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Friday January 20, 2017, 12:05 PM

CIRM Approves New Funding to UC San Diego Researchers Fighting Zika Virus and Cancer

University of California San Diego Health Sciences

The Independent Citizens Oversight Committee of the California Institute for Regenerative Medicine (CIRM) has approved a pair of $2 million awards to University of California San Diego School of Medicine researchers to advance studies of new treatments for Zika virus infections and the use of stem cell-derived natural killer (NK) cells to target ovarian cancer and other malignancies.

Friday January 20, 2017, 10:05 AM

Researchers Unlock Mechanism of Drug Resistance in Aggressive Breast Cancer

University of North Carolina Health Care System

In the journal Cancer Discovery, UNC Lineberger Comprehensive Cancer Center researchers and colleagues report findings of how triple negative breast cancer cells are able to bypass treatment with trametinib, a U.S. Food and Drug Administration-approved drug that belongs to a class of commonly used anti-cancer drugs called kinase inhibitors. The researchers also reported findings from laboratory models of breast cancer testing a potential treatment approach that could prevent the onset of resistance.

Thursday January 19, 2017, 03:05 PM

Molecular Subgroups of Non-Small Cell Lung Cancer Predict Tumor Behavior, Reveal Treatment Targets

Sbarro Health Research Organization (SHRO)

EGFR mutations is associated with a longer median overall survival (almost double) compared with those without EGFR mutations when treated with specific targeted agents.

Thursday January 19, 2017, 02:05 PM

Breast Cancer Prognosis of African-American Patients May Improve with Administration of Chemotherapy Before Surgery, Study Finds

Georgia State University

Administering chemotherapy to African-American breast cancer patients prior to surgery could improve their prognosis and survival rates from the disease, according to a new study.

Thursday January 19, 2017, 02:05 PM

Brain Tumor Survivor Moves Into Next Phase of Life Thanks to Rehab Experts

Harris Health System

Physical therapist Jorge Neira is helping Ruben Arellano regain use of his arms and the ability to walk. Arellano had a baseball-sized tumor removed from his head. The two share successes and setbacks on the arduous road to recovery at Harris Health System's CARF-accredited hospital.

Thursday January 19, 2017, 12:05 PM

As Cells Age, the Fat Content Within Them Shifts

University at Buffalo

As cells age and stop dividing, their fat content changes, along with the way they produce and break down fat and other molecules classified as lipids. By providing broad insights into the connection between lipids and cellular aging, the findings open the door for additional research that could one day support the development of lipid-based approaches to preventing cell death or hastening it in cancerous tumors.

Thursday January 19, 2017, 12:00 AM

Public Reporting of Lung Cancer Surgery Outcomes Provides Valuable Information About Quality of Patient Care

The Society of Thoracic Surgeons

The Society of Thoracic Surgeons (STS) has released the first publicly accessible national report of outcomes from lobectomy.

Wednesday January 18, 2017, 04:05 PM

$1.8M Grant Aids Exploration of Chronic Stress Role in Cancer Development

Rutgers Cancer Institute of New Jersey

A five-year, $1.8 million grant (R01CA203965) from the National Cancer Institute awarded to Rutgers Cancer Institute of New Jersey resident research member Wenwei Hu, PhD, will support research to further explore how chronic stress impacts cancer development.

Wednesday January 18, 2017, 02:05 PM

Small Intestine GIST Associated with Better Prognosis in Younger Patients

University of California San Diego Health Sciences

Gastrointestinal stromal tumors (GIST) are tumors that arise is the wall of the digestive tract, and most often occur in the stomach or small intestine. Though more common in later in life, GISTs can occur in adolescents and young adults (AYA) under 40 years old as well. Researchers at the University of California San Diego School of Medicine report findings from the first population-based analysis of AYA patients with GIST.

Wednesday January 18, 2017, 01:00 PM

'Collateral' Lethality May Offer New Therapeutic Approach for Cancers of the Pancreas, Stomach and Colon

University of Texas M. D. Anderson Cancer Center

Cancer cells often delete genes that normally suppress tumor formation. These deletions also may extend to neighboring genes, an event known as "collateral lethality," which may create new options for development of therapies for several cancers.

Tuesday January 17, 2017, 02:05 PM

UC Davis and Nation's Cancer Centers Jointly Endorse Updated HPV Vaccine Recommendations

UC Davis Comprehensive Cancer Center

Recognizing a critical need to improve national vaccination rates for the human papillomavirus (HPV), UC Davis Comprehensive Cancer Center has again united with each of the 69 National Cancer Institute (NCI)-designated cancer centers in issuing a joint statement in support of recently revised recommendations from the U.S. Centers for Disease Control and Prevention (CDC)

Tuesday January 17, 2017, 01:05 PM

As Thyroid Cancer Rates Rise, Focus on Detection - UCLA Health Advisory

University of California, Los Angeles (UCLA), Health Sciences

Thyroid cancer typically affects more women than men and can be difficult to diagnose.

