Latest News from: University of North Carolina Health Care System

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Newswise: Berkowitz Authors NEJM Perspective Piece on Food Insecurity
Released: 26-Feb-2024 2:05 PM EST
Berkowitz Authors NEJM Perspective Piece on Food Insecurity
University of North Carolina Health Care System

Published in the New England Journal of Medicine, Seth A. Berkowitz, MD, MPH, associate professor of medicine at the UNC School of Medicine, wrote perspective piece on how medically tailored meals address health consequences of food insecurity.

Newswise: Drug in OUtMATCH Clinical Trial FDA-Approved for the Reduction of Allergic Reactions from Accidental Food Exposures
Released: 26-Feb-2024 11:05 AM EST
Drug in OUtMATCH Clinical Trial FDA-Approved for the Reduction of Allergic Reactions from Accidental Food Exposures
University of North Carolina Health Care System

Stage one results from the OUtMATCH clinical trial, published in the New England Journal of Medicine, show that a monoclonal antibody, omalizumab, increased the amount of peanut, tree nuts, egg, milk and wheat that multi-food allergic children as young as age one could consume without an allergic reaction. Edwin Kim, MD, Corinne Keet, MD, PhD, and Mike Kulis, PhD, are contributing authors.

Newswise: UNC Lineberger named as a national research hub for NIH cancer screening study
20-Feb-2024 12:05 PM EST
UNC Lineberger named as a national research hub for NIH cancer screening study
University of North Carolina Health Care System

UNC Lineberger Comprehensive Cancer Center has been selected as one of nine national research sites for the National Cancer Institute’s newly launched Cancer Screening Research Network, which will evaluate promising and emerging cancer screening technologies.

Newswise: How Two Sisters Continue to Soar with Sickle Cell Disease
Released: 2-Feb-2024 9:30 AM EST
How Two Sisters Continue to Soar with Sickle Cell Disease
University of North Carolina Health Care System

Sydney and Sheridan Taylor of Durham, North Carolina, have lived with this rare genetic disorder all of their lives.

Newswise: UNC Hospitals Performs First Domino Liver Transplant in Decades
Released: 1-Feb-2024 10:05 AM EST
UNC Hospitals Performs First Domino Liver Transplant in Decades
University of North Carolina Health Care System

Chirag Desai, MD, FACS, an abdominal organ transplant and hepatobiliary-pancreatic surgeon at UNC Hospitals, performed a “domino” liver transplant, which helped two patients from a single donor without splitting a liver.

Newswise: Scientists Reveal Role of Notorious Cell Subpopulation in Antibiotic Failure
Released: 11-Jan-2024 11:05 AM EST
Scientists Reveal Role of Notorious Cell Subpopulation in Antibiotic Failure
University of North Carolina Health Care System

Antibiotic overuse can lead to antibiotic resistance, a global health problem. But UNC School of Medicine scientists with Duke School of Medicine colleagues have documented another culprit in clinical antibiotic failure: bacterial persister cells.

   
Newswise: Vosshall Named 22nd Perl-UNC Neuroscience Prize Recipient
Released: 9-Jan-2024 9:05 AM EST
Vosshall Named 22nd Perl-UNC Neuroscience Prize Recipient
University of North Carolina Health Care System

Leslie B. Vosshall, PhD, the Robin Chemers Neustein Professor of Neurogenetics and Behavior at The Rockefeller University, will receive the Perl-UNC Neuroscience Prize for her work on receptors that drive host-seeking behavior in the mosquito.

   
Newswise: Removing the Penicillin Allergic Label: Researchers Introduce PADME
Released: 4-Jan-2024 1:05 PM EST
Removing the Penicillin Allergic Label: Researchers Introduce PADME
University of North Carolina Health Care System

Doctors at the UNC School of Medicine and Cincinnati Children’s collaborate to develop an innovative, patient-initiated online platform designed to remove the penicillin allergy label from misdiagnosed pediatric patients.

