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Metals, DNA, metal-containing drugs , Drugs, Cancer, Molecular Mechanisms, chemotherapeutic, Agents, Leticia González , University of Vienna, Jacinto Sá, Uppsala University , Interact

How Do Metals Interact with DNA?

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Since a couple of decades, metal-containing drugs have been successfully used to fight against certain types of cancer. The lack of knowledge about the underlying molecular mechanisms slows down the search for new and more efficient chemotherapeutic agents. An international team of scientists, led by Leticia González from the University of Vienna and Jacinto Sá from the Uppsala University, have developed a protocol that is able to detect how metal-based drugs interact with DNA.

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Tendon, Tendon Injury, stretch, Bioengineering, Engineering

Combating Wear and Tear

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University of Utah bioengineering researchers have discovered that damage to collagen, the main building block of all human tissue, can occur much earlier at a molecular level from too much physical stress. This could be helpful for some who want to know earlier if they are developing diseases such as arthritis or for athletes whose bodies are taking a toll.

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Seal Beach, California, Wetlands, Earthquakes, paleoseismology, U.S. Geological Survey

Sinking of Seal Beach Wetlands Tied to Ancient Quakes

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When geologists went in search for evidence of ancient tsunamis along Southern California’s coastal wetlands, they found something else. Their discoveries have implications for seismic hazard and risk assessment in coastal Southern California.

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Materials Science, Advanced Photon Source (APS), Center for Nanoscale Materials (CNM), Nanoscience, Surface & interface studies, Synchrotron Radiation, Synchrotron instruments & techniques, X-ray imaging & holography, X-ray scattering & detection

Single-Angle Ptychography Allows 3D Imaging of Stressed Materials

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Scientists have used a new X-ray diffraction technique called Bragg single-angle ptychography to get a clear picture of how planes of atoms shift and squeeze under stress.

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rare plants, seed predation, Population Biology, Lupines

Scientists Follow Seeds to Solve Ecological Puzzle

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A four-year study of one rare and one common lupine growing in coastal dunes showed that a native mouse steals most of the rare lupines seeds while they are still attached to the plant. The mouse is a "subsidized species," given cover for nocturnal forays by European beachgrass, originally planted to stabilize the dunes.

Medicine

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Medical Research, Biomedical Research, Research Funding, Vision Research, Congressional budget, National Instituate of Health, National Eye Institute (NEI), National Science Foundation (NSF)

ARVO Opposes Cuts to Medical Research Budget; Urges Increased Investment

The Association for Research in Vision and Ophthalmology (ARVO) urges Congressional leaders to reject the U.S. administration’s recent FY18 budget proposal, which seeks to drastically cut National Institute of Health funding by nearly $6 billion, or 20%. These cuts would be devastating to the current and future efforts of the eye and vision research community and to patients who desperately count on the efforts of researchers and clinicians to save their sight.

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Transgender, College, Alcohol, Coping mechanisms, alcohol consequences, high-risk drinking, Social Anxiety, Self Esteem, male-to-female

Transgender College Students May Use Alcohol as a Coping Mechanism

Although college can be demanding for young adults, it may be particularly so for transgender students struggling with identity-formation and other emotional, social, and developmental challenges. Prior research suggests that transgender students may experience greater drinking and negative alcohol-related consequences than their cisgender peers (i.e., those whose gender matches their sex at birth). This study examined levels of drinking, frequency of blackouts and other alcohol-related consequences, and drinking motivations among transgender college students.

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Chemisry, exascale computing, Software, Manycore, HPC, Supercomputer, Computational Chemistry

Berkeley Lab Researchers Make NWChem’s Planewave “Purr” on Intel’s Knight Landing Architectures

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Berkeley Lab researchers have successfully added thread-level parallelism on top of MPI-level parallelism in the planewave density functional theory method within the popular software suite NWChem. An important step to ensuring that computational chemists are prepared to compute efficiently on next-generation exascale machines.

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Roger Penrose, Quantum Mechanics, Artificial Intelligence, consciousness; neuroscience; neural correlates; AI; evolution of life; , Schrodinger Cat Paradox, mental and cognitive disorders, quantum effects , brain functions, Oxford University

Roger Penrose Institute to Form in San Diego

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A unique institute is being formed to develop and investigate the forward-thinking ideas of eminent British physicist Sir Roger Penrose. To be based in San Diego, California, with collaborations in London and Oxford in the UK, and Tucson, Arizona, the Institute will examine the interplay between quantum mechanics and general relativity and the possible implications on our understanding of consciousness.

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New Software Tool Powers Up Genomic Research

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A group of computational biological researchers, led by Stony Brook University’s Rob Patro, an Assistant Professor in the Department of Computer Science in the College of Engineering and Applied Sciences, has developed a new software tool, Salmon — a lightweight method to provide fast and bias-aware quantification from RNA-sequencing reads. The research was published in the March 6 edition of Nature Methods. .







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