The Association for Molecular Pathology has published best practice recommendations for validating and reporting clinical circulating tumor DNA (ctDNA) or liquid biopsy assays and their related scientific publications.
Basic Research Findings by Johns Hopkins Scientists Focus on Gene Sequencing, Hearing Loss and a Brain Disorder
Michael Berger, PhD, has been awarded a grant by The Israel Cancer Research Fund (ICRF) and the Cancer Research Institute (CRI).
Investigators have been awarded a grant to find a better way to protect muscle mass in patients. Muscle mass plays a critical role in quality of life and cancer survival.
The University of Texas MD Anderson Cancer Center will host its annual Leading Edge of Cancer Research Symposium Nov. 16-17, 2023, featuring presentations and discussions on genomics, immunity and inflammation, computational approaches for spatial biology, and emerging technologies that are driving the next wave of cancer breakthroughs.
A new study led by Yale scientists shows that the activity of a portion of a human papillomavirus (HPV) protein does not depend on its amino acid sequence or composition.
In a new article published today in Science Translational Medicine, a team of Moffitt Cancer Center researchers, in collaboration with NFlection Therapeutics and researchers at Stanford University, reports the identification of a new drug, NFX-179, that can be applied to the skin and was shown to prevent the development of cutaneous squamous cell carcinoma in pre-clinical models.
Through a novel approach detailed in Nature, a massive computational analysis of microbiome datasets more than doubled the number of known protein families. This is the first time protein structures have been used to help characterize the vast array of microbial “dark matter.”
Do you know your risk for breast and ovarian cancer? How about steps you can take to reduce your chances of developing cancer or what a family history might mean for your risk of the disease?
One of the world’s largest crop pathogen surveillance systems is set to expand its capacity to protect wheat productivity in food vulnerable areas of East Africa and South Asia.
Susan G. Komen® will hold a Metastatic Breast Cancer Impact Series Conference in Philadelphia that will include sessions with leading experts, survivor stories, wellness guidance, and interactive Q&A, offering attendees valuable insights, inspiration, practical tips, and community support.
Generating specific cell lineages from induced pluripotent stem cells and embryonic stem cells is the holy grail of regenerative medicine.
Immune cells play a key role during pregnancy, adjusting immune system response in a way that enables the fetus to develop while also protecting the parent and fetus from outside assaults like viruses.
The Indiana University Melvin and Bren Simon Comprehensive Cancer Center was awarded a prestigious grant to train the next generation of cancer drug discovery and development researchers. Known as a T32 grant, the five-year, $794,000 National Cancer Institute award will establish the Pediatric and Adult Translational Cancer Drug Discovery and Development Training Program (PACT-D3).
Inflammatory breast cancer is a rare type of breast cancer. It only accounts for one to five percent of all breast cancer cases, but it’s important to know your risk and the warning signs, as this form of the disease is aggressive, fast-growing, and hard to detect early. For October, during Breast Cancer Awareness Month, the American Cancer Society is highlighting IBC to help women be aware of this invasive cancer.
Fragile X syndrome, the most common form of inherited intellectual disability, may be unfolding in brain cells even before birth, despite typically going undiagnosed until age 3 or later.
By better understanding the cellular and molecular processes involved in mucus formation, scientists aim to uncover how to treat gastrointestinal-related diseases.
Plant pathogens can hitch rides on dust and remain viable, with the potential for traveling across the planet, according to a new Cornell University study – a finding with important implications for global food security and predicting future outbreaks.
The Faculty of Medicine, Chulalongkorn University, cordially invites all to attend the “Thailand Hub of Talent for Cancer Immunotherapy International Conference: Portal to Global Collaboration for Next Generation Cell and Gene Therapy Development” on November 16-17, 2023 at Bhumisiri Mangklanusorn Building, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Researchers at the UCLA Jonsson Comprehensive Cancer Center have identified a new role for a protein called extracellular signal-regulated kinase (ERK) in a pathway activated by interferon-gamma that can trigger cells to self-destruct.
Mercy's breast health experts Dr. Deepa Masrani and Dr. Wen C. Liang are guests for the October 2023 edition of "Medoscopy"; October is National Breast Cancer Awareness Month.
Amanda Butler and Isabella Bugatti, both just entering their 30s, were blindsided by a diagnosis that is on the rise among women their age: breast cancer.
Miriam Merad, MD, PhD, an esteemed immunologist at the Icahn School of Medicine at Mount Sinai, has been elected to the National Academy of Medicine (NAM) in recognition of her pioneering contributions to the fields of immunology and cell biology.
Scientists testing a new method of sequencing single cells have unexpectedly changed our understanding of the rules of genetics.
Once thought to be the trash can of the cell, a little bubble of cellular stuff called the midbody remnant is actually packing working genetic material with the power to change the fate of other cells — including turning them into cancer.
In 2019, St. Jude lentiviral gene therapy restored the immune system in multiple infants of X-linked severe combined immunodeficiency disorder (SCID-X1) or “bubble boy disease” at the DNA level. These children can now produce functional immune systems.
A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 18, entitled, “Biomedical generative pre-trained based transformer language model for age-related disease target discovery.”
In a study co-led by investigators at Dana-Farber Cancer Institute, researchers developed a low-cost, ultrasensitive blood test to detect minute levels of a cancer biomarker that is highly specific to multiple common cancers.
The American College of Surgeons (ACS) strongly supports the Find it Early Act (H.R. 3086).
