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Stem Cells

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Science

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Tooth regeneration, Stem Cells, Hydrogel, Tissue Engineering

New Stem Cell Delivery Approach Regenerates Dental Pulp-Like Tissue in a Rodent Model

Delivery of stem cells to damaged tooth roots using a collagen-derived biomaterial is effective at regenerating dental pulp-like tissue and shows promise as a potential therapy for restoring natural tooth function in a rodent model.

Medicine

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Stem Cell ‘Living Bandage’ for Knee Injuries Trialled in Humans

A ‘living bandage’ made from stem cells, which could revolutionise the treatment and prognosis of a common sporting knee injury, has been trialled in humans for the first time by scientists at the Universities of Liverpool and Bristol.

Medicine

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Glioma, glioblastoma multiforme (GBM, Neuroscience, Neurosurgery, FOXD1, ALDH1A3, Glioma stem cells

Attractive Drug Candidate Identified to Target Glioma Brain Tumors

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In a Cancer Research paper, researchers: 1) identify a biomarker enzyme associated with aggressive glioma brain tumors, 2) reveal the regulatory mechanism for that enzyme, and 3) demonstrate potent efficacy, using a mouse model of glioma, for a small molecule inhibitor they have developed.

Medicine

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Zambidis, Kimmel Cancer Center, Embryonic Stem Cells, ESCs

Researchers Turn Back the Clock on Human Embryonic Stem Cells

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Johns Hopkins scientists report success in using a cocktail of cell-signaling chemicals to further wind back the biological clock of human embryonic stem cells (ESCs), giving the cells the same flexibility researchers have prized in mice ESCs.

Medicine

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Stem Cells, Pacemaker Cells, Heart, Biological Pacemaker, Toronto General Hospital, McEwen Centre for Regenerative Medicine, University Health Network

McEwen Centre Scientists Produce Functional Heart Pacemaker Cells

Scientists from the McEwen Centre for Regenerative Medicine, University Health Network, have developed the first functional pacemaker cells from human stem cells, paving the way for alternate, biological pacemaker therapy.

Medicine

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Osteolectin, Bone Marrow, Stem Cell, bone cells, Ut Southwestern

CRI Scientists Discover New Bone-Forming Growth Factor That Reverses Osteoporosis in Mice

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A team of scientists at the Children’s Medical Center Research Institute at UT Southwestern (CRI) discovered a new bone-forming growth factor, Osteolectin (Clec11a), which reverses osteoporosis in mice and has implications for regenerative medicine.

Medicine

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Mount Sinai, Mount Sinai Health System, Icahn School of Medicine at Mount Sinai, Stem Cell, stem cell memory

Stem Cell Memories May Hold Answer to Their Reproduction, Mount Sinai Study Finds

Blood-forming stem cells are able to count and store memories of the number of times that they divide, findings which could have major implications for disease research, scientists at the Icahn School of Medicine at Mount Sinai have found.

Science

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How to Make a Motor Neuron

A team of scientists has uncovered details of the cellular mechanisms that control the direct programming of stem cells into motor neurons.

Medicine

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Leukemia, Acute Myeloid Leukemia (AML), Stem Cells, Gene signature, princess margaret cancer centre, University Health Network

Stem Cell-Based Test Predicts Leukemia Patients’ Response to Therapy to Help Tailor Treatment

Leukemia researchers at Princess Margaret Cancer Centre have developed a 17-gene signature derived from leukemia stem cells that can predict at diagnosis if patients with acute myeloid leukemia (AML) will respond to standard treatment.

Science

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TET Proteins Drive Early Neurogenesis

The fate of stem cells is determined by series of choices that sequentially narrow their available options until stem cells’ offspring have found their station and purpose in the body. Their decisions are guided in part by TET proteins rewriting the epigenome, the regulatory layer of chemical flags that adorn the genome and influence gene activity, report researchers at La Jolla Institute for Allergy and Immunology and UC San Diego.







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