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Medicine

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mitochondria fuels tumor progression, Cancers, Wistar Institute

Newly Identified Pathway in Mitochondria Fuels Tumor Progression Across Cancer Types

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Wistar Scientists identified a novel protein pathway across several types of cancer that controls how tumor cells acquire the energy necessary for movement, invasion and metastasis.

Medicine

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Cancer, Association for Molecular Pathology, American Society of Clinical Oncology, College of American Pathologists, Genomics, next-generation sequencing, NGS

AMP Issues New Joint Guidelines to Standardize Interpretation and Reporting of Sequence Variants in Cancer

AMP has published guideline recommendations for both clinical laboratory professionals and oncologists that assess the status of next-generation sequencing (NGS)-based cancer tests and establish standardized classification, annotation, interpretation, and reporting conventions for somatic sequence variants.

Medicine

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Cancer, cancer mutation, Bioinfomatics, Biomedical Engineering, computational medicine

New Bioinformatics Tool Tests Methods for Finding Mutant Genes That ‘Drive’ Cancer

Computational scientists and cancer experts have devised bioinformatics software to evaluate how well current strategies distinguish cancer-promoting mutations from benign mutations in cancer cells.

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Stem Cell ‘Living Bandage’ for Knee Injuries Trialled in Humans

A ‘living bandage’ made from stem cells, which could revolutionise the treatment and prognosis of a common sporting knee injury, has been trialled in humans for the first time by scientists at the Universities of Liverpool and Bristol.

Medicine

Science

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Genome, lipidome, glycome, Glycobiology, Genomics, Glycomics, omics

There’s an “Ome” for That

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The genome was just the beginning. Rapid advances in technology and computational tools are allowing researchers to categorize many aspects of the biological world.

Science

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Drosophila, hostone modifications, Gene Expression

New Finding Reveals Battle Behind Gene Expression

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The complex process regulating gene expression is often compared to following a recipe. Miss a genetic ingredient, or add it in the wrong order, and you could have a disaster on your hands.

Medicine

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non-Hodgkin's lymphoma, Lymphoma

Mayo Clinic First in U.S. To Offer Lymphoma Genomic Diagnostic Test for Patients

Mayo Clinic has created a genetic test to help guide diagnosis and treatment of patients with diffuse large B-cell lymphoma, the most common type of non-Hodgkin’s lymphoma. The Lymph2Cx test helps determine where the lymphoma started, assigning “cell-of-origin” groups using a 20-gene expression-based assay. It is the first test to go into the Mayo practice from the new Mayo Clinic Molecular Diagnostic Arizona Laboratory. The lab enables Mayo physicians and researchers to access new and existing tests rapidly to improve patient care.

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Blocking Hormone Activity in Mosquitoes Could Help Reduce Malaria Spread

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Mathematical model suggests new malaria control approach could work as well as insecticides

Medicine

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Glioma, glioblastoma multiforme (GBM, Neuroscience, Neurosurgery, FOXD1, ALDH1A3, Glioma stem cells

Attractive Drug Candidate Identified to Target Glioma Brain Tumors

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In a Cancer Research paper, researchers: 1) identify a biomarker enzyme associated with aggressive glioma brain tumors, 2) reveal the regulatory mechanism for that enzyme, and 3) demonstrate potent efficacy, using a mouse model of glioma, for a small molecule inhibitor they have developed.

Medicine

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Chengfeng Merriman", Dax Fu, Diabetes, Type 2, Gene, Protein, zinc transporter 8, ZnT8

Search on for Drug to Tame 'Hyperactive' Zinc Transporter and Lower Type 2 Diabetes Risk

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Gene variants associated with disease are typically considered faulty; problems arise when the proteins they make don't adequately carry out their designated role.

Medicine

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Stomach Cancer

Gastric Cancer Fueled by ‘Crosstalk’ Between Nerves and Cancer Cells

Gastric tumors are started by specialized cells in the stomach that signal nerves to make more acetylcholine, according to a study in mice. But blocking nerve growth factor inhibits the formation of stomach tumors.

Medicine

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Cancer, Gastroenterology, Gastrointestinal Cancers, GIST, Genetics, Oncogenes

New Gene Fusions and Mutations Linked to Gastrointestinal Stromal Tumors

In recent years, researchers have identified specific gene mutations linked to gastrointestinal stromal tumors (GIST), which primarily occur in the stomach or small intestine, but 10 to 15 percent of adult GIST cases and most pediatric cases lack the tell-tale mutations, making identification and treatment difficult. Researchers at University of California San Diego School of Medicine and Moores Cancer Center have identified new gene fusions and mutations associated with this subset of GIST patients.

Science

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Proteins, X-Ray, Ut Southwestern

UT Southwestern Scientists Invent New Way to See Proteins in Motion

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UT Southwestern Medical Center researchers developed a new imaging technique that makes X-ray images of proteins as they move in response to electric field pulses.

Medicine

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Department Of Defense, National Institute of Health (NIH), Prostate Cancer, Tumor Progression, cell reprogramming

Patient Prostate Tissue Used to Create Unique Model of Prostate Cancer Biology

For the first time, researchers have been able to grow, in a lab, both normal and primary cancerous prostate cells from a patient, and then implant a million of the cancer cells into a mouse to track how the tumor progresses. The achievement, say researchers at Georgetown University Medical Center who led the research, represents a critical advance in the effort to understand the origin and drivers of this puzzling cancer — the most common in men.

Science

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SLAC National Accelerator Laboratory, LCLS , Linac Coherent Light Source, SSRL, Stanford Synchrotron Radiation Lightsource, lightsource, X-ray science, X-ray Crystallogaphy

Masters of Crystallization

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Biology isn't just for biologists anymore. That's nowhere more apparent than in the newly furnished lab in room 097 of the Shriram Center basement, where flasks of bacterial and animal cells, snug in their incubators, are churning out proteins destined for jobs they may not have done in nature.

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Newly Revealed Amino Acid Function Could Be Used to Boost Antioxidant Levels

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Protecting the body against oxidative stress

Medicine

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Zambidis, Kimmel Cancer Center, Embryonic Stem Cells, ESCs

Researchers Turn Back the Clock on Human Embryonic Stem Cells

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Johns Hopkins scientists report success in using a cocktail of cell-signaling chemicals to further wind back the biological clock of human embryonic stem cells (ESCs), giving the cells the same flexibility researchers have prized in mice ESCs.

Medicine

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Molecular Biology, Cancer, Cell Biology, Biology (Biochemistry), Tumor, Hypoxia, Hypoxia Inducible Factor

Scientist Discovers New Cancer Connection

A biologist at The University of Texas at Dallas and his colleagues have discovered that two enzymes previously linked independently with keeping cancer cells alive actually work in tandem to spur tumor growth.

Medicine

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Vision, Vision Recovery, retinal cell transplantation, retinal cells, Retina, Photoreceptors, Krembil Neuroscience Centre, Toronto Western Hospital, University Health Network

Krembil Research Prompts Rethink on Established Vision Recovery Theory

A team of researchers at the Krembil Research Institute has published a paper that is expected to change the way scientists think about vision recovery after retinal cell transplantation.

Medicine

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Biology, DNA, genes, Neuromuscular, neurodegernative, Huntington's Disease, Genetics

Runaway DNA Repair Process May Cause Dozen Debilitating Diseases

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Researchers have discovered a possible explanation for a genetic error that causes over a dozen neuromuscular and neurodegenerative disorders.







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