Feature Channels: Genetics

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Newswise: How Air Pollution Accelerates Alzheimer’s Disease
Released: 3-Nov-2023 7:05 PM EDT
How Air Pollution Accelerates Alzheimer’s Disease
Cedars-Sinai

Investigators from the Department of Neurosurgery at Cedars-Sinai have determined that exposure to polluted air could accelerate development of Alzheimer’s disease in those with genetic risk factors for the neurodegenerative condition.

Released: 3-Nov-2023 1:05 PM EDT
‘Lab on a chip’ genetic test device can identify viruses within three minutes with top-level accuracy
University of Bath

Compact genetic testing device created for Covid-19 could be used to detect a range of pathogens, or conditions including cancer

Released: 2-Nov-2023 9:05 PM EDT
Researchers identify female sex determining gene in mice
Francis Crick Institute

Researchers at the Francis Crick Institute and the Université Cote d’Azur, together with other labs in France and Switzerland, have identified a gene which is an early determining factor of ovary development in mice.

Newswise: How organs of male and female mammals differ
Released: 2-Nov-2023 9:05 PM EDT
How organs of male and female mammals differ
Universität Heidelberg

The development of sex-specific characteristics is frequently seen in mammals. These characteristics stem from the activation of corresponding genetic programmes that until now have been largely undescribed by the scientific community.

1-Nov-2023 1:05 PM EDT
Penn Medicine Researchers Develop Gene Editing Approaches for Phenylketonuria Treatment
Perelman School of Medicine at the University of Pennsylvania

Phenylketonuria (PKU) is a rare newborn genetic disease that impacts between 1 in 10,000 to 1 in 20,000 people, depending on the individuals’ genetic ancestry. PKU causes an amino acid—called phenylalanine (Phe)—to build up in the bloodstream.

Newswise: FSU researchers capture high-resolution images of magnesium ions interacting with CRISPR gene-editing enzyme
Released: 2-Nov-2023 4:05 PM EDT
FSU researchers capture high-resolution images of magnesium ions interacting with CRISPR gene-editing enzyme
Florida State University

In research published in Nature Catalysis, scientists at Florida State University produced the first high-resolution, time-lapsed images showing magnesium ions interacting with the CRISPR-Cas9 enzyme while it cut strands of DNA, providing clear evidence that magnesium plays a role in both chemical bond breakage and near-simultaneous DNA cutting.

Released: 2-Nov-2023 3:00 PM EDT
Cancer drug shows promise targeting genetic weakness in some tumors, comments Virginia Tech expert
Virginia Tech

In an invited commentary, Kathleen Mulvaney, assistant professor with the Fralin Biomedical Research Institute at VTC, talks about the potential of a new drug that has shown early promise in clinical trials for solid tumors by killing cancer cells that lack specific tumor suppressor genes.

Released: 2-Nov-2023 7:05 AM EDT
Being taller throughout life may protect against heart disease and stroke
University of Bristol

Being taller during the course of a person’s lifetime could protect against heart disease and stroke in later life, according to a new University of Bristol-led study. The research, which analysed height and genetic data on over 454,000 individuals, is published in the pre-print publication* medRxiv.

Newswise: Urine biomarkers can outperform serum biomarkers in certain diseases
Released: 2-Nov-2023 7:05 AM EDT
Urine biomarkers can outperform serum biomarkers in certain diseases
Chinese Academy of Sciences

Urinary biomarkers have the potential to surpass serum biomarkers in disease diagnosis and monitoring. This review highlights their non-invasive, stable, and specific nature. It explores a range of urinary biomarkers, such as proteins, genes, metabolites, electrolytes, and extracellular vesicles, showing their superiority.

