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Released: 11-Dec-2019 11:00 AM EST
Genetic Syndrome of Intellectual Disability Fixed in Mice Using Precision Epigenome Editing
Johns Hopkins Medicine

Using a targeted gene epigenome editing approach in the developing mouse brain, Johns Hopkins Medicine researchers reversed one gene mutation that leads to the genetic disorder WAGR syndrome, which causes intellectual disability and obesity in people. This specific editing was unique in that it changed the epigenome — how the genes are regulated — without changing the actual genetic code of the gene being regulated.

Released: 11-Dec-2019 10:05 AM EST
Study reveals rapid increases in cannabis use among individuals with depression
Columbia University, Mailman School of Public Health

Results of a new study suggest that over the past decade (2005-2017), the prevalence of cannabis use in the United States has increased among persons with and without depression, though the increase is significantly more rapid among those with depression.

10-Dec-2019 5:05 PM EST
Adding tucatinib to drug combination extends survival for advanced HER2+ breast cancer patients
University of Texas MD Anderson Cancer Center

Researchers from The University of Texas MD Anderson Cancer Center today reported study results showing the addition of tucatinib to capecitabine (Xeloda) and trastuzumab (Herceptin) significantly improved progression-free survival (PFS) and overall survival (OS) in patients with advanced HER2-positive breast cancer, with and without brain metastasis according to results of the HER2CLIMB clinical trial.

Released: 10-Dec-2019 4:05 PM EST
Pregnancy disorder subject of Tulane study
Tulane University

Researchers hope to develop new imaging methods to improve the treatment of preeclampsia.

4-Dec-2019 11:50 AM EST
Combination therapy results in 98% response rate for some newly diagnosed leukemia patients
University of Texas MD Anderson Cancer Center

A study combining low-dose chemotherapy with a monoclonal antibody is effective for older patients with Philadelphia chromosome-negative ALL.

9-Dec-2019 10:50 AM EST
Yale Cancer Center study suggests new approaches needed to manage ibrutinib-related toxicities in CLL patients
Yale Cancer Center/Smilow Cancer Hospital

New findings by Yale Cancer Center (YCC) and Smilow Cancer Hospital researchers show that as the use of the drug ibrutinib climbs in patients with chronic lymphocytic leukemia (CLL), so do the rates of patients who stop taking the drug.

Released: 9-Dec-2019 3:15 PM EST
Researchers identify ‘Achilles’ heel’ of drug-resistant superbug
University of Texas Health Science Center at Houston

Researchers at The University of Texas Health Science Center at Houston (UTHealth) have identified a protein that allows vancomycin-resistant enterococci to defy antibiotic treatment and immune system attacks. Their discovery opens the door for future treatment options in the fight against antibiotic resistance.

Released: 9-Dec-2019 2:45 PM EST
Research at Argonne's Advanced Photon Source leads to new Ebola drug
Argonne National Laboratory

Scientists using specialized beamlines at Argonne's Structural Biology Center (SBC), a facility for macromolecular crystallography at the Advanced Photon Source, derived insights that led to the discovery of a promising new drug for Ebola.

   
4-Dec-2019 12:40 PM EST
CAR T-cell therapy effective for relapsed mantle cell lymphoma patients
University of Texas MD Anderson Cancer Center

A one-year follow-up study revealed a majority of patients with mantle cell lymphoma resistant to prior therapies may benefit from treatment with CD19-targeting chimeric antigen receptor (CAR) .

Released: 9-Dec-2019 2:35 PM EST
Researchers receive nearly $5 million to curb opioid cravings
Penn State College of Medicine

Two researchers from Penn State College of Medicine have received nearly $5 million from the National Institutes of Health to study whether an already-approved drug can be used to reduce cravings and prevent relapse in those struggling with opioid addiction.

Released: 9-Dec-2019 11:20 AM EST
Yale Cancer Center study highlights challenges for care of AML patients during initial chemotherapy
Yale Cancer Center/Smilow Cancer Hospital

A new study by Yale Cancer Center (YCC) researchers shows understanding treatment patterns for patients with acute myeloid leukemia (AML) is vital to develop strategies to improve outcomes.

Released: 9-Dec-2019 11:05 AM EST
Yale Cancer Center researchers show promising new treatment for patients with myelodysplastic syndromes
Yale Cancer Center/Smilow Cancer Hospital

A new study by Yale Cancer Center (YCC) and Smilow Cancer Hospital researchers suggests that the drug venetoclax aids therapy for relapsed/refractory myelodysplastic syndromes, especially when paired with azacytidine.

