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Medicine

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Lymphoma, Lymphoma Research, Lymphoma treatment, Diffuse large B-cell lymphoma, Clinical Trial, Clinical Trial participation, oral cancer drugs

UNMC Seeking Lymphoma Patients for Oral Two-Drug Study

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Most cancer treatments come in the form of chemotherapy given intravenously. This is unique because it uses a combination of two oral medications.

Medicine

Science

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Antibiotic Resistance, scientist profile, Profile, Microbiome, Drug Resistant Bacteria, Gut commensal microbiota

The Irresistible Resistome: How Infant Diapers Might Help Combat Antibiotic Resistance (Sort of)

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Biochemist Gautam Dantas inspects what’s deposited on infant diapers for clues about antibiotic resistance.

Medicine

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Personaized Medicine, drug cocktails, Drug Combinations, Modeling, Cancer Treatment, Alon

How to Mix the Perfect (Drug) Cocktail

The fine art of mixing drug cocktails is incredibly complicated, with virtually infinite numbers of possible interactions and side effects. Now, a new model from the Weizmann Institute lab of Prof. Uri Alon lets scientists compare combinations of drugs to determine efficacy – a major step forward in personalized medicine.

Medicine

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Emergency Medicine, Blood

New Trial to Examine Use of Pre-Hospital Blood Products

University of Warwick is collaborating with researchers at the NIHR Surgical Reconstruction and Microbiology Research Centre (SRMRC) to support a ground-breaking new study to investigate the effectiveness of giving patients blood products immediately after a major injury or trauma - before they reach hospital.

Medicine

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Opioid, Pain Medication, Opioid Addiction, opioid abuse, Primary Care Physicians, medical management

Overcoming the Opioid Crisis in the Primary Care Setting

Through monitoring and dosing guidelines, provider education and training and better alternatives for patient pain management, medical group reduces monthly average of written pain medicine prescriptions by 20 percent, while the number of providers within the medical group grew by 22 percent and the number of patients grew by 12 percent.

Medicine

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Endocrine Society, Insulin, Diabetes, Diabetes & Endocrinology, drug prices, drug pricing, Endocrinology

Endocrine Society Calls for Solutions Regarding Insulin Price Crisis

The Endocrine Society lauds Novo Nordisk’s recent announcement that it would limit price increases for its therapies, including insulin, and hopes that other entities in the insulin supply chain including manufacturers, pharmacy benefit managers, and insurers will also demonstrate similar restraint to address this important issue.

Medicine

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Parkinson Disease, Parkinson Disease Treatment

Diabetes Drug Slows Experimental Parkinson’s Disease Progression, Human Trials to Begin Next Year

A new investigational drug originally developed for type 2 diabetes is being readied for human clinical trials in search of the world’s first treatment to impede the progression of Parkinson’s disease following publication of research findings today in the journal Science Translational Medicine.

Medicine

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Molecular Biology, Pharmaceutical Chemistry, Cancer, Immunology, Inflammation, Chemokine Receptor, Structural Biology, Drug Development

Researchers Reveal 3D Structure of Cell’s Inflammation Sensor and Its Inhibitors

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Researchers at the Skaggs School of Pharmacy and Pharmaceutical Sciences at University of California San Diego have now determined the 3D structure of CCR2 simultaneously bound to two inhibitors. Understanding how these molecules fit together may better enable pharmaceutical companies to develop anti-inflammatory drugs that bind and inhibit CCR2 in a similar manner. The study is published December 7 by Nature.

Science

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Alzheimer's Disease, Blood Brain Barrier, neurotrophic growth factor, Jagdish Singh, NDSU Research, Nerve Growth Factor, Gene Therapy, Pharmaceutical Sciences, Dementia

NDSU Researcher Awarded $1.89 Million Grant for Alzheimer’s Study

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Jagdish Singh, chair and professor of pharmaceutical sciences at North Dakota State University, is receiving a $1.89 million grant award for his research to develop a nanotechnology-based system that effectively delivers Nerve Growth Factor across the blood brain barrier to treat Alzheimer's disease.

