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Medicine

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Microbiome, Precision Medicine

Making the Microbiome Part of Precision Medicine

Studies of the microbiome should be integral to future precision medicine initiatives, argue scientists from the University of Chicago in a new commentary published Nov. 1 in Trends in Pharmacological Sciences.

Medicine

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differential pricing, drug pricing

Plenary 2 of ISPOR 19th Annual European Congress Focuses on Differential Pricing of Medicines in Europe

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The International Society for Pharmacoeconomics and Outcomes Research (ISPOR) held its second plenary session, "Differential Pricing of Medicines in Europe: Implications for Access, Innovation, and Affordability," this morning at the Society’s 19th Annual European Congress in Vienna, Austria.

Medicine

Science

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Pharamcuetical Chemistry, Medicines

New Discovery Could Help Oral Medicines Work Better

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A team of researchers from the University of Minnesota and The Dow Chemical Company have discovered a new method for customizing ingredients that help oral medications dissolve in the body and be absorbed into the bloodstream. The materials discovered in this study could allow life-saving drugs to work faster and more efficiently.

Medicine

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ISPOR Annual European Congress, Effectiveness Of Drugs, effectiveness research, Medical Devices

ISPOR 19th Annual European Congress Explores How Incentives Could Support Effectiveness Research of Medical Devices

The International Society for Pharmacoeconomics and Outcomes Research (ISPOR) held a workshop this morning on Incentivizing Research Into the Effectiveness of Medical Devices at the Society’s 19th Annual European Congress in Vienna, Austria.

Medicine

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HTA, voice of the patient, rare disease, Orphan Drugs

ISPOR 19th Annual European Congress Explores How HTA Bodies Can Consider the Voice of Patients with Rare Diseases

The International Society for Pharmacoeconomics and Outcomes Research (ISPOR) led a session this afternoon entitled, "From Testimonials to Qualitative Research Embedded in Clinical Trials: How Do Health Technology Assessment Bodies Consider the Voice of Rare Disease Patients When Granting Access to Orphan Drugs?" The discussion took place at the Society’s 19th Annual European Congress—in Vienna, Austria.

Medicine

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Rna Interference, Rnai, Drug Development, RNA, RXi Pharmaceuticals, Geert Cauwenbergh, sd-rxRNA, RXI-109, connective tissue growth factor, CTGF, Fibrosis, scar formation, retinal scarring, age-related macular degeneration, AMD, hypertrophic scar

Expert: How Can ‘RNA Interference’ Enhance Drug Development?

Medicine

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Breast Cancer, Mammogram, 3D mammography, tomosynthesis, Yale Cancer Center

Yale Expert to Speak on Tomosynthesis for Breast Cancer Detection

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Medicine

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pembrolizumab, Tecentriq, Lung Cancer, Herbst, Yale Cancer Center, atezolizumab

FDA Approves Keytruda for First-Line Treatment of PD-L1–Expressing Metastatic NSCLC

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The FDA granted approval to pembrolizumab for the first-line treatment of patients with metastatic non–small cell lung cancer whose tumors express programmed death ligand-1 as determined by an FDA–approved test.

Medicine

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ASHP, Standardize 4 Safety Initiative, Medication Safety, Medication Errors, IV infusions, FDA Safe Use Initiative, Medication Therapy, Deborah Pasko, Aami, ppag, ismp, pediatric pharmacy advocacy group, Institute for Safe Medication Practices, Association For The Advancement Of Medical Instrumentation, Johns Hopkins School of Medicine, Pharmacists, Physi

Standardize 4 Safety Initiative Releases Final IV Recommendations for Medication Safety

ASHP announced that its Standardize 4 Safety initiative has finalized its list of recommended concentrations for adult IV continuous infusions. The list, which marks the first major milestone in Phase I of the initiative, is posted on ASHP’s Standardize 4 Safety website. ASHP also announced today that it is now seeking comments and discussion on dosage recommendations for compounded oral liquids. The comment period begins today and will remain open for 60 days.

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Stability of Exhausted T Cells Limits Durability of Cancer Checkpoint Drugs

Reinvigorating exhausted T cells in mice using a PD-L1 blockade caused very few T memory cells to develop. After the blockade, re-invigorated T cells became re-exhausted if antigen from the virus remained high, and failed to become memory T cells when the virus was cleared.