5-Dec-2019 12:25 PM EST
UCLA study shows inhibition of gene helps overcome resistance to immunotherapy
University of California, Los Angeles (UCLA), Health Sciences

A new study from scientists at UCLA helps explain why some people with advanced cancer may not respond to one of the leading immunotherapies, PD-1 blockade, and how a new combination approach may help overcome resistance to the immunotherapy drug.

5-Dec-2019 12:50 PM EST
Secret behind diabetes drug’s benefits revealed
McMaster University

Scientists were surprised when they found out that metformin caused the secretion of GDF15, a protein which is known to suppress appetite.

4-Dec-2019 12:30 PM EST
Combination therapy more effective than chemotherapy alone for many newly diagnosed leukemia patients
University of Texas MD Anderson Cancer Center

A Phase II study pairing azacitidine with enasidenib boosts complete remission in patients with AML with IDH2 mutations.

Released: 9-Dec-2019 10:10 AM EST
Aspirin’s health benefits under scrutiny
University of Georgia

Taking a baby aspirin every day to prevent a heart attack or stroke should no longer be recommended to patients who haven’t already experienced one of these events.

5-Dec-2019 12:05 PM EST
Use of venetoclax in reduced-intensity transplant conditioning regimen in patients with high-risk myeloid cancers shows promise in early trial
Dana-Farber Cancer Institute

For patients with high-risk myeloid cancers undergoing a donor stem cell transplant, adding the targeted drug venetoclax to a reduced-intensity drug regimen prior to transplant is safe and does not impair the ability of the donor cells to take root in recipients’ bodies, a study led by Dana-Farber Cancer Institute researchers suggests.

2-Dec-2019 12:00 PM EST
Lymphoma Patients May Have New Path to Remission, Even When CAR T Therapy Fails
Perelman School of Medicine at the University of Pennsylvania

A new, experimental immunotherapy can put patients with B-cell non-Hodgkin lymphoma (NHL) that is resistant to or has come back after multiple other therapies, including CAR T therapy, into remission.

Released: 6-Dec-2019 7:00 PM EST
Co-addiction of meth and opioids hinders treatment
University of Washington School of Medicine

A study published in the Journal of Substance Abuse Treatment of 799 patients in three locations found that methamphetamine use was associated with more than twice the risk for dropping out of treatment for opioid-use disorder.

Released: 6-Dec-2019 2:05 PM EST
Rutgers-led Team Launches Science and Medicine Research Initiative to Transform Health Care in New Jersey
Rutgers University-New Brunswick

At an event Thursday at Rutgers, thought leaders from academia, health care, government and the pharmaceutical industry discussed the future of scientific and clinical trial innovation in the state, as a result of an innovative consortium between Rutgers University, Princeton University and the New Jersey Institute of Technology.

     
Released: 6-Dec-2019 1:05 PM EST
Technique shows how individual cancer cells react to drugs
University of Washington School of Medicine

A new technique reported in Science offers more detail, at the single cell level, on how large, pooled samples of various cells react to drugs or other agents. The data might reveal mode of action or the effect of genetic differences in varying responses.

3-Dec-2019 2:45 PM EST
“Seeing Others Suffer Is Too Stressful”: Why People Buy, Trade, Donate Medications on the Black Market
University of Utah Health

Altruism and a lack of access and affordability are three reasons why people with chronic illnesses are turning to the “black market” for medicines and supplies, new research shows. Scientists at University of Utah Health and University of Colorado ran surveys to understand why individuals are looking beyond pharmacies and medical equipment companies to meet essential needs. The reasons listed were many but centered on a single theme: traditional healthcare is failing them.

Released: 5-Dec-2019 1:50 PM EST
Maternal Antibiotic Treatment May Harm Preemies’ Lungs
American Physiological Society (APS)

New research in mice suggests that exposure to antibiotics before birth may impair lung development in premature infants. The study, the first to explore the gut-lung axis in prematurity, is published ahead of print in the American Journal of Physiology—Lung Cellular and Molecular Physiology and was chosen as an APSselect article for December.