Released: 1-Nov-2023 1:05 PM EDT
Epigenetic signature for obesity found in study of twins
Washington State University

WSU study finds epigenetic signature in cheek cells of obese people, suggesting a biomarker test for obesity could be developed

Released: 1-Nov-2023 1:05 PM EDT
Maternal microbiota can affect fetal development
University of Helsinki

In a Finnish study, significant differences in the gene activity of the foetal intestine, brain and placenta were identified, depending on the microbes in the mother’s body and the compounds produced by them. The findings indicate that maternal microbes are important to her offspring’s development and health

Newswise: Dravet syndrome and the influence of the genome: Dr. Sanjay Sisodiya
Released: 1-Nov-2023 11:05 AM EDT
Dravet syndrome and the influence of the genome: Dr. Sanjay Sisodiya
International League Against Epilepsy

Dravet syndrome is a rare, severe epilepsy caused by certain changes in the SCN1A gene. But people with Dravet have a wide range of clinical characteristics that cannot be fully explained by these changes. What else is going on?

Newswise: Markey Cancer Center study provides valuable insights into drivers of cancer risk
Released: 1-Nov-2023 10:05 AM EDT
Markey Cancer Center study provides valuable insights into drivers of cancer risk
University of Kentucky

As people age, the DNA in their cells begins to accumulate genetic mutations. Mosaic chromosomal alterations (mCAs), a category of mutations acquired in blood cells, are linked with a 10-fold increased risk of developing blood cancer.  mCAs hold promise as a tool to identify people at high risk of developing certain cancers and diseases, but they have not yet been studied among a large, diverse cohort of people – a critical step required before such testing can be developed. University of Kentucky Markey Cancer Center researcher Yasminka A. Jakubek, Ph.D., has led the first large-scale effort to understand the co-occurrence of mCAs among individuals of diverse ancestries. The study was published in Nature Genetics Oct. 30.

Newswise: Cancer drug shows promise targeting genetic weakness in some tumors, comments Virginia Tech expert
31-Oct-2023 12:00 AM EDT
Cancer drug shows promise targeting genetic weakness in some tumors, comments Virginia Tech expert
Virginia Tech

In an invited commentary, Kathleen Mulvaney, assistant professor with the Fralin Biomedical Research Institute at VTC, talks about the potential of a new drug that has shown early promise in clinical trials for solid tumors by killing cancer cells that lack specific tumor suppressor genes.

Released: 31-Oct-2023 1:05 PM EDT
Individuals with severe sickle cell disease express high risk tolerance for gene therapies
American Society of Hematology (ASH)

Adults and parents of children living with sickle cell disease suggest their acceptance of gene therapy risks grows significantly with condition severity.

Newswise: Could Epigenetic Age Acceleration, Not Actual Age, Better Predict How Well You Remember?
Released: 31-Oct-2023 12:05 PM EDT
Could Epigenetic Age Acceleration, Not Actual Age, Better Predict How Well You Remember?
Stony Brook University

A study led by researchers at Stony Brook University shows that age acceleration, when one’s so-called biological clock runs quicker than one’s actual age, is linked to poorer memory and slower rates of processing information. The team measured biological “clocks” derived from the DNA of 142 adults aged 25-65 years old and had the participants complete daily cognitive tests on smartphones. Their findings, which imply that epigenetic age acceleration could be a better indicator of how well a person remembers information and how quickly they work with information, are detailed in the Journal of Gerontology: Biological Sciences.

Newswise: Researchers Show SARS-Cov-2 Infection Affects Energy Stores in the Body, Causing Organ Failure
Released: 31-Oct-2023 11:05 AM EDT
Researchers Show SARS-Cov-2 Infection Affects Energy Stores in the Body, Causing Organ Failure
University of North Carolina School of Medicine

An international research team, including Jonathan C. Schisler, PhD, in the UNC School of Medicine, has found how SARS-CoV-2 causes widespread “energy outages” throughout major organs, and how these effects contribute to debilitating long COVID symptoms.

Newswise: Binghamton researchers get FDA approval for drug to treat world's most common neuromuscular genetic disease
Released: 31-Oct-2023 10:05 AM EDT
Binghamton researchers get FDA approval for drug to treat world's most common neuromuscular genetic disease
Binghamton University, State University of New York

A new drug developed by professors from the School of Pharmacy and Pharmaceutical Sciences at Binghamton University, State University of New York has received FDA approval for the treatment of patients with Duchenne muscular dystrophy, a common genetic disease that mostly affects young boys.

