Researchers have found that ozone treatment and subsequent chlorination can convert trace amounts of some pharmaceuticals in wastewater into DBPs called halonitromethanes.
Lawrence Livermore National Laboratory engineers and biologists have developed a “brain-on-a-chip” device capable of recording the neural activity of living brain cell cultures in three-dimensions, a significant advancement in the realistic modeling of the human brain outside of the body.
The February 2020 issue of Toxicological Sciences includes cutting-edge research spanning the toxicological field, from molecular, biochemical, and systems toxicology and nanotoxicology to regulatory science, risk assessment, and decision-making.
A new study shows that having general anesthesia in a cesarean delivery is linked with significantly increased odds of severe postpartum depression requiring hospitalization, thoughts of suicide or self-inflicted injury.
The February special issue of SLAS Discovery, “Advances in Cellular Target Engagement and Target Deconvolution,” features 13 articles focused on multiple aspects and technologies of cellular target engagement.
Physician-Scientists and other researchers at Rush University Medical Center, in collaboration with colleagues at other institutions, have revealed a new treatment target that may help change the outcome for patients at risk of AKI.
Welcome to the Heart Health Month Special Edition of Beth Israel Deaconess Medical Center’s (BIDMC) Research & Health News Digest. February is Heart Health Month. This special edition includes consumer-friendly news and research briefs specifically tailored to Heart Health Month:
ISPOR--The Professional Society for Health Economics and Outcomes Research has released its third annual "Top 10 Health Economics and Outcomes Research (HEOR) Trends" report. The full report is available at www.ispor.org/top10trends.
As published today in the Royal Society of Chemistry’s Chemical Communications, a novel compound — known as “C1” — uses a novel mechanism to efficiently prevent the enzyme gamma-secretase from producing amyloids, the abnormal proteins that form toxic clumps inside the brains of patients with Alzheimer’s Disease.
In a study in Nature Medicine, researchers describe how injection of neutralizing antibodies are associated with enhanced T cell responses that specifically recognize HIV.
Most medicines work by binding to and blocking the effect of disease-causing molecules. Now to accelerate the identification of potential new medicines, bioengineers have created a computer model that mimics the way molecules bind.
اكتشف باحثو Mayo Clinic جزيئًا متحولًا يستطيع تنشيط مادة في الحيوانات، هذا الجزيء المتحول له القدرة على علاج أضرار الاضطرابات العصبية مثل التصلب المتعدد. الأبحاث الأولية على النماذج الحيوانية تبشر بإمكانية تطوير علاج اعتمدته إدارة الغذاء والدواء الأمريكية سابقًا، وكذلك قد تقود إلى أساليب جديدة في علاج أمراض الجهاز العصبي المركزي.
تزيد تكلفة أشكال الأنسولين الأكثر استخدامًا في الولايات المتحدة بمقدار 10 مرات عن أي دولة من الدول المتقدمة الأخرى، وفقًا لتعليق في مجلة Mayo Clinic Proceedings. وبسبب هذه التكلفة الباهظة، يلجأ بعض مرضى السكري من النوع الأول في الولايات المتحدة إلى الاقتصاد في كمية الأنسولين التي يستخدمونها، الأمر الذي له تداعيات تهدد حياتهم.
Medication controls seizures in many people with epilepsy. The drugs are not a cure, but seizures don't always last a lifetime. After years without seizures, is it safe for some people to gradually come off their medications?
A collaboration between scientists at Rutgers University and The Scripps Research Institute led to the discovery of a small molecule that may slow down or stop the progression of Parkinson's Disease.
University of Colorado Cancer Center study presented at the 2020 Gastrointestinal Cancers Symposium shows patients with locally advanced rectal cancer receiving lower-than-recommended doses of neoadjuvant chemotherapy in fact saw their tumors shrink more than patients receiving the full dose.
UC San Diego Health launches pilot project using drones to move medical samples, supplies and documents between Jacobs Medical Center, Moores Cancer Center and the Center for Advanced Laboratory Medicine, speeding delivery of services and patient care currently managed through ground transport.
The Society for Laboratory Automation and Screening (SLAS) announced the winners of its annual New Product Awards Monday afternoon at the 9th Annual SLAS International Conference and Exhibition in San Diego, CA, USA.
University of Wisconsin–Madison researchers have developed nanoparticles that, in the lab, can activate immune responses to cancer cells. If they are shown to work as well in the body as they do in the lab, the nanoparticles might provide an effective and more affordable way to fight cancer.
The American Society for Cell Biology (ASCB) offers two, week-long, hand-on courses to help current or recent PhDs transition into biotechnology, medical technology, or pharmaceutical careers.
Traditional Chinese medicine used an herb, Stemona sessilifolia, as a remedy for parasitic infections. Researchers reporting in ACS’ Journal of Agricultural and Food Chemistry identified 10 compounds responsible for it's success.
Following up on their landmark 2016 study, researchers at NYU Grossman School of Medicine found that a one-time, single-dose treatment of psilocybin, a compound found in psychedelic mushrooms, combined with psychotherapy appears to be associated with significant improvements in emotional and existential distress in cancer patients.
