In a recent study, scientists led by Professor Stefan Müller from Goethe University’s Institute of Biochemistry II investigated a specific form of blood cancer known as acute myeloid leukemia, or AML. The disease mainly occurs in adulthood and often ends up being fatal for older patients.
In a world where plant-based lifestyles are on the rise, the power of foods such as broccoli, celery, and tofu, which are rich in flavonoids, is becoming clearer. Flavonoids are phenolic compounds produced by plants that are essential for plant development and defense and have long been said to have therapeutic and preventive effects against cancer and heart disease.
Two antibody drug conjugates (ADCs), trastuzumab deruxtecan (T-DXd) and sacituzumab govitecan (SG), were approved by the FDA to treat metastatic breast cancers. ADCs are a type of targeted therapy that release cancer drugs to specific tumor cells. The efficacy of T-DXd and SG depends on target expression and the best method for measuring that expression is still not known.
Self-folding polymers containing gadolinium forming nanosized complexes could be the key to enhanced magnetic resonance imaging and next-generation drug delivery, as demonstrated by scientists at Tokyo Tech. Thanks to their small size, low toxicity, and good tumor accumulation and penetration, these complexes represent a leap forward in contrast agents for cancer diagnosis, as well as neutron capture radiotherapy.
Based on the results from this phase III trial, Yale Cancer Center expert Dr. Amer Zeidan says imetelstat, a first-in-class telomerase inhibitor, leads to durable red blood cell transfusion independence and a significant improvement in anemia in heavily transfused lower risk MDS patients.
Dr. Kathryn Lemberg in her lab. Credit: Norm Barker Combining a pair of experimental drugs may help treat malignant peripheral nerve sheath tumors with fewer harmful side effects, according to preliminary animal studies led by investigators at the Johns Hopkins Kimmel Cancer Center and Johns Hopkins Drug Discovery.
The American Society for Pharmacology and Experimental Therapeutics President Namandjé Bumpus will take over as the U.S. Food and Drug Administration’s (FDA) Principal Deputy Commissioner early next year.
In today's medical landscape, antibiotics are pivotal in combatting bacterial infections. These potent compounds, produced by bacteria and fungi, act as natural defenses against microbial attacks.
Scientists have created tiny moving biological robots from human tracheal cells that can encourage the growth of neurons across artificial ‘wounds’ in the lab. Using patients’ own cells could permit growth of Anthrobots that assist healing and regeneration in the future with no need for immune suppression. Lead researchers Prof Michael Levin and Gizem Gumuskaya from Tufts University will provide a brief commentary on the science and potential impact of this discovery, followed by Q&A with reporters.
Presage Biosciences, a pioneering translational oncology company whose mission is to use CIVO and spatial molecular profiling to understand the complexity of drug response in the tumor microenvironment (TME), has entered into an agreement with AstraZeneca (LSE/STO/Nasdaq: AZN), a global biopharmaceutical company.
A nearly decade-long study by UCLA researchers found that substance abuse treatment of any kind may help to reduce methamphetamine usage among men who have sex with other men.
For many people with migraine, it can be difficult to find a treatment that is effective and reliable, and information on how medications compare to one another is lacking. A new study draws data from nearly 300,000 people using a smartphone app to help people make decisions about their medications. The study found that certain migraine medications like triptans, ergots and anti-emetics may be two to five times more effective than ibuprofen for treating migraine attacks, according to new research published in the November 29, 2023, online issue of Neurology®, the medical journal of the American Academy of Neurology.
The clinical trial, led by Mirnela Byku, MD, PhD, MBA, at the UNC School of Medicine, found that excluding aspirin from the antithrombotic regimen in patients with a levitated left ventricular assist device is safe.
A new Phase Ib/II study from researchers at The University of Texas MD Anderson Cancer Center and Moffitt Cancer Center found that combining sensitizing drugs with a specific form of radiation therapy may be more effective in patients with locally advanced pancreatic cancer, yielding a higher progression-free survival (PFS) and overall response rate (ORR).
A large proportion of patients who start taking ADHD medication, especially young adults, stop within the first year. However, people who use ADHD medicine for a long time and in higher-than-average doses seem to have a higher risk of some cardiovascular diseases.
A five-year, $2 million grant to study the pharmacological effects of the areca nut, commonly known as the betel nut, was awarded to a UTHealth Houston researcher by the National Institute on Drug Abuse, part of the National Institutes of Health (NIH).
Far too many antibiotics are used around the world. As a result, bacteria are becoming resistant. Curing bacterial diseases is becoming more difficult than before, because antibiotics are perhaps our foremost weapons in the fight against them.
Scientists at the University of Bath have used nature as inspiration in developing a new tool that will help researchers develop new pharmaceutical treatments in a cleaner, greener, and less expensive way.
Traditional cancer treatments such as chemotherapy and radiation can come with collateral damage. In the process of killing cancer, the treatments harm normal cells, too, leading to both short- and long-term side effects. Even today’s targeted drugs and immunotherapy can have effects on normal tissues.
Si usted corre el riesgo de enfermedad cardíaca, el equipo de atención médica podría utilizar la herramienta de la ecuación de cohorte agrupada para determinar su riesgo a largo plazo y si la administración de estatinas (medicamentos para reducir el colesterol) es una buena opción.
