Cedars-Sinai July Research Highlights
Cedars-SinaiA roundup of the latest medical discoveries and faculty news at Cedars-Sinai.
A roundup of the latest medical discoveries and faculty news at Cedars-Sinai.
Niki Patel, MD, a fellowship-trained hematologist-oncologist board certified in internal medicine and medical oncology, has joined the Division of Medical Oncology at Cedars-Sinai Cancer. She is treating patients in Pasadena at Huntington Cancer Center at Huntington Health, an affiliate of Cedars-Sinai.
Lab-on-a-chip technologies can ensure a more successful transfusion workflow by enabling objective assessment of stored RBC units using quality metrics identified by -omics and machine learning.
In a step forward in the development of genetic medicines, researchers at Children’s Hospital of Philadelphia (CHOP) and the Perelman School of Medicine at the University of Pennsylvania have developed a proof-of-concept model for delivering gene editing tools to treat blood disorders, allowing for the modification of diseased blood cells directly within the body. If translated into the clinic, this approach could expand access and reduce the cost of gene therapies for blood disorders, many of which currently require patients receive chemotherapy and a stem cell transplant. The findings were published today in the journal Science.
Chimeric antigen receptor (CAR)-T cells are a powerful, new form of cancer therapy that are being studied to treat blood cancers. Using a new approach, Yale Cancer Center researchers at Yale School of Medicine found a new way to substantially improve the effectiveness of CAR-T cell therapy. The new study was published in Nature Immunology on July 27.
Blood banks always say it’s safe to give blood. But is it safe to receive? A Penn State Health expert discusses all the ways professionals keep your blood pathogen-free.
Scientists at UT Southwestern Medical Center and Children’s Medical Center Dallas have discovered in mice how high cholesterol causes blood vessels to become inflamed, a necessary prerequisite for atherosclerosis – the “hardening of the arteries” responsible for most heart attacks and strokes. The findings, published in Nature Communications, could lead to new interventions to protect against cardiovascular diseases (CVD), the leading cause of death globally.
Chula Medicine researchers have successfully published an article on the injection of patient’s own platelets rich plasma into the shoulder ligaments resulting in pain reduction, heal torn ligaments and restore torn muscles as an alternative to surgery while reducing the side effects of prolonged use of pain medications.
New Day Diagnostics LLC is pleased to announce that it has entered into an asset purchase agreement with Epigenomics AG (Frankfurt Prime Standard: ECX, OTCQX: EPGNY), a molecular diagnostics company focused on blood testing for the early detection of cancer.
Cedars-Sinai Guerin Children’s investigators have advanced our understanding of the role that blood platelets play in Kawasaki disease, a serious illness that primarily affects children younger than 5 years old and causes their blood vessels to swell.
In a new study, University of Utah Health researchers have shown that a particular version of a gene may contribute to the higher severity of stroke seen among Black Americans. The findings could help scientists develop more effective stroke medications for people who carry the gene.
At the 2023 AACC Annual Scientific Meeting & Clinical Lab Expo, laboratory experts will present cutting-edge research and technology that is shaping the future of clinical testing and patient care.
During the AACC - Annual Scientific Meeting & Clinical Lab Expo, held in Anaheim, California (USA) from July 23rd to 27th, the Brazilian health tech company Hilab, specializing in clinical analysis tests, participated in the congress alongside ABIMO - Brazilian Association of Medical Devices Industry.
University of Maryland School of Medicine (UMSOM) researchers engineered a new type of CAR T-cell therapy that, in preclinical studies, selectively attacked cancer cells while sparing healthy cells, potentially reducing the likelihood of toxic side effects from this innovative cancer treatment.
The University of Texas MD Anderson Cancer Center’s Research Highlights showcases the latest breakthroughs in cancer care, research and prevention. These advances are made possible through seamless collaboration between MD Anderson’s world-leading clinicians and scientists, bringing discoveries from the lab to the clinic and back.
A team of researchers from the Cancer Science Institute of Singapore (CSI Singapore) at the National University of Singapore (NUS), led by Assistant Professor Anand Jeyasekharan, has discovered a unique combination of oncogenes that could predict treatment resistance, and hence unfavourable outcomes, of patients with Diffuse large B cell lymphoma (DLBCL), the most common type of blood cancer in Singapore and globally.
Routine blood pressure readings recorded in the first half of pregnancy can be divided into 6 distinct patterns that can effectively stratify patients by their risk of developing preeclampsia and gestational hypertension later in pregnancy, Kaiser Permanente researchers found.
Researchers continue to refine and improve targeted drug therapies that have changed the most common form of adult leukemia – from an incurable to a chronic condition. New data published in the New England Journal of Medicine offers another treatment option for patients who have stopped responding to the first and second generation drugs.
Gene therapy that alters hemoglobin genes may be an answer to curing sickle cell disease and beta thalassemia. Scientists at St. Jude Children’s Research Hospital and the Broad Institute of MIT and Harvard found base editing increased fetal hemoglobin production in a new treatment.
The results of a clinical trial have shown that a drug commonly used for patients with bleeding disorders has the potential to be used to lessen the side effects of blood-thinning drugs for patients who have experienced a stroke.
A national study of blood ferritin and hemoglobin levels from tween, teen and young adult females suggests routine screening might be needed for iron deficiency and anemia.
A blood-based four-protein panel (4MP), when combined with a lung cancer risk model (PLCOm2012), can better identify those at high risk of dying from lung cancer than the current U.S. Preventive Services Task Force (USPSTF) criteria.
