Feature Channels: Pharmaceuticals

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31-Jan-2020 10:00 AM EST
Treating wastewater with ozone could convert pharmaceuticals into toxic compounds
American Chemical Society (ACS)

Researchers have found that ozone treatment and subsequent chlorination can convert trace amounts of some pharmaceuticals in wastewater into DBPs called halonitromethanes.

Released: 5-Feb-2020 6:05 AM EST
LLNL develops 3D ‘brain-on-a-chip’ device capable of long-term recording of neural activity
Lawrence Livermore National Laboratory

Lawrence Livermore National Laboratory engineers and biologists have developed a “brain-on-a-chip” device capable of recording the neural activity of living brain cell cultures in three-dimensions, a significant advancement in the realistic modeling of the human brain outside of the body.

Released: 4-Feb-2020 4:35 PM EST
Serum Biomarkers, Metabolite Indicators for Kidney Toxicity, Estrogenic Compound Screening, and More Featured in February 2020 Toxicological Sciences
Society of Toxicology

The February 2020 issue of Toxicological Sciences includes cutting-edge research spanning the toxicological field, from molecular, biochemical, and systems toxicology and nanotoxicology to regulatory science, risk assessment, and decision-making.

   
Released: 4-Feb-2020 3:40 PM EST
General anesthesia in cesarean deliveries increases odds of postpartum depression by 54 percent
Columbia University, Mailman School of Public Health

A new study shows that having general anesthesia in a cesarean delivery is linked with significantly increased odds of severe postpartum depression requiring hospitalization, thoughts of suicide or self-inflicted injury.

Released: 4-Feb-2020 3:15 PM EST
SLAS Discovery Publishes February Special Issue
SLAS

The February special issue of SLAS Discovery, “Advances in Cellular Target Engagement and Target Deconvolution,” features 13 articles focused on multiple aspects and technologies of cellular target engagement.

Released: 4-Feb-2020 1:15 PM EST
Researchers Reveal Target in Acute Kidney Injury Prevention
RUSH

Physician-Scientists and other researchers at Rush University Medical Center, in collaboration with colleagues at other institutions, have revealed a new treatment target that may help change the outcome for patients at risk of AKI.

Released: 4-Feb-2020 11:35 AM EST
Heart Health Month Special Edition of BIDMC’s Research & Health News Digest
Beth Israel Lahey Health

Welcome to the Heart Health Month Special Edition of Beth Israel Deaconess Medical Center’s (BIDMC) Research & Health News Digest. February is Heart Health Month. This special edition includes consumer-friendly news and research briefs specifically tailored to Heart Health Month:

Released: 3-Feb-2020 2:30 PM EST
ISPOR 2020 Top 10 HEOR Trends
ISPOR—The Professional Society for Health Economics and Outcomes Research

ISPOR--The Professional Society for Health Economics and Outcomes Research has released its third annual "Top 10 Health Economics and Outcomes Research (HEOR) Trends" report. The full report is available at www.ispor.org/top10trends.

Released: 3-Feb-2020 2:20 PM EST
Novel Compound is Promising Drug Candidate for Alzheimer’s Disease
Rensselaer Polytechnic Institute (RPI)

As published today in the Royal Society of Chemistry’s Chemical Communications, a novel compound — known as “C1” — uses a novel mechanism to efficiently prevent the enzyme gamma-secretase from producing amyloids, the abnormal proteins that form toxic clumps inside the brains of patients with Alzheimer’s Disease.

   
31-Jan-2020 11:55 AM EST
HIV antibody therapy is associated with enhanced immune responses in infected individuals
Universite de Montreal

In a study in Nature Medicine, researchers describe how injection of neutralizing antibodies are associated with enhanced T cell responses that specifically recognize HIV.

Released: 3-Feb-2020 9:35 AM EST
Computer model mines medicines
National Institute of Biomedical Imaging and Bioengineering

Most medicines work by binding to and blocking the effect of disease-causing molecules. Now to accelerate the identification of potential new medicines, bioengineers have created a computer model that mimics the way molecules bind.

Released: 3-Feb-2020 8:50 AM EST
بحث لـ Mayo Clinic يكتشف طريقة لعلاج اضطرابات الجهاز العصبي المركزي باستخدام جزيء متحول
Mayo Clinic

اكتشف باحثو Mayo Clinic جزيئًا متحولًا يستطيع تنشيط مادة في الحيوانات، هذا الجزيء المتحول له القدرة على علاج أضرار الاضطرابات العصبية مثل التصلب المتعدد. الأبحاث الأولية على النماذج الحيوانية تبشر بإمكانية تطوير علاج اعتمدته إدارة الغذاء والدواء الأمريكية سابقًا، وكذلك قد تقود إلى أساليب جديدة في علاج أمراض الجهاز العصبي المركزي.