Newswise: Jean-Laurent Casanova is Recipient of 2023 Maria I. New International Prize for Biomedical Research
Released: 31-Oct-2023 9:00 AM EDT
Jean-Laurent Casanova is Recipient of 2023 Maria I. New International Prize for Biomedical Research
Mount Sinai Health System

The Icahn School of Medicine at Mount Sinai will award its 2023 Maria I. New International Prize for Biomedical Research to Jean-Laurent Casanova, MD, PhD, for revolutionizing our understanding of human infectious diseases through the discovery of genetic and immunological determinants that underpin both rare and common infectious illnesses. The prize honors medical pioneers in the tradition of Maria I. New, MD, a world-renowned researcher in pediatric genetic disorders with a special focus on endocrinology over her six-decade career. Dr. Casanova will receive a prize of $20,000 and will present the Maria I. New Distinguished Lecture during a ceremony to be held in at Icahn Mount Sinai in New York City on November 21, 2023.

Released: 27-Oct-2023 10:05 AM EDT
Find-and-replace genome editing with CRISPR: A promising therapeutic Strategy
Bar-Ilan University

CRISPR-Cas9-based genome editing offers hope for treating severe immunodeficiency disorders like SCID, with a novel approach for precise gene replacement, reducing risks and potentially aiding various genetic diseases.

26-Oct-2023 5:05 PM EDT
Find-and-Replace Genome Editing with CRISPR: A Promising Therapeutic Strategy
Bar-Ilan University

A novel replacement strategy termed GE x HDR 2.0: Find and Replace, developed by researchers from Bar-Ilan University and described in published today in Nature Communications, combines CRISPR-Cas9-mediated genome editing with recombinant adeno-associated serotype 6 (rAAV6) DNA donor vectors to precisely replace the RAG2 coding sequence while preserving regulatory elements.

Newswise: IU cancer center researchers identify biology behind aggressive breast cancers in Black women
Released: 25-Oct-2023 10:05 AM EDT
IU cancer center researchers identify biology behind aggressive breast cancers in Black women
Indiana University

Researchers at Indiana University Melvin and Bren Simon Comprehensive Cancer Center are unlocking the biology behind aggressive breast cancers in Black women.

Released: 24-Oct-2023 6:05 PM EDT
New methods for effective transport of large genes in gene therapy
University of Zurich

Gene therapy currently represents the most promising approach for the treatment of hereditary diseases. Yet despite significant breakthroughs in recent years, there are still a number of hurdles that hinder the wider application of gene therapies.

Released: 24-Oct-2023 12:05 PM EDT
How to slow the spread of deadly ‘superbugs’
University of Technology, Sydney

Harnessing new advances in genomic surveillance technology could help detect the rise of deadly ‘superbugs’

Released: 24-Oct-2023 10:05 AM EDT
Finding the genes that help kingfishers dive without hurting their brains
Field Museum

Scientists discover genes that help kingfishers dive without hurting their brains

Released: 23-Oct-2023 11:05 AM EDT
Researchers develop DANGER analysis tool for the safer design of gene editing
Hiroshima University

Risk-averse on/off-target assessment for CRISPR editing without reference genome

Newswise: You say genome editing, I say natural mutation
Released: 19-Oct-2023 7:05 PM EDT
You say genome editing, I say natural mutation
Cold Spring Harbor Laboratory

For tens of thousands of years, evolution shaped tomatoes through natural mutations. Then, humans came along. For centuries, we’ve bred and cherry-picked tomatoes with our preferred traits.