Science

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Triclosan, antibacterial resistance, FDA, Policy

Ban on Triclosan Shows Need for New Chemicals to Demonstrate Efficacy and Safety

A new commentary cautions that the Food and Drug Administration’s ban on triclosan and 18 other biocidal chemicals that promote antibiotic resistance is only a starting point. Triclosan’s long-term impact, as well the risks substitute chemicals may pose, must also be addressed.

Medicine

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TSRI Scientists Find Mechanism Behind Side Effects in Vision-Loss Treatment

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A common class of drugs for vision loss may actually add to the problem in some patients, according to new research co-led by scientists at The Scripps Research Institute (TSRI).

Medicine

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Influenza, flu, Vaccine, Pharmaceticals, genes

New, More Effective Strategy for Producing Flu Vaccines

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A team of researchers led by Yoshihiro Kawaoka, professor of pathobiological sciences at the University of Wisconsin–Madison School of Veterinary Medicine, has developed technology that could improve the production of vaccines that protect people from influenza B.

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ASRA Board Weighs in on the Opioid Crisis with Official Position Statement

The opioid crisis in America is the result of a number of complicating factors and, therefore, does not have a simple solution. Addressing this important issue requires a comprehensive, multidisciplinary, interdisciplinary approach, according to the authors of ASRA's Statement on the Opioid Crisis, approved by the Board of Directors at its November 2016 meeting.

Medicine

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Leukemia Drug Combo Is Encouraging in Early Phase I Clinical Trial

In a Phase I study, 8 out of 12 patients with relapsed and/or chemotherapy refractory blood cancers responded to a combination of the chemotherapy drugs thioguanine and decitabine; some of the responders had relapsed after treatment with decitabine alone.

Medicine

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Case Western Reserve University, case school of engineering, Case Western Reserve School of Medicine

Filling Need for Fast and Accurate Assessment of Blood’s Ability to Clot

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Case Western Reserve University researchers have developed a portable sensor that can assess the clotting ability of a person’s blood 95 times faster than current methods—using only a single drop of blood.

Medicine

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Acute Myeloid Leukemia

CPX-351 Improves Survival Following Allogeneic Hematopoietic Cell Transplant in Older High-Risk Acute Myeloid Leukemia Patients, Says Moffitt Cancer Center Physician

Analysis of a phase 3 trial shows that older patients with high-risk or secondary AML, who received initial treatment with CPX-351, had improved survival following allogeneic hematopoietic cell transplant, when compared with patients who received standard 7+3 cytarabine and daunorubicin as initial therapy.

Medicine

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myelodysplastic syndromes (MDS)

Moffitt Cancer Center Study Shows Improved Response Rates in Myelodysplastic Syndromes Patients Treated with Lenalidomide and Epoetin Alpha

Patients with myelodysplastic syndromes (MDS) suffer from a reduction in the number of different types of blood cells, including red blood cells leading to the development of anemia. Many patients with lower-risk MDS benefit from treatment with recombinant-erythropoietin (rHuEPO), which stimulates blood cell production.

Medicine

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Pharmaceutical Research, Biopharmaceuticals, Drug shelf life, pharmaceutical shelf life

New Method Improves Stability, Extends Shelf Life of Protein Drugs

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Matthew Webber, University of Notre Dame professor, tested a novel route for non-covalent protein modification and results reveal a new way to improve the stability of common protein drugs and extend shelf-life.

Medicine

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Hearing Deficits in Schizophrenia Tied to Specific Brain Receptor

Columbia University researchers reported that people with schizophrenia who have difficulty hearing subtle changes in pitch may be helped with auditory training exercises and a drug that targets NMDA receptors in the brain.

Science

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Gates Foundation, Grant Award, Taste, pharmaceutical compliance, Children, Bitter Taste Sensitivity, parasitic infections, Schistosomiasis, recurrent diarrhea, sensory science, taste cells, screening assays, develolping nations, Pharmaceuticals, Interdisciplinary Research, taste blockers

Monell Center Receives Funding to Develop Technologies to Improve Taste of Lifesaving Drugs

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The Monell Center announced today that it has received a $345,000 grant from the Bill & Melinda Gates Foundation. The grant supports an innovative global health research project titled, "Developing Novel Pediatric Formulation Technologies for Global Health: Human Taste Assays."







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