Released: 3-Feb-2020 8:50 AM EST
آثار ارتفاع تكلفة الأنسولين على حياة مرضى السكري
Mayo Clinic

تزيد تكلفة أشكال الأنسولين الأكثر استخدامًا في الولايات المتحدة بمقدار 10 مرات عن أي دولة من الدول المتقدمة الأخرى، وفقًا لتعليق في مجلة Mayo Clinic Proceedings. وبسبب هذه التكلفة الباهظة، يلجأ بعض مرضى السكري من النوع الأول في الولايات المتحدة إلى الاقتصاد في كمية الأنسولين التي يستخدمونها، الأمر الذي له تداعيات تهدد حياتهم.

Released: 3-Feb-2020 8:05 AM EST
Should People with Epilepsy Ever Stop Taking Medication?
International League Against Epilepsy

Medication controls seizures in many people with epilepsy. The drugs are not a cure, but seizures don't always last a lifetime. After years without seizures, is it safe for some people to gradually come off their medications?

Released: 30-Jan-2020 11:05 AM EST
Rutgers Robert Wood Johnson Medical SchoolStudy Finds a Drug-Like Compound That May Prevent Parkinson’s Disease Progression
Rutgers Robert Wood Johnson Medical School

A collaboration between scientists at Rutgers University and The Scripps Research Institute led to the discovery of a small molecule that may slow down or stop the progression of Parkinson's Disease.

23-Jan-2020 11:05 AM EST
Putrid Compound May Have a Sweet Side Gig as Atherosclerosis Treatment
Columbia University Irving Medical Center

A compound associated with the smell of death may have potential as a treatment for atherosclerosis and other chronic inflammatory diseases.

Released: 30-Jan-2020 10:55 AM EST
Less chemotherapy may have more benefit in rectal cancer
University of Colorado Cancer Center

University of Colorado Cancer Center study presented at the 2020 Gastrointestinal Cancers Symposium shows patients with locally advanced rectal cancer receiving lower-than-recommended doses of neoadjuvant chemotherapy in fact saw their tumors shrink more than patients receiving the full dose.

Released: 29-Jan-2020 6:15 PM EST
UC San Diego Health Launches Drone Transport Program with UPS, Matternet
UC San Diego Health

UC San Diego Health launches pilot project using drones to move medical samples, supplies and documents between Jacobs Medical Center, Moores Cancer Center and the Center for Advanced Laboratory Medicine, speeding delivery of services and patient care currently managed through ground transport.

   
Released: 29-Jan-2020 2:40 PM EST
New Product Award Winners Announced at SLAS2020
SLAS

The Society for Laboratory Automation and Screening (SLAS) announced the winners of its annual New Product Awards Monday afternoon at the 9th Annual SLAS International Conference and Exhibition in San Diego, CA, USA.

Released: 29-Jan-2020 11:35 AM EST
Cheap nanoparticles stimulate immune response to cancer in the lab
University of Wisconsin–Madison

University of Wisconsin–Madison researchers have developed nanoparticles that, in the lab, can activate immune responses to cancer cells. If they are shown to work as well in the body as they do in the lab, the nanoparticles might provide an effective and more affordable way to fight cancer.

Released: 29-Jan-2020 9:00 AM EST
Biotech courses return to east, west campuses for summer
American Society for Cell Biology (ASCB)

The American Society for Cell Biology (ASCB) offers two, week-long, hand-on courses to help current or recent PhDs transition into biotechnology, medical technology, or pharmaceutical careers.

24-Jan-2020 9:55 AM EST
Traditional Chinese medicinal plant yields new insecticide compounds
American Chemical Society (ACS)

Traditional Chinese medicine used an herb, Stemona sessilifolia, as a remedy for parasitic infections. Researchers reporting in ACS’ Journal of Agricultural and Food Chemistry identified 10 compounds responsible for it's success.

   
Released: 28-Jan-2020 12:10 PM EST
Research offers promise for treating schizophrenia
University of Georgia

Research by a University of Georgia psychologist shows that targeting one particular symptom of schizophrenia has a positive effect on other symptoms.

21-Jan-2020 10:45 AM EST
Antianxiety and Antidepressant Effects from a Single Dose of Psychedelic Drug Persist Years Later in Cancer Patients
NYU Langone Health

Following up on their landmark 2016 study, researchers at NYU Grossman School of Medicine found that a one-time, single-dose treatment of psilocybin, a compound found in psychedelic mushrooms, combined with psychotherapy appears to be associated with significant improvements in emotional and existential distress in cancer patients.