Newswise:Video Embedded pursuing-three-gene-therapies-for-rare-inherited-disease
VIDEO
Released: 19-Oct-2023 3:05 PM EDT
Pursuing Three Gene Therapies for Rare Inherited Disease
Harvard Medical School

Researchers hope at least one will treat progressive blindness caused by Usher syndrome type 1F

Released: 19-Oct-2023 2:05 PM EDT
Científicos de Mayo Clinic descifran el código genético de especies bacterianas patógenas para mejorar los resultados en pacientes
Mayo Clinic

Científicos de Mayo Clinic están creando una biblioteca extensa de prototipos de ADN de especies bacterianas patógenas. Esta colección única de secuencias genómicas sirve como base de datos de referencia para ayudar a los médicos a brindar diagnósticos certeros y rápidos, y a precisar tratamientos dirigidos para, posiblemente, mejorar los resultados que obtienen los pacientes.

Newswise: DNA shows where Washington culvert replacements helped spawning salmon
Released: 19-Oct-2023 2:05 PM EDT
DNA shows where Washington culvert replacements helped spawning salmon
University of Washington

Genetic evidence looked at how salmon were affected by two major culvert replacements near the city of Bellingham. One project, a major upgrade under Interstate-5, had a big impact, while the other old culvert may have been less of a barrier to fish. Researchers at the University of Washington and NOAA are studying the use of eDNA in future environmental impact reporting.

Released: 19-Oct-2023 12:05 PM EDT
Genetics influence the risk of blood clots in oral contraceptive users
Uppsala University

Women with a high genetic predisposition for blood clots are six times more likely to develop a blood clot during the first two years of using contraceptive pills according to a new study from Uppsala University. The results have been published in the American Journal of Obstetrics and Gynaecology

Released: 18-Oct-2023 5:05 PM EDT
The encounter between Neanderthals and Sapiens as told by their genomes
Université de Genève (University of Geneva)

About 40,000 years ago, Neanderthals, who had lived for hundreds of thousands of years in the western part of the Eurasian continent, gave way to Homo sapiens, who had arrived from Africa.

Newswise:Video Embedded genetic-connection-between-aerobic-fitness-and-disease-is-not-what-you-d-expect
VIDEO
Released: 18-Oct-2023 3:05 PM EDT
Genetic Connection between Aerobic Fitness and Disease Is Not What You’d Expect
American Physiological Society (APS)

New research examines the complex relationship between gene variants, cardiorespiratory fitness and the development of chronic disease. The study is published ahead of print in Physiological Genomics. It was chosen as an APSselect article for October.

Newswise: New insights into the genetics of the common octopus: genome at the chromosome level decoded
18-Oct-2023 5:00 AM EDT
New insights into the genetics of the common octopus: genome at the chromosome level decoded
University of Vienna

Octopuses are fascinating animals – and serve as important model organisms in neuroscience, cognition research and developmental biology. To gain a deeper understanding of their biology and evolutionary history, validated data on the composition of their genome is needed, which has been lacking until now.

Released: 17-Oct-2023 5:05 PM EDT
Whaling wiped out far more fin whales than previously thought
University of California Los Angeles (UCLA)

A new genomic study by UCLA biologists shows that whaling in the 20th century destroyed 99% of the Eastern North Pacific fin whale breeding, or “effective,” population — 29% more than previously thought.

Released: 17-Oct-2023 5:05 PM EDT
Multi-drug resistant strain of E.coli battles bacteria in healthy gut
University of Birmingham

Different strains of E.coli can outcompete one another to take over the gut, a new study reveals.

Newswise: Art with DNA – Digitally creating 16 million colors by chemistry
Released: 17-Oct-2023 5:00 AM EDT
Art with DNA – Digitally creating 16 million colors by chemistry
University of Vienna

The DNA double helix is composed of two DNA molecules whose sequences are complementary to each other. The stability of the duplex can be fine-tuned in the lab by controlling the amount and location of imperfect complementary sequences.

Newswise: Study: Deep neural networks don’t see the world the way we do
Released: 16-Oct-2023 6:05 PM EDT
Study: Deep neural networks don’t see the world the way we do
Massachusetts Institute of Technology (MIT)

Human sensory systems are very good at recognizing objects that we see or words that we hear, even if the object is upside down or the word is spoken by a voice we’ve never heard.

