Researchers presenting preliminary data from a clinical trial aimed at discovering a cure for sickle cell disease reveal positive results among its first patients. Sickle cell disease, a genetic blood disorder, is a painful and debilitating condition for which there are few approved therapies.
In this project volumetric bioprinting was for the first time successfully combined with melt electrowriting.
The University of Texas MD Anderson Cancer Center’s Research Highlights showcases the latest breakthroughs in cancer care, research and prevention.
A new study has uncovered evidence of a “coupling” mechanism between the malaria parasite and its human host, which could one day lead to new treatments for a disease that claims the life of a child under age 5 every minute.
A common cause of myocardial infarction and stroke is the rupture of atherosclerotic plaques. The exact location of plaque ruptures has previously been unknown, but now researchers at Lund University have mapped this. The research team has also identified an enzyme, a marker, that they hope will help predict who is at risk of having a myocardial infarction or a stroke due to a ruptured atherosclerotic plaque.
Research has shown that the immune system doesn’t function properly in patients with multiple myeloma, a blood cancer that occurs when plasma cells — a type of white blood cell — multiply out of control. But a clinical trial led by Jens Hillengass, MD, PhD, Chief of Myeloma at Roswell Park Comprehensive Cancer Center, shows that exercise may have the power to strengthen the immune system in those patients, providing a non-pharmaceutical method of helping control the disease.
Scientists at St. Jude Children’s Research Hospital found key “on” switch, NLRP12, for innate immune cell death in diseases that cause red blood cells to rupture, which can lead to inflammation and multi-organ failure.
Below are summaries of recent Fred Hutchinson Cancer Center research findings and other news. If you’re covering the American Society for Clinical Oncology’s annual meeting, June 2-6 in Chicago, Illinois, see our list of Fred Hutch research highlights at ASCO and contact [email protected] to set up interviews with experts.
In the case of blood poisoning, the bacteria in the blood must be identified as fast as possible so that a life-saving therapy can be started. Empa researchers have now developed "sepsis sensors" with magnetic nanoparticles that detect bacterial pathogens within a short period of time and identify suitable candidates for antibiotic therapies.
The American College of Surgeons (ACS) strongly supports the Prevent Blood Loss with Emergency Equipment Devices (BLEEDing) Act recently reintroduced in the United States Senate.
Chimeric antigen receptor (CAR) T-cell therapy amplifies the immune system’s ability to recognize and kill cancer cells. The first CAR T-cell therapy was approved by the Food and Drug Administration (FDA) in 2017. Today, there are 6 FDA-approved CAR-based therapies to treat certain types of leukemia, lymphoma and myeloma, all of which are available at The University of Kansas Cancer Center.
Treatment with luspatercept improved red blood cell counts and erythroid responses compared to treatment with epoetin alfa in patients with myelodysplastic syndromes (MDS), allowing the majority to no longer require regular blood transfusions. Results from the Phase III COMMANDS trial, led by researchers at The University of Texas MD Anderson Cancer Center, were reported at the 2023 American Society of Clinical Oncology (ASCO) Annual Meeting.
Low-load blood flow-restricted resistance exercise helped counter age-related muscle decay “with a modest exercise volume and in a very time-efficient manner.” The study is published ahead of print in the Journal of Applied Physiology. It was chosen as an APSselect article for May.
Regular physical activity and exercise may reduce bleeding in individuals with intracerebral hemorrhage, a University of Gothenburg study shows. The researchers emphasize the importance of physical activity to protect the brain.
Physicians and scientists from the UCLA Jonsson Comprehensive Cancer Center will discuss the latest research and clinical trial results on combination therapies for breast cancer, a potential new treatment for patients with recurrent glioma, and advances in PSMA PET guided radiotherapy for patients with prostate cancer, among other topics, at the American Society of Clinical Oncology’s annual meeting.
Blood vessel abnormalities in the eye are a major factor in the progression of Alzheimer’s disease, according to research from Cedars-Sinai investigators published in the peer-reviewed journal Alzheimer's & Dementia: The Journal of the Alzheimer's Association.
Yale Cancer Center and Smilow Cancer Hospital scientists and clinicians will present new research at the 2023 Annual Meeting of the American Society of Clinical Oncology (ASCO), June 2nd to June 6th at McCormick Place in Chicago, Illinois. This year’s scientific program will feature more than 2,900 abstracts, covering all major diseases and research areas, including breast, lung, head and neck, gynecological, prostate, and gastric cancers.
Canadian researchers have identified a new role for vitamin K and gamma-carboxylation in beta cells and their potentially protective role in diabetes, achieving a first in 15 years of basic research.
The number of deaths worldwide from ischemic stroke increased from 2 million in 1990 to more than 3 million in 2019, and is expected to increase to nearly 5 million by 2030, according to a study published in the May 17, 2023, online issue of Neurology®, the medical journal of the American Academy of Neurology. The study focused on ischemic stroke, which is caused by a blockage of blood flow to the brain and is the most common type of stroke.
Surviving a stroke can bring many long-term effects – including a much higher risk of dementia. But a study suggests that blood sugar may play a key role in that risk.