Released: 27-Jan-2020 12:35 PM EST
Tiny containers transport targeted treatments
National Institute of Biomedical Imaging and Bioengineering

Promising intracellular protein-based therapeutics have been of limited use due to the difficulty of delivery into diseased cells. Now bioengineers have developed nanoparticles that can deliver these therapeutics to their targets—avoiding degradation and toxic interactions with healthy tissues.

   
Released: 27-Jan-2020 12:30 PM EST
Study shows orthostatic hypotension not associated with higher risk of adverse events among patients undergoing more intensive blood pressure treatment
Beth Israel Lahey Health

Researchers at Beth Israel Deaconess Medical Center (BIDMC) have found that orthostatic hypotension was not associated with higher risk of cardiovascular events, falls, or fainting among participants in The Systolic Blood Pressure Intervention Trial. In a study published in the journal Hypertension, the scientists showed that hypertension treatment had no impact on the link between OH and cardiovascular outcomes or other adverse events.

Released: 27-Jan-2020 12:30 PM EST
Blood pressure drug linked to lower risk of gout
Beth Israel Lahey Health

A new study led by physician-researchers at Beth Israel Deaconess Medical Center (BIDMC) reports that the antihypertensive drug amlodipine lowered long-term gout risk compared to two other drugs commonly prescribed to lower blood pressure. The findings are published in the Journal of Hypertension.

Released: 27-Jan-2020 9:55 AM EST
Technology Used in Space Experiments Could Reveal Key Information about Human Health
Rensselaer Polytechnic Institute (RPI)

In an article published recently in Microgravity, a Nature Journal, researchers at Rensselaer Polytechnic Institute demonstrate a unique method for studying the mechanisms behind the formation of amyloid fibrils associated with diseases like Alzheimer’s and Parkinson’s.

   
Released: 27-Jan-2020 8:35 AM EST
NCCN Oncology Research Program to Oversee Trials of the FGFR Inhibitor Futibatinib in Tumors with Aberrant FGFR Expression, in Collaboration with Taiho Oncology
National Comprehensive Cancer Network® (NCCN®)

The National Comprehensive Cancer Network (NCCN) Oncology Research Program (ORP) announces plans to evaluate futibatinib (TAS-120), an inhibitor of the fibroblast growth factor receptor (FGFR).

Released: 27-Jan-2020 7:30 AM EST
New drug that could aid earlier MS diagnoses approved by FDA for first human clinical trials
Case Western Reserve University

A new drug that could make it easier for doctors to diagnose multiple sclerosis (MS) in its earlier stages has been approved for its first human trials by the U.S. Food and Drug Administration (FDA).

Released: 27-Jan-2020 6:15 AM EST
Infectious diseases to be detected and prevented thanks to £4m grant
University of Warwick

Infectious diseases could be detected, prevented and controlled thanks to a new £4m grant from the NIHR to the University of Warwick. Researchers will work with partners to develop the use of cutting edge genomics to protect public health.

22-Jan-2020 11:35 AM EST
Scientists trace the molecular roots of potentially fatal heart condition
Harvard Medical School

At a glance: Research using heart cells from squirrels, mice and people identifies an evolutionary mechanism critical for heart muscle function Gene defect that affects a protein found in the heart muscle interferes with this mechanism to cause hypertrophic cardiomyopathy, a potentially fatal heart condition Imbalance in the ratio of active and inactive protein disrupts heart muscle’s ability to contract and relax normally, interferes with heart muscle’s energy consumption Treatment with a small-molecule drug restores proper contraction, energy consumption in human and rodent heart cells If affirmed in subsequent studies, the results can inform therapies that could halt disease progression, help prevent common complications, including arrhythmias and heart failure

Released: 25-Jan-2020 6:00 AM EST
National CRNA Week: The House of Representatives Recognizes the Contributions of Nurse Anesthetists
American Association of Nurse Anesthesiology

In honor of National CRNA Week (Jan. 19-25, 2020), Reps. Jan Schakowsky (D-IL), Lucille Roybal-Allard (D-CA), and Sam Graves (R-MO) today introduced a bipartisan resolution on the House floor, “Recognizing the roles and the contributions of America’s Certified Registered Nurse Anesthetists (CRNAs) and their role in providing quality health care for the public.”

Released: 24-Jan-2020 12:50 PM EST
Study IDs non-hormonal options for menopause symptoms
University of Washington School of Medicine

Cognitive therapy, depression drugs are found to relieve night sweats, hot flashes and also help with sleep.

