Scientists identified a neural circuit in the hypothalamus as the primary mechanism mediating the hormone leptin’s anti-obesity and anti-diabetes effects and found two mechanisms underlying leptin’s inhibition of appetite. The work in mice advances efforts to treat human obesity and diabetes.
Researchers announce new definition of Alzheimer’s disease.
Despite deep rifts in health care opinions across party lines, a physician’s party affiliation appears to have no effect on clinical decisions in end-of-life care. Researchers found no cross-party differences among physicians in their choice of care protocols, including the intensity of life-sustaining treatments, among terminally ill patients.
For the first time, a team of neuroscientists at Beth Israel Deaconess Medical Center (BIDMC) has demonstrated circadian control of aggression in male mice and identified the specific neurons and circuitry regulating the daily pattern.
Scientists will discuss latest research, new gene therapies at international sensory biology conference
We are the first to demonstrate that pTregs are important in autoimmune diabetes, and we hypothesize that microbes in the gut, where most of this pTreg cell population is switched on, may be responsible for generating these protective cells and thus protecting against the autoimmune attack on pancreatic beta cells that cause type 1 diabetes.
A national working group led by an investigator at Beth Israel Deaconess Medical Center (BIDMC) has developed a Consensus Statement intended to inform safe prescribing of opioids for hospitalized adults with acute pain.
A new study led by investigators at Beth Israel Deaconess Medical Center (BIDMC), Massachusetts General Hospital (MGH), and the Benson-Henry Institute for Mind Body Medicine at MGH identified genes associated with the body’s response to relaxation techniques and sheds light on the molecular mechanisms by which these interventions may work to lower blood pressure. The findings were published today in the Journal of Alternative and Complementary Medicine.
Babson’s Women Innovating Now (WIN) Lab® in Boston has appointed business leader Kara Miller as director. She will lead the fifth WIN Lab cohort into their finale event at Babson Boston on May 2, 2018.
Massachusetts Eye and Ear researchers have shown that mifepristone, a drug currently FDA-approved for chemical abortion, prevents the growth of vestibular schwannoma (also known as acoustic neuroma) cells. This sometimes-lethal intracranial tumor typically causes hearing loss and tinnitus. The findings, published online today in Scientific Reports, suggest that mifepristone is a promising drug candidate to be repositioned for the treatment of these tumors.
This year’s recipients—David Bornstein and Tina Rosenberg, Co-Founders of the Solutions Journalism Network, and Jeffrey Brown ’86, CEO of Brown's Superstores and Founder of Uplift Solutions, were recognized on the Wellesley campus on March 28, 2018.
Hospital payment experiment in Maryland failed to deliver on the promise of shifting care from hospitals toward less expensive outpatient and primary care settings. Researchers say that weak incentives for physicians may have limited the program’s effectiveness.
• Scientists untangle the structure of a recently discovered bacterial wall-building protein, found in nearly all bacteria • The discovery unveils potential weak spots in the protein’s molecular make-up • Findings can pave the way to next-generation broad-spectrum drugs that disrupt the protein’s function and disarm harmful bacteria
The 2018 Youth Electoral Significance Index (YESI) from Tisch College at Tufts University may answer how young voters will shape the future American political landscape by ranking the top districts and states where young people could have significant influence.
New research finds significant differences in hospitals’ performance when readmissions were assessed for non-Medicare patients and for conditions other than those currently reported, showing that when these additional factors are taken into account, half of hospitals would be subject to a change in their financial penalty status.
Researchers at Tufts University have created a genetically modified yeast that can more efficiently consume a novel nutrient, xylose, enabling the yeast to grow faster and to higher cell densities, raising the prospect of a significantly faster path toward the design of new synthetic organisms for industrial applications, according to a study published today in Nature Communications.
-Scientists identify mechanism behind vascular aging, muscle demise in mice. -Treatment with chemical compounds reversed vascular aging, stimulated blood vessel growth and blood flow, boosted exercise capacity in aging animals. -Findings set the stage for therapies in humans to stave off a range of conditions linked to vascular aging.
Different tissues have shockingly variable sensitivities to genes that drive normal and malignant cell proliferation, study shows. Research unmasks hundreds of cancer-driving genes invisible to gene sequencing. Findings could explain why individual cancer drivers appear in some tumors and not others, could inspire tissue-specific strategies for cancer treatment.
Miniaturized sensors when mounted directly on a tooth and communicating wirelessly with a mobile device, can transmit information on sugars, alcohol and salt. Researchers note that future adaptations of these sensors could enable the detection and recording of a wide range of nutrients, chemicals and physiological states.
