Feature Channels: Immunology

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Newswise: Jean-Laurent Casanova is Recipient of 2023 Maria I. New International Prize for Biomedical Research
Released: 31-Oct-2023 9:00 AM EDT
Jean-Laurent Casanova is Recipient of 2023 Maria I. New International Prize for Biomedical Research
Mount Sinai Health System

The Icahn School of Medicine at Mount Sinai will award its 2023 Maria I. New International Prize for Biomedical Research to Jean-Laurent Casanova, MD, PhD, for revolutionizing our understanding of human infectious diseases through the discovery of genetic and immunological determinants that underpin both rare and common infectious illnesses. The prize honors medical pioneers in the tradition of Maria I. New, MD, a world-renowned researcher in pediatric genetic disorders with a special focus on endocrinology over her six-decade career. Dr. Casanova will receive a prize of $20,000 and will present the Maria I. New Distinguished Lecture during a ceremony to be held in at Icahn Mount Sinai in New York City on November 21, 2023.

Newswise: Intestinal bacteria metabolite promotes capture of antigens by dendritic cells
Released: 30-Oct-2023 11:05 AM EDT
Intestinal bacteria metabolite promotes capture of antigens by dendritic cells
Okayama University

Dendritic cells play a key role in the mammalian immune system. These cells are present throughout the human body and are known to capture foreign bodies, i.e., antigens, using extendable “arms” called dendrites

Newswise: Cancer Research Institute to Honor Dr. Ananda Goldrath with 2023 Alt Award
Released: 27-Oct-2023 2:45 PM EDT
Cancer Research Institute to Honor Dr. Ananda Goldrath with 2023 Alt Award
Cancer Research Institute

The Cancer Research Institute is proudly awarding Dr. Ananda Goldrath with the 2023 Fredrick W. Alt award for New Discoveries in Immunology.

26-Oct-2023 5:05 PM EDT
Find-and-Replace Genome Editing with CRISPR: A Promising Therapeutic Strategy
Bar-Ilan University

A novel replacement strategy termed GE x HDR 2.0: Find and Replace, developed by researchers from Bar-Ilan University and described in published today in Nature Communications, combines CRISPR-Cas9-mediated genome editing with recombinant adeno-associated serotype 6 (rAAV6) DNA donor vectors to precisely replace the RAG2 coding sequence while preserving regulatory elements.

Released: 25-Oct-2023 9:30 AM EDT
Rutgers Awarded NIH Grant to Study How Previous Infections Affect Immune Response to Lung Disease
Rutgers University-New Brunswick

Researchers will examine how the body’s adaptations to viruses, fungi and parasites change its ability to combat unrelated respiratory infections.

Newswise: Preliminary Data Support Novel Immunotherapy for Advanced Malignant Melanoma in Dogs
Released: 24-Oct-2023 5:05 PM EDT
Preliminary Data Support Novel Immunotherapy for Advanced Malignant Melanoma in Dogs
College of Veterinary Medicine, University of Illinois Urbana-Champaign

A clinical study of 11 dogs with advanced malignant melanoma demonstrated the efficacy, safety, and tolerability profile of cANK-101, a canine interleukin-12 anchored immunotherapy.

Released: 24-Oct-2023 12:05 PM EDT
How to slow the spread of deadly ‘superbugs’
University of Technology, Sydney

Harnessing new advances in genomic surveillance technology could help detect the rise of deadly ‘superbugs’

Released: 23-Oct-2023 6:05 PM EDT
Researchers identify ‘switch’ to activate cancer cell death
UC Davis Health

A research team from the UC Davis Comprehensive Cancer Center has identified a crucial epitope (a protein section that can activate the larger protein) on the CD95 receptor that can cause cells to die.

Newswise: New insight into the immune response forges a path toward improved medical implants
Released: 23-Oct-2023 11:05 AM EDT
New insight into the immune response forges a path toward improved medical implants
National Institute of Biomedical Imaging and Bioengineering

Introducing medical devices — commonly made of materials such as titanium, silicone, or collagen — into our bodies can elicit a host of different immune responses. While some responses can harm our bodies, others can help heal them. Researchers have not fully grasped the rhyme or reason behind the body’s reactions, but a new study fills in a critical piece of the puzzle.

