ER visits did not rise with Medicaid expansion under Affordable Care Act
University of California, Los Angeles (UCLA), Health Sciences
Using a targeted gene epigenome editing approach in the developing mouse brain, Johns Hopkins Medicine researchers reversed one gene mutation that leads to the genetic disorder WAGR syndrome, which causes intellectual disability and obesity in people. This specific editing was unique in that it changed the epigenome — how the genes are regulated — without changing the actual genetic code of the gene being regulated.
Results of a new study suggest that over the past decade (2005-2017), the prevalence of cannabis use in the United States has increased among persons with and without depression, though the increase is significantly more rapid among those with depression.
Researchers from The University of Texas MD Anderson Cancer Center today reported study results showing the addition of tucatinib to capecitabine (Xeloda) and trastuzumab (Herceptin) significantly improved progression-free survival (PFS) and overall survival (OS) in patients with advanced HER2-positive breast cancer, with and without brain metastasis according to results of the HER2CLIMB clinical trial.
Researchers hope to develop new imaging methods to improve the treatment of preeclampsia.
A study combining low-dose chemotherapy with a monoclonal antibody is effective for older patients with Philadelphia chromosome-negative ALL.
New findings by Yale Cancer Center (YCC) and Smilow Cancer Hospital researchers show that as the use of the drug ibrutinib climbs in patients with chronic lymphocytic leukemia (CLL), so do the rates of patients who stop taking the drug.
Researchers at The University of Texas Health Science Center at Houston (UTHealth) have identified a protein that allows vancomycin-resistant enterococci to defy antibiotic treatment and immune system attacks. Their discovery opens the door for future treatment options in the fight against antibiotic resistance.
Scientists using specialized beamlines at Argonne's Structural Biology Center (SBC), a facility for macromolecular crystallography at the Advanced Photon Source, derived insights that led to the discovery of a promising new drug for Ebola.
A one-year follow-up study revealed a majority of patients with mantle cell lymphoma resistant to prior therapies may benefit from treatment with CD19-targeting chimeric antigen receptor (CAR) .
Two researchers from Penn State College of Medicine have received nearly $5 million from the National Institutes of Health to study whether an already-approved drug can be used to reduce cravings and prevent relapse in those struggling with opioid addiction.
A new study by Yale Cancer Center (YCC) researchers shows understanding treatment patterns for patients with acute myeloid leukemia (AML) is vital to develop strategies to improve outcomes.
A new study by Yale Cancer Center (YCC) and Smilow Cancer Hospital researchers suggests that the drug venetoclax aids therapy for relapsed/refractory myelodysplastic syndromes, especially when paired with azacytidine.
A new study from scientists at UCLA helps explain why some people with advanced cancer may not respond to one of the leading immunotherapies, PD-1 blockade, and how a new combination approach may help overcome resistance to the immunotherapy drug.
Scientists were surprised when they found out that metformin caused the secretion of GDF15, a protein which is known to suppress appetite.
A Phase II study pairing azacitidine with enasidenib boosts complete remission in patients with AML with IDH2 mutations.
Taking a baby aspirin every day to prevent a heart attack or stroke should no longer be recommended to patients who haven’t already experienced one of these events.
For patients with high-risk myeloid cancers undergoing a donor stem cell transplant, adding the targeted drug venetoclax to a reduced-intensity drug regimen prior to transplant is safe and does not impair the ability of the donor cells to take root in recipients’ bodies, a study led by Dana-Farber Cancer Institute researchers suggests.
A new, experimental immunotherapy can put patients with B-cell non-Hodgkin lymphoma (NHL) that is resistant to or has come back after multiple other therapies, including CAR T therapy, into remission.
A study published in the Journal of Substance Abuse Treatment of 799 patients in three locations found that methamphetamine use was associated with more than twice the risk for dropping out of treatment for opioid-use disorder.
At an event Thursday at Rutgers, thought leaders from academia, health care, government and the pharmaceutical industry discussed the future of scientific and clinical trial innovation in the state, as a result of an innovative consortium between Rutgers University, Princeton University and the New Jersey Institute of Technology.
A new technique reported in Science offers more detail, at the single cell level, on how large, pooled samples of various cells react to drugs or other agents. The data might reveal mode of action or the effect of genetic differences in varying responses.
Altruism and a lack of access and affordability are three reasons why people with chronic illnesses are turning to the “black market” for medicines and supplies, new research shows. Scientists at University of Utah Health and University of Colorado ran surveys to understand why individuals are looking beyond pharmacies and medical equipment companies to meet essential needs. The reasons listed were many but centered on a single theme: traditional healthcare is failing them.
New research in mice suggests that exposure to antibiotics before birth may impair lung development in premature infants. The study, the first to explore the gut-lung axis in prematurity, is published ahead of print in the American Journal of Physiology—Lung Cellular and Molecular Physiology and was chosen as an APSselect article for December.
