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Medicine

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Melanoma Metastasis , Brain Metastasis, Ipilimumab, BRAF mutations , vemurafenib, Dabrafenib, Blood Brain Barrier

Researchers Identify New Treatment Approaches to Melanoma Brain Metastases

In a recent article published in MELANOMA RESEARCH and a subsequent commentary in British medical journal THE LANCET, researchers at Moffitt Cancer Center discussed new therapeutic options for the management of melanoma brain metastases. Patients with advanced melanoma are at high risk for developing brain metastases. Once brain metastases are present, these patients tend to have poor outcomes.

Medicine

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Parasites, Global Health, Infectious Diseases, Drug Development, Orphan Drugs

Drug Found for Parasite That Is Major Cause of Death Worldwide

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Research by a collaborative group of scientists from UC San Diego School of Medicine, UC San Francisco and Wake Forest School of Medicine has led to identification of an existing drug that is effective against Entamoeba histolytica. This parasite causes amebic dysentery and liver abscesses and results in the death of more than 70,000 people worldwide each year.

Medicine

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Dysentery, Entamoeba histolytica, auranofin , E. histolytica, metronidazole

Lab Tests Show Arthritis Drug Effective Against Global Parasite

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A team of researchers from UCSF and UC San Diego has identified an approved arthritis drug that is effective against amoebas in lab and animal studies, suggesting it could offer a low-dose, low cost treatment for the amoebic infections that cause human dysentery throughout the world.

Science

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interaction energy, Molecule, Van Der Waals Forces, computational physics, Chemistry, Materials Science, Quantum Mechanics

New Method Predicts Interaction Energy of Biomolecules Used for Drug Development

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Krzysztof Szalewicz, professor of physics and astronomy at the University of Delaware, and Rafal Podeszwa of the University of Silesia Institute of Chemistry in Poland have developed and validated a more accurate method for predicting the interaction energy of large molecules, such as biomolecules used to develop new drugs.

Medicine

Channels:

Lipitor, Generic Medications, Generic Drug, Cholesterol, Medication, Drug Therapy, Pharmacy, Pharmaceutical

New Generics Soon Available for Best-Selling Drug Lipitor

New generic medications are set to come to market in June after the exclusivity agreement with Lipitor expires. This could lead to confusion at pharmacy counters as many on the medication may see changes. Clark Kebodeaux, Pharm.D., is a practicing pharmacist who can explain to your audience about the changes, what it means for your out of pocket costs, and help anticipate questions audience members may have for pharmacists.

Medicine

Channels:

Diabetes, obesity, hormone,

New Inflammation Hormone Link May Pave Way to Study New Drugs for Type 2 Diabetes

A new link between obesity and type 2 diabetes found in mice could open the door to exploring new potential drug treatments for diabetes, University of Michigan Health System research has found.

Medicine

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Immune Drug Doesn’t Help Kids with Hard-to-Treat Kidney Disorder

Highlights • Children with a particular kidney immune disorder that is unresponsive to standard treatments do not benefit from the immune drug rituximab. • Additional studies are needed to fully understand the disease and to develop effective therapies for hard-to-treat cases.

Medicine

Channels:

Osteoporosis, biophosphonate, Bone Fractures, Clinical Trials, Bone Density

Long-Term Use of Osteoporosis Medication May Reduce Bone Fracture Risk for Some Patients

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Continuing a popular but controversial treatment for osteoporosis could reduce spine fracture risk for a particular group of patients, but others could see little to no change if they discontinue it. Based on available evidence, a UCSF researcher reevaluated his 2006 finding from a randomized 10-year study of alendronate, a type of bisphosphonate – a class of drugs that prevent loss of bone mass.

Medicine

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pediatric cardiology, Echocardiography, Pediatrics, Congenital Heart Disease, single-ventricle defects, Erectile Dysfunction, Sildenafil, Children's Hospital Of Philadelphia

Erectile Dysfunction Drug May Benefit Cardiac Function in Young Patients with Heart Defects

Sildenafil, also known as the erectile dysfunction drug Viagra, may give a boost to underdeveloped hearts in children and young adults with congenital heart defects.

Medicine

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Dr. Vivek L. Patel, Dr. James B. Bussel , Platelet, Rituximab

Rituximab Promotes Long-Term Response for Patients with Immune Destruction of Platelets

A new analysis concludes that rituximab, a drug commonly used to treat blood cancers, leads to treatment responses lasting at least five years in approximately one quarter of patients with low platelet counts and a risk of bleeding due to chronic immune thrombocytopenic purpura (ITP). In study results published online today in Blood, the Journal of the American Society of Hematology (ASH), investigators at Weill Cornell Medical College provide the very first long-term outcome data for patients with chronic ITP treated with rituxamab.

