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Medicine

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onj, Osteonecrosis Of The Jaw, Bisphosphonates, Cancer Care, Osteoporosis, Osteoporosis Drug, Dental Care

Study Pinpoints Genetic Variation that Raises Risk of Serious Complication Linked to Osteoporosis Drugs

Researchers at the Columbia University College of Dental Medicine have identified a genetic variation that raises the risk of developing serious necrotic jaw bone lesions in patients who take bisphosphonates, a common class of osteoclastic inhibitors.

Medicine

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Neurotransmitters, Epilepsy, Depression, antidepressant drugs , Antiepileptic Drugs, Cataracts, glutamate receptors, Memory formation

Brain Receptor in Eyes May Link Epilepsy, Cataracts and Antidepressants

Researchers have discovered that the most common receptor for the major neurotransmitter in the brain is also present in the eye, which may explain links between cataracts, epilepsy and use of a number of antiepileptic and antidepressant drugs.

Medicine

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antivetroviral drugs and HIV complications, Cleft Palate and HIV complications, HIV drugs and birth defects

Antiretroviral Drugs Guard Against HIV but May Lead to Birth Defects

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HIV-positive mothers have been able to guard against transmitting the disease to their babies by taking antiretroviral drugs during pregnancy. Although the drugs prevent children from being born with HIV, they could cause birth defects, such as cleft lip and palate. A new study explores any links between antiretroviral prophylaxis and cleft lip and palate.

Medicine

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Novo Nordisk Establishes Type 1 Diabetes R&D Center in Seattle

Novo Nordisk (NYSE:NVO) announced today that the company will establish a type 1 diabetes research and development center in Seattle, Wash., U.S. The new center will combine Novo Nordisk's history of innovation and leadership in diabetes treatment with the company's growing expertise in immunotherapy.

Science

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Stony Brook University, Drug Discovery, Sanofi, Tuberculosis, Treatment, CDC, Iwao Ojima, Institute of Chemical Biology & Drug Discovery, Mycobacterium Tuberculosis, FtsZ, Pharmaceutical

Stony Brook University Announces Collaboration with Sanofi on Pioneering Tuberculosis Drug

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The Institute of Chemical Biology & Drug Discovery (ICB&DD) at Stony Brook University announced a multi-year research collaboration with Sanofi, a multinational pharmaceutical company, on a potential treatment for Tuberculosis (TB) and other bacterial infections.

Medicine

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Study Shows Allergy to Plavix Can Be Overcome

Allergies to Plavix®, also know by its chemical name, Clopidogrel occur in about six percent of patients given the drug, vital for the prevention of life-threatening stent thrombosis after angioplasty and percutaneous coronary interventions. Researchers at Thomas Jefferson University found that a combination of steroids and antihistamines can successfully alleviate the allergic reaction and enable patients to remain on the drug. Until now, hypersensitivity required drug interruption, placing the patient at risk for restenosis or a major coronary event.

Medicine

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malignant hyperthermia, Malignant Hyperthermia Association of the United States, Heat Stroke, Baylor College Of Medicine, University of Rochester Medical Center

A New Drug for Heat Stroke? Implications for Malignant Hyperthermia

Malignant hyperthermia (MH) is a life-threatening genetic muscle disorder, most commonly triggered in those at risk by certain types of drugs used during anesthesia. Heat stroke, on the other hand, most commonly occurs in individuals in response to physical exertion in hot/humid environments. While their common triggers may differ, the signs associated with MH and heat stroke are remarkably similar – uncontrolled muscle contractions, dangerous increases in body temperature, and muscle breakdown leading to the release of toxins in the blood which may cause cardiac arrhythmias and death. Immediate treatment for these conditions is crucial. Each year many individuals die or suffer consequences of heat stroke. Heat stroke is not uncommon in the military as well as in athletic competitions. This would be the first demonstration that a medication can be effective in preventing certain forms of heat stroke.

Medicine

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Pharmaceuticals, Pharmaceutical Science, Drug Discovery

Roche Funds Drug Discovery Projects at UC San Diego

The new UC San Diego-Roche Extending Innovation Network (EIN) program has been launched with selection of its first three research projects at the University of California, San Diego School of Medicine. The UC San Diego-Roche EIN program, which was formalized in June 2011, aims to accelerate the discovery of new drug therapies through research innovation at the interface of industry and academia.

Medicine

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Drug to Treat HIV in Children Shows Promise Via National Clinical Trial

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For children with HIV infection, the Food and Drug Administration (FDA) approval of the use of raltegravir, an antiretroviral drug that slows the spread of HIV infection, offers a new weapon to treat HIV infection in children.