Newswise: Lung cancer outcomes significantly improved with immunotherapy-based treatment given before and after surgery
20-Oct-2023 6:00 PM EDT
Lung cancer outcomes significantly improved with immunotherapy-based treatment given before and after surgery
University of Texas MD Anderson Cancer Center

A regimen of pre-surgical immunotherapy and chemotherapy followed by post-surgical immunotherapy significantly improved event-free survival (EFS) and pathologic complete response (pCR) rates compared to chemotherapy alone for patients with operable non-small cell lung cancer (NSCLC), according to results of a Phase III trial reported by researchers at The University of Texas MD Anderson Cancer Center.

20-Oct-2023 10:05 AM EDT
Adding Immunotherapy to Chemotherapy Regimen Improves Survival in Metastatic Bladder Cancer Patients
Mount Sinai Health System

A clinical trial co-led by Mount Sinai researchers is the first to show that using chemotherapy with immunotherapy resulted in improved survival in patients with an advanced type of bladder cancer. The results were simultaneously reported in The New England Journal of Medicine and at the annual meeting of the European Society for Medical Oncology.

Newswise:Video Embedded esmo-parp-inhibitor-plus-immunotherapy-lowers-risk-of-endometrial-cancer-progression-over-chemotherapy-alone
VIDEO
Released: 21-Oct-2023 3:05 AM EDT
ESMO: PARP inhibitor plus immunotherapy lowers risk of endometrial cancer progression over chemotherapy alone
University of Texas MD Anderson Cancer Center

Immunotherapy with the anti-PD-L1 monoclonal antibody durvalumab improved progression-free survival (PFS) in patients with newly diagnosed advanced or recurrent endometrial cancer compared with chemotherapy alone, with further benefits gained from the addition of the PARP inhibitor olaparib in maintenance setting, according to researchers from The University of Texas MD Anderson Cancer Center.

Released: 19-Oct-2023 3:40 PM EDT
MD Anderson Research Highlights: ESMO 2023 Special Edition
University of Texas MD Anderson Cancer Center

This special edition features upcoming oral presentations by MD Anderson researchers at the 2023 European Society for Medical Oncology (ESMO) Congress focused on clinical advances across a variety of cancer types.

Released: 19-Oct-2023 10:00 AM EDT
Penn Medicine Research Sheds New Light on Immune Response During SARS-CoV-2 Breakthrough Infections
Perelman School of Medicine at the University of Pennsylvania

While COVID-19 breakthrough infections—a SARS-CoV-2 infection that occurs after receiving COVID-19 vaccines—can occur, for healthy individuals with vaccine-induced immunity, these breakthrough infections do not often cause severe disease.

Newswise: Converting brain immune cells into neurons helps mice recover after stroke
Released: 18-Oct-2023 6:05 PM EDT
Converting brain immune cells into neurons helps mice recover after stroke
Kyushu University

Researchers at Kyushu University have discovered that turning brain immune cells into neurons successfully restores brain function after stroke-like injury in mice. These findings, published on October 10 in PNAS, suggest that replenishing neurons from immune cells could be a promising avenue for treating stroke in humans.

   
Newswise: Fred Hutch announces eight recipients of 2023 Dr. Eddie Méndez Scholar Award
Released: 17-Oct-2023 2:05 PM EDT
Fred Hutch announces eight recipients of 2023 Dr. Eddie Méndez Scholar Award
Fred Hutchinson Cancer Center

SEATTLE – OCTOBER 17, 2023 – Fred Hutchinson Cancer Center has announced the recipients of the 2023 Dr. Eddie Méndez Scholar Award, which recognizes early-career underrepresented minority scientists and scientists with disabilities.

Released: 17-Oct-2023 9:05 AM EDT
Braidwood Management v Becerra Puts Over a Decade of Progress in Preventive Health Care At Risk
George Washington University

A brief filed on behalf of 111 public health and health law and policy Deans and Scholars, the American Public Health Association, the Robert Wood Johnson Foundation, Trust for America’s Health, and ChangeLab Solutions highlights new findings on the preventive health gains at stake in Braidwood Management v Becerra.

