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Medicine

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Pancreatic Cancer, KRAS, Exosome, Cancer Biology, Cancer Biology & Therapy

Innovative Therapy Strategy for Pancreatic Cancer Uses Engineered Exosomes Targeting Mutated KRAS Gene

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Genetic manipulation of exosomes, virus-sized particles released by all cells, may offer a new therapeutic approach to treating pancreatic cancer, according to a study at The University of Texas MD Anderson Cancer Center.

Medicine

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Jonathan P. Schneck, Jonathan Schneck, Nano Particles, Nanoparticles, mmunoswitch, immune, Tumor, Antibodies

"Immunoswitch" Particles May Be Key to More-Effective Cancer Immunotherapy

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Scientists at Johns Hopkins have created a nanoparticle that carries two different antibodies capable of simultaneously switching off cancer cells' defensive properties while switching on a robust anticancer immune response in mice. Experiments with the tiny, double-duty "immunoswitch" found it able to dramatically slow the growth of mouse melanoma and colon cancer and even eradicate tumors in test animals, the researchers report.

Medicine

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Atherosclerosis, Trehalose, Macrophages, Autophagy

Type of Sugar May Treat Atherosclerosis, Mouse Study Shows

Studying mice, researchers at Washington University School of Medicine in St. Louis have shown that a natural sugar called trehalose revs up the immune system’s cellular housekeeping abilities. These souped-up housecleaners then are able to reduce atherosclerotic plaque that has built up inside arteries. Such plaques are a hallmark of cardiovascular disease and lead to an increased risk of heart attack.

Science

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Acetylation, protein acetylation

Yeast Study Examines How Cells Respond and Adapt to Heat Stress

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A University of Arkansas biologist is studying heat-stress response in yeast to help determine the role of protein acetylation in cells

Science

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Sex Differences, Obesity, Diabetes & Endocrinology, Metabolic Diseases, Sex And Gender Differences, Tulane University

Does The Sex Of A Cell Matter In Research?

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A Tulane endocrinologist has co-authored a guide in the latest issue of Cell Metabolism to help scientists who study obesity, diabetes or other metabolic diseases better account for inherent sex differences in research.

Medicine

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Breast Cancer, Cancer, Cell Signaling, Cell Biology, Drug Resistance, Unfolded Protein Response (UPR)

Cancer Cells Send Signals Boosting Survival and Drug Resistance in Other Cancer Cells

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Researchers at University of California San Diego School of Medicine report that cancer cells appear to communicate to other cancer cells, activating an internal mechanism that boosts resistance to common chemotherapies and promotes tumor survival.

Medicine

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Cancer, Ovarian Cancer, Immunotherapy, T-cell engineering, Cancer Research, ASCO 2017

Roswell Park’s Dr. Kunle Odunsi Gives Update on Ovarian Cancer Immunotherapy Study at ASCO Annual Meeting

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Dr. Kunle Odunsi of Roswell Park Cancer Institute presented an update about an ongoing clinical trial involving T-cell engineering to treat advanced ovarian cancer at the ASCO Annual Meeting in Chicago.

Medicine

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St. Jude Children's Research Hospital, Medulloblastoma, sonic hedgehog pathway, SHH medulloblastoma, Smoothened, primary cilium, Phospholipase A2, Cell And Molecular Research, Cell and Molecular Biology

Researchers Identify a Key Controller of Biological Machinery in Cell’s ‘Antenna’

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St. Jude Children’s Research Hospital discovery of a regulatory enzyme working at the primary cilium could lead to treatments for the brain tumor medulloblastoma

Medicine

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Stem Cell, regen med

UIC Launches Center for Stem Cell and Regenerative Medicine

The University of Illinois at Chicago College of Medicine will launch a new center that will focus on understanding tissue regeneration and pioneering future developments in stem cell biology as a means to repair diseased organs and tissues.

Medicine

Science

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collective dynamics, Collective Decision Making, Neural Cells, Neural Activity

How Neurons Use Crowdsourcing to Make Decisions

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When many individual neurons collect data, how do they reach a unanimous decision? New research from the Santa Fe Institute's collective computation group suggests a two-phase process.







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