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HIPPO’s Molecular Balancing Act Helps Nerves Not Short Circuit

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Scientists report in Nature Communications it may be possible to therapeutically fine tune a constantly shifting balance of molecular signals to ensure the body’s peripheral nerves are insulated and functioning normally. In a study published April...
25-Apr-2017 11:00 AM EDT Add to Favorites

Experimental Drug Targets Nucleus of Allergen-Sensitized Cells

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Transcription factors, the tiny proteins that switch genes on or off in the nucleus of cells, are considered unreachable molecular targets for drugs attempting to treat medical conditions. Overcoming this challenge, researchers discovered a small...
17-Apr-2017 12:30 AM EDT Add to Favorites

Kids’ Hands May Be a Source of Significant Nicotine Exposure

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Children may carry significant levels of nicotine on their hands just by coming into contact with items or surfaces contaminated with tobacco smoke residues, even when no one is actively smoking around them at the time. A study in Tobacco Control...
6-Apr-2017 10:05 AM EDT Add to Favorites

MicroRNA Treatment Restores Nerve Insulation, Limb Function in Mice with MS

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Scientists partially re-insulated ravaged nerves in mouse models of multiple sclerosis (MS) and restored limb mobility by treating the animals with a small non-coding RNA called a microRNA. In a study published online March 27 in Developmental...
23-Mar-2017 9:00 AM EDT Add to Favorites

Scientists Find Possible Achilles Heel of Treatment Resistant Cancers

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Scientists identify two signaling proteins in cancer cells that make them resistant to chemotherapy, and show that blocking the proteins along with chemotherapy eliminate human leukemia in mouse models. Reporting results March 20 in Nature Medicine,...
16-Mar-2017 12:00 PM EDT Add to Favorites

Poison Prevention Awareness Week Kicks Off on March 19

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The Cincinnati Drug and Poison Information Center (DPIC) at Cincinnati Children’s Hospital Medical Center is a 24-hour emergency and information telephone service for anyone with concerns about poisons or drugs. In 2016, DPIC received more than...
19-Mar-2017 12:05 AM EDT Add to Favorites

Study Identifies Molecular Clues for Age-Related Intestinal Issues

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Intestinal stem cells rejuvenate daily so bowels will stay healthy and function normally, but a new study in Cell Reports suggests they also age along with people and lose their regenerative capacity. Reporting their data online March 14,...
9-Mar-2017 10:00 AM EST Add to Favorites

Study Describes Potential Clinical Test and Treatment for Preterm Birth

Scientists identified a molecular driver of inflammation that may finally answer a key question about what causes mild systemic prenatal infections to trigger preterm birth. The finding is an important step to developing a treatment or clinical test...
7-Mar-2017 8:45 AM EST Add to Favorites

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