The funding will be used to advance a novel technology, which combines Raman spectroscopy and machine learning to identify body fluid traces at crime scenes.
The University of Texas MD Anderson Cancer Center’s Research Highlights showcases the latest breakthroughs in cancer care, research and prevention. These advances are made possible through seamless collaboration between MD Anderson’s world-leading clinicians and scientists, bringing discoveries from the lab to the clinic and back. Recent developments at MD Anderson include a computer game that helps breast cancer survivors improve symptoms of peripheral neuropathy, a publicly available single-cell atlas of CD19 chimeric antigen receptor (CAR) T cells, new targets for TP53-mutant acute myeloid leukemia (AML), a preclinical target for preventing chemobrain, a blood test to help identify patients at higher risk of developing pancreatic cancer, and genomic insights to predict the risk of outcomes in patients with bone cancer.
The company, based on science from the Hackensack Meridian Center for Discovery and Innovation, promises to capture biomarkers for early diagnostics detecting cancer and a variety of diseases.
This asynchronous beating comes from how the flight muscles interact with the physics of the insect’s springy exoskeleton. This decoupling of neural commands and muscle contractions is common in only four distinct insect groups. For years, scientists assumed these four groups evolved these ultrafast wingbeats separately, but research from the Georgia Institute of Technology and the University of California, San Diego (UC San Diego) shows that they evolved from a single common ancestor. This discovery demonstrates evolution has repeatedly turned on and off this particular mode of flight. The researchers developed physics models and robotics to test how these transitions could occur.
Memory B cells depend on autophagy for their survival, but the protein Rubicon is thought to hinder this process. Researchers from Osaka University have discovered a shorter isoform of Rubicon called RUBCN100, which enhances autophagy in B cells.
In a common metaphor used to describe human fertilization, sperm cells are competitors racing to penetrate a passive egg. But as critics have noted, the description is also a “fairy tale,” rooted in cultural beliefs about masculinity and femininity.
Cornell University scientists have characterized the genome of a metal-loving bacteria with an affinity for rare earth elements. The research paves the way towards replacing the harsh chemical processing of these elements with a benign practice called biosorption.
An international team of researchers has released a landmark study on contemporary evolutionary change in natural populations. Their study uses one of the largest genomic datasets ever produced for animals in their natural environment, comprising nearly 4,000 Darwin’s finches.
Researchers at Stanford University School of Medicine, Yale University School of Medicine, and the Hospital for Special Surgery Research Institute have uncovered new details about how the immune system prevents the production of antibodies that can recognize and damage the body’s own, healthy tissues. The study, to be published September 29 in the Journal of Experimental Medicine (JEM), also reveals how this process is impaired in autoimmune disorders such as systemic sclerosis and systemic lupus erythematosus and suggests potential new strategies to treat these diseases.
The organisms that cause visceral leishmaniasis, a potentially deadly version of the parasitic disease that most often affects the skin, appear to have a secret weapon, new research suggests: They can infect non-immune cells and persist in those uncommon environments.
Irvine, Calif., Sept. 28, 2023 — With a two-year, $2 million grant from the California Institute for Regenerative Medicine, the University of California, Irvine has earned membership in CIRM’s Cell and Gene Therapy Manufacturing Network.
A discovery of a mutation in the gene ACTA2 has given researchers, led by Dianna Milewicz, MD, PhD, with UTHealth Houston, insight into understanding the cause of a rare and progressive problem with arteries in the brain and a cause of strokes in young children, called moyamoya disease.
Treating cancer with immunotherapies known as an immune checkpoint blockade (ICB) prior to surgery (so-called neoadjuvant immunotherapy) has been a rapidly growing area of research, but the scientific community is just scratching the surface of what is possible, according to a review article co-authored by several current and former investigators from the Bloomberg~Kimmel Institute for Cancer Immunotherapy and the Johns Hopkins Kimmel Cancer Center.
St. Jude researchers shed light on a key player in cancer development by exploring the ability of fusion oncoproteins to form condensates in cells.
A Ludwig Cancer Research study has for the first time exhaustively analyzed neutrophils that reside in brain tumors, detailing how the immune cells support brain cancer survival and how they’re turned by the tumor microenvironment into enablers of malignant growth.
Scientists have long understood that parts of cells, called organelles, evolved to have certain shapes and sizes because their forms are closely related to how they function.
In a groundbreaking study, a team of Georgia Tech researchers has unveiled a remarkable discovery: the identification of novel bacterial proteins that play a vital role in the formation and stability of methane clathrates, which trap gigatons of greenhouse gas beneath the seafloor. These newfound proteins not only suppress methane clathrate growth as effectively as toxic chemicals used in drilling but also prove to be eco-friendly and scalable. This innovative breakthrough not only promises to enhance environmental safety in natural gas transportation but also sheds light on the potential for similar biomolecules to support life beyond Earth.
A readily available, inexpensive small molecule drug can improve the fitness of hematopoietic stem and progenitor cells (HSPCs) that are modified outside of the body, potentially improving the success of procedures like ex vivo gene therapy, according to a new study by researchers at Children’s Hospital of Philadelphia (CHOP).
Patterns of chemical interactions are thought to create patterns in nature such as stripes and spots. This new study shows that the mathematical basis of these patterns also governs how sperm tail moves.
Our cells have a fleet of 300 molecular machines, called cullin-RING ligases, or "CRLs" for short, that each is capable of triggering destruction of specific proteins for the well-being of our cells.
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