Feature Channels: Drug Resistance

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Released: 22-Sep-2020 8:30 AM EDT
Tufts center for antimicrobial resistance renamed for Stuart B. Levy
Tufts University

The Center for Integrated Management of Antimicrobial Resistance, a collaborative effort supported by Tufts University and Tufts Medical Center, has been renamed the Stuart B. Levy Center for Integrated Management of Antimicrobial Resistance, to honor the pioneering antibiotic-resistance researcher.

   
Released: 16-Sep-2020 11:00 AM EDT
Building bridges: PARP enzymes bring broken DNA together
St. Jude Children's Research Hospital

St. Jude researchers capture the structure of PARP enzymes at work, leading to a new understanding of DNA repair that may aid cancer treatments targeting the process.

Released: 11-Sep-2020 2:45 PM EDT
Poor home hygiene contributing to antibiotic resistance, warn global hygiene experts
SPINK HEALTH

According to the Global Hygiene Council's (GHC) public health experts, following a risk-based approach to home hygiene is essential to help curb the growing threat of antibiotic resistance.

Released: 26-Aug-2020 8:20 AM EDT
Too many COVID-19 patients get unneeded “just in case” antibiotics
Michigan Medicine - University of Michigan

More than half of patients hospitalized with suspected COVID-19 in Michigan during the state’s peak months received antibiotics soon after they arrive, just in case they had a bacterial infection in addition to the virus, a new study shows. But testing soon showed that 96.5% of them only had the coronavirus, which antibiotics don’t affect.

Released: 26-Aug-2020 6:00 AM EDT
Seizures During Menstrual Cycle Linked to Drug-Resistant Epilepsy
Rutgers University-New Brunswick

More frequent seizures during the menstrual cycle in women with genetic generalized epilepsy have been linked for the first time to drug-resistant epilepsy, when anti-seizure medications don’t work, according to a Rutgers coauthored study that may help lead to tailored treatments. Women with a form of genetic generalized epilepsy called catamenial epilepsy – when seizure frequency increases during their menstrual cycle – were nearly four times more likely to have drug-resistant epilepsy than women who experience no changes in frequency, according to the study in the journal Neurology. This association was found in two independent samples.

Released: 25-Aug-2020 2:45 PM EDT
Treating COVID-19 could lead to increased antimicrobial resistance
University of Plymouth

The use of antibiotics in people with COVID-19 could result in increased resistance to the drugs' benefits among the wider population, a new study suggests.

Released: 24-Aug-2020 12:20 PM EDT
Frequent use of antimicrobial drugs in early life shifts bacterial profiles in saliva
University of Helsinki

The human microbiota plays an important role in health and well-being by assisting in digestion, producing nutrients, resisting invading pathogens and regulating metabolism and the immune system.

Released: 21-Aug-2020 1:05 PM EDT
Long-acting, Injectable Drug Could Strengthen Efforts to Prevent, Treat HIV
University of Utah Health

Scientists have developed an injectable drug that blocks HIV from entering cells. They say the new drug potentially offers long-lasting protection from the infection with fewer side effects.

Released: 14-Aug-2020 4:05 PM EDT
Poor hygiene is significant risk for antimicrobial-resistant bacteria colonization
Washington State University

Scientists have found clear indicators for how the interaction of poor hygiene and antibiotic use contribute to the colonization of antimicrobial-resistant (AMR) bacteria in humans, a problem that contributes to hundreds of thousands of deaths annually.

10-Aug-2020 3:25 PM EDT
MS Drug May be Used to Inhibit HIV Infection and Reduce Latent Reservoir
George Washington University

A multiple sclerosis drug may be used to block HIV infection and reduce the latent reservoir, according to research published in PLOS Pathogens by a team at the RGeorge Washington University.

Released: 13-Aug-2020 1:05 PM EDT
Pollution linked to antibiotic resistance
University of Georgia

Antibiotic resistance is an increasing health problem, but new research suggests it is not only caused by the overuse of antibiotics. It’s also caused by pollution.

Released: 11-Aug-2020 6:55 AM EDT
A wound dressing that kills bacteria
Empa, Swiss Federal Laboratories for Materials Science and Technology

In order to combat bacterial wound infections, Empa researchers have developed cellulose membranes equipped with antimicrobial peptides. Initial results show: The skin-friendly membranes made of plant-based materials kill bacteria very efficiently.