Two drugs already on the market to treat type two diabetes are being tested in nonhuman primates to see if they can impact the aging process. Researchers dosed marmosets with Metformin and Acarbose and found no adverse side effects
First patient enrolled at The University of Kansas Cancer Center in expansion cohort study characterizing the safety, pharmacokinetics and pharmacodynamics of fosciclopirox in bladder cancer patients
A single infusion of ketamine plus behavioral therapy helped alcohol-dependent individuals reduce their drinking, a new study finds.
Researchers studying the brain found that women taking oral contraceptives, commonly known as birth control pills, had significantly smaller hypothalamus volume, compared to women not taking the pill, according to a new study presented today at the annual meeting of the Radiological Society of North America (RSNA).
Long-term treatment with gabapentin, a commonly prescribed drug for nerve pain, could help restore upper limb function after a spinal cord injury, new research in mice suggests.
DARPA-funded project called STOP PAIN aimed at the design of safer, more effective pain treatments Research to focus on understanding the biology of pain as a way to transform clinical care, help stem the public health crisis fueled by opioids Efforts will encompass expertise from fields including neurobiology, stem cell biology, artificial intelligence and computational and medicinal chemistry
Using innovative RNA sequencing techniques, researchers at the University of Maryland School of Medicine (UMSOM) identified a promising novel treatment for lymphatic filariasis, a disabling parasitic disease that is difficult to treat.
A research team led by Dr. Dean Tang at Roswell Park Comprehensive Cancer Center has identified the molecule LRIG1 as an important endogenous tumor suppressor in prostate cancer.
Evidence from 13 randomized trials of the treatment of migraine in 4,222 patients and tens of thousands of patients in prevention of recurrent attacks supports the use of high dose aspirin from 900 to 1,300 milligrams to treat acute migraine as well as low dose daily aspirin from 81 to 325 milligrams to prevent recurrent attacks. Aspirin is available without a prescription, is inexpensive, and has a relatively favorable side effect profile compared to alternative more expensive medications.
Researchers at The University of Texas MD Anderson Cancer Center have found that a protein involved in immune response to microbes, TBK1, also can fuel cancer development and suppress immune response to the disease.
This story is part of a series, called Georgia Groundbreakers, that celebrates innovative and visionary faculty, students, alumni and leaders throughout the history of the University of Georgia – and their profound, enduring impact on our state, our nation and the world.
Despite improvements in drug delivery mechanisms, treating brain tumors has remained challenging. Researchers have studied the processes affecting therapeutic drug penetration into brain tumors and will present two strategies for improving the delivery of therapeutic agents during at the 178th ASA Meeting. One approach is to use microbubbles to help overcome vascular barriers within the tumors and improve nanoparticle penetration across the vessel wall. The second method uses ultrasound in combination with temperature-sensitive nanoparticles.
GRAND RAPIDS, Mich. (Dec. 2, 2019) — Understanding how the brain processes sweet, bitter and umami tastes may one day help researchers design more effective drugs for neurological disorders.
A new clinical trial in the emergency department finds no difference in efficacy or adverse effects of three commonly used treatments for patients with refractory status epilepticus.
Network and hospital officials celebrated the opening of the Hackensack Meridian Health pharmacy at Ocean Medical Center with a ribbon cutting ceremony. The retail pharmacy expanded services to fill prescriptions for team members, patients being discharged, and to provide hard to find medical supplies and high-quality nutritionals for the community.
A new study from researchers at the University of Illinois at Chicago is the first to show that some antiarrhythmic medications used to treat AFib are less effective in patients who are obese. The results of this study, which followed more than 300 patients in the UIC AFib Registry, are published in JAMA Cardiology.
Of all the nutritional supplements on stores shelves, only three have been shown to provide any benefit to the heart.
The popular heartburn drug ranitidine, commonly known as Zantac, was voluntarily recalled due to the contamination of a human carcinogen that could potentially cause cancer. The recall includes oral tablets, capsules, and syrup.
In a recent study using mice, lab-grown human retinal cells and patient samples, Johns Hopkins Medicine scientists say they found evidence of a new pathway that may contribute to degeneration of the light sensitive tissue at the back of the eye. The findings, they conclude, bring scientists a step closer to developing new drugs for a central vision-destroying complication of diabetes that affects an estimated 750,000 Americans.
In this issue, Guest Editor Veli-Pekka Jaakola, Ph.D., (Confo Therapeutics, Belgium) includes a series of articles focused on new screening tools and assays that find new chemical matter for medically relevant membrane protein targets. In addition, an overview of a new and emerging protein-lipid reconstitution methodology utilizing Styrene Maleic Acid (SMA) polymers is featured.
Scientists at Oregon State University may have proven how much people love coffee, tea, chocolate, soda and energy drinks as they validated their new method for studying how different drugs interact in the body.
Inhaled cannabis reduces self-reported headache severity by 47.3% and migraine severity by 49.6%, according to a recent study led by Carrie Cuttler, a Washington State University assistant professor of psychology.
University of Wisconsin-Madison researchers examined the effects of baloxavir treatment on influenza virus samples collected from patients before and after treatment.
A process called sporulation that helps the dangerous bacterium Clostridium difficile (C. difficile) to survive inhospitable conditions and spread is regulated by epigenetics, factors that affect gene expression beyond the DNA genetic code.