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Respiratory Diseases and Disorders

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Medicine

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Translational Medicine, lung, Lung Transplant, Lung Transplantation, BOS, bronchiolitis obliterans syndrome

New Test Announced for Major Killer of Lung Transplant Patients

A lung transplant can mean a new chance at life. But many who receive one develop a debilitating, fatal condition that causes scar tissue to build up in the lungs and chokes off the ability to breathe. University of Michigan researchers hope a new diagnostic tool they developed to predict bronchiolitis obliterans syndrome (BOS) will allow doctors to intervene earlier and, ultimately, to provide life-saving treatments.

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Protein Involved in Cystic Fibrosis Also Plays Role in Emphysema, Chronic Lung Disease

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A team of Johns Hopkins Children's Center researchers has discovered that a protein involved in cystic fibrosis (CF) also regulates inflammation and cell death in emphysema and may be responsible for other chronic lung diseases.

Medicine

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Cystic Fibrosis, Cystic Fibrosis Lung Disease, Pulmonary and Respiratory Medicine, Clinical Trial

Novel Drug Offers Hope for Early Intervention in Cystic Fibrosis Patients

Cystic fibrosis (CF) patients with normal to mildly impaired lung function may benefit from a new investigational drug designed to help prevent formation of the sticky mucus that is a hallmark of the disease, according to researchers involved in a phase 3 clinical trial of the drug. Called denufosol, the investigational medication can be given early in the CF disease process, and may help delay the progression of lung disease in these patients, the researchers found.

Medicine

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COPD, Autoimmunity

COPD Could Be a Problem with Autoimmunity

Moderate to severe chronic obstructive pulmonary disease (COPD) may be an auto-immunity problem, according to researchers in Spain, who studied the presence of auto-antibodies in patients with COPD and compared them to levels of control subjects. They found that a significant number of patients with COPD had significant levels of auto-antibodies circulating in their blood, about 5 to 10 times the level in controls.

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Novel Approach Shows Promise for Cystic Fibrosis

An investigational drug targeting a defective protein that causes cystic fibrosis has been shown to improve lung function in a small study of CF patients. The investigational drug, VX-770, appeared to improve function of what is known as CFTR--the faulty protein responsible for CF.

Medicine

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Cystic Fibrosis, Cystic Fibrosis Lung Disease, CFTR gene

Cystic Fibrosis Gene Typo Is a Double Whammy

Researchers at the University of North Carolina at Chapel Hill School of Medicine have demonstrated that the gene mutated in cystic fibrosis not only controls traffic on the chloride highway, but also keeps the sodium highway from being overused.

Science

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Obstructive Sleep Apnea (Osa), Gray Matter, Brain

Sleep Apnea Linked to Cognitive Difficulties and Deficits in Gray Matter

Patients with obstructive sleep apnea (OSA) may blame their daytime difficulties on simple sleepiness, but new research suggests that their brains may be to blame. Specifically, their cognitive challenges may be caused by structural deficits in gray matter, brought on by the intermittent oxygen deprivation that comes with OSA.

Medicine

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IPF, Idiopathic Pulmonary Fibrosis, Pulmonary and Respiratory Medicine, Translational Medicine

New Indicator Found for Rapidly Progressing Form of Deadly Lung Disease

Idiopathic pulmonary fibrosis is a little-known disease that kills as many people each year as breast cancer. University of Michigan researchers have found a new indicator for the more aggressive form of IPF and they hope targeting it may help develop new treatments.

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Science

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Deadly Monkeypox Virus Might Cause Disease by Breaking Down Lung Tissue

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Study findings might help better understand bronchitis, emphysema, other lung diseases.

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COPD, Air Pollution

Air Pollution Exposure Increases Risk of Severe COPD

Long term exposure to low-level air pollution may increase the risk of severe chronic obstructive pulmonary disease (COPD), according to researcher s in Denmark. While acute exposure of several days to high level air pollution was known to be a risk factor for exacerbation in pre-existing COPD, until now there had been no studies linking long-term air pollution exposure to the development or progression of the disease.







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