Released: 7-Aug-2020 8:05 PM EDT
Penn Medicine-Led Research Suggests Greater Access to Specific HIV and Tuberculosis Medications is Needed Worldwide
Perelman School of Medicine at the University of Pennsylvania

A specific combination of HIV and TB treatments, difficult to obtain in certain parts of the world, decreased mortality risk for patients with HIV and multidrug-resistant TB

4-Aug-2020 7:10 PM EDT
Test accurately IDs people whose gonorrhea can be cured with simple oral antibiotic
University of California, Los Angeles (UCLA), Health Sciences

A test designed by UCLA researchers can pinpoint which people with gonorrhea will respond successfully to the inexpensive oral antibiotic ciprofloxacin, which had previously been sidelined over concerns the bacterium that causes the infection was becoming resistant to it.

Released: 4-Aug-2020 1:05 PM EDT
Scientists Develop New Models to Accelerate Progress in Preventing Drug Resistance in Lung and Pancreas Cancers
Huntsman Cancer Institute at the University of Utah

Scientists at Huntsman Cancer Institute at the University of Utah report today the development of new models to study molecular characteristics of tumors of the lung and pancreas that are driven by mutations in a gene named NTRK1. The findings were published today in the journal Cell Reports.

27-Jul-2020 9:00 AM EDT
Medieval medicine remedy could provide new treatment for modern day infections
University of Warwick

To fight antibiotic resistance more antimicrobials are needed to treat bacterial biofilms, which protect an infection from antibiotics

   
Released: 24-Jul-2020 2:40 PM EDT
High levels of antibiotic-resistant bacteria found on equipment in communal gyms
American Society for Microbiology (ASM)

Research presented at ASM Microbe Online found that 43% of Staphylococcus bacteria found on exercise equipment in university gyms were ampicillin-resistant, with 73% of those isolates being resistant to multiple additional drugs. The late Xin Fan, Ph.D., and her student Chase A. Weikel of West Chester University (WCU) conducted the research in cooperation with WCU's John M. Pisciotta, Ph.D., associate professor of Biology.

   
Released: 23-Jul-2020 7:05 PM EDT
Phage therapy shows potential for treating prosthetic joint infections
Mayo Clinic

Bacteriophages, or phages, may play a significant role in treating complex bacterial infections in prosthetic joints, according to new Mayo Clinic research. Suggesting phage therapy could provide a potential treatment for managing such infections, including those involving antibiotic-resistant microbes.

Released: 23-Jul-2020 11:45 AM EDT
New cell profiling method could speed TB drug discovery
Tufts University

A new cell profiling technology combines high throughput imaging and machine learning to provide a rapid, cost-effective way to determine how specific compounds act to destroy the bacterium that causes tuberculosis. It could speed discovery of anti-TB drugs and be applied to other pathogens.

   
Released: 8-Jul-2020 11:50 AM EDT
Pandemic could make drug resistance epidemic worse
University of Georgia

Researchers fear that widespread use of antibiotics during the coronavirus pandemic will add fuel to the fire, making more common infections that were once treatable possibly life threatening.

Released: 1-Jul-2020 1:10 PM EDT
Cancer cells make blood vessels drug resistant during chemotherapy
Hokkaido University

Scientists at Hokkaido University and collaborators have identified how inflammatory changes in tumors caused by chemotherapy trigger blood vessel anomalies and thus drug-resistance, resulting in poor prognosis of cancer patients.

Released: 2-Jun-2020 3:40 PM EDT
Antibiotic-destroying genes widespread in bacteria in soil and on people
Washington University in St. Louis

Researchers at Washington University in St. Louis and the National Institutes of Health (NIH) have found that genes that confer the power to destroy tetracycline antibiotics are widespread in bacteria. But the researchers have also created a chemical compound that shields tetracyclines from destruction, restoring the antibiotics lethality. The findings indicate an emerging threat to one of the most widely used classes of antibiotics — but also a promising way to protect against that threat.

Released: 21-May-2020 11:20 AM EDT
$5 million supports research into neglected tropical diseases
Washington University in St. Louis

Researchers at Washington University School of Medicine in St. Louis have received two grants from the National Institutes of Health (NIH) totaling more than $5 million to study two types of parasitic worm infection that cause devastating illness in millions of people worldwide. One project will focus on onchocerciasis, commonly known as river blindness. The second project will target fascioliasis, commonly found in cattle-farming operations.

Released: 21-May-2020 5:50 AM EDT
Next-gen nano technologies to tackle infection and diagnose disease
University of South Australia

Next-gen nano technologies that can prevent infection and diagnose disease are set to transform the medical industry as this important UniSA research is awarded more than $2 million dollars under the National Health and Medical Research Council (NHMRC) 2021 Investigator Grants.