Promising intracellular protein-based therapeutics have been of limited use due to the difficulty of delivery into diseased cells. Now bioengineers have developed nanoparticles that can deliver these therapeutics to their targets—avoiding degradation and toxic interactions with healthy tissues.
Researchers at Beth Israel Deaconess Medical Center (BIDMC) have found that orthostatic hypotension was not associated with higher risk of cardiovascular events, falls, or fainting among participants in The Systolic Blood Pressure Intervention Trial. In a study published in the journal Hypertension, the scientists showed that hypertension treatment had no impact on the link between OH and cardiovascular outcomes or other adverse events.
A new study led by physician-researchers at Beth Israel Deaconess Medical Center (BIDMC) reports that the antihypertensive drug amlodipine lowered long-term gout risk compared to two other drugs commonly prescribed to lower blood pressure. The findings are published in the Journal of Hypertension.
In an article published recently in Microgravity, a Nature Journal, researchers at Rensselaer Polytechnic Institute demonstrate a unique method for studying the mechanisms behind the formation of amyloid fibrils associated with diseases like Alzheimer’s and Parkinson’s.
The National Comprehensive Cancer Network (NCCN) Oncology Research Program (ORP) announces plans to evaluate futibatinib (TAS-120), an inhibitor of the fibroblast growth factor receptor (FGFR).
A new drug that could make it easier for doctors to diagnose multiple sclerosis (MS) in its earlier stages has been approved for its first human trials by the U.S. Food and Drug Administration (FDA).
Infectious diseases could be detected, prevented and controlled thanks to a new £4m grant from the NIHR to the University of Warwick. Researchers will work with partners to develop the use of cutting edge genomics to protect public health.
At a glance:
Research using heart cells from squirrels, mice and people identifies an evolutionary mechanism critical for heart muscle function
Gene defect that affects a protein found in the heart muscle interferes with this mechanism to cause hypertrophic cardiomyopathy, a potentially fatal heart condition
Imbalance in the ratio of active and inactive protein disrupts heart muscle’s ability to contract and relax normally, interferes with heart muscle’s energy consumption
Treatment with a small-molecule drug restores proper contraction, energy consumption in human and rodent heart cells
If affirmed in subsequent studies, the results can inform therapies that could halt disease progression, help prevent common complications, including arrhythmias and heart failure
In honor of National CRNA Week (Jan. 19-25, 2020), Reps. Jan Schakowsky (D-IL), Lucille Roybal-Allard (D-CA), and Sam Graves (R-MO) today introduced a bipartisan resolution on the House floor, “Recognizing the roles and the contributions of America’s Certified Registered Nurse Anesthetists (CRNAs) and their role in providing quality health care for the public.”
Researchers have solved the long-standing mystery of how adrenaline regulates a key class of membrane proteins that are responsible for initiating the contraction of heart cells. The findings provide a mechanistic description of how adrenaline stimulates the heart and present new targets for cardiovascular drug discovery, including the potential development of alternative therapeutics to beta-blockers.
Researchers have identified a novel cellular entry factor for adeno-associated virus vector (AAV) types—the most commonly used viral vectors for in vivo gene therapy.
Sara Piccirillo, PhD, is passionate about finding a way to beat glioblastoma, the most aggressive type of brain cancer. Her research focuses on a feature of glioblastoma tumors that appears to be the source of their strength: the extreme differences among their tumor cells.
Scientists at Princess Margaret Cancer Centre have identified the drivers of a crucial gene involved in prostate cancer, revealing new targets for drug design.
A group of University of Chicago scientists has uncovered a previously unknown way that our genes are made into reality. Rather than directions going one-way from DNA to RNA to proteins, the latest study shows that RNA itself modulates how DNA is transcribed—using a chemical process that is increasingly apparent to be vital to biology. The discovery has significant implications for our understanding of human disease and drug design.
Overcoming HIV latency – activating HIV in CD4+ T cells that lay dormant – is a needed step toward a cure. Scientists at UNC-Chapel Hill, Emory University, and Qura Therapeutics – a partnership between UNC and ViiV Healthcare – showed it’s possible to drive HIV out of latency in two animal models.
Osteoarthritis affects 240 million people worldwide and is one of the most common causes of disability in both humans and animals. Currently, no therapeutics exist to prevent this disease, but recent multidisciplinary research at Cornell reveals that the application of a proprietary peptide known as SS-31 may protect cartilage from the injury that leads to arthritis.
A study published in the International Journal of Radiation Oncology • Biology • Physics finds that patients who celebrate the end of cancer treatment by ringing a bell report more distressful memories of treatment than those who finish without ringing a bell.
Surgeons at Houston Methodist Hospital are stemming the tide of addiction to prescription opioids by managing patients’ pain after surgery. By using long-acting local anesthetics at the site of surgery and scheduled non-narcotic pain medicine, they decreased opioid prescriptions from 87% to 10% after surgery.
However, San Diego Supercomputer Center (SDSC) Research Scientist Igor Tsigelny recently collaborated Researchers from the San Diego Supercomputer at UC San Diego and colleagues from Sweden’s Karolinska Institute and the Pasteur Institute in France released a study focused on improving the prognosis for glioblastoma patients.