Latest News from: Perelman School of Medicine at the University of Pennsylvania

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Why Social Isolation Can Bring a Greater Risk of Illness

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In the fruit fly, social isolation leads to sleep loss, which in turn leads to cellular stress and the activation of a defense mechanism called the unfolded protein response.

Medicine

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Dermatolgoy, Guatamala, Medical Education, Residency education, Perelman School of Medicine at the University of Pennsylvania

Creating New Borders for Clinical Rotations Abroad

Unlike traditional clinical rotations abroad for medical residents, the University of Pennsylvania has created an equal education exchange with Guatemala's INDERMA program, meaning that not only do Penn Dermatology residents spend time in Guatemala, but INDERMA residents come to Philadelphia for clinical rotations and lectures.

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AML, Leukemia, gilteritinib, FLT3

New Inhibitor Drug Shows Promise in Relapsed Leukemia

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A new drug shows promise in its ability to target one of the most common and sinister mutations of acute myeloid leukemia (AML), according to researchers at the Perelman School of Medicine at the University of Pennsylvania and Penn’s Abramson Cancer Center. The Fms-like tyrosine kinase 3 (FLT3) gene mutation is a known predictor of AML relapse and is associated with short survival. In a first-in-human study, researchers treated relapsed patients with gilteritinib, an FLT3 inhibitor, and found it was a well-tolerated drug that led to frequent and more-sustained-than-expected clinical responses, almost exclusively in patients with this mutation.

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Pew Charitable Trusts, Immunology

Penn Immunologist Selected as Pew Scholar in Biomedical Sciences

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— Jorge Henao-Mejia, MD, PhD, an assistant professor of Pathology and Laboratory Medicine in the Perelman School of Medicine at the University of Pennsylvania and Children’s Hospital of Philadelphia, has been recognized by The Pew Charitable Trusts as one of its 22 national Pew Scholars in Biomedical Sciences.

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Microbiome, Antibiotics, antiseptics

Penn Study Details Impact of Antibiotics, Antiseptics on Skin Microbiomes

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The use of topical antibiotics can dramatically alter communities of bacteria that live on the skin, while the use of antiseptics has a much smaller, less durable impact. The study, conducted in mice in the laboratory of Elizabeth Grice, PhD, an assistant professor of Dermatology in the Perelman School of Medicine at the University of Pennsylvania, is the first to show the long-term effects of antimicrobial drugs on the skin microbiome.

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When I Die, Let Me Live

The first two-part episode of Lauren Kelly, MD’s podcast, “When I Die, Let Me Live,” is not always an easy listen — but that’s kinda the point. Kelly, who graduated from the Perelman School of Medicine earlier this year, aims to present the listener with firsthand stories from patients, families, and caretakers dealing with the myriad physical, mental, emotional, and moral complexities of end-of-life care.

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Trauma Care, Intensive Care Units, Penn Medicine, Surgery, Hospital occupancy, Crowding, icu transfer, ICU residents

Surgery Patients Placed in Alternate ICUs Due to Crowding Get Less Attention from Doctors

Overcrowding of intensive care units (ICUs) is a growing problem in American hospitals, often resulting in the need to place patients in alternate intensive care units within a hospital. Research has indicated that these “ICU boarder” patients — for example, a brain surgery patient staying in a cardiac ICU — have worse outcomes as a result of this alternate placement, and now, a new study suggests one reason for these worse outcomes is that ICU boarders, compared to non-boarders, appear to get markedly less attention from doctors and other caregivers.

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Neurodegenative Disease

Hi-Res View of Protein Complex Shows How It Breaks Up Protein Tangles

A new, high-resolution view of the structure of Hsp104 (heat shock protein 104), a natural yeast protein nanomachine with six subunits, may show news ways to dismantle harmful protein clumps in disease.

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Burroughs Wellcome Fund Awards $1.9 Million in Grants to Three Penn Researchers

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Penn winners among just 24 total recipients

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Thyroid Cancer, radioiodine therapy, radioiodine-refractory thyroid cancer, Levatinib

Inhibitor Drug Improves Overall Survival in Older Radioiodine Resistant Thyroid Cancer Patients

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The drug lenvatinib can significantly improve overall survival rates in a group of thyroid cancer patients whose disease is resistant to standard radioiodine treatment, according to new research from the Perelman School of Medicine at the University of Pennsylvania. The study, published today in the Journal of Clinical Oncology, is the first to show lenvatinib has a definitive impact on overall survival (OS). Researchers found OS improves in patients older than 65 years of age and that the drug is well-tolerated.







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