Tuesday January 17, 2017, 12:05 PM

Immune Responses Against a Virus-Related Skin Cancer Suggest Ways to Improve Immunotherapy

Fred Hutchinson Cancer Research Center

Researchers at Seattle's Fred Hutchinson Cancer Research Center and the University of Washington say a new study suggests ways to improve immune therapy for certain cancers including a virus-associated form of Merkel cell carcinoma, a rare, aggressive skin cancer.

Tuesday January 17, 2017, 02:00 AM

Common Heart Drug Repurposed to Treat Rare Cancer in Europe

Texas Tech University Health Sciences Center El Paso

A drug that's commonly used to treat high blood pressure is being repurposed for a rare tissue cancer in Europe. The medication, named propranolol, was recently granted Orphan Drug Designation by the European Commission (EC).

Monday January 16, 2017, 05:00 PM

Ludwig Study Reveals Why Cancer Cells Spread Within the Body

Ludwig Cancer Research

Findings uncover an ancient mechanism that makes cancer cells invasive, explains melanoma's resistance to therapy and opens the door to development of novel cancer therapies

Monday January 16, 2017, 11:00 AM

Potentially Reversible Changes in Gene Control 'Prime' Pancreatic Cancer Cells to Spread

Johns Hopkins Medicine

A multicenter team of researchers reports that a full genomic analysis of tumor samples from a small number of people who died of pancreatic cancer suggests that chemical changes to DNA that do not affect the DNA sequence itself yet control how it operates confer survival advantages on subsets of pancreatic cancer cells.

Friday January 13, 2017, 05:05 PM

Lonely Hearts and Your Health - UCLA Health Advisory

University of California, Los Angeles (UCLA), Health Sciences

Studies show that people who are chronically lonely have significantly more heart disease, are more prone to advanced cancers and strokes, and are more likely to develop neurodegenerative diseases such as Alzheimer's.

Friday January 13, 2017, 08:00 AM

Young Scientists Get Boost in Funding From Johns Hopkins and Bladder Cancer Advocacy Network

Johns Hopkins Medicine

Young scientists interested in bladder cancer research can compete for up to two awards totaling $100,000 from a joint effort between the Johns Hopkins Greenberg Bladder Cancer Institute and the Bladder Cancer Advocacy Network (BCAN).

Thursday January 12, 2017, 12:05 PM

"Mysterious" Non-Protein-Coding RNAs Play Important Roles in Gene Expression

Perelman School of Medicine at the University of Pennsylvania

Enhancers boost the rate of gene expression from nearby protein-coding genes so a cell can pump out more of a needed protein molecule. A mysterious subset of non-coding RNAs - enhancer RNAs (eRNAs) are transcribed from enhancer sequences. Shedding new light on these elusive eRNAs, researchers showed that CBP, an enzyme that activates transcription from enhancers, binds directly to eRNAs to control patterns of gene expression by acetylation.

Thursday January 12, 2017, 12:05 PM

NCI-Designated Cancer Centers Endorse Updated HPV Vaccination Recommendations

Yale Cancer Center

Recognizing a critical need to improve national vaccination rates for the human papillomavirus (HPV), Yale Cancer Center has again united with each of the 69 National Cancer Institute (NCI)-designated cancer centers in issuing a joint statement in support of recently revised recommendations from the Centers for Disease Control and Prevention (CDC).

Wednesday January 11, 2017, 05:05 PM

Medical Imaging Innovator Christine Hendon Wins Presidential Honor

Columbia University School of Engineering and Applied Science

Christine Hendon, assistant professor of electrical engineering at Columbia Engineering, has won the Presidential Early Career Award (PECASE), the highest honor the U.S. government gives to young scientists and engineers. Hendon, who develops innovative medical imaging instruments for use in surgery and breast cancer detection, is one of 102 researchers from across the nation named by President Obama on January 9.

Wednesday January 11, 2017, 05:00 PM

Cost, Technology Issues Are Barriers to Real-Time Cancer Patient Symptom Reporting

University of North Carolina Health Care System

In a perspective published in the New England Journal of Medicine, a UNC Lineberger Comprehensive Cancer Center researcher addresses the need for - and the barriers preventing - electronic reporting of patients' symptoms between visits.

