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Stem Cells

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Medicine

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Organ Transplantation, Mesanchymal Stem Cells, Adult Steam Cells, Inflammatory Bowel Disease, Traumatic Brain Injury, Regenerative Medicine

Researchers First to Use Common Virus to “Fortify” Adult Stem Cells

Using the same strategy that a common virus employs to evade the human immune system, researchers at Wake Forest Baptist Medical Center’s Institute for Regenerative Medicine have modified adult stem cells to increase their survival – with the goal of giving the cells time to exert their natural healing abilities.

Medicine

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Glioblastoma, Stem Cells, Brain Cancer

Using Fat to Fight Brain Cancer

In laboratory studies, Johns Hopkins researchers say they have found that stem cells from a patient’s own fat may have the potential to deliver new treatments directly into the brain after the surgical removal of a glioblastoma, the most common and aggressive form of brain tumor.

Medicine

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Spinal Cord Injury, spinal cord injured patients, Spinal Cord Regeneration, Stem Cells, Stem Cell Transplantation, Stem Cell Therapy, Bone Marrow Derived Stem Cells, Mesenchymal Stem Cells, Spinal Injury, Physical Therapy, Spinal Cord Trauma, Cervical Spinal Cord Injury, thoracic spinal cord injury, Robert Wood Johnson Medical School, Cancer Institute o

New Hope for Reversing the Effects of Spinal Cord Injury

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New hope for reversing the effects of spinal cord injury may be found in a combination of stem cell therapy and physical therapy according to new findings from Robert Wood Johnson Medical School

Medicine

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Tissue Engineering, Stem Cell, cell behavior, Vasculature, Heart Cell Regeneration, Skeleton, Microenvironment

Designing Interlocking Building Blocks to Create Complex Tissues

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Columbia Engineering’s new “plug-and-play” method to assemble complex cell microenvironments is a scalable, highly precise way to fabricate tissues with any spatial organization or interest—like those found in the heart or skeleton or vasculature. The PNAS study reveals new ways to better mimic the enormous complexity of tissue development, regeneration, and disease.

Medicine

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Jmjd3, Adult Stem Cells, pluripotent stem cells, stem cell reprogramming, Ipscs, inducible pluripotent stem cells, Rong-fu Wang, PHF20, Epigenetics, Chromatin Remodeling, Cancer, Cell Cycle, Inflammation, inflammatory response

Reprogramming Adult Cells to Stem Cells Works Better with One Gene Turned Off

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The removal of a genetic roadblock could improve the efficiency of converting adult cells into stem cells by 10 to 30 times, report scientists from The Methodist Hospital Research Institute and two other institutions in the latest issue of Cell.

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Twice Given, Twice Used: Infusion of Stem Cells and Specially Generated T-Cells From Same Donor Improves Leukemia Survival

In a significant advance for harnessing the immune system to treat leukemias, researchers at Fred Hutchinson Cancer Research Center for the first time have successfully infused large numbers of donor T-cells specific for a key anti-leukemic antigen to prolong survival in high-risk and relapsed leukemia patients after stem cell transplantation. Both the stem cells for transplant and the T-cells came from the same matched donors.

Medicine

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Stem Cell Transplants, Chemotherapy, Bone Marrow, Leukemia, Multiple Myeloma, Cxcl12

Distinct Niches in Bone Marrow Nurture Blood Stem Cells

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In research that could one day improve the success of stem cell transplants and chemotherapy, scientists have found that distinct niches exist in bone marrow to nurture different types of blood stem cells.

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Stash of Stem Cells Found in a Human Parasite

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Researchers have now found stem cells inside the parasite that cause schistosomiasis, one of the most common parasitic infections in the world. These stem cells can regenerate worn-down organs, which may help explain how they can live for years or even decades inside their host.

Medicine

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mice models, emphysema, Alveoli, Lungs, Pulmonary Disease, HGF, COPD

Lung Researchers Create New Air Sacs In Mouse Model Of Emphysema Using A Novel Growth Factor

In a study of mice, researchers at Johns Hopkins have identified a new molecular pathway involved in the growth of tiny air sacs called alveoli that are crucial for breathing. The scientists say their experiments may lead to the first successful treatments to regrow the air sacs in people who suffer from diseases such as emphysema in which the air sacs have been destroyed by years of smoking. The work may also suggest new therapy for premature infants born before their lungs are fully developed.

Medicine

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Breast, triple-negative, Claudin, MANI, Cancer, Stem Cell, EMT, Epithelial, Mesenchymal, Resistance, Metastasis, Sunitinib, DRGU

Protein Central to Cancer Stem Cell Formation Provides New Potential Target

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Researchers have identified a pivotal protein in a cellular transformation that makes a cancer cell more resistant to treatment and more capable of growing and spreading, making it an inviting new target for drug development.







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