Curated News: Nature (journal)

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Axi-cel CAR T targets the CD19 molecule on large B-cell lymphoma cells. The ZUMA-7 trial demonstrated that axi-cel reduced the risk of disease progression, the need for new therapy, or death by 60% compared to standard therapy. Despite these positive outcomes in event-free survival and overall survival, some patients did not respond well to therapy or relapsed quickly after treatment. Researchers wanted to assess if there were specific tumor characteristics associated with improved outcomes that could better inform treatment selection. Their findings were published today in Nature Medicine.

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Sensors built with a new manufacturing approach are capable of recording activity deep within the brain from large populations of individual neurons--with a resolution of as few as one or two neurons--in humans as well as a range of animal models, according to a study published in the Jan. 17, 2024 issue of the journal Nature Communications.

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Researchers from Osaka University and their collaborating partners improve the efficiency of thermoelectric conversion from a semiconductor, which could help optimize the efficiency and sustainability of the global digital transformation.

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By taking advantage of mechanisms that allow cancer cells to evade immune attack, UT Southwestern Medical Center researchers have developed a new strategy in animal models that has potential for treating ulcerative colitis.

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An Indiana University biologist has been awarded $2.8 million from the National Institutes of Health to advance research on DNA folding errors, which have been traced to a wide variety of diseases, including genetic disorders that can cause birth defects or problems with wound healing, as well as certain types of cancer.

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Innovation may be what drives progress in the arts, business, sciences and technology, but the novel ideas that drive innovation often face headwinds that hinder or even prevent their adoption.

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Textbook models will need to be re-drawn after a team of researchers found that water molecules at the surface of salt water are organised differently than previously thought.

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Researchers have developed a platform that combines automated experiments with AI to predict how chemicals will react with one another, which could accelerate the design process for new drugs.

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New findings debunk previous wisdom that solid-state qubits need to be super dilute in an ultra-clean material to achieve long lifetimes. Instead, cram lots of rare-earth ions into a crystal and some will form pairs that act as highly coherent qubits, shows paper in Nature Physics.

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Researchers at Sandia National Laboratories are taking a closer look at what’s causing a decrease in sunlight reflectivity, or albedo, in the Arctic.

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The research, which was conducted on mice, demonstrates how these tiny nanomachines are propelled by urea present in urine and precisely target the tumour, attacking it with a radioisotope carried on their surface.

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New research has cracked a vital process in the creation of a unique rock type from the Moon. The discovery explains its signature composition and very presence on the lunar surface at all, unravelling a mystery which has long eluded scientists.

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An international scientific team made up of more than 40 authors from seven different countries, led by the researcher at the University of Malaga Juan Pascual Anaya, has managed to sequence the first genome of the myxini –also known as ‘hagfish’–, the only large group of vertebrates for which there was no reference genome of any of its species yet.

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Physicians who are notified that a patient has died of a drug overdose are more judicious in issuing controlled substances if the notification includes a plan for what to do during subsequent patient visits, according to a study published today in Nature Communications.

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An international team of scientists provide an overview of the latest research on light-matter interactions.

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Ethylene is sometimes called the most important chemical in the petrochemical industry because it serves as the feedstock for a huge range of everyday products.

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The latest advanced potato clones from the Texas A&M Potato Breeding Program, especially those for the french fry and fresh markets, will be highlighted during the National Potato Expo by Isabel Vales, Ph.D., Texas A&M AgriLife potato breeder in the Department of Horticultural Sciences in the Texas A&M College of Agriculture and Life Sciences.

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This experimental milestone allows for the preservation of quantum information even when entanglement is fragile.

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Identification of genes under recent selection provides insights into the molecular mechanisms of human-related adaptation in Candida pathogens.

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The first genome of hagfish – the only vertebrate lineage without a reference genome - has been sequenced by an international team of scientists.

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Today's most advanced chips house nearly 50 billion transistors within a space no larger than your thumbnail. The task of cramming even more transistors into that confined area has become more and more difficult, according to Penn State researchers.

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Scientists at St. Jude Children’s Research Hospital refined and enhanced the classification system for a type of pediatric leukemia using genomic and transcriptomic analysis.

