University of Cambridge

A new study has found that a highly antibiotic-resistant strain of the superbug MRSA – methicillin resistant Staphylococcus aureus – has emerged in livestock in the last 50 years, probably due to widespread antibiotic use in pig farming.

   
Newswise: Caught in the act: Researchers find deadly fungus can multiply by having sex, which could produce more drug-resistant, virulent strains
Released: 27-Jun-2022 9:00 AM EDT
Caught in the act: Researchers find deadly fungus can multiply by having sex, which could produce more drug-resistant, virulent strains
McMaster University

Researchers at McMaster University have unlocked an evolutionary mystery of a deadly pathogen responsible for fueling the superbug crisis: it can reproduce by having sex.

Newswise: National Researcher of the Year 2022 Decodes Drug Resistance in Animals – A Step towards Sustainable Solutions
Released: 24-Jun-2022 8:15 AM EDT
National Researcher of the Year 2022 Decodes Drug Resistance in Animals – A Step towards Sustainable Solutions
Chulalongkorn University

Chula Veterinary Lecturer and “National Outstanding Researcher 2022” has revealed the genetic code that causes drug resistance in animals that affects human health, animals, and the environment, and suggests comprehensive solutions under the concept “One Health”.

Newswise: Computer Simulations of Proteins Help Unravel Why Chemotherapy Resistance Occurs
Released: 21-Jun-2022 8:05 AM EDT
Computer Simulations of Proteins Help Unravel Why Chemotherapy Resistance Occurs
Stony Brook University

Understanding why and how chemotherapy resistance occurs is a major step toward optimizing treatments for cancer. A team of scientists including Markus Seeliger, PhD, of the Renaissance School of Medicine at Stony Brook University, believe they have found a new process through which drug resistance happens.

Released: 15-Jun-2022 2:30 PM EDT
Moffitt Researchers Contribute to Discovery of Mechanism Leading to Drug Resistance in Prostate Cancer
Moffitt Cancer Center

In a new article published in Science Translational Medicine, Moffitt Cancer Center researchers reveal a mechanism by which prostate cancer cells become resistant through molecular modification of the androgen receptor protein and identify a potential treatment approach that could overcome this resistance.

Released: 7-Jun-2022 5:05 PM EDT
Scientists Show How Fast-Growing Bacteria Can Resist Antibiotics
eLife

Scientists have demonstrated how some fast-growing bacteria can retreatment with antibiotics, according to a study published today in eLife.

Released: 7-Jun-2022 3:05 PM EDT
Common Drug-Resistant Superbug Develops Fast Resistance to ‘Last Resort’ Antibiotic
University of Oxford

A study published today in Cell Reports reveals how populations of a bacterium called Pseudomonas respond to being treated with Colistin, a 'last resort' antibiotic for patients who have developed multi-drug resistant infections.

Released: 31-May-2022 3:05 PM EDT
Most Doctors Still Believe in Prescribing Unnecessary Antibiotics to Treat Asymptomatic Infections, UM School of Medicine Study Suggests
University of Maryland School of Medicine

An estimated 70 percent of primary care physicians reported in a survey that they would still prescribe antibiotics to treat asymptomatic infections based solely on a positive urine specimen.

Newswise: Mystery Mechanism in Small Peptide Shows Big Promise for Fighting Antibiotic-Resistant Bacteria
Released: 26-May-2022 4:00 PM EDT
Mystery Mechanism in Small Peptide Shows Big Promise for Fighting Antibiotic-Resistant Bacteria
Oak Ridge National Laboratory

Using neutrons, researchers at Oak Ridge National Laboratory pieced together the molecular mechanics behind a peptide’s ability to deal significant damage to bacterial cells. Their findings could inform new therapeutic strategies for treating bacterial infections where antibiotics have fallen short.

Newswise: Diabetes Drug Improves Antibacterial Treatment Speed and Effectiveness, Researchers Report
Released: 26-May-2022 2:05 PM EDT
Diabetes Drug Improves Antibacterial Treatment Speed and Effectiveness, Researchers Report
Tsinghua University Press

Old dogs may not learn new tricks, but old drugs can, according to a research team based in China.