Newswise: UNC Researchers Reveal Prevalence of Persistent Symptoms in Patients with Microscopic Colitis
Released: 13-Dec-2023 1:05 PM EST
UNC Researchers Reveal Prevalence of Persistent Symptoms in Patients with Microscopic Colitis
University of North Carolina Health Care System

A new study led by Walker Redd, MD, at the UNC School of Medicine, examines how multiple factors contribute to the miscommunication and understanding of the digestive disease, microscopic colitis.

Newswise: Doctors Discover Many Patients at UNC’s Inflammatory Bowel Disease Clinic Screen Positive for Malnutrition
Released: 8-Dec-2023 3:05 PM EST
Doctors Discover Many Patients at UNC’s Inflammatory Bowel Disease Clinic Screen Positive for Malnutrition
University of North Carolina Health Care System

Research led by first and second authors Aaron C. Viser, Adelaide R. Cooke, and corresponding author Anne F. Peery, MD, associate professor of medicine at the UNC School of Medicine, reveals how a screening tool can measure the prevalence of malnutrition among patients at the UNC Multidisciplinary Inflammatory Bowel Disease Clinic.

Newswise: Antibodies to Cow’s Milk Linked to Increased Risk of Cardiovascular Death
9-Nov-2023 4:05 AM EST
Antibodies to Cow’s Milk Linked to Increased Risk of Cardiovascular Death
University of North Carolina Health Care System

Analyses led by Corinne Keet, MD, PhD, at the University of North Carolina School of Medicine, of two longitudinal studies reveal how an increased level of an antibody called immunoglobin (IgE) to cow’s milk is associated to cardiovascular-related death.

Newswise: New, Promising Clinical Trial for Glioblastoma Starting at UNC Health
Released: 7-Nov-2023 1:05 PM EST
New, Promising Clinical Trial for Glioblastoma Starting at UNC Health
University of North Carolina Health Care System

UNC Health is the only academic healthcare system in North Carolina and the South participating in the randomized trial, which aims to assess the safety and efficacy of a combination immunotherapy for newly diagnosed glioblastoma patients.

Newswise: New Procedure at UNC Restores Eyesight, Sensation for Patients with Rare Eye Condition
Released: 31-Oct-2023 10:05 AM EDT
New Procedure at UNC Restores Eyesight, Sensation for Patients with Rare Eye Condition
University of North Carolina Health Care System

Matthew Miller, MD, Daniel Rubinstein, MD, and Hussam Banna, MD, from the UNC School of Medicine joined forces to perform the first corneal neurotization procedure at UNC, a life-changing surgery for patients who have neurotrophic keratitis.

Newswise: For Toddlers Allergic to Peanuts, a Tiny Bit of Protein Therapy Under the Tongue Could Be The Best Approach
Released: 12-Oct-2023 9:05 PM EDT
For Toddlers Allergic to Peanuts, a Tiny Bit of Protein Therapy Under the Tongue Could Be The Best Approach
University of North Carolina Health Care System

A clinical study led by Edwin Kim, MD, at the UNC School of Medicine, showed how Peanut Sublingual Immunotherapy (Peanut SLIT) is safe and effective in children ranging from 1-to-4 years of age. Remission of peanut allergy was also possible after three months of stopping the treatment.

Newswise: Poor oral health could lessen survival from head and neck cancer
15-Sep-2023 2:10 PM EDT
Poor oral health could lessen survival from head and neck cancer
University of North Carolina Health Care System

An international study has revealed strong associations between oral health and survival among people diagnosed with head and neck cancer. Specifically, better oral health, as evidenced by the number of natural teeth and dental visits prior to the time of diagnosis, was associated with increased survival.

Newswise: Higher Doses of Oral Semaglutide Improves Blood Sugar Control and Weight Loss
Released: 26-Jun-2023 5:05 PM EDT
Higher Doses of Oral Semaglutide Improves Blood Sugar Control and Weight Loss
University of North Carolina Health Care System

John Buse, MD, PhD, the Verne S. Caviness Distinguished Professor of Medicine in the Division of Endocrinology and Metabolism, and an international team of researchers have presented new findings about new higher-dose formulations of oral semaglutide. Their study found that once-daily oral semaglutide taken at 25 mg and 50 mg did a better job in lowering blood sugar levels and promoting weight loss than the lowest dose of 14 mg.

