Recent historical, political and public health events, most notably the COVID-19 pandemic, have collectively contributed to increased stress and mental health challenges among many groups of people — including adolescents in racial and ethnic minorities.
A gene associated with colorectal cancer appears to also play a role in the development of other solid tumors, according to a study of over 350,000 patient biopsy samples conducted by researchers at the Johns Hopkins Kimmel Cancer Center, the Johns Hopkins Bloomberg School of Public Health and Foundation Medicine.
Using data from both mice and humans, a Johns Hopkins Medicine research team has found that a cell surface protein that senses odors and chemicals may be responsible for — and help explain — sex differences in mammalian blood pressure.
Monitoring levels of DNA shed by tumors and circulating in the bloodstream could help doctors accurately assess how gastroesophageal cancers are responding to treatment, and potentially predict future prognosis, suggests a new study led by researchers at the Johns Hopkins Kimmel Cancer Center and its Bloomberg~Kimmel Institute for Cancer Immunotherapy.
Two progressively degenerative diseases, amyotrophic lateral sclerosis (ALS, commonly known as Lou Gehrig’s disease) and frontotemporal dementia (FTD, recently in the news with the diagnoses of actor Bruce Willis and talk show host Wendy Williams), are linked by more than the fact that they both damage nerve cells critical to normal functioning — the former affecting nerves in the brain and spinal cord leading to loss of movement, the latter eroding the brain regions controlling personality, behavior and language.
Spring will soon be in bloom, bringing runny and stuffy noses, sneezes and itchy, watery eyes.
Repeats of DNA sequences, often referred to as “junk DNA” or “dark matter,” that are found in chromosomes and could contribute to cancer or other diseases have been challenging to identify and characterize. Now, investigators at the Johns Hopkins Kimmel Cancer Center have developed a novel approach that uses machine learning to identify these elements in cancerous tissue, as well as in cell-free DNA (cfDNA) — fragments that are shed from tumors and float in the bloodstream. This new method could provide a noninvasive means of detecting cancers or monitoring response to therapy. Machine learning is a type of artificial intelligence that uses data and computer algorithms to perform complex tasks and accelerate research.
Targeting a non-encoding stretch of RNA may help shrink tumors caused by an aggressive type of brain cancer in children, according to new research in mice reported March 8 in Cell Reports by Johns Hopkins Kimmel Cancer Center investigators.
Age-related changes that cause the skin to stiffen and become less elastic may also contribute to higher rates of metastatic skin cancer in older people, according to research by investigators from the Johns Hopkins Kimmel Cancer Center.
Combining the anticancer drugs enfortumab vedotin and pembrolizumab (EV+P) led to significantly improved survival rates among patients with advanced urothelial cancer (the most common type of bladder cancer) compared with standard chemotherapy, according to results of a large international clinical trial involving 185 sites, including the Johns Hopkins Kimmel Cancer Center’s Greenberg Bladder Cancer Institute, in 25 countries.
Research co-led by an investigator at Johns Hopkins Children’s Center shows that four children born with HIV who were safely removed from antiretroviral therapy (ART) continued to have undetectable levels of the virus for about a year or more without treatment. The children were among 54 newborns who were given very early treatment within the first 48 hours of life — rather than within weeks or months, as is typical. [email protected]
Researchers at the Johns Hopkins Kimmel Cancer Center and the Department of Gynecology and Obstetrics at the Johns Hopkins University School of Medicine have developed an algorithm to identify high-risk precancerous lesions on the fallopian tubes.
People with cancer have different amounts of a type of repetitive DNA — called Alu elements — than people without cancer.
Thanks to generous donations from listeners and others, the 35th annual Mix 106.5 radiothon raised $1,453,157.35 for Johns Hopkins Children’s Center. The final total from the event was announced on the radio on Monday, March 4. During the event, DJs from the station broadcast live last week from the Children’s Center for 26 hours over two days.
Johns Hopkins Medicine neuroscientists say they have found a new function for the SYNGAP1 gene, a DNA sequence that controls memory and learning in mammals, including mice and humans.