   
13-May-2020 12:35 PM EDT
Researchers find one-two punch may help fight against Salmonella
McMaster University

Researchers found that co-administering dephostatin and colistin in mice with a lethal Salmonella infection significantly prolonged animal survival and used a lower concentration of colistin than is normally required for treatment, thereby reducing its toxic effect.

Released: 13-May-2020 9:00 AM EDT
Computer model IDs drug-resistant mutations
National Institute of Biomedical Imaging and Bioengineering

To counter drug resistance Penn State engineers have developed a new approach for predicting which mutation has expanded the most in a population and should be targeted to design the most effective new drug.

   
Released: 5-May-2020 9:50 AM EDT
Intensive farming increases risk of epidemics, warn scientists
University of Sheffield

Research from the University of Sheffield and the University of Bath has discovered how a common pathogen is able to infect both cattle and humans

Released: 27-Apr-2020 1:55 PM EDT
Bacteria That Are Persistently Resistant to One Antibiotic Are ‘Primed’ to Become Multidrug-Resistant Bugs
University of Washington

For a bacterial pathogen already resistant to an antibiotic, prolonged exposure to that antibiotic not only boosted its ability to retain its resistance gene, but also made the pathogen more readily pick up and maintain resistance to a second antibiotic and become a dangerous, multidrug-resistant strain.

   
Released: 20-Apr-2020 3:55 PM EDT
What’s old is new again
Stowers Institute for Medical Research

Drug resistance is a major obstacle in cancer treatment—leading to relapse for many patients. In a new study, published online April 20, 2020, in Nature Cell Biology, researchers from the Stowers Institute for Medical Research, Children’s Mercy Kansas City, and The University of Kansas Cancer Center report on a promising new strategy to overcome drug resistance in leukemia, using targeted doses of the widely-used chemotherapy drug doxorubicin.

Released: 20-Apr-2020 11:10 AM EDT
Study describes cocktail of pharmaceuticals in waters in Bangladesh
University at Buffalo

An analysis revealed that water samples held a cocktail of pharmaceuticals and other compounds, including antibiotics, antifungals, anticonvulsants, anesthetics, antihypertensive drugs, pesticides, flame retardants and more. Not all chemicals were found at every test site.

Released: 14-Apr-2020 1:35 PM EDT
Scientists provide new insight on how bacteria share drug resistance genes
eLife

Researchers have been able to identify and track the exchange of genes among bacteria that allow them to become resistant to drugs, according to a new study published today in eLife.

Released: 6-Apr-2020 3:35 PM EDT
Lifestyle trumps geography in determining makeup of gut microbiome
Washington University in St. Louis

Researchers from Washington University in St. Louis studied the gut microbiomes of wild apes in the Republic of Congo, of captive apes in zoos in the U.S., and of people from around the world and discovered that lifestyle is more important than geography or even species in determining the makeup of the gut microbiome.

   
Released: 25-Mar-2020 10:05 AM EDT
New study: Cannabis helps fight resistant bacteria
University of Southern Denmark

Since the discovery of penicillin in 1928 by Sir Alexander Fleming, antibiotics have saved millions of lives from fatal infections world-wide. However, with time bacteria have developed mechanisms to escape the effects of antibiotics - they have become resistant.

20-Mar-2020 11:00 AM EDT
Burying or burning garbage boosts airborne bacteria, antibiotic resistance genes
American Chemical Society (ACS)

Researchers reporting in Environmental Science & Technology have shown that when waste is burned or buried, it can be a source of antibiotic-resistance genes in the air.

Released: 23-Mar-2020 6:00 AM EDT
New Device Quickly Detects Harmful Bacteria in Blood
Rutgers University-New Brunswick

Engineers have created a tiny device that can rapidly detect harmful bacteria in blood, allowing health care professionals to pinpoint the cause of potentially deadly infections and fight them with drugs. The Rutgers coauthored study, led by researchers at Rochester Institute of Technology, is published in the journal ACS Applied Materials & Interfaces.

   
6-Mar-2020 8:15 AM EST
St. Jude finds cancer drug resistance genes and possibly how to limit their effects
St. Jude Children's Research Hospital

Drug resistance is a leading cause of cancer death in children and adults with leukemia. St. Jude Children’s Research Hospital scientists have developed a novel strategy to find the genes responsible.

Released: 3-Mar-2020 2:10 PM EST
Starve a tumor: How cancers can resist drugs
University of California, Irvine

With drug resistance a major challenge in the fight against cancer, a discovery by University of California, Irvine biologists could offer new approaches to overcoming the obstacle. Their research reveals that a mechanism enabling the diseased cells to scavenge dead cell debris for nourishment holds a pivotal role.