Newswise: Mammalian Evolution Provides Hints for Understanding the Origins of Human Disease
Released: 27-Apr-2023 2:00 PM EDT
Mammalian Evolution Provides Hints for Understanding the Origins of Human Disease
University of North Carolina Health Care System

Even though it is important to know where these variations are located in the genome, it's also useful to know how or why these genetic variations happened in the first place. Sullivan hopes that other researchers will make use of the new and extensive document to reach their own conclusions regarding the genetics underlying a variety of human diseases.

Newswise: A New Primary Care Model Proves Effective for Patients with Severe Mental Illness
Released: 10-Apr-2023 4:15 PM EDT
A New Primary Care Model Proves Effective for Patients with Severe Mental Illness
University of North Carolina Health Care System

A new analysis led by Alex K. Gertner, MD, PhD, psychiatry resident at UNC Hospitals, has added further evidence that the new model is effective.

Newswise: Researchers Leverage Cell Self-Destruction to Treat Brain Tumors
Released: 7-Apr-2023 8:05 AM EDT
Researchers Leverage Cell Self-Destruction to Treat Brain Tumors
University of North Carolina Health Care System

Dominique Higgins, MD, PhD, an assistant professor in the Department of Neurosurgery, and a team of researchers at Columbia University have found that glioblastoma tumor cells are particularly sensitive to ferroptosis - a type of cell death that can be triggered by removing certain amino acids from the diet.

Newswise: Researchers Announce Findings from Landmark Clinical Trial for Pediatric Crohn’s Disease
Released: 3-Apr-2023 5:15 PM EDT
Researchers Announce Findings from Landmark Clinical Trial for Pediatric Crohn’s Disease
University of North Carolina Health Care System

A significant clinical trial under the direction of Michael Kappelman, MD, MPH, professor of pediatrics at UNC School of Medicine, found that patients receiving the tumor necrosis factor inhibitor adalimumab combined with a low dose of methotrexate, a second immunosuppressant, did better than those treated with infliximab alone. Patients who received infliximab, another tumor necrosis factor inhibitor, had similar outcomes with or without methotrexate.

Newswise: New Research Shows That Bacteria Get “Hangry,
Released: 3-Apr-2023 11:00 AM EDT
New Research Shows That Bacteria Get “Hangry," Too
University of North Carolina Health Care System

The findings, published in Nature Microbiology, are particularly important in understanding how and why bacterial communities defer duties to certain cells – and could lead to new ways to tackle antibiotic tolerance further down the line.

Newswise: Reducing the Appeal of Smoking: Study Confirms Tobacco Warnings on Packages Need Improvement
Released: 30-Mar-2023 4:05 PM EDT
Reducing the Appeal of Smoking: Study Confirms Tobacco Warnings on Packages Need Improvement
University of North Carolina Health Care System

Research has been underway to assess adoption of warning labels for combustible tobacco products worldwide.

Newswise: How to Help Your Gut Microbiome, With and Without Probiotics
Released: 28-Mar-2023 4:20 PM EDT
How to Help Your Gut Microbiome, With and Without Probiotics
University of North Carolina Health Care System

Bacteria have thousands of genes and functions that we, the human host, do not have. For instance, bacteria can help us digest fiber, provide support to our immune systems, and absorb important nutrients. But reaping the benefits of “good bacteria” is easier said than done.

Newswise: What You Should Know about the Lone Star Tick’s Impact on Our Gut and Diet
Released: 21-Mar-2023 5:00 PM EDT
What You Should Know about the Lone Star Tick’s Impact on Our Gut and Diet
University of North Carolina Health Care System

Along with UNC colleagues Scott Commins, MD, PhD, and Michael Croglio, MD, McGill was one of the first to describe the condition in gastroenterology patients. McGill has now published a national clinical practice update in the journal Clinical Gastroenterology and Hepatology of the American Gastroenterological Association.