Released: 23-Jan-2020 12:50 PM EST
Oral Hormone-Blocking Drug May Help with Heavy Menstrual Bleeding
Thomas Jefferson University

In women with uterine fibroids, the drug elagolix suppresses ovarian hormone production and prevents heavy menstrual bleeding

Released: 23-Jan-2020 12:10 PM EST
Researchers uncover two-drug combo that halts the growth of cancer cells
UT Southwestern Medical Center

UT Southwestern Simmons Cancer Center researchers have discovered a two-drug combo that halts the growth of cancer cells that carry HER2 mutations.

Released: 23-Jan-2020 12:05 PM EST
Adrenaline Handbrake
Harvard Medical School

Researchers have solved the long-standing mystery of how adrenaline regulates a key class of membrane proteins that are responsible for initiating the contraction of heart cells. The findings provide a mechanistic description of how adrenaline stimulates the heart and present new targets for cardiovascular drug discovery, including the potential development of alternative therapeutics to beta-blockers.

Released: 23-Jan-2020 11:15 AM EST
Researchers Uncover Mechanism for How Common Gene Therapy Vectors Enter Cells
Massachusetts Eye and Ear

Researchers have identified a novel cellular entry factor for adeno-associated virus vector (AAV) types—the most commonly used viral vectors for in vivo gene therapy.

Released: 23-Jan-2020 8:05 AM EST
A Menu of Brain Cancer Treatments
University of New Mexico Comprehensive Cancer Center

Sara Piccirillo, PhD, is passionate about finding a way to beat glioblastoma, the most aggressive type of brain cancer. Her research focuses on a feature of glioblastoma tumors that appears to be the source of their strength: the extreme differences among their tumor cells.

22-Jan-2020 5:55 PM EST
New Drug Target for Prostate Cancer Found in the Non-Coding Genome
University Health Network (UHN)

Scientists at Princess Margaret Cancer Centre have identified the drivers of a crucial gene involved in prostate cancer, revealing new targets for drug design.

Released: 22-Jan-2020 2:50 PM EST
Surprise discovery shakes up our understanding of gene expression
University of Chicago

A group of University of Chicago scientists has uncovered a previously unknown way that our genes are made into reality. Rather than directions going one-way from DNA to RNA to proteins, the latest study shows that RNA itself modulates how DNA is transcribed—using a chemical process that is increasingly apparent to be vital to biology. The discovery has significant implications for our understanding of human disease and drug design.

   
21-Jan-2020 11:10 AM EST
Researchers Reverse HIV Latency, Important Scientific Step Toward Cure
University of North Carolina School of Medicine

Overcoming HIV latency – activating HIV in CD4+ T cells that lay dormant – is a needed step toward a cure. Scientists at UNC-Chapel Hill, Emory University, and Qura Therapeutics – a partnership between UNC and ViiV Healthcare – showed it’s possible to drive HIV out of latency in two animal models.

Released: 22-Jan-2020 12:15 PM EST
Collaboration reveals potential new therapy for osteoarthritis
Cornell University

Osteoarthritis affects 240 million people worldwide and is one of the most common causes of disability in both humans and animals. Currently, no therapeutics exist to prevent this disease, but recent multidisciplinary research at Cornell reveals that the application of a proprietary peptide known as SS-31 may protect cartilage from the injury that leads to arthritis.

Released: 22-Jan-2020 10:35 AM EST
Is it time to stop ringing the cancer bell?
American Society for Radiation Oncology (ASTRO)

A study published in the International Journal of Radiation Oncology • Biology • Physics finds that patients who celebrate the end of cancer treatment by ringing a bell report more distressful memories of treatment than those who finish without ringing a bell.

Released: 22-Jan-2020 8:00 AM EST
Hope for patients with a rare genetic condition linked to severe infections
Universite de Montreal

A research team sheds light on the mechanisms underlying chronic granulomatous disease.

Released: 22-Jan-2020 8:00 AM EST
Program reduces narcotic prescriptions after surgery with over-the-counter pain medicine
Houston Methodist

Surgeons at Houston Methodist Hospital are stemming the tide of addiction to prescription opioids by managing patients’ pain after surgery. By using long-acting local anesthetics at the site of surgery and scheduled non-narcotic pain medicine, they decreased opioid prescriptions from 87% to 10% after surgery.

Released: 21-Jan-2020 6:35 PM EST
International Research Team Confirms Potential Glioblastoma Inhibitors
University of California San Diego

However, San Diego Supercomputer Center (SDSC) Research Scientist Igor Tsigelny recently collaborated Researchers from the San Diego Supercomputer at UC San Diego and colleagues from Sweden’s Karolinska Institute and the Pasteur Institute in France released a study focused on improving the prognosis for glioblastoma patients.



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