Released: 4-Dec-2019 1:30 PM EST
Common Diabetes Medications Tested for Anti-Aging Effects
Texas Biomedical Research Institute

Two drugs already on the market to treat type two diabetes are being tested in nonhuman primates to see if they can impact the aging process. Researchers dosed marmosets with Metformin and Acarbose and found no adverse side effects

Released: 4-Dec-2019 12:35 PM EST
CicloMed Expands Fosciclopirox Phase 1 Trial to Include Cisplatin-Ineligible Muscle-Invasive Bladder Cancer Patients
University of Kansas Cancer Center

First patient enrolled at The University of Kansas Cancer Center in expansion cohort study characterizing the safety, pharmacokinetics and pharmacodynamics of fosciclopirox in bladder cancer patients

Released: 4-Dec-2019 12:20 PM EST
Single Dose of Ketamine Plus Talk Therapy May Reduce Alcohol Use
Columbia University Irving Medical Center

A single infusion of ketamine plus behavioral therapy helped alcohol-dependent individuals reduce their drinking, a new study finds.

Released: 4-Dec-2019 11:05 AM EST
Study finds key brain region smaller in birth control pill users
Radiological Society of North America (RSNA)

Researchers studying the brain found that women taking oral contraceptives, commonly known as birth control pills, had significantly smaller hypothalamus volume, compared to women not taking the pill, according to a new study presented today at the annual meeting of the Radiological Society of North America (RSNA).

Released: 3-Dec-2019 4:50 PM EST
A common drug could help restore limb function after spinal cord injury
Ohio State University

Long-term treatment with gabapentin, a commonly prescribed drug for nerve pain, could help restore upper limb function after a spinal cord injury, new research in mice suggests.

Released: 3-Dec-2019 1:35 PM EST
Harvard Medical School Launches Project to Transform the Treatment of Pain
Harvard Medical School

DARPA-funded project called STOP PAIN aimed at the design of safer, more effective pain treatments Research to focus on understanding the biology of pain as a way to transform clinical care, help stem the public health crisis fueled by opioids Efforts will encompass expertise from fields including neurobiology, stem cell biology, artificial intelligence and computational and medicinal chemistry

2-Dec-2019 3:30 PM EST
Researchers Use Genomics to Discover Potential New Treatment for Parasite Disease
University of Maryland Medical Center

Using innovative RNA sequencing techniques, researchers at the University of Maryland School of Medicine (UMSOM) identified a promising novel treatment for lymphatic filariasis, a disabling parasitic disease that is difficult to treat.

Released: 3-Dec-2019 11:10 AM EST
Roswell Park Team Identifies New Tumor Suppressor Protein in Prostate Cancer
Roswell Park Comprehensive Cancer Center

A research team led by Dr. Dean Tang at Roswell Park Comprehensive Cancer Center has identified the molecule LRIG1 as an important endogenous tumor suppressor in prostate cancer.

Released: 3-Dec-2019 8:55 AM EST
Migraine Headaches? Consider Aspirin for Treatment and Prevention
Florida Atlantic University

Evidence from 13 randomized trials of the treatment of migraine in 4,222 patients and tens of thousands of patients in prevention of recurrent attacks supports the use of high dose aspirin from 900 to 1,300 milligrams to treat acute migraine as well as low dose daily aspirin from 81 to 325 milligrams to prevent recurrent attacks. Aspirin is available without a prescription, is inexpensive, and has a relatively favorable side effect profile compared to alternative more expensive medications.

Released: 2-Dec-2019 2:55 PM EST
Researchers Find Protein Promotes Cancer, Suppresses Anti-Tumor Immunity
University of Texas MD Anderson Cancer Center

Researchers at The University of Texas MD Anderson Cancer Center have found that a protein involved in immune response to microbes, TBK1, also can fuel cancer development and suppress immune response to the disease.

Released: 2-Dec-2019 2:40 PM EST
Cori Bargmann: Reshaping science to save lives
University of Georgia

This story is part of a series, called Georgia Groundbreakers, that celebrates innovative and visionary faculty, students, alumni and leaders throughout the history of the University of Georgia – and their profound, enduring impact on our state, our nation and the world.

27-Nov-2019 9:00 AM EST
Improving Drug Delivery for Brain Tumor Treatment
Acoustical Society of America (ASA)

Despite improvements in drug delivery mechanisms, treating brain tumors has remained challenging. Researchers have studied the processes affecting therapeutic drug penetration into brain tumors and will present two strategies for improving the delivery of therapeutic agents during at the 178th ASA Meeting. One approach is to use microbubbles to help overcome vascular barriers within the tumors and improve nanoparticle penetration across the vessel wall. The second method uses ultrasound in combination with temperature-sensitive nanoparticles.