Released: 16-Oct-2023 3:05 PM EDT
Genomic analysis in snakes shows link between neutral, functional genetic diversity
Ohio State University

A new study suggests making a transition from “old school” genetics to “new school” genomics for species conservation purposes probably isn’t necessary in all cases.

Released: 16-Oct-2023 12:05 PM EDT
Holy immunity! Bat genes key against COVID, cancer
Cold Spring Harbor Laboratory

Bats have acquired remarkable traits throughout their evolution. They’re the only mammals that can fly, and they live much longer than other animals their size. But perhaps most impressive is their robust immune system. It protects bats from viruses that wreak havoc in humans, like COVID-19 or Ebola. It also keeps bats relatively cancer-free. How? According to Cold Spring Harbor Laboratory (CSHL) scientists, it’s all in the genes.

Newswise: Most accurate test to date developed to measure biological aging
Released: 13-Oct-2023 7:05 PM EDT
Most accurate test to date developed to measure biological aging
Karolinska Institute

A team of European researchers has developed a new test that can accurately measure biological aging in a clinical setting. The discovery was made while studying patients for the aging effects of chronic kidney disease.

Released: 13-Oct-2023 12:05 PM EDT
Groundbreaking genomics project will improve global diversity in population health insight
University of Bristol

An international collaboration is aiming to improve global health by uncovering the effects of genomic and environmental diversity on differences in disease risk observed across the global population, thanks to a new partnership of 20 research groups from around the world.

Newswise: Brain tumor treatment by targeting TUG1, a gene that controls replication stress
Released: 12-Oct-2023 6:05 PM EDT
Brain tumor treatment by targeting TUG1, a gene that controls replication stress
Nagoya University

A new study has unravelled a crucial link between how cancer cells cope with replication stress and the role of Taurine Upregulated Gene 1 (TUG1). By targeting TUG1 with a drug, the researchers were able to control brain tumor growth in mice, suggesting a potential strategy to combat aggressive brain tumors such as glioblastomas.

Newswise: Newsmakers: Basic Research Findings by Johns Hopkins Scientists Focus on Gene Sequencing, Hearing Loss and a Brain Disorder
Released: 11-Oct-2023 11:05 PM EDT
Newsmakers: Basic Research Findings by Johns Hopkins Scientists Focus on Gene Sequencing, Hearing Loss and a Brain Disorder
Johns Hopkins Medicine

Basic Research Findings by Johns Hopkins Scientists Focus on Gene Sequencing, Hearing Loss and a Brain Disorder

Newswise: Evolutionary secrets of ‘Old Tom’ and the killer whales of Eden revealed by genetic study
Released: 11-Oct-2023 5:05 PM EDT
Evolutionary secrets of ‘Old Tom’ and the killer whales of Eden revealed by genetic study
Flinders University

Evolutionary biologists have for the first time decoded the genetic lineage of a famous killer whale and a pod that once worked alongside whale hunters off the coast of New South Wales.

Newswise: Detection and Extraction of Similar Features in the Disease-Related Gene Groups
Released: 11-Oct-2023 4:35 PM EDT
Detection and Extraction of Similar Features in the Disease-Related Gene Groups
Chuo University

Multiomics3 analysis that integrates different layers of profiles altogether is challenging, since the number of variables in profile substantially differ from each other. For instance, gene expression profile and genomic DNA methylation profile are often analyzed together, however, there are only tens of thousands of genes, whereas the number of DNA methylation sites are as many as tens of millions.

Newswise: Gene Discoveries Could Help Prevent Deadly Coronary Artery Disease
Released: 11-Oct-2023 3:15 PM EDT
Gene Discoveries Could Help Prevent Deadly Coronary Artery Disease
University of Virginia Health System

An international team of scientists has identified nearly a dozen genes that contribute to calcium buildup in our coronary arteries that can lead to life-threatening coronary artery disease, a condition responsible for up to one in four deaths in the United States. Doctors may be able to target these genes with existing medications – or possibly even nutritional supplements – to slow or halt the disease’s progression.



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