Newswise — Experts in diet and metabolism have found that replacing low calorie ‘diet’ drinks with water can help increase the rate of weight loss in obese women with type 2 diabetes and improve insulin sensitivity. The scientists at The University of Nottingham and Tehran University of Medical Sciences set out to test the effect of replacing diet drinks with water by comparing weight loss in two randomly selected groups of type 2 diabetic women during a 24 week diet programme. The results are published in the journal Diabetes, Obesity and Metabolism. 81 overweight and obese women with type 2 diabetes who were trying to lose weight to control their diabetes were recruited from the NovinDiet Clinic, Tehran, Iran. The women were all taking the same medication to control their diabetes and were all self-reported habitual consumers of diet drinks and otherwise healthy non-smokers. The women were asked either to substitute water for diet drinks, or to continue drinking diet drinks five times a week after their lunch for the duration of the weight loss programme. Both groups were allowed to drink water at other times but were not allowed to have diet drinks at any other time. The two groups were also asked not to drink anything while eating their lunch and not to add low calorie sweeteners to drinks such as tea or coffee. The women followed a hypo-energetic diet and their post-lunch drink option for 24 weeks with the aim of losing 7-10 per cent of their body weight at a rate of 0.5 to 1 kilogram a week. A physical activity programme was also undertaken which gradually increased during the trial to achieve 60 minutes of moderate activity five days a week. Body weight was measured at the start, at 12 weeks and at 24 weeks. Waist circumference was also measured and BMI calculated at the same intervals. Fasting blood samples were collected also at the start, 12 and 24 weeks to check diabetes indicators. Dr Hamid Farshchi, from The University of Nottingham’s School of Life Sciences, said: “Our results are very interesting. They show that the women drinking water after their main meal at lunch time over 24 weeks lost on average 1.16kg more than the women who drank diet drinks after their meal. We think that by drinking water instead of sweet-tasting diet drinks, the women may be adhering better to the weight loss diet because artificial sweeteners may increase desire for sweetened and more energy dense foods. “We also found that the women who drank water achieved a better improvement in insulin sensitivity.” Professor of Metabolic Physiology, Ian Macdonald, said: “Many obese people trying to lose weight believe that low calorie or diet drinks can help them to lose weight. This study shows that while they can still lose weight, they may not be losing as much as they would if they drank water in place of diet drinks. Our results also question whether consuming diet drinks is the most effective way for people with diabetes to manage their condition. But since the consumption of diet soda is higher among people with diabetes, the potential implications of our study needs further and larger scale research.” —Ends— More information is available from Professor Ian Macdonald in the School of Life Sciences, University of Nottingham on +44 (0)115 823 0100, [email protected]; or Emma Rayner, Media Relations Manager for the Faculty of Medicine and Health Sciences at The University of Nottingham, on +44 (0)115 951 5793, [email protected] Our academics can now be interviewed for broadcast via our Media Hub, which offers a Globelynx fixed camera and ISDN line facilities at University Park campus. For further information please contact a member of the Communications team on +44 (0)115 951 5798, email [email protected] or see the Globelynx website for how to register for this service. For up to the minute media alerts, follow us on Twitter Notes to editors: The University of Nottingham has 43,000 students and is ‘the nearest Britain has to a truly global university, with a “distinct” approach to internationalisation, which rests on those full-scale campuses in China and Malaysia, as well as a large presence in its home city.’ (Times Good University Guide 2016). It is also one of the most popular universities in the UK among graduate employers and the winner of ‘Outstanding Support for Early Career Researchers’ at the Times Higher Education Awards 2015. It is ranked in the world’s top 75 by the QS World University Rankings 2015/16. More than 97 per cent of research at The University of Nottingham is recognised internationally and it is 8th in the UK by research power according to the Research Excellence Framework 2014. It has been voted the world’s greenest campus for four years running, according to Greenmetrics Ranking of World Universities. Impact: The Nottingham Campaign, its biggest-ever fundraising campaign, is delivering the University’s vision to change lives, tackle global issues and shape the future.

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Diabetes, Obesity and Metabolism