Newswise: Novel Peanut Allergy Treatment Shown to be Safe, Effective, and Lasting
Released: 17-Mar-2023 12:30 PM EDT
Novel Peanut Allergy Treatment Shown to be Safe, Effective, and Lasting
University of North Carolina Health Care System

A four-year phase 2 clinical trial demonstrated that a peanut allergy treatment called sublingual immunotherapy, or SLIT, is effective and safe, while offering durable desensitization to peanuts in peanut-allergic children.

Newswise: Grad Student Kaitlan Smith Reflects on Lumbee Heritage While Embarking on Curiosity-driven Science
Released: 27-Feb-2023 11:30 AM EST
Grad Student Kaitlan Smith Reflects on Lumbee Heritage While Embarking on Curiosity-driven Science
University of North Carolina Health Care System

Pharmacology graduate student Kaitlan Smith was recently awarded a diversity supplement from the National Institute on Aging (NIA) to study the effects of aging and necroptosis. She shares her resilient journey into scientific research while reflecting on her Lumbee roots.

Newswise: How a New Blood-Vessel-on-a-Chip Can Help Researchers Further Understand Vascular Malformations
Released: 24-Feb-2023 1:40 PM EST
How a New Blood-Vessel-on-a-Chip Can Help Researchers Further Understand Vascular Malformations
University of North Carolina Health Care System

Vascular malformations (VMs), a group of rare genetic disorders that causes an abnormal formation of veins, arteries, capillaries, or lymphatic vessels at birth, can interfere with the duties of our circulatory system by causing blockages, poor drainage, and the formation of cysts and tangles.

Newswise: Researchers Uncover Mechanisms of Brexanolone and the Role of Inflammation in Post-partum Depression
Released: 20-Feb-2023 2:45 PM EST
Researchers Uncover Mechanisms of Brexanolone and the Role of Inflammation in Post-partum Depression
University of North Carolina Health Care System

Brexanolone, an IV infusion comprised of a derivative of progesterone, was approved by the U.S. Food and Drug Administration for the treatment of PPD in 2019. The fast-acting medication significantly reduces depression symptoms and provides effects for up to 90 days. However, exactly how the drug provides these therapeutic effects has remained a mystery – until now.

Newswise: Novel Optical and fMRI Platform Identifies Brain Regions that Control Large-scale Brain Network
Released: 15-Feb-2023 2:00 PM EST
Novel Optical and fMRI Platform Identifies Brain Regions that Control Large-scale Brain Network
University of North Carolina Health Care System

Neuroimaging techniques, like functional magnetic resonance imaging (fMRI), are not able to directly measure neuronal activity. To address this knowledge gap, a research team led by Ian Shih, PhD, professor and vice chair of the Department of Neurology and associate director of the Biomedical Research Imaging Center, has created a novel experimental platform that is able to optically record local neuronal activity during brain-wide fMRI in rodents.

Newswise: CDC-UNC Collaboration Yields Potential Long-term HIV Protection
Released: 9-Feb-2023 8:45 AM EST
CDC-UNC Collaboration Yields Potential Long-term HIV Protection
University of North Carolina Health Care System

Since 2017, the lab of Rahima Benhabbour, PhD, MSc, associate professor in the UNC/NCSU Joint Department of Biomedical Engineering, has been working with a research team at the Centers for Disease Control and Prevention (CDC) and others at UNC to develop an injectable implant that can release HIV pre-exposure prophylaxis (PrEP) medications into the body for a long period of time. Their latest research, published in Nature Communications, shows that the team’s latest formulation can provide up to six months of full protection.

Newswise: How Do Cancer-Causing Viruses Evade Immune Responses?
Released: 6-Feb-2023 12:00 PM EST
How Do Cancer-Causing Viruses Evade Immune Responses?
University of North Carolina Health Care System

This research suggests that BAF and related proteins could be therapeutic targets to prevent these viruses from spreading and leading to cancers, such as Kaposi sarcoma, non-Hodgkin lymphoma, Hodgkin lymphoma, multicentric Castleman disease, nasopharyngeal carcinoma, and gastric cancer.