Newswise: Directing vaccines to dendritic cells
Released: 16-Oct-2023 11:05 AM EDT
Directing vaccines to dendritic cells
National Institute of Biomedical Imaging and Bioengineering

Dendritic cells are key orchestrators of the immune response, but most vaccination strategies don’t effectively target them. NIBIB-funded researchers have developed biodegradable nanoparticles that are designed to deliver mRNA cargo to dendritic cells in the spleen.

Newswise: Immune system ageing can be revealed by CT scan
Released: 13-Oct-2023 7:05 PM EDT
Immune system ageing can be revealed by CT scan
Linkoping University

Thymus, a small and relatively unknown organ, may play a bigger role in the immune system of adults than was previously believed.

Newswise: Vaccines: A few minutes now could spare you misery later
Released: 13-Oct-2023 8:05 AM EDT
Vaccines: A few minutes now could spare you misery later
Michigan Medicine - University of Michigan

A guide to vaccines that adults - especially older adults and those with underlying health issues - should get to avoid serious illness this fall and winter, and beyond.

Released: 12-Oct-2023 9:05 AM EDT
Association for Molecular Pathology Publishes Best Practice Recommendations for Liquid Biopsy Assay Validations
Association for Molecular Pathology

The Association for Molecular Pathology has published best practice recommendations for validating and reporting clinical circulating tumor DNA (ctDNA) or liquid biopsy assays and their related scientific publications.

Released: 11-Oct-2023 6:05 PM EDT
Pure capped mRNA vaccine opens the door to more effective vaccines with lower chances of inflammation
Nagoya University

A research group from Japan has developed a method to produce highly active mRNA vaccines at high purity using a unique cap to easily separate the desired capped mRNA.

Newswise: Which one is the optimal choice for swiftly increasing platelet levels in adult relapsed ITP: IVIg, glucocorticoids, or the combination of IVIg and glucocorticoids?
Released: 11-Oct-2023 5:05 PM EDT
Which one is the optimal choice for swiftly increasing platelet levels in adult relapsed ITP: IVIg, glucocorticoids, or the combination of IVIg and glucocorticoids?
Higher Education Press

Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences &Peking Union Medical College, conducted a multicenter comprehensive retrospective analysis to assess the effectiveness and safety of primary single-agent and combination therapies in treating adult patients with relapsed immune thrombocytopenia (ITP).

Newswise: Drug-Filled Nanocapsule Helps Make Immunotherapy More Effective in Mice
10-Oct-2023 1:05 PM EDT
Drug-Filled Nanocapsule Helps Make Immunotherapy More Effective in Mice
University of California, Los Angeles (UCLA), Health Sciences

UCLA researchers have developed a new treatment method using a tiny nanocapsule to help boost the immune response, making it easier for the immune system to fight and kill solid tumors.

Released: 11-Oct-2023 7:05 AM EDT
Protein key to placental heath could be target for reproductive conditions
Yale University

Immune cells play a key role during pregnancy, adjusting immune system response in a way that enables the fetus to develop while also protecting the parent and fetus from outside assaults like viruses.

Released: 9-Oct-2023 6:05 PM EDT
Cancer drug restores immune system’s ability to fight tumors
University of Texas at Austin (UT Austin)

A new, bio-inspired drug restores the effectiveness of immune cells in fighting cancer, a team led by researchers at The University of Texas at Austin has found. In mouse models of melanoma, bladder cancer, leukemia and colon cancer, the drug slows the growth of tumors, extends lifespan and boosts the efficacy of immunotherapy.

Released: 9-Oct-2023 5:05 PM EDT
Scientists identify new pathway activated by interferon-gamma that leads to tumor cell death
University of California, Los Angeles (UCLA), Health Sciences

Researchers at the UCLA Jonsson Comprehensive Cancer Center have identified a new role for a protein called extracellular signal-regulated kinase (ERK) in a pathway activated by interferon-gamma that can trigger cells to self-destruct.