Wednesday January 11, 2017, 10:05 AM

Walking the Tightrope

Perelman School of Medicine at the University of Pennsylvania

Antibiotic use represents a special challenge, in which too much of a good thing can be dangerous to public health as a whole. The fight against a common, costly, hospital-acquired infection known as Clostridium difficile, or C. diff offers an illuminating case study in the area of so-called antibiotic stewardship.

Wednesday January 11, 2017, 10:05 AM

Simmons Cancer Center Joins National Cancer Institute, CDC Calling for Increased HPV Vaccinations to Prevent Cancer

UT Southwestern Medical Center

More than a decade after the HPV vaccine was deemed both safe and effective by the FDA for preventing several types of cancer, the vaccine is still underused by those who could benefit.

Wednesday January 11, 2017, 10:00 AM

Study: For Men with Prostate Cancer, Emotional Distress May Lead to More Aggressive Treatment

University at Buffalo

The anxiety many men experience after being diagnosed with prostate cancer may lead them to choose potentially unnecessary treatment options, researchers from the University at Buffalo and Roswell Park Cancer Institute report in a new study.

Wednesday January 11, 2017, 08:05 AM

UVA, Other NCI-Designated Cancer Centers Endorse Latest HPV Vaccination Recommendations

University of Virginia Health System

Together with the other 68 National Cancer Institute-designated cancer centers, University of Virginia Cancer Center supports the latest human papillomavirus (HPV) vaccination recommendations to help prevent HPV-related cancers. The U.S. Centers for Disease Control and Prevention now recommends two doses of the HPV vaccine at least six months apart for 11- to 12-year-old boys and girls.

Wednesday January 11, 2017, 12:05 AM

Cervical Cancer: A Preventable Disease

Rutgers Cancer Institute of New Jersey

As the nation's 69 National Cancer Institute-designated cancer centers come together in support of recently updated HPV vaccination recommendations, a Rutgers Cancer Institute of New Jersey gynecologic oncologist shares insight on how this vaccine can help prevent cervical cancer.

Wednesday January 11, 2017, 12:05 AM

MD Anderson and Nation's Cancer Centers Jointly Endorse Updated HPV Vaccine Recommendations

University of Texas M. D. Anderson Cancer Center

As national vaccination rates for the human papillomavirus (HPV) remain low, The University of Texas MD Anderson Cancer Center has again united with the 68 other National Cancer Institute (NCI)-designated cancer centers in issuing a joint statement endorsing the recently revised vaccination recommendations from the Centers for Disease Control and Prevention (CDC).

Tuesday January 10, 2017, 01:05 PM

Tucatinib (ONT-380) Progressing in Pivotal Trial Against HER2+ Breast Cancer

University of Colorado Cancer Center

Twenty-seven percent of 50 heavily pretreated patients with stage IV breast cancer saw clinical benefit from the drug, with at least "stable disease" at 24 or more weeks after the start of treatment.

Monday January 09, 2017, 05:05 PM

Translating Basic Biological Research to Cancer Drug Discovery

Department of Energy, Office of Science

New information on the details of a key protein, obtained using DOE user facilities, could help scientists design ways to inhibit tumor growth without activating other tumor-producing pathways.

Monday January 09, 2017, 01:05 PM

Drawing People of Color Into Clinical Trials

Yale Cancer Center

Monday January 09, 2017, 01:00 PM

NCCN Publishes Patient Education Resources for Gliomas--Its First in a Series on Brain Cancer

National Comprehensive Cancer Network(r) (NCCN(r))

NCCN has published NCCN Guidelines for Patients(r): Brain Cancer - Gliomas, available today on NCCN.org/patients and NCCN Patient Guides for Cancer mobile app

Monday January 09, 2017, 10:30 AM

World Renowned Surgeon and Researcher to Lead New Pancreatic Cancer Center at NYU Langone

NYU Langone Medical Center

NYU Langone Medical Center has announced that internationally recognized surgeon and scientist Diane M. Simeone, MD, will join its Perlmutter Cancer Center on March 1 to serve as associate director for translational research and to lead its newly established pancreatic cancer center.

Monday January 09, 2017, 10:05 AM

Animal Study Shows Harmful Effects of Secondhand Smoke Even Before Pregnancy

Duke Health

Exposure to second-hand tobacco smoke -- even before conception -- appears to have a lingering impact that can later impair the brain development of a fetus, researchers at Duke Health report.