Medicine

Channels:

Drug Discovery, Interferon, Antiviral Compounds, Immunity, Virus, Idarubicin

New Technique Could Identify Drugs That Help Fight Broad Range of Viruses

Results of a new study demonstrate the feasibility of a novel strategy in drug discovery: screening large numbers of existing drugs — often already approved for other uses — to see which ones activate genes that boost natural immunity.

Medicine

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NSAIDs and Cardiovascular Risk Explained

After nearly 13 years of study and intense debate, a pair of new papers from the Perelman School of Medicine, at the University of Pennsylvania have confirmed exactly how a once-popular class of anti-inflammatory drugs leads to cardiovascular risk for people taking it.

Life

Law and Public Policy

Channels:

Foster Care, Foster Children, child welfare system, psychotropic medication, Psychotropics

48-State Study Lays Groundwork to Address Use of Psychotropic Medications for Children in Foster Care

⎯ A few months after the federal Government Accountability Office (GAO) issued a report on the use of psychoactive drugs by children in foster care in five states, a national study from PolicyLab at The Children’s Hospital of Philadelphia describes prescription patterns over time in 48 states. The updated findings show the percentage of children in foster care taking antipsychotics--a class of psychoactive drugs associated with serious side effects for children-- continued to climb in the last decade. At the same time, a slight decline was seen in the use of other psychoactive medications, including the percentage of children receiving 3 or more classes of these medications at once (polypharmacy).

Medicine

Channels:

moxonidine, Heart Failure, Experimental Biology 2012

Second-Generation Drug Used for Hypertension Aids Heart Function Independent of Blood Pressure Effect

Study of anti-hypertensive drug moxonidine finds, in an animal model, that the drug can improve heart function and survival independent of its effect on blood pressure

Medicine

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AMPK, Salicylate, Asprin And Cancer

McMaster Researchers Find Potential for New Uses of Old Drug

Researchers in Canada, Scotland and Australia have discovered that salicylate, the active ingredient in aspirin, directly increases the activity of the protein AMPK (AMP-activated protein kinase), a key player in regulating cell growth and metabolism. Salicylate, which is derived from willow bark, and is the active ingredient in aspirin, is believed to be one of the oldest drugs in the world with first reports of its use dating back to an Egyptian papyrus in 1543 BC.

Medicine

Channels:

Seizure, Epilepsy, Perampanel, Glutamate, Receptor

New Medication Offers Hope to Patients with Frequent, Uncontrollable Seizures

A new type of anti-epilepsy medication that selectively targets proteins in the brain that control excitability may significantly reduce seizure frequency in people whose recurrent seizures have been resistant to even the latest medications, new Johns Hopkins-led research suggests.

Business

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Research & Development, ROI, Innovation

New R&D Tool, Developed at WUSTL, Could Add $1 Trillion to Public Firms’ Market Value

The nation’s top 20 public firms could have added nearly $1 trillion to their market value if, in 2010, they had used a new tool, known as the research quotient (RQ), to determine their research and development (R&D) budgets, says its creator, Anne Marie Knott, PhD, associate professor of strategy at Washington University in St. Louis.

Medicine

Channels:

Poison Control, Poisoning, Accidents, drug storage, pre, Medicine, poll

Nearly 1 in 4 Grandparents Store Prescription Medicines Where Children Can Find Them

Unintentional poisonings from medicines cause more emergency room visits for young children each year than do car accidents. But nearly 1 of every 4 grandparents says that they store prescription medicines in easy-access ways, according to a new poll.

Medicine

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Study Links Toxic Component in Herbal Remedies to Kidney Failure and Cancer

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Aristolochic acid (AA), a component of a plant used in herbal remedies since ancient times, leads to kidney failure and upper urinary tract cancer (UUC) in individuals exposed to the toxin.

Medicine

Channels:

Prescription Drug Programs, Health Insurance

Process for Determining Prescription Drug Coverage Varies Widely Among Health Plans

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As medical advancements and an expanding pharmaceutical industry bring new prescription drugs into the market, deciding which ones to cover is becoming an even more difficult choice for health plans to make. How those decisions are made – and what information is used in the process – was the focus of a recent study by researchers at RTI International.







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