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Cities play a key role in climate change and biodiversity and are one of the most recognizable features of the Anthropocene. They also accelerate innovation and shape social networks, while perpetuating and intensifying inequalities.

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Scientists at the U.S. Department of Energy’s (DOE) Brookhaven National Laboratory and Columbia University have developed a way to convert carbon dioxide (CO2), a potent greenhouse gas, into carbon nanofibers, materials with a wide range of unique properties and many potential long-term uses.

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In a recent article published in Nature Communications, Moffitt Cancer Center researchers, in collaboration with The Tisch Cancer Institute; St. Jude Children’s Research Hospital; the Agency for Science, Technology and Research in Singapore; and the University of Otago in New Zealand, demonstrate that deregulation of a protein called RBFOX2, involved in RNA splicing, contributes to the progression and metastasis of pancreatic cancer.

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A Johns Hopkins Children’s Center study of children and youth with diabetes concludes that so-called autonomous artificial intelligence (AI) diabetic eye exams significantly increase completion rates of screenings designed to prevent potentially blinding diabetes eye diseases (DED).

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For the first time, scientists have succeeded in the stabilisation and direct imaging of small clusters of noble gas atoms at room temperature. This achievement opens up exciting possibilities for fundamental research in condensed matter physics and applications in quantum information technology.

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Researchers at the University of California San Diego have developed a neural implant that provides information about activity deep inside the brain while sitting on its surface.

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Urban agriculture has the potential to decentralize food supplies, provide environmental benefits like wildlife habitat, and mitigate environmental footprints, but researchers have identified knowledge gaps regarding both the benefits and risks of urban agriculture and the social processes of growing more food in urban areas.

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The University of Texas MD Anderson Cancer Center’s Research Highlights showcases the latest breakthroughs in cancer care, research and prevention. These advances are made possible through seamless collaboration between MD Anderson’s world-leading clinicians and scientists, bringing discoveries from the lab to the clinic and back. Recent developments at MD Anderson include insights into the effects of the gut microbiome on remote tumors, a screening strategy for ovarian cancer early detection, a combination approach to overcome PARP inhibitor resistance, further understanding of ferroptosis resistance, a ferroptosis-based strategy for overcoming treatment resistance in acute myeloid leukemia (AML), potential targets for p53 mutations that lead to cancer progression, a signature for more accurately predicting risk in patients with AML given low-intensity treatments, and a prognostic tool to stratify patients with colorectal cancer.

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An international group of researchers finds that conserving about half of global land area could maintain nearly all of nature’s contributions to people and still meet biodiversity targets for tens of thousands of species.

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A vaccine showed potential to prevent relapse of KRAS-mutated pancreatic and colorectal cancers for patients who had previously undergone surgery, according to a Phase I trial led by researchers at The University of Texas MD Anderson Cancer Center.

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A team led by UC San Diego Professor of Astronomy and Astrophysics Alison Coil believes they may have found the origin of the universe's giant odd radio circles: they are shells formed by outflowing galactic winds, possibly from massive exploding stars known as supernovae.

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Sleep is a fundamental need, just like food or water. “You’ll die without it,” said Keith Hengen, an assistant professor of biology at Washington University in St. Louis. But what does sleep actually accomplish? For years, the best researchers could say is that sleep reduces sleepiness — hardly a satisfying explanation for a basic requirement of life.

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About three years before he retired, David Campbell noticed something weird happening as he typed.

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For military veterans, many of the deepest wounds of war are invisible: Traumatic brain injuries resulting from head trauma or blast explosions are a leading cause of post-traumatic stress disorder, anxiety, depression and suicide among veterans.

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Cell replication in our bodies is triggered by a cascade of molecular signals transmitted between proteins. Compounds that block these signals show potential as cancer drugs. Recently, scientists uncovered the molecular mechanisms that underlie a step in the signal-transmission pathway that requires three proteins to link up. This points the way to new targets for drugs that fight certain types of cancer.

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“The aim of our multidisciplinary and broad-based project is to establish antimicrobial stewardship in sub-Saharan Africa and to prevent the transmission of infectious diseases through a One Health approach,” says Dr Ahmed Abd El Wahed.