A multi-faceted device for effectively treating deep, non-compressible, and irregularly-shaped wounds has been engineered by the scientists at the Terasaki Institute for Biomedical Innovation (TIBI).
An experimental antibody treatment largely prevented a bone marrow transplant complication called graft versus host disease (GVHD) in the intestines, without causing broad immune suppression, in a preclinical study led by researchers from Penn Medicine and Dana-Farber/Boston Children’s Cancer and Blood Disorders Center and published today in Science Translational Medicine.
A new collective named the Great Lakes Clinical Center (GLCC) for the ARDS, Pneumonia and Sepsis (APS) Phenotyping Consortium will be intensely focused on examining the various mechanisms underpinning these conditions to better understand their impact on disease development, trajectory and outcomes.
For many patients with hypertension—an elevated blood pressure that can lead to stroke or heart attack—medication keeps the condition at bay. But what happens when medication that physicians usually prescribe doesn’t work? Known as apparent resistant hypertension (aRH), this form of high blood pressure requires more medication and medical management.
Pessoas com obesidade grave e uma variante genética específica correm maior risco de pressão alta, descobriu um estudo da Mayo Clinic.
Las personas con obesidad severa y una variante genética específica tienen un mayor riesgo de hipertensión, según descubrió un estudio de Mayo Clinic.
مع السمنة ، يزداد خطر الإصابة بأمراض القلب والأوعية الدموية ، والتي تشمل السكتة الدماغية وفشل القلب الاحتقاني واحتشاء عضلة القلب. السمنة مرض متعدد العوامل ينتج عن اختلال توازن الطاقة. السمنة عامل خطر قابل للتعديل لأمراض القلب والأوعية الدموية.
According to an accepted manuscript published in ARRS’ own American Journal of Roentgenology (AJR), preferential use of pulmonary MR angiography (MRA) for diagnosing pulmonary embolus (PE) in the general population helped conserve iodinated contrast media during the 2022 shortage.
A new tool will enable patients with sickle cell disease to reliably and conveniently monitor their disease in the same way patients with diabetes can monitor their disease using a glucometer. The goal of managing this inherited, lifelong blood disorder is to prevent acute, painful crises due to sickling and unsickling of red blood cells.
Survival rates of babies after bone-marrow transplants jumped significantly after screening for SCID – severe combined immunodeficiency disease – started in North America in 2008, a major study finds.
Participating in hot yoga over four weeks reduced blood pressure in Black women, according to a study from Texas State University. Researchers also found the blood pressure drop and a widening of the participants’ arteries occurred despite three days of high salt intake.
Certain conditions can make the increased heart rate associated with exercise dangerous: Researchers found that an elevated heart rate can induce a stroke in patients with highly blocked carotid arteries. Contrastingly, for healthy patients and those with only slightly blocked arteries, exercise is beneficial for maintaining healthy blood flow. In healthy patients, an elevated heart rate increases and stabilizes the drag force blood exerts on the vessel wall, reducing stenosis risk. But for patients already experiencing stenosis, it may not be as beneficial.
Today, Veravas, a leading innovator in clinical diagnostics, announced the launch of its groundbreaking VeraBIND™ (Biomarker Isolation and N-richment for Detection) technology
New study shows that cholesterol aggregates can promote SARS-CoV-2 infection to help the virus invade cells
Researchers from Hackensack Meridian Children's Health at Joseph M. Sanzari Children's Hospital at Hackensack University Medical Center presented seven studies at the American Society of Pediatric Hematology/Oncology (ASPHO) Conference in Fort Worth in May.
As we enter the summer months in the Northern Hemisphere and the possibility of extreme heat becomes more common, it’s important to stay up-to-date on the science of heat waves and take measures to protect ourselves from this growing public health threat.
An innovative project to rapidly deliver blood and plasma to injured soldiers is set to save lives in warzones. The UK Ministry of Defence's Blood Far Forward programme aims to deliver blood and plasma within 30 minutes of injury to soldiers in active warzones.
Kyowa Kirin, Inc., an affiliate of Kyowa Kirin Co., Ltd. (Kyowa Kirin, TSE: 4151), a global specialty pharmaceutical company, today announced an initiative, Proactively Recognizing Occurrence in Blood through Education (PROBE) housed on PROBEinCTCL.com which was developed to educate HCPs on the importance of assessing blood involvement in Sézary Syndrome and Mycosis Fungoides—two subtypes of cutaneous T-cell lymphoma (CTCL).
Carlos Rene Valdez’s dance through life was interrupted by a cancer diagnosis, but it was the struggle to move on after recovery that ended his career and threatened his life. Wellness, Resilience and Survivorship programming, a part of the Patient and Family Support Program at Cedars-Sinai Cancer, gave him his life back.
A first-of-its-kind prognostic test approved by the FDA can now help doctors in the United States predict whether a woman will develop severe preeclampsia during pregnancy.
A new study by researchers at The University of Texas MD Anderson Cancer Center highlights novel insights into the evolution of multiple myeloma from precursor disease, which may help better identify patients likely to progress and develop new interventions
Researchers presenting preliminary data from a clinical trial aimed at discovering a cure for sickle cell disease reveal positive results among its first patients. Sickle cell disease, a genetic blood disorder, is a painful and debilitating condition for which there are few approved therapies.
In this project volumetric bioprinting was for the first time successfully combined with melt electrowriting.
The University of Texas MD Anderson Cancer Center’s Research Highlights showcases the latest breakthroughs in cancer care, research and prevention.