Released: 2-Dec-2019 1:35 PM EST
Taste-related protein provides target for drugs to treat neurological disorders
Van Andel Institute

GRAND RAPIDS, Mich. (Dec. 2, 2019) — Understanding how the brain processes sweet, bitter and umami tastes may one day help researchers design more effective drugs for neurological disorders.

27-Nov-2019 10:30 AM EST
Head-to-Head Comparison Finds Three Anti-Seizure Drugs Equally Effective for Severe Form of Epilepsy
Michigan Medicine - University of Michigan

A new clinical trial in the emergency department finds no difference in efficacy or adverse effects of three commonly used treatments for patients with refractory status epilepticus.

Released: 27-Nov-2019 12:40 PM EST
Ocean Medical Center Officially Opens New Pharmacy with Ribbon Cutting Ceremony
Hackensack Meridian Health

Network and hospital officials celebrated the opening of the Hackensack Meridian Health pharmacy at Ocean Medical Center with a ribbon cutting ceremony. The retail pharmacy expanded services to fill prescriptions for team members, patients being discharged, and to provide hard to find medical supplies and high-quality nutritionals for the community.

Released: 27-Nov-2019 11:30 AM EST
Can obesity limit antiarrhythmic drug effectiveness?
University of Illinois Chicago

A new study from researchers at the University of Illinois at Chicago is the first to show that some antiarrhythmic medications used to treat AFib are less effective in patients who are obese. The results of this study, which followed more than 300 patients in the UIC AFib Registry, are published in JAMA Cardiology.

Released: 27-Nov-2019 11:10 AM EST
Only handful of nutritional supplements benefit the heart
Houston Methodist

Of all the nutritional supplements on stores shelves, only three have been shown to provide any benefit to the heart.

Released: 27-Nov-2019 9:55 AM EST
Zantac Recalled for Carcinogen Levels Above FDA Standards
Vanderbilt University Medical Center

The popular heartburn drug ranitidine, commonly known as Zantac, was voluntarily recalled due to the contamination of a human carcinogen that could potentially cause cancer. The recall includes oral tablets, capsules, and syrup.

Released: 27-Nov-2019 8:00 AM EST
Helper Protein Worsens Diabetic Eye Disease
Johns Hopkins Medicine

In a recent study using mice, lab-grown human retinal cells and patient samples, Johns Hopkins Medicine scientists say they found evidence of a new pathway that may contribute to degeneration of the light sensitive tissue at the back of the eye. The findings, they conclude, bring scientists a step closer to developing new drugs for a central vision-destroying complication of diabetes that affects an estimated 750,000 Americans.

Released: 26-Nov-2019 12:20 PM EST
December’s SLAS Discovery Special Issue Now Available
SLAS

In this issue, Guest Editor Veli-Pekka Jaakola, Ph.D., (Confo Therapeutics, Belgium) includes a series of articles focused on new screening tools and assays that find new chemical matter for medically relevant membrane protein targets. In addition, an overview of a new and emerging protein-lipid reconstitution methodology utilizing Styrene Maleic Acid (SMA) polymers is featured.

Released: 26-Nov-2019 10:05 AM EST
We love coffee, tea, chocolate and soft drinks so much, caffeine is literally in our blood
Oregon State University

Scientists at Oregon State University may have proven how much people love coffee, tea, chocolate, soda and energy drinks as they validated their new method for studying how different drugs interact in the body.

   
Released: 25-Nov-2019 11:05 AM EST
Cannabis reduces headache and migraine pain by nearly half
Washington State University

Inhaled cannabis reduces self-reported headache severity by 47.3% and migraine severity by 49.6%, according to a recent study led by Carrie Cuttler, a Washington State University assistant professor of psychology.

19-Nov-2019 1:45 PM EST
New flu drug drives drug resistance in influenza viruses
University of Wisconsin–Madison

University of Wisconsin-Madison researchers examined the effects of baloxavir treatment on influenza virus samples collected from patients before and after treatment.

19-Nov-2019 2:15 PM EST
New Discovery in C. difficile Biology Could Lead to Treatments for Dangerous Bacterial Infections
Mount Sinai Health System

A process called sporulation that helps the dangerous bacterium Clostridium difficile (C. difficile) to survive inhospitable conditions and spread is regulated by epigenetics, factors that affect gene expression beyond the DNA genetic code.



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