The leap year day, Feb. 29, occurs only once every four years, and each year around this time comes a global effort to recognize rare diseases. Some 30 million people in the U.S. — 10% of the population — have a rare disease, and Johns Hopkins Medicine experts are working alongside others around the globe to highlight rare disease impacts on research and treatments and ways to seek expert care.
People who have had a kidney transplant are at high risk for developing skin cancers. New research directed by investigators from the Johns Hopkins Kimmel Cancer Center is exploring the best combination of treatments to target skin cancers while preserving the transplanted organs.
The colon is often thought of as one organ, but the right and left parts of the colon have different molecular features in cancers. New research in mice from investigators at the Johns Hopkins Kimmel Cancer Center demonstrates that these regions also have distinct transcriptional programs, or cellular processes, that regulate the development of normal and cancerous cells.
A study led by Johns Hopkins Children’s Center shows omalizumab — an injectable, Food and Drug Administration (FDA)-approved medication for treating asthma and other allergic conditions — substantially reduced potentially life-threatening reactions in patients with an allergy to peanut and other common food allergies.
Drugs that target a receptor on immune cells called activin receptor 1C may combat tumor-induced immune suppression and help patients’ immune systems fight back against cancer, according to a study by investigators at the Johns Hopkins Kimmel Cancer Center and its Bloomberg~Kimmel Institute for Cancer Immunotherapy.
Older people may be at greater risk of developing pancreatic cancer and have poorer prognoses because of age-related changes in cells in the pancreas called fibroblasts, according to research led by investigators from the Johns Hopkins Kimmel Cancer Center, the Johns Hopkins Bloomberg School of Public Health and the Bloomberg~Kimmel Institute for Cancer Immunotherapy.
Beau Turfle is all smiles, says his family. But even at 3 months old, he’s already overcome a life-threatening heart concern.
A novel three-drug combination achieved notable responses in patients with advanced HER2-negative breast cancer, according to new research directed by investigators from the Johns Hopkins Kimmel Cancer Center.
In a study involving nearly 1,000 patients seen at the Baltimore Convention Center Field Hospital (BCCFH) during a five-month period in 2022 — researchers at Johns Hopkins Medicine, the University of Maryland School of Medicine and five other collaborators report that a rapid antigen test (RAT) for detecting SARS-CoV-2, the virus that causes COVID-19, can be used at home with accuracy comparable to the same test being administered by a health care professional.
Researchers in a Johns Hopkins Children’s Center-led study say they have made progress in developing a blood test to identify disease-associated changes in the brain specifically linked to postpartum depression and other psychiatric and neurological disorders.
Across the United States, a growing number of families with low income are being displaced from their homes due to inability to afford rising housing costs.
A combination of two cancer drugs could be effective against malignant peripheral nerve sheath tumors (MPNSTs), according to a laboratory study led by researchers at the Johns Hopkins Kimmel Cancer Center.
Evolutionary biologists at Johns Hopkins Medicine report they have combined PET scans of modern pigeons along with studies of dinosaur fossils to help answer an enduring question in biology: How did the brains of birds evolve to enable them to fly?
February is American Heart Month, a time for awareness of heart-related conditions that affect adults and children. Johns Hopkins Medicine experts are available all month to discuss various aspects of heart health.
Working with mammalian retinal cells, neuroscientists at Johns Hopkins Medicine have shown that, unlike most light-sensing cells (photoreceptors) in the retina, one special type uses two different pathways at the same time to transmit electrical “vision” signals to the brain.
An international academic consortium has identified 13 biomarkers that significantly improve the ability to accurately predict cardiovascular disease risk in people with type 2 diabetes.
A Johns Hopkins Children’s Center study of children and youth with diabetes concludes that so-called autonomous artificial intelligence (AI) diabetic eye exams significantly increase completion rates of screenings designed to prevent potentially blinding diabetes eye diseases (DED).