Released: 26-May-2022 11:55 AM EDT
Gut bacteria can make blood pressure medication less effective
University of Toledo

A new study from The University of Toledo College of Medicine and Life Sciences has shown gut bacteria can reduce the effectiveness of certain blood pressure drugs.

24-May-2022 5:05 PM EDT
Inappropriate Antibiotics for Nonhospitalized Kids Cost US at Least $74 Million
Washington University in St. Louis

Children who were prescribed antibiotics inappropriately were more likely to develop complications such as diarrhea and skin rashes than children who were treated according to medical guidelines, according to a new study from Washington University School of Medicine in St. Louis and The Pew Charitable Trusts. This misuse of antibiotics resulted in at least $74 million in excess health-care costs in the U.S. in 2017.

Newswise: Hospitals Can Reduce Antibiotic Overuse by Avoiding Unnecessary Blood Draws in Critically Ill Children, Study Shows
Released: 2-May-2022 11:05 AM EDT
Hospitals Can Reduce Antibiotic Overuse by Avoiding Unnecessary Blood Draws in Critically Ill Children, Study Shows
Johns Hopkins Medicine

A Johns Hopkins Children’s Center-led national quality improvement collaborative highlights a “less is more” method that may prevent antibiotic overprescribing

26-Apr-2022 12:35 PM EDT
New Model for Antibacterial Mechanism: Toxic Misinformation
Brookhaven National Laboratory

Biologists have discovered an aberrant protein that’s deadly to bacteria. The discovery could help scientists unravel the lethal mechanism of certain antibiotics—and potentially point the way to future antibacterial drugs.

Newswise: Study Reveals Genetic Diversity of a Particularly Problematic Pathogen
Released: 27-Apr-2022 3:55 PM EDT
Study Reveals Genetic Diversity of a Particularly Problematic Pathogen
UC San Diego Health

Researchers at UC San Diego have used a systems biology approach to parse the genetic diversity of Clostridioides difficile, a particularly problematic pathogen, particularly in health care settings.

Released: 25-Apr-2022 2:05 PM EDT
Offspring weakens, when parents are given antibiotics
University of Southern Denmark

Antibiotics have once proclaimed the salvation of the world. Today, researchers fear that antibiotics could become a threat to public health and the natural environment.

   
Released: 25-Apr-2022 11:05 AM EDT
US study suggests COVID-19 pandemic may be accelerating antimicrobial resistance
European Society of Clinical Microbiology and Infectious Diseases

Among those hospitalised during the pandemic, both COVID-19 patients and those tested for SARS-COV-2 but negative, had higher rates of antibiotic-resistant bacterial infections compared to patients hospitalised before the pandemic, according to a study evaluating the pandemic’s impact on antimicrobial resistance (AMR) in 271 hospitals across the USA, to be presented at this year’s European Congress of Clinical Microbiology & Infectious Diseases (ECCMID) in Lisbon, Portugal (23-26 April).

Released: 21-Apr-2022 3:05 PM EDT
Scientists use machine learning to identify antibiotic resistant bacteria that can spread between animals, humans and the environment
University of Nottingham

Experts from the University of Nottingham have developed a ground-breaking software, which combines DNA sequencing and machine learning to help them find where, and to what extent, antibiotic resistant bacteria is being transmitted between humans, animals and the environment.

Released: 19-Apr-2022 5:50 PM EDT
New study on mice sheds light on the anti-obesity effects of vitamin E
Shibaura Institute of Technology

Over the past few decades, obesity has become increasingly common throughout the entire world.

Newswise: Targeting “Cell Clustering” by Gene Deletion Reduces Drug Resistance
Released: 15-Apr-2022 7:05 AM EDT
Targeting “Cell Clustering” by Gene Deletion Reduces Drug Resistance
Stony Brook University

A recent study published in the journal Communications Biology shows manipulating and deleting a specific gene (AMN1) from yeast could provide a foundation for a new approach to combatting drug resistance when treating microbial infections or cancer.