Skin cancer is the most prevalent form of cancer in the United States, with over 5 million cases diagnosed annually. The Centers for Disease Control and Prevention reports that melanoma alone accounts for more than 8,000 deaths each year. Thankfully, skin cancer is highly preventable, making it crucial to prioritize protection. Below are some of the latest headlines in the Dermatology channel.
Giving people at high risk of PFAS exposure the opportunity to easily self-test could improve access to testing for these “forever chemicals” and lead to the early detection of detrimental health conditions, according to a new Michigan State University study. The study tested an improved approach for people to collect their own blood samples to test for PFAS without being part of an academic research study.
The University of Texas MD Anderson Cancer Center was awarded more than $5.7 million in grants from Break Through Cancer to support collaborative research teams working to discover novel molecular targets to eradicate minimal residual disease in acute myeloid leukemia (AML) and to treat clonal hematopoiesis, a precursor to AML.
Seemingly healthy people whose blood contained antibodies associated with a condition called antiphospholipid syndrome (APS) were significantly more likely to experience a cardiovascular event such as a heart attack or stroke than those without, a study led by UT Southwestern Medical Center scientists shows
Indiana University School of Medicine researchers studying clonal hematopoiesis of indeterminate potential (CHIP), a blood condition that may increase the risk of blood cancer, discovered that obesity was strongly associated with the condition. Their findings were recently published in the Journal of Clinical Investigation.
Dr. David Shapiro describes the STOP THE BLEED® program and how he has seen the program make a direct impact in his community.
Researchers from Sanford Burnham Prebys and the Chinese University of Hong Kong have developed a computational approach to predict whether a person with type 2 diabetes will develop kidney disease. The findings could help doctors prevent or better manage kidney disease in people with type 2 diabetes.
At TTUHSC El Paso, addressing health disparities remains at the forefront of our mission.
Ischemic stroke, caused by a blockage of blood flow to the brain, is a common cause of death and disability.
The University of Texas MD Anderson Cancer Center’s Research Highlights showcases the latest breakthroughs in cancer care, research and prevention. These advances are made possible through seamless collaboration between MD Anderson’s world-leading clinicians and scientists, bringing discoveries from the lab to the clinic and back.
Many people have experienced infections from E. coli, which are primarily seen as inconvenient and unpleasant. For some patients, like those with blood cancer, however, there is a risk that the bacteria will travel into the bloodstream.
Fitterfly’s diabetes digital therapeutics program shows real-world effectiveness in improving glycemic control and weight management among people with type 2 diabetes mellitus
The Kathryn F. Kirk Center for Comprehensive Cancer Care and Women’s Cancers is a major expansion of Huntsman Cancer Institute, designed with the most advanced cancer care expertise and technology.
En Cedars-Sinai, hay otra gran razón para donar sangre: lo que muchos consideran la parte más dolorosa del proceso—la punción en el dedo de una aguja para medir el nivel de hemoglobina—ya tiene otra opción.
AACC has issued expert guidance on clinical testing for procalcitonin, a blood marker that helps detect serious bacterial infections and sepsis. By giving clinicians and laboratory professionals much-needed clarity on how to best use procalcitonin tests, the new guidelines could improve the treatment of critically ill patients and those with certain lower respiratory infections.
In a study of 17 people from five families, Johns Hopkins Medicine researchers say they found that ultra-lengthy DNA endcaps called telomeres fail to provide the longevity presumed for such people. Instead, people with long telomeres tend to develop a range of benign and cancerous tumors, as well as the age-related blood condition clonal hematopoiesis.
Glucocorticoid therapy is widely used during pregnancies at risk of premature delivery to promote fetal lung maturation. While it is an effective treatment, it can also trigger heart and blood vessel problems. New research published in The FASEB Journal uncovers the mechanisms behind the cardiovascular-related effects of the most commonly used glucocorticoids, Dexamethasone (Dex) and Betamethasone (Beta).
A new study from Washington University School of Medicine in St. Louis suggests that some dangerous bloodstream infections in premature infants may be caused by strains of bacteria already lurking in their gut microbiomes.
Left ventricular conduction disease occurs when there is an electrical blockage of the heart’s normal electrical conduction system. Treatment to lessen its effects involves implanting a permanent pacemaker, but there have been no proven preventive strategies for this condition. In a study publishing May 3, 2023 in JAMA Cardiology, first author Emilie Frimodt-Møller, MD, and senior author Gregory Marcus, MD, MAS, found that intensive BP control is associated with lower risk of left ventricular conduction disease, indicating left ventricular conduction disease may be preventable.
In observance of National STOP THE BLEED® Month in May, the American College of Surgeons (ACS) continues to pioneer efforts to educate and empower the public to learn simple bleeding control techniques that can save a life.
A roundup of the latest medical discoveries and faculty news at Cedars-Sinai for April 2023.
When Russia’s War on Ukraine began, individuals around the world mobilized to support the Ukrainian people. Among those offering help is a group from Michigan Medicine’s Max Harry Weil Institute for Critical Care Research and Innovation.
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