Medicine

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Drug Delivery, Ocular, Ophthalmic, microinjection, Microneedle, Macular Degeneration

Startup Wins $4 Million for Drug Delivery to the Eye

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Technology developed by researchers at the Georgia Institute of Technology and Emory University for delivering drugs and other therapeutics to specific locations in the eye provides the foundation for a startup company that has received a $4 million venture capital investment.

Medicine

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Thyroid Cancer, Medicine, Drugs Prescrption

New Drug Screening Identifies Chemical Agents with Potent Anti-Cancer Activity

Drugs already approved for clinical use across a variety of therapeutic categories can be screened to identify effective agents for thyroid cancer according to a recent study accepted for publication in The Endocrine Society’s Journal of Clinical Endocrinology & Metabolism (JCEM). These findings could rapidly be implemented into a clinical trial to test how effective the treatment would be.

Medicine

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Should Pharmacists Prescribe Medicine? Some Already Do.

Pharmacists’ prescribing medications is a topic often discussed when health policy experts explore how to improve patient safety, medication-use outcomes, and access to medical services. The Dec. 15 issue of the American Journal of Health-System Pharmacy (AJHP) examines the sometimes-controversial topic in its current issue.

Science

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Antibiotic Resistance, Kinases

Drugs Used to Overcome Cancer May Also Combat Antibiotic Resistance

The pharmaceutical sector has made a big investment in targeting kinases proteins, so there are a lot of compounds and drugs out there that, although they were designed to overcome cancer, they can in fact be looked at with fresh eyes and maybe repurposed to address the problem of antibiotic resistance.

Medicine

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Plaque, Artherosclerosis, Cardiovascular Disease, Heart Attack, Stroke, Nyu Langone Medical Center, Nyu School Of Medicine, Arteries, Cholesterol, Statins, cholesterol-lowering, C-C chemokine receptor type 7, Ccr7, Macrophages, Arterial Plaque, HMG-CoA reductase, Blockage

Cholesterol-Lowering Medication Accelerates Depletion of Plaque in Arteries

In a new study, NYU Langone Medical Center researchers have discovered how cholesterol-lowering drugs called statins promote the breakdown of plaque in the arteries.

Science

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Drugs, Pharmacy, Research, Obesity

Model Developed for Future Obesity Drug Testing

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A University of Maryland School of Pharmacy report pinpoints a previously unidentified role for a cellular protein in controlling body weight.

Medicine

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Malaria Parasite, Malaria, Transition-state Chemistry, Transition State, Infectious Diseases, Biochemistry

Novel Drug Wipes Out Deadliest Malaria Parasite Through Starvation

An antimalarial agent developed by researchers at Albert Einstein College of Medicine of Yeshiva University proved effective at clearing infections caused by the malaria parasite most lethal to humans – by literally starving the parasites to death. The study, published in the November 11, 2011 issue of PLoS ONE, was led by senior author Vern Schramm, Ph.D., professor and Ruth Merns Chair in Biochemistry at Einstein.

Medicine

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Medical Marijuana, Pharmacology, Pain Management, UCSF, Opiates

Medical Marijuana Could Help Patients Reduce Pain with Opiates

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A UCSF study suggests patients with chronic pain may experience greater relief if their doctors add cannabinoids – the main ingredient in cannabis or medical marijuana – to an opiates-only treatment. The findings, from a small-scale study, also suggest that a combined therapy could result in reduced opiate dosages.

Medicine

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antibacterial resistance, Aganocide, Novabay Pharmaceuticals, MRSA, Mrsa Infections

AgaDerm® (NVC-422 Gel) May Be A Welcome Alternative To Bacitracin And Neomycin For Treating Skin Infections

Recent study implicates widely used topical antibiotics in the spread of MRSA.

Medicine

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Valproate, Lamotrigine, NEAD, NIH, American Epilepsy Society, American Epilepsy Society Annual Meeting, Prenatal, IQ, Developmental Delay, prenatal epileps, Maternal

Adverse Cognitive Effects of Epilepsy Drug Persist

Researchers in the U.S. and U.K. are conducting an ongoing investigation of the cognitive effect of fetal exposure across four commonly used antiepileptic drugs (AEDs) as part of an NIH-funded Neurodevelopmental Effects of Antiepileptic Drugs (NEAD) Study. An early NEAD analysis found that fetal exposure to valproate impairs IQ at age three.

Medicine

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Bromide, dravet syndrome, Epilepsy, children and epilepsy, American Epilepsy Society, American Epilepsy Society Annual Meeting

Potential New Role for a 19th Century Epilepsy Drug

Bromide is not FDA-approved for use in the United States. But it is among anticonvulsants available in Germany and other European countries. Research reported today at the American Epilepsy Society’s 65th annual meeting by investigators from Germany suggests that bromide may have promise in treating patients with SCN1A-associated Dravet syndrome with intractable seizures.







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