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Stem Cells Collected From Fat May Have Use in Anti-Aging Treatments

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Adult stem cells collected directly from human fat are more stable than other cells – such as fibroblasts from the skin – and have the potential for use in anti-aging treatments, according to researchers from the Perelman School of Medicine at the University of Pennsylvania. They made the discovery after developing a new model to study chronological aging of these cells.

Medicine

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Acute Myeloid Leukemia (AML), Cancer, Leukemia, Hematopoietic Stem Cell, FLT3, RUNX1

Tumor Suppressor Promotes Some Acute Myeloid Leukemias, Study Reveals

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Researchers in Germany have discovered that a tumor suppressor protein thought to prevent acute myeloid leukemia (AML) can actually promote a particularly deadly form of the disease. The study, “RUNX1 cooperates with FLT3-ITD to induce leukemia,” which will be published online February 17 in The Journal of Experimental Medicine, suggests that targeting this protein could be an effective treatment for certain AML patients.

Science

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Tissue Engineering, Nervous System, Intestinal, Diabetes

Researchers Engineer Intestinal Tissue with Functioning Nervous System

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For the first time, NIH-funded researchers have used stem cells to grow intestinal tissues with a functioning nervous system. The advance creates new opportunities for studying intestinal diseases, nutritional health, and diabetes. It also brings researchers one step closer to growing patient-specific human intestines for transplant.

Medicine

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Stem Cell, Leukemia, MDs, Myelodysplastic Syndrome, Acute Myeloid Leukemia, CRISPR, Mount Sinai Health System

Scientists Create Novel Model That Shows Progression From Normal Blood Cells to Leukemia

Mount Sinai researchers have created a novel model that shows the step-by-step progression from normal blood cells to leukemia and its precursor diseases, creating replicas of the stages of the disease to test the efficacy of therapeutic interventions at each stage, according to a study to be published in Cell Stem Cell. This research marked the first time scientists have been able to transplant leukemia from humans to a test tube and then into mice for study, a landmark feat that will allow for valuable research to help find therapies for blood cancer patients in the future.

Medicine

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Children’s Hospital of Philadelphia, Congenital Heart Defect, Dr. Timothy Nelson, Hypoplastic Left Heart Syndrome, Medical Research, Minnesota News Releases, news releases, Regenerative Medicine, Stem Cells

Mayo Clinic, Children’s Hospital of Philadelphia Announce Rare Congenital Heart Defect Collaboration

Mayo Clinic’s Todd and Karen Wanek Family Program for Hypoplastic Left Heart Syndrome and Children’s Hospital of Philadelphia are collaborating to delay and prevent heart failure for hypoplastic left heart syndrome, a rare and complex form of congenital heart disease in which the left side of a child's heart is severely underdeveloped.

Medicine

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Myelodysplastic Syndrome, Genetics, Genetic Profiling, Dana-Farber Cancer Institute, Blood Cancers, Cancer Alternative Medicine Biology Breast Cancer Nutrition/Nutrients Public Health, MDs

Genetic Profiling Can Guide Stem Cell Transplantation for Patients with Myelodysplastic Syndrome, Study Finds

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A single blood test and basic information about a patient’s medical status can indicate which patients with myelodysplastic syndrome (MDS) are likely to benefit from a stem cell transplant, according to new research by scientists at Dana-Farber Cancer Institute.

Medicine

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Osteomyelitis, MRSA, Mrsa Infections, MRSA strains, MRSA superbug, Stem Cell, stem cell activation, stem cell bio-manufacturing, Stem Cell Development, Scaffold, Scaffold Proteins, Scaffolding, Scaffolds, Bone Infections, Bone Regeneration, silver ions, Silver

A Silver Bullet Against MRSA: Silver Ion-Coated Medical Devices Could Fight MRSA While Creating New Bone

The rise of MRSA infections is limiting the treatment options for physicians and surgeons. Now, an international team of researchers, led by Elizabeth Loboa, dean of the University of Missouri College of Engineering, has used silver ion-coated scaffolds, or biomaterials that are created to hold stem cells, which slow the spread of or kill MRSA while regenerating new bone. Scientists feel that the biodegradable and biocompatible scaffolds could be the first step in the fight against MRSA in patients.

Medicine

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Organoids, Miller-Dieker Syndrome , Brain Development, Lissencephaly, Stem Cells

Human Brain ‘Organoids’ Offer New Insight into Rare Developmental Disease

Research led by scientists at UC San Francisco and Case Western Reserve University School of Medicine has used brain “organoids” — tiny 3D models of human organs that scientists grow in a dish to study disease — to identify root causes of Miller-Dieker Syndrome (MDS), a rare genetic disorder that causes fatal brain malformations.

Medicine

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Stem Cells, bone, Cells, mice, Biotechnology, Biomedical Engineering

UW Scientists Find Key Cues to Regulate Bone-Building Cells

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The prospect of regenerating bone lost to cancer or trauma is a step closer to the clinic as University of Wisconsin-Madison scientists have identified two proteins found in bone marrow as key regulators of the master cells responsible for making new bone.

Medicine

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'Mini-Guts' Offer Clues to Pediatric GI Illness

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Using immature stem cells to create a miniature model of the gut in the laboratory, researchers at Washington University School of Medicine in St. Louis and the University of Pittsburgh have determined how infection-causing enteroviruses enter the intestine.







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