Newswise: Evidence from the remains of 1918 flu pandemic victims contradicts long-held belief that healthy young adults were particularly vulnerable
5-Oct-2023 12:20 PM EDT
Evidence from the remains of 1918 flu pandemic victims contradicts long-held belief that healthy young adults were particularly vulnerable
McMaster University

New analysis of the remains of victims of the 1918 influenza pandemic, which killed an estimated 50 million people worldwide, contradicts the widespread belief the flu disproportionately impacted healthy young adults.

   
Newswise: Capturing Immunotherapy Response in a Blood Drop
4-Oct-2023 11:00 AM EDT
Capturing Immunotherapy Response in a Blood Drop
Johns Hopkins Medicine

Liquid biopsies are blood tests that can serially measure circulating tumor DNA (cell-free DNA that is shed into the bloodstream by dying cancer cells). When used in patients with advanced non-small cell lung cancer undergoing immunotherapy, they may identify patients who could benefit from treatment with additional drugs, according to a phase 2 clinical trial in the U.S. and Canada. The trial is led by investigators at the Johns Hopkins Kimmel Cancer Center and its Bloomberg~Kimmel Institute for Cancer Immunotherapy, BC Cancer and the Canadian Cancer trials Group (CCTG).

Newswise: Miriam Merad, MD, PhD, Elected to the National Academy of Medicine for Seminal Work in Immunology and Cell Biology
9-Oct-2023 10:30 AM EDT
Miriam Merad, MD, PhD, Elected to the National Academy of Medicine for Seminal Work in Immunology and Cell Biology
Mount Sinai Health System

Miriam Merad, MD, PhD, an esteemed immunologist at the Icahn School of Medicine at Mount Sinai, has been elected to the National Academy of Medicine (NAM) in recognition of her pioneering contributions to the fields of immunology and cell biology.

Released: 9-Oct-2023 4:05 AM EDT
Vulnerability to different COVID-19 mutations depends on previous infections and vaccination, study suggests
University of Cambridge

A person’s immune response to variants of SARS-CoV-2, the virus that causes COVID-19, depends on their previous exposure – and differences in the focus of immune responses will help scientists understand how to optimise vaccines in the future to provide broad protection.

Newswise: World-first research breakthrough sparks new hope for bowel cancer patients
Released: 9-Oct-2023 3:05 AM EDT
World-first research breakthrough sparks new hope for bowel cancer patients
La Trobe University

Every year, over 15,500 Australians are diagnosed with bowel cancer, and it is the second leading cause of cancer deaths in the country. Over 1,700 (one in ten) of those diagnosed are young Australians aged under 50, and this incidence is increasing.

Newswise: 3D genome architecture influences SCID-X1 gene therapy success
Released: 6-Oct-2023 2:05 PM EDT
3D genome architecture influences SCID-X1 gene therapy success
St. Jude Children's Research Hospital

In 2019, St. Jude lentiviral gene therapy restored the immune system in multiple infants of X-linked severe combined immunodeficiency disorder (SCID-X1) or “bubble boy disease” at the DNA level. These children can now produce functional immune systems.

   
Released: 6-Oct-2023 7:05 AM EDT
Vaccine via the nasal passage could be the new line of defence against Strep A
Griffith University

As Streptococcus A cases continue to be prevalent in Queensland and internationally, a new nasal vaccine could provide long-term protection from the deadly bacteria.

Released: 4-Oct-2023 9:00 AM EDT
How an ICD-10 Code Is Improving Care for Children With MOGAD
Children's Hospital Los Angeles

ICD-10 codes are not the kind of thing that Jonathan Santoro, MD, learned about in medical school, or in his yearslong training to become a pediatric neurologist and neuroimmunologist. In fact, for most of his career he never spent any time thinking about them.