Soy compounds called isoflavones are among the plant-derived compounds that may significantly reduce the risk of breast cancer recurrence or death, according to a new meta-analysis co-directed by investigators from the Johns Hopkins Kimmel Cancer Center. The results were published Jan. 10 in the journal JNCI Cancer Spectrum.
Care for patients with human papillomavirus (HPV)-related squamous cell cancers of the oropharynx (an area in back of the throat) is shifting toward community cancer centers, but patients treated in this setting may be less likely to survive, according to new research by investigators from the Johns Hopkins Kimmel Cancer Center and its Head and Neck Cancer Center.
Scientists at the Johns Hopkins University School of Medicine and the National Institutes of Health have identified a protein in the visual system of mice that appears to be key for stabilizing the body’s circadian rhythms by buffering the brain’s response to light.
Three Johns Hopkins researchers are urging the medical community to dismiss a widely held, but scientifically unsupported belief that many people who are transgender and gender diverse (TGD), and undergo gender affirming surgery (GAS), later regret their decision to undergo such procedures.
The Radiopharmaceutical Therapy and Dosimetry Lab at Johns Hopkins Medicine, headed by George Sgouros, Ph.D., has been awarded a $15 million grant, to be dispersed over the next five years, from the National Cancer Institute at the National Institutes of Health.
A so-called pathological protein long associated with Parkinson’s disease has been found in a new study to trigger cells to increase protein synthesis, an event that eventually kills the subset of brain cells that die off in this neurodegenerative condition.
Using cells from kidney biopsies, Johns Hopkins Medicine, researchers report progress in the search for more accurate and easier-to-obtain markers to help predict, manage and assess treatment of acute kidney injury (AKI).
A new study out of the Johns Hopkins Medicine Lyme Disease Research Center has revealed disparities in the diagnosis and treatment of Lyme disease between Black and White patients with the condition.
By monitoring changes in circulating tumor DNA (ctDNA) among 30 patients treated with immunotherapies for metastatic non-small cell lung cancers, researchers were able to determine molecular response — the clearance of tumor genetic material in the bloodstream.
A national, multicenter clinical trial (BMT CTN 1507) of low-dose haploidentical (half-matched) bone marrow transplant to treat severe sickle cell disease found the treatment to be safe and curative for adults with serious sickle cell-related health complications.
Comparing PET scans of more than 90 adults with and without mild cognitive impairment (MCI), Johns Hopkins Medicine researchers say relatively lower levels of the so-called “happiness” chemical, serotonin, in parts of the brain of those with MCI may play a role in memory problems including Alzheimer’s disease.
A study of more than 50 babies through 2 yeard old in Africa, Asia, North America and South America has added substantially to evidence that giving antiretroviral therapy (ART) to newborns with HIV within the first days — rather than within weeks or months — of life can safely suppress amounts of HIV in the blood to undetectable levels. Findings of the study, which was co-led by Johns Hopkins Children’s Center physician-scientist and researcher Deborah Persaud, M.D., and sponsored by the National Institutes of Health (NIH) and the International Maternal Pediatric Adolescent AIDS Clinical Trials Network, were published Dec. 4 in the journal The Lancet HIV.
Johns Hopkins physicians can offer expert advice on how to have a healthy and safe holiday season.
Dr. Kathryn Lemberg in her lab. Credit: Norm Barker Combining a pair of experimental drugs may help treat malignant peripheral nerve sheath tumors with fewer harmful side effects, according to preliminary animal studies led by investigators at the Johns Hopkins Kimmel Cancer Center and Johns Hopkins Drug Discovery.
In a new study using brain scans of former NFL athletes, Johns Hopkins Medicine researchers say they found high levels of a repair protein present long after a traumatic brain injury such as a concussion takes place.
Thyrotoxicosis — excess thyroid hormone levels in the body — has been linked to an increased risk of cognitive disorders among older adults, according to a new study from Johns Hopkins Medicine.
For years, researchers and clinicians have known that lupus, an autoimmune condition, occurs in women at a rate nine times higher than in men.
November is National Epilepsy Awareness Month, a time to raise awareness about this common disorder of the nervous system, its challenges, symptoms and treatment options.
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