Newswise: Researchers Unveil New Collection of Human Brain Atlases that Charts the Early Developing Brain in Fine Detail
Released: 26-Jan-2023 10:35 AM EST
Researchers Unveil New Collection of Human Brain Atlases that Charts the Early Developing Brain in Fine Detail
University of North Carolina Health Care System

Human brain atlases can be used by medical professionals to track normative trends over time and to pinpoint crucial aspects of early brain development. By using these atlases, they are able to see what typical structural and functional development looks like, making it easier for them to spot the symptoms of abnormal development, such as attention-deficit / hyperactivity disorder (ADHD), dyslexia, and cerebral palsy.

Newswise: Getting to the Heart of Chemotherapeutic Cardiotoxicity
Released: 9-Jan-2023 11:05 AM EST
Getting to the Heart of Chemotherapeutic Cardiotoxicity
University of North Carolina Health Care System

On any given Tuesday, you will find Brian C. Jensen, MD, cardiologist and physician-scientist, tending to patients in his cardio-oncology clinic. His schedule is packed to the brim with cancer patients. But not patients with heart cancer. The largest number of patients he sees are cancer patients who have developed, or are at risk of developing, heart damage in response to their chemotherapy regimens.

Newswise: UNC Researchers Tackle the E-cigarette or Vaping Product Use–associated Lung Injury (EVALI) Epidemic
Released: 4-Jan-2023 10:05 AM EST
UNC Researchers Tackle the E-cigarette or Vaping Product Use–associated Lung Injury (EVALI) Epidemic
University of North Carolina Health Care System

Although doctors and researchers sympathize with smokers wanting to quit smoking, scientists are discovering that vaping might not be a healthier alternative to smoking, especially in adolescents. E-cigarette products have recently been linked to a new, serious lung condition known as E-cigarette or Vaping Product Use-associated Lung Injury, or EVALI, which primarily affects youth and young adults. In 2019, the illness was declared an epidemic by the CDC.

Newswise: UNC Health Provider Ushers in First FDA-Approved Medication for Eosinophilic Esophagitis
Released: 22-Dec-2022 3:45 PM EST
UNC Health Provider Ushers in First FDA-Approved Medication for Eosinophilic Esophagitis
University of North Carolina Health Care System

Eosinophilic esophagitis (EoE) is an allergic condition of the esophagus that is on the rise throughout the United States. Patients with the condition typically have inflammation throughout their esophagus and trouble swallowing food – known as dysphagia.Without proper treatment, the lining of the esophagus becomes fibrous, and the passage becomes so narrowed, or strictured, that food can lodge in the esophagus, requiring medical attention.

Released: 5-Jul-2022 12:30 PM EDT
Fourth-generation Vaping Devices Increase Risk to Immune Cells
University of North Carolina Health Care System

Users of fourth-generation nicotine-salt-containing devices, such as Juul and disposable devices, display a unique mix of cellular biomarkers indicative of immune suppression.

Newswise: UNC Health to Implement New Software to Support Cancer Care, Create Comprehensive Treatments
Released: 14-Mar-2022 2:15 PM EDT
UNC Health to Implement New Software to Support Cancer Care, Create Comprehensive Treatments
University of North Carolina Health Care System

This fall UNC Health is implementing a new software called Oncology Clinical Pathways that will facilitate a common high quality, evidence-based care standard across the entire UNC Health system of hospitals in North Carolina, ensuring that each patient receives the most up-to-date course of recommended cancer treatment.

Released: 15-Dec-2021 12:15 PM EST
Scientists Unveil Drug Discovery Tool to Screen More Than 11 Billion Compounds
University of North Carolina Health Care System

Scientists created a way to identify the best combinations of chemical building blocks to serve as seeds that can grow into a hierarchy of molecules with the best predicted ability to bind to the receptor targets. This allowed them to test 11 billion compounds, the largest drug screen to date.

Released: 14-Jun-2021 10:15 AM EDT
UNC Medical Center Awarded for High Performance in Treating Heart Attack Patients
University of North Carolina Health Care System

UNC Medical Center has received the American College of Cardiology’s NCDR “Chest Pain ̶ MI Registry Platinum Performance Achievement Award” for 2021, one of only 212 hospitals nationwide to receive the honor.

