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Stem Cells

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Science

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Stem Cell, ELL3, Pluripotency, Polymerase

Investigators’ Study Hints That Stem Cells Prepare for Maturity Much Earlier Than Anticipated

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Unlike less versatile muscle or nerve cells, embryonic stem cells are by definition equipped to assume any cellular role. Scientists call this flexibility “pluripotency,” meaning that as an organism develops, stem cells must be ready at a moment’s notice to activate highly diverse gene expression programs used to turn them into blood, brain, or kidney cells.

Medicine

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Cancer, Leukemia, Stem Cells, Genetics, Inflammation, Chronic Myeloid Leukemia

Enzyme Accelerates Malignant Stem Cell Cloning in Chronic Myeloid Leukemia

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An international team, headed by researchers at the University of California, San Diego School of Medicine, has identified a key enzyme in the reprogramming process that promotes malignant stem cell cloning and the growth of chronic myeloid leukemia (CML), a cancer of the blood and marrow that experts say is increasing in prevalence.

Science

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Circulatory System, Blood Vessels, chemical and biomolecular engineering, Stem Cell

Steering Stem Cells to Become Two Different Building Blocks for New Blood Vessels

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Growing new blood vessels in the lab is a tough challenge, but a Johns Hopkins engineering team has solved a major stumbling block: how to prod stem cells to become two different types of tissue that are needed to build tiny networks of veins and arteries.

Medicine

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Mitochondrial Disease, Stem Cell Therapy, Genetics

Scientists Develop Technique to Help Prevent Inherited Disorders in Humans

A joint team of scientists from The New York Stem Cell Foundation (NYSCF) Laboratory and Columbia University Medical Center (CUMC) has developed a technique that may prevent the inheritance of mitochondrial diseases in children. The study is published online today in Nature.

Medicine

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Stem Cell, Umbilical, cord, Blood, Transplant, Shpall, Delima

Pre-Transplant Umbilical Cord Blood Expansion in Lab Speeds Establishment of New Blood Supply in Patients, Reducing High-Risk Time to Recovery

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Donated umbilical cord blood establishes a new blood supply in patients more quickly after transplantation when it is first expanded in the lab on a bed of cells that mimics conditions in the bone marrow, researchers report in the Dec. 13 edition of the New England Journal of Medicine.

Science

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New Biomaterial Gets “Sticky” with Stem Cells

Just like the bones that hold up your body, your cells have their own scaffolding that holds them up. This scaffolding, known as the extracellular matrix, or ECM, not only props up cells but also provides attachment sites, or “sticky spots,” to which cells can bind, just as bones hold muscles in place.

Medicine

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stem cell production, Regenerative Medicine, Stem Cell Therapies

Salk Scientists Develop Faster, Safer Method for Producing Stem Cells

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A new method for generating stem cells from mature cells promises to boost stem cell production in the laboratory, helping to remove a barrier to regenerative medicine therapies that would replace damaged or unhealthy body tissues.

Medicine

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Stem Cell, Bone Marrow, Mayo Clinic

Stem Cell 101: Mayo Clinic Expert Answers Commonly Asked Questions

Next week, more than 1,200 people from 25 countries are expected to attend the 8th Annual World Stem Cell Summit in West Palm Beach, Fla., a gathering co-sponsored by Mayo Clinic. As those close to the science explore potential stem cell applications, many patients have questions about what stem cells are and how they are being used. Timothy Nelson, M.D., Ph.D., director of Mayo Clinic’s Regenerative Medicine Consult Service, answers some of the most commonly asked questions about stem cells.

Medicine

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Stem Cells, Personalized Medicine, Riley-Day syndrome

Study Advances Use of Stem Cells in Personalized Medicine

Johns Hopkins researchers report concrete steps in the use of human stem cells to test how diseased cells respond to drugs. Their success highlights a pathway toward faster, cheaper drug development for some genetic illnesses, as well as the ability to pre-test a therapy’s safety and effectiveness on cultured clones of a patient’s own cells.

Science

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IPS, Regenerative Medicine, Yamanaka factors, stem cell reprogramming, Stem Cell

Penn Study Decodes Molecular Mechanisms Underlying Stem Cell Reprogramming

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Thanks to some careful detective work, scientist better understand just how iPS cells form – and why the Yamanaka process is inefficient, an important step to work out for regenerative medicine. The findings uncover cellular impediments to iPS cell development that, if overcome, could dramatically improve the efficiency and speed of iPS cell generation.







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