Medicine

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Drug Labels, Older Patients, Prescribed Medications, Pharmaceuticals

Prescription Medication Tragedies Could Be Prevented by Simple Pictures

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Simple images designed to convey information about prescription drugs could help save lives and reduce the economic burden of non-adherence to treatment. New research published in Applied Ergonomics shows that including pictograms on written medication instructions helps seniors take their drugs correctly.

Medicine

Science

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Leukemia, Lymphoma, Md Anderson, Draetta, Jones, glycolysis , MD Anderson Cancer Center, Konopleva, IACS, AML, IACS-10759

Drug Targeting Tumor Metabolism Discovered by MD Anderson’s Institute for Applied Cancer Science Enters Clinical Trial

The University of Texas MD Anderson Cancer Center’s Institute for Applied Cancer Science (IACS) has initiated the first clinical study of a novel drug designed to starve cancer cells, IACS-10759.

Medicine

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Glioblastoma, Brain Tumor, Apoptosis, Cell Death, PPAR inhibitors, Cell Cycle, Cancer, Sbarro Health Research Organization, Temple University

Researchers Slow Glioblastoma by Inhibiting Tumor’s PPARα Receptor

One of the most remarkable features of glioblastoma is the metabolic reprogramming of cancerous cells, resulting in uncontrolled cell proliferation, hypoxic conditions and angiogenesis. Metabolic reprogramming enables tumor cells with a faster way to produce energy and form new membranes. For this and other reasons, glioblastoma is presently incurable and the affected patients have a poor outcome.

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Paper vs. Electronic: How a Dermatology Prescription Is Written Affects Adherence

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A UNC School of Medicine dermatologist recently conducted a study to determine if the way a prescription was written – either traditionally or electronically – played a role in whether a patient filled and picked up the medication.

Medicine

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Anesthesia, Anesthesia And Critical Care, Alzheimer's Disease

Experimental Drug Shows Promise in Treating Alzheimer’s Disease

An experimental drug shows promise in treating Alzheimer’s disease by preventing inflammation and removing abnormal protein clumps in the brain that are associated with the disease, suggests a study in mice presented at the ANESTHESIOLOGY® 2016 annual meeting.

Medicine

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Anesthesia And Critical Care, Anesthesiology and Perioperative Medicine, surgical anesthesia, Anesthesia

Simple Instruction Sheet Helps Patients Correctly Take Regular Medications Before Surgery

Patients may be more likely to take their regularly prescribed medications for chronic conditions such as diabetes and hypertension correctly before surgery when provided a simple instruction sheet, reveals a study presented at the ANESTHESIOLOGY® 2016 annual meeting. Taking medication correctly before surgery can improve patient safety and comfort, and reduce day-of-surgery cancellations.

Medicine

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Texas A&M University, Ivan Rusyn, tissue chip, Drug Testing, Clinical Trial, drub screening

Texas A&M Researchers Use ‘Tissue Chips’ To Test Safety And Efficacy Of Drugs

A new and more informative process to test the safety and efficacy of drugs—employing a “tissue chip” technique—is underway at Texas A&M University.

Science

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TNBC, triple negative breast cancer, Breast Cancer, PIM, Myc-related cancers

Drug Target for Triple-Negative Breast Cancer Found in New Study

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A team of researchers led by UC San Francisco scientists has identified a new drug target for triple-negative breast cancer, an aggressive disease subtype that has the poorest outcomes and accounts for as many as one in five cases. The findings are particularly noteworthy because drugs that act on the newly discovered target, a protein known as PIM1, are already in clinical trials for leukemia and multiple myeloma.

Medicine

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Anesthesia, Anesthesiology and Perioperative Medicine, surgical anesthesia

Public Health Insurance May Be a Predictor of Pain in Post Anesthesia Care Unit

Patients using public health insurance were more likely to experience high pain levels in the post anesthesia care unit (PACU) following surgery to remove their tonsils and/or adenoids, according to a study presented at the ANESTHESIOLOGY® 2016 annual meeting. This single characteristic showed a disparity in patients’ PACU experience, independent of overall health, age, gender, race or neighborhood median income.

Medicine

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Pediatrics, Pediatric Medicine

Expert Availability: NewYork-Presbyterian, Columbia University Medical Center and Weill Cornell Medicine Experts to Present at the 63rd Annual American Academy of Child Adolescent Psychiatry (AACAP) Meeting

Physicians and scientists from NewYork-Presbyterian, Columbia University Medical Center and Weill Cornell Medicine will attend the 2016 63rd Annual American Academy of Child Adolescent Psychiatry (AACAP) Meeting from October 24-29.







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