Monday January 09, 2017, 10:05 AM

The Role of Common Risk Factors in ER-Positive, ER-Negative Breast Cancer

UCSF Helen Diller Family Comprehensive Cancer Center

Karla Kerlikowske, MD, and team recently published a paper in the Journal of the National Cancer Institute that examined the role of common risk factors in the development of ER-positive and ER-negative breast cancers. The study sheds new light on how a woman's age, weight, and menopausal status affect her risk for breast cancer. Dr. Kerlikowske discusses the findings below.

Friday January 06, 2017, 02:05 PM

National Organization of Italian American Women Will Honor Dr. Pat LoRusso

Yale Cancer Center

The Connecticut Region of the National Organization of Italian American Women (NOIAW) will honor three of Connecticut's most prominent and pioneering women at its eighth annual Epiphany Celebration brunch and silent auction event, on Sunday, January 15, 2017, at the New Haven Lawn Club in New Haven, CT.

Friday January 06, 2017, 11:05 AM

Yale Expert on Novel Immunotherapy Research in Bladder Cancer

Yale Cancer Center

Friday January 06, 2017, 10:05 AM

Unexpected Role for Epigenetic Enzymes in Cancer

Yale Cancer Center

In a Yale-led study, Qin Yan and his co-authors focused on a family of enzymes -- known as KDM5 -- that have been shown in previous studies to be involved in cancer cell growth and spreading.

Friday January 06, 2017, 10:05 AM

Researchers Find Key Genetic Driver for Rare Type of Triple-Negative Breast Cancer

University of Michigan Health System

By developing a new mouse model to study a poorly understood protein, researchers uncovered its link to metaplastic breast cancer, opening the door to better understanding of this challenging breast cancer subtype.

Friday January 06, 2017, 10:05 AM

Aspirin Use Found to Lower Risk of Pancreatic Cancer

Yale Cancer Center

The regular use of aspirin lowers the risk for pancreatic cancer by almost 50 percent, a new study in China led by the Yale School of Public Health finds.

Friday January 06, 2017, 10:05 AM

Lung Cancer Patients May Benefit From Delayed Chemotherapy After Surgery

Yale Cancer Center

A new Yale study suggests that patients with a common form of lung cancer may still benefit from delayed chemotherapy started up to four months after surgery, according to the researchers.

Thursday January 05, 2017, 11:05 AM

Graduate Research Explores Glioblastoma Tumor Cells Invasion in 3D Environments

Wichita State University

Wichita State graduate student Pranita Kaphle is researching the migration of cancer cells in a 3D environment. She is targeting glioblastoma multiforme in the brain, a rapid spreading and aggressive high-grade tumor. Kaphle hopes to pursue a career studying the cancer cells and finding a way to inhibit tumor cell invasion.

Thursday January 05, 2017, 10:00 AM

Cancers Evade Immunotherapy by 'Discarding the Evidence' of Tumor-Specific Mutations

Johns Hopkins Medicine

Results of an initial study of tumors from patients with lung cancer or head and neck cancer suggest that the widespread acquired resistance to immunotherapy drugs known as checkpoint inhibitors may be due to the elimination of certain genetic mutations needed to enable the immune system to recognize and attack malignant cells.

Wednesday January 04, 2017, 02:00 PM

Implantable Microrobots: Innovative Manufacturing Platform Makes Intricate Biocompatible Micromachines

Columbia University School of Engineering and Applied Science

Columbia Engineering researchers have developed a way to manufacture microscale-sized machines from biomaterials that can safely be implanted in the body. Working with hydrogels, they have invented a new technique that stacks the soft material in layers to make devices that have three-dimensional, freely moving parts. The study demonstrates a fast manufacturing method they call "implantable microelectromechanical systems" (iMEMS). (Science Robotics 1/4/17)

Wednesday January 04, 2017, 01:00 PM

Comprehensive Study of Esophageal Cancer Reveals Several Molecular Subtypes, Provides New Insight Into Increasingly Prevalent Disease

Van Andel Research Institute

A comprehensive analysis of 559 esophageal and gastric cancer samples, collected from patients around the world, suggests the two main types of esophageal cancer differ markedly in their molecular characteristics and should be considered separate diseases.

Wednesday January 04, 2017, 12:05 PM

Immunotherapy, Gene Therapy Combination Shows Promise Against Glioblastoma

University of Michigan Health System

In a new University of Michigan study, gene therapy deployed with immune checkpoint inhibitors demonstrates potential benefit for devastating brain cancer.

Tuesday January 03, 2017, 01:05 PM

Researchers Uncover Mechanism for Cancer-Killing Properties of Pepper Plant

UT Southwestern Medical Center

- UT Southwestern Medical Center scientists have uncovered the chemical process behind anti-cancer properties of a spicy Indian pepper plant called the long pepper, whose suspected medicinal properties date back thousands of years.