Released: 14-Apr-2022 9:00 AM EDT
NIH Grant Awarded to Study HIV Drug-Resistant Genetic Mutations Across Africa
Institute of Human Virology at the University of Maryland School of Medicine

University of Maryland School of Medicine (UMSOM)’s Institute of Human Virology (IHV) researchers received funding from the National Institutes of Health’s National Institute of Allergy and Infectious Diseases (NIAID) for $2.7 million to study genetic changes in two genes from the HIV-1 virus that may make it resistant to antiretroviral therapy.

7-Apr-2022 3:25 PM EDT
From Rare Soil Microbe, a New Antibiotic Candidate
Washington University in St. Louis

Demand for new kinds of antibiotics is surging, as drug-resistant and emerging infections are becoming an increasingly serious global health threat. Researchers are racing to reexamine certain microbes that serve as one of our most successful sources of therapeutics: the actinomycetes.

Newswise: Microbiology expert advocates for One Health approach to tackling antibiotic resistance globally
Released: 8-Apr-2022 1:05 PM EDT
Microbiology expert advocates for One Health approach to tackling antibiotic resistance globally
University of California, Irvine

Dr. Oladele "Dele" Ogunseitan, UC Presidential Chair and Professor of Population Health and Disease Prevention at the University of California, Irvine Program in Public Health, discusses using a One Health approach to combating global antibiotic resistance.

Newswise: How a narrow-spectrum antibiotic takes aim at C. Diff
Released: 6-Apr-2022 2:00 PM EDT
How a narrow-spectrum antibiotic takes aim at C. Diff
Rockefeller University

Most antibiotics are double-edged swords. Besides killing the pathogen they are prescribed for, they also decimate beneficial bacteria and change the composition of the gut microbiome.

Released: 5-Apr-2022 3:55 PM EDT
The latest news on clinical trials is here on Newswise
Newswise

Here are some of the latest articles that have been added to the Clinical Trials channel on Newswise.

       
Released: 29-Mar-2022 2:55 PM EDT
妙佑医疗国际研究发现纳米孔测序法可快速检测和鉴定抗生素耐药性微生物
Mayo Clinic

有越来越多人因抗生素耐药性感染而面临死亡。此类感染是微生物物种通过突变以躲避制药破坏性攻击所引发的。仅2019年,全球便有超过120万人死于抗生素耐药性感染。

Released: 29-Mar-2022 2:50 PM EDT
أبحاث مايو كلينك تُظهر أن أسلوب تسلسل الثقوب النانوية يكتشف ويحدد الميكروبات المقاومة للمضادات الحيوية بسرعة
Mayo Clinic

مدينة روتشستر، ولاية مينيسوتا- يموت عدد متزايد من الناس بسبب العَدوى المقاومة للمضادات الحيوية. وهذه العَدوى تغذيها أنواع الميكروبات التي تتحور لتتجنب الأدوية المطورة بهدف تدميرها. توفي أكثر من 1.2 مليون شخص حول العالم في عام 2019 بسبب العَدوى المقاومة للمضادات الحيوية.

Released: 29-Mar-2022 1:45 PM EDT
Pesquisa da Mayo Clinic mostra que método de sequenciamento por nanoporos detecta e identifica rapidamente micróbios resistentes a antibióticos
Mayo Clinic

Cada vez mais pessoas estão morrendo por infecções resistentes a antibióticos. Essas infecções são alimentadas por espécies microbianas que estão em mutação para escapar das drogas desenvolvidas para destruí-las.

Released: 29-Mar-2022 1:35 PM EDT
El método de secuenciación de nanoporos detecta e identifica rápidamente microbios resistentes a antibióticos, demuestra estudio de Mayo Clinic
Mayo Clinic

Una creciente cantidad de personas muere debido a infecciones resistentes a los antibióticos. Estas infecciones son propiciadas por especies bacterianas que mutan a fin de evadir a los fármacos creados para destruirlas.

Newswise: Drug-resistant bacteria flaunt their curves
Released: 15-Mar-2022 11:45 AM EDT
Drug-resistant bacteria flaunt their curves
Osaka University

If you’ve been hitting the gym and getting results, you know it’s time to strut your stuff; and it turns out bacteria feel the same way.



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