Released: 1-Jun-2021 1:40 PM EDT
COVID-19 Simulation Shows Importance of Continued Safety Efforts During Vaccine Distribution
University of North Carolina Health Care System

Research published by JAMA Network Open shows how non-pharmaceutical interventions (NPIs) like mask wearing and physical distancing can help prevent spikes in COVID-19 cases as populations continue to get vaccinated.

Released: 18-May-2020 1:55 PM EDT
New study sheds light on IBD patients with COVID
University of North Carolina Health Care System

In an upcoming study to be published in Gastroenterology, researchers at the Icahn School of Medicine at Mount Sinai and the University of North Carolina School of Medicine report on the clinical course of COVID-19 and risk factors for adverse outcomes in a large cohort of patients with IBD collected through an international registry.

Released: 19-Mar-2020 9:55 AM EDT
E-cigarette users had substances linked to bladder cancer in urine
University of North Carolina Health Care System

In the review published in the journal European Urology Oncology, researchers compiled the results of 22 different studies that analyzed the urine of people who used e-cigarettes or other tobacco products, including cigarettes, to check for evidence of cancer-linked compounds or biomarkers of those compounds. They found six biomarkers or compounds with a strong link to bladder cancer.

Released: 9-Mar-2020 8:00 AM EDT
CAR-T immunotherapy for lymphoma studied at UNC Lineberger receives fast-track designation from FDA
University of North Carolina Health Care System

Based on proof-of-concept results from clinical trials at University of North Carolina Lineberger Comprehensive Cancer Center and Baylor College of Medicine, an investigational cellular immunotherapy for Hodgkin lymphoma has received a Regenerative Medicine Advanced Therapy designation from the U.S. Food and Drug Administration.

Released: 3-Mar-2020 10:10 AM EST
Five-year survival improves for certain cancers in adolescent and young adults
University of North Carolina Health Care System

The five-year survival rate for adolescents and young adults with cancer has significantly improved from 1975 to 2005 in the United States overall, but this was not the case for all cancers, according to a report in the Journal of the National Cancer Institute.

Released: 13-Feb-2020 9:00 AM EST
Approval processes for clinical practice guidelines introduce potential conflicts of interest, review finds
University of North Carolina Health Care System

A new study of the approval processes used by the 43 medical-specialty-society members of the Council of Medical Specialty Societies in the U.S. to create evidence-based guidelines finds that most use an approval procedure that has the potential to undermine editorial independence of the guideline development committee.

Released: 7-Feb-2020 10:15 AM EST
Study shows promise for urine-based test for HPV-linked cervical cancer
University of North Carolina Health Care System

In a recent study published in the Journal of Clinical Microbiology, researchers compared urine testing to other screening methods in detecting women at risk for HPV-linked cervical cancer. While they found the urine test showed promise, additional research is needed to improve the test’s accuracy.

28-Jan-2020 9:05 AM EST
Discovery would allow researchers to fine-tune CAR-T activity
University of North Carolina Health Care System

In a study published in Cancer Cell, researchers reported new findings about the regulation of co-stimulatory molecules that could be used to activate cancer-killing immune cells – chimeric antigen receptor T-cells, or CAR-T – or decrease their activity.

Released: 14-Nov-2019 11:05 AM EST
Findings could help identify aggressive breast cancers that will respond to immunotherapy
University of North Carolina Health Care System

University of North Carolina Lineberger Comprehensive Cancer Center researchers have discovered a promising method to identify aggressive breast cancer tumors that will respond to drugs that unleash the immune system against cancer.

Released: 24-Oct-2019 12:40 PM EDT
Researchers Identify Possible Approach to Block Medulloblastoma Growth
University of North Carolina Health Care System

University of North Carolina Lineberger Comprehensive Cancer Center researchers have identified a potential approach to stop the growth of the most common type of brain tumor in children.

Released: 14-Oct-2019 1:05 PM EDT
NCI grant to help patients navigate costs of cancer care
University of North Carolina Health Care System

The National Cancer Institute has awarded a four-year, more than $1.87 million grant to University of North Carolina Lineberger Comprehensive Cancer Center researchers to study the impact of implementing financial navigation services at five rural cancer centers in North Carolina to help patients cope with the financial burden, or financial toxicity, related to cancer care.



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