Newswise: Researchers Report Protein Mutation Creates ‘Super’ T Cells with Potential to Fight Off Cancer and Infections
Released: 3-Oct-2023 12:00 PM EDT
Researchers Report Protein Mutation Creates ‘Super’ T Cells with Potential to Fight Off Cancer and Infections
Johns Hopkins Medicine

Using laboratory-grown cells from humans and genetically engineered mice, scientists at Johns Hopkins Medicine say they have evidence that modifying a specific protein in immune white blood cells known as CD8+ T cells can make the cells more robust, potentially opening the door for better use of people’s own immune system T cells to fight cancer.

Newswise: To Eat or Not to Eat: Targeting autophagy to enhance memory immune responses
Released: 3-Oct-2023 6:05 AM EDT
To Eat or Not to Eat: Targeting autophagy to enhance memory immune responses
Osaka University

Memory B cells depend on autophagy for their survival, but the protein Rubicon is thought to hinder this process. Researchers from Osaka University have discovered a shorter isoform of Rubicon called RUBCN100, which enhances autophagy in B cells.

Newswise: Researchers Discover Promising Treatment to Combat Hospital Superbug
Released: 2-Oct-2023 12:05 PM EDT
Researchers Discover Promising Treatment to Combat Hospital Superbug
California State University, Fullerton

Cal State Fullerton antibiotic-resistance researcher María Soledad Ramírez and her students have discovered a promising new therapeutic to treat Acinetobacter baumannii, a superbug commonly found in hospitals and resistant to many antibiotics.

Released: 2-Oct-2023 11:05 AM EDT
Joint IAFNS-USDA Webinar Series Tackles Gut Health, Immune Function
Institute for the Advancement of Food and Nutrition Sciences

Collaborative webinars to focus on key scientific trends and findings related to gut microbiome and nutrition, and the interaction of diet, stress and immune function.

29-Sep-2023 11:00 AM EDT
Advanced Bladder Cancer Patients Could Keep Their Bladder Under New Treatment Regime, Clinical Trial Shows
Mount Sinai Health System

Mount Sinai investigators have developed a new approach for treating invasive bladder cancer without the need for surgical removal of the bladder, according to a study published in Nature Medicine in September.

Released: 2-Oct-2023 7:05 AM EDT
Allergy study on 'wild' mice challenges the hygiene hypothesis
Karolinska Institute

The notion that some level of microbial exposure might reduce our risk of developing allergies has arisen over the last few decades and has been termed the hygiene hypothesis.

Newswise: Study identifies new pathway to suppressing autoimmunity
25-Sep-2023 2:05 PM EDT
Study identifies new pathway to suppressing autoimmunity
The Rockefeller University Press

Researchers at Stanford University School of Medicine, Yale University School of Medicine, and the Hospital for Special Surgery Research Institute have uncovered new details about how the immune system prevents the production of antibodies that can recognize and damage the body’s own, healthy tissues. The study, to be published September 29 in the Journal of Experimental Medicine (JEM), also reveals how this process is impaired in autoimmune disorders such as systemic sclerosis and systemic lupus erythematosus and suggests potential new strategies to treat these diseases.

Released: 29-Sep-2023 8:05 AM EDT
A lethal parasite’s secret weapon: infecting non-immune cells
Ohio State University

The organisms that cause visceral leishmaniasis, a potentially deadly version of the parasitic disease that most often affects the skin, appear to have a secret weapon, new research suggests: They can infect non-immune cells and persist in those uncommon environments.

Newswise: Immune Checkpoint Blockade Prior to Surgery Promising in Multiple Cancer Types
Released: 28-Sep-2023 11:00 AM EDT
Immune Checkpoint Blockade Prior to Surgery Promising in Multiple Cancer Types
Johns Hopkins Medicine

Treating cancer with immunotherapies known as an immune checkpoint blockade (ICB) prior to surgery (so-called neoadjuvant immunotherapy) has been a rapidly growing area of research, but the scientific community is just scratching the surface of what is possible, according to a review article co-authored by several current and former investigators from the Bloomberg~Kimmel Institute for Cancer Immunotherapy and the Johns Hopkins Kimmel Cancer Center.

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This news release is embargoed until 28-Sep-2023 11:00 AM EDT Released to reporters: 28-Sep-2023 10:45 AM EDT

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