Released: 26-Feb-2020 4:55 PM EST
UTEP and EPCC Study Focuses on Antibiotic Resistance in Rio Grande
University of Texas at El Paso

Researchers at The University of Texas at El Paso and El Paso Community College discovered that the Rio Grande is a “hotspot” for multidrug-resistant bacteria, antibiotic residues and antimicrobial resistant genes.

   
Released: 26-Feb-2020 11:40 AM EST
No Benefit Found in Using Broad-spectrum Antibiotics as Initial Pneumonia Treatment
University of Utah Health

Doctors who use drugs that target antibiotic-resistant bacteria as a first-line defense against pneumonia should probably reconsider this approach, according to a new study of more than 88,000 veterans hospitalized with the disease. The study found that pneumonia patients given these medications in the first few days after hospitalization fared no better than those receiving standard medical care for the condition.

21-Feb-2020 11:05 AM EST
Antibodies: the body’s own antidepressants
Max Planck Society (Max-Planck-Gesellschaft)

Antibodies can be a blessing or a curse to the brain - it all depends on their concentration

Released: 13-Feb-2020 1:35 PM EST
Researchers explore role of antibiotic resistance in pandemic risk
 Johns Hopkins University

Researchers investigating the drug prescription response to a “superbug” enzyme that renders bacteria resistant to antibiotics are available to discuss why such resistance is posing a growing risk during pandemics such as the current coronavirus.

   
10-Feb-2020 3:40 PM EST
Antibiotics discovered that kill bacteria in a new way: McMaster
McMaster University

A new group of antibiotics with a unique approach to attacking bacteria has been discovered, making it a promising clinical candidate in the fight against antimicrobial resistance. The newly-found corbomycin and the lesser-known complestatin have a never-before-seen way to kill bacteria, which is achieved by blocking the function of the bacterial cell wall. The discovery comes from a family of antibiotics called glycopeptides that are produced by soil bacteria.

Released: 30-Jan-2020 7:35 PM EST
Science Snapshot From Berkeley Lab - a biocompatible material that turns up the heat on antibacterial-resistant diseases
Lawrence Berkeley National Laboratory

Scientists at Berkeley Lab’s Molecular Foundry have designed a biocompatible polymer that has the potential to advance photothermal therapy, a technique that deploys near-infrared light to combat antibacterial-resistant infections and cancer.

Released: 29-Jan-2020 6:20 PM EST
Immune responses to tuberculosis mapped across 3 species
Washington University in St. Louis

A new study led by Washington University School of Medicine in St. Louis offers a genetic road map detailing the similarities and differences in immune responses to TB across three species — mice, macaques and humans. According to the researchers, the insight into the immune pathways that are activated in diverse models of TB infection will serve as a valuable tool for scientists studying and working to eradicate the disease.

27-Jan-2020 11:05 AM EST
Discovery reveals antibiotic-resistant strep throat may be too close for comfort
Houston Methodist

Infectious disease scientists identified strains of group A streptococcus that are less susceptible to commonly used antibiotics, a sign that the germ causing strep throat and flesh-eating disease may be moving closer to resistance to penicillin and other related antibiotics known as beta-lactams.

28-Jan-2020 10:25 AM EST
Does Lung Damage Speed Pancreatic Cancer?
Thomas Jefferson University

High levels of CO2 in the body, due to chronic respiratory disorders, may exacerbate pancreatic cancer, making it more aggressive and resistant to therapy.

24-Jan-2020 10:00 AM EST
Color-changing bandages sense and treat bacterial infections
American Chemical Society (ACS)

Researchers reporting in ACS Central Science have developed color-changing bandages that can sense drug-resistant and drug-sensitive bacteria in wounds and treat them accordingly.

Released: 28-Jan-2020 7:05 PM EST
1 in 4 kids who get antibiotics in children’s hospitals are prescribed the drugs incorrectly
Washington University in St. Louis

New research led by Washington University School of Medicine in St. Louis indicates that 1 in 4 of the children given antibiotics in U.S. children's hospitals are prescribed the drugs inappropriately. The overuse of antibiotics poses an increasing threat to children who develop — or already have — drug-resistant infections.

Released: 28-Jan-2020 11:05 AM EST
Major Asian Gene Study to Help Doctors Battle Disease
University of Virginia Health System

“Under-representation of Asian populations in genetic studies has meant that medical relevance for more than half of the human population is reduced,” one researcher said.

Released: 27-Jan-2020 6:15 AM EST
Infectious diseases to be detected and prevented thanks to £4m grant
University of Warwick

Infectious diseases could be detected, prevented and controlled thanks to a new £4m grant from the NIHR to the University of Warwick. Researchers will work with partners to develop the use of cutting edge genomics to protect public health.



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