مدينة روتشستر، ولاية مينيسوتا—إذا كنت مهددًا بخطرالإصابة بمرض القلب فقد يستخدم فريق الرعاية الصحية أداة معادلة تقييم المخاطر المُشتركة بين الفئات العمرية(PCE) لتحديد خطر إصابتك على المدى الطويل وما إذا كان تناول أدوية خافِضة للكوليسترول — أدوية خفض الكوليستيرول، خيار مناسب لك أم لا.
Se você está sob o risco de ter uma doença cardíaca, a equipe de cuidados médicos pode usar a ferramenta de equação de coorte agrupada (PCE) para determinar o seu risco de longo prazo, e se a administração de estatinas (medicamentos para reduzir o colesterol) é uma boa opção.
Cancer cells with multiple mutations alter the function of cell competition and use it to enhance their own invasive ability.
New study finds that anti-rheumatic drugs used for rheumatoid arthritis might prevent the development of autoimmune thyroid disease.
Lidocaine activates certain bitter taste receptors through two unique mechanisms that result in cancer cell death, according to researchers from the Perelman School of Medicine at the University of Pennsylvania. Their findings, published today in Cell Reports, pave the way for a clinical trial to test the addition of lidocaine to the standard of care therapy for patients with head and neck cancers.
The American Society for Pharmacology and Experimental Therapeutics (ASPET) has selected 16 individuals as 2023 ASPET Fellows.
Stay informed! Keep up with the latest research on the COVID-19 virus in the Coronavirus channel on Newswise.
Cleveland Clinic researchers analyzed genes and brain tissue of patients with Alzheimer’s and found that differences in brain immunometabolism – the interactions between the immune system and the ways cells create energy – may contribute to women’s increased risk for the disease and its severity.
A new study shows that a drug that boosts bone growth in children with achondroplasia, the most common form of dwarfism, may also reduce their chances of sudden infant death syndrome (SIDS), sleep apnea, and needing surgery.
Proof of concept of new material for long lasting relief from dry mouth conditions
Researchers at Chalmers University of Technology have developed a new method to capture many proteins in nano-sized traps. This method can be used to study the formation of protein clumps, which are linked to many diseases.
University of B.C. researchers have uncovered startling connections between micronutrient deficiencies and the composition of gut microbiomes in early life that could help explain why resistance to antibiotics has been rising across the globe.
Migraine is more than just a headache. Often the pain is accompanied by nausea, vomiting, light sensitivity, and sound sensitivity. Chronic migraine can be disabling and may prevent many, especially women, from contributing to working life.
Redispensing cancer drugs reduces both environmental impact and medical costs, according to research from Radboudumc pharmacy published in JAMA Oncology. The annual savings could amount to tens of millions.
An analysis of U.S. Food and Drug Administration (FDA) and patent records revealed how manufacturers have extended periods of market exclusivity for brand-name insulin products.
La epilepsia descontrolada de Lisa Lindahl la obligó a ser creativa a la hora de trabajar. En 1977 inventó el sujetador deportivo, que cambió la vida de miles de millones de mujeres y niñas en todo el mundo, y ahora es un mercado global de 40.000 millones de dólares.
A study showed that patient pain scores were a good predictor for opioid use, but younger patients and those who hadn’t used opioids before were less likely to take them
Sarosh Rana, MD, MPH has been named the inaugural Chief Obstetrical Transformation Officer for the University of Chicago Medicine health system.
MCRA, LLC, a leading medical device and biologics focused clinical research organization (CRO) and advisory firm integrating seven core services [U.S. and International Regulatory Affairs, Clinical Trial Operations, Reimbursement and Market Access, Healthcare Compliance, Cybersecurity, Quality Assurance, and Japan Distribution Logistics (DMAH)] is pleased to announce the hiring of Dr. Carolyn Yong and Dr. Iris Marklein as the Vice President and Senior Director, respectively, of Regulatory Affairs for Regenerative Medicine and Biologics Quality.
An existing drug that targets senescent, or sleeping cells could provide the answer to treating lower back pain, according to a new study.
Genomic surveillance of AMR pathogens has the potential to revolutionize AMR control, but barriers such as lack of resources and training need to be overcome.
By: Bill Wellock | Published: November 14, 2023 | 2:43 pm | SHARE: The U.S. Food and Drug Administration recently approved the medication Zepbound for weight management treatment.Tirzepatide, the active ingredient in the Eli Lilly and Company’s trademarked Zepbound, was already approved to help improve blood sugar (glucose) in adults with type 2 diabetes mellitus.
A first-of-its-kind study has identified overactive inflammation and loss of critical protection mechanisms in the brain as potential contributors to suicide risk.
Researchers at the University of Leicester have discovered the mechanism by which cholesterol in our diet is absorbed into our cells
The American Association of Physicists in Medicine is pleased to announce C. David Gammel as its incoming Executive Director.
Physicists from the University of Luxembourg together with experts from Avant-garde Materials Simulation (AMS) and seven pharmaceutical companies have redefined the state-of-the-art in modeling and predicting the free energy of crystals.
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