Mexican cavefish have insulin resistance, a hallmark of many human metabolic disorders and a precursor to type 2 diabetes that can lead to an overworked pancreas, excess fat storage and chronically elevated blood sugar. Despite dysregulated blood sugar, the fish don’t suffer the same health consequences people do. Study offers a fresh opportunity to understand how animals thrive with traits that sicken humans and could point the way to new interventions for disease.
The 3rd Babson India Symposium took place March 10th, 2018 at the Babson College Wellesley campus, bringing together students, alumni, faculty, and staff to connect, build relationships, and network with esteemed speakers and their peers.
Massachusetts Eye and Ear made medical history on Tuesday by performing the first post-FDA approval gene therapy for patients with a form of inherited blindness. The occasion marks the beginning of a new era in medicine, as it is the first time any FDA-approved gene therapy has been given to a patient for any inherited disease.
Beth Israel Deaconess Medical Center’s Christos Mantzoros, MD, MSC, the first scientist to document the role of the hormone leptin in regulating the body’s response to hunger in humans, is the recipient of the Endocrine Society’s Outstanding Clinical Investigator Award for 2018. Mantzoros accepted the award today at a special ceremony at the Society’s 100th annual meeting in Chicago.
Women in Diabetes Research and Care
•The ability of the “cold sore” herpes simplex virus to establish quiet infections and reawaken periodically has long mystified scientists. •A new study in mice reveals that a key host protein acts as a critical regulator of the virus’s sleep-wake cycle. •Disabling two viral binding sites for the protein weakened the virus’s ability to come out of hiding.
A new, large-scale study – led by researchers at the Smith Center for Outcomes Research in Cardiology at Beth Israel Deaconess Medical Center (BIDMC) and published online today in Circulation: Cardiovascular Quality and Outcomes – examined the relationship between 30-day episode spending for inpatient and post-discharge care and patient mortality following a hospital admission for heart attack.
Tufts biologists have demonstrated for the first time that electrical patterns in developing embryos can be predicted, mapped and manipulated to prevent defects caused by harmful substances such as nicotine. The study suggests that targeting bioelectric states may be a new treatment modality for regenerative repair in brain development and disease.
A team led by engineers at Tufts University has opened a window into the cell by developing an optical tool that can read metabolism at subcellular resolution. The researchers were able to use the method to identify specific metabolic signatures that could arise in diabetes, cancer, cardiovascular and neurodegenerative diseases.
Babson College has partnered with Ashoka U to co-host the 2018 Ashoka U Exchange on April 5-7, 2018 in Boston, MA. As one of the original Changemaker Campuses, Babson continues its commitment to social innovation by bringing the Ashoka U Exchange to the only city in the world that has three Ashoka U campuses.
Heart-attack sufferers who receive treatment during periods when interventional cardiologists are away at academic conferences are more likely to survive in the month after their heart attack than patients receiving treatment during nonmeeting days.
Wellesley College, widely recognized as the world’s premier college for women, will present The African Women’s Leadership Conference, a first-of-its-kind gathering in the United States of some of the most influential voices in African women’s leadership—from education and politics to health and technology, entertainment, and the law.
Dana-Farber Cancer Institute is establishing a bank of patient-derived xenograft models of more than 750 human tumors.
A sizable percentage of elderly patients with blood-related cancers such as leukemia and multiple myeloma are apt to show signs of diminished cognitive functioning
Financial Times (FT) ranks Babson’s Blended Learning MBA program No. 3 in the United States and No. 6 worldwide in its 2018 Online MBA ranking.
Neurons that carry nerve signals to and from the lungs suppress immune response during fatal lung infections with the bacterium Staphylococcus aureus. Animal experiments show that disabling these neurons can boost immune response and promote bacterial clearance to aid recovery. Targeting neuro-immune signaling in the lungs can pave the way to nonantibiotic therapies for bacterial pneumonia.
Wellesley College is launching a website that just might help get women closer to closing the gender wage gap—by leveraging the College’s singular career education model and its network of women, widely acknowledged as the most powerful women’s network in the world.
Gun injuries fall by 20 percent during the dates of the National Rifle Association’s annual convention. Some 80,000 gun owners attend the NRA’s national convention, including many experienced users. A brief period of gun abstinence, even by experienced, well-trained gun owners, appears to yield safety benefits.
Diplomats, scholars and activists from across the globe, including United Nations Deputy Secretary-General Amina J. Mohammed, former Foreign Minister of Poland Radoslaw Sikorski, and former Canadian Justice Minister Allan Rock, will gather at Tufts University’s Institute for Global Leadership’s annual symposium March 1 through March 3.
New nonprofit organization will bring treatments to clinical trial for people at risk for blindness due to ultra-rare inherited retinal diseases. Boston, Mass. — Scientists and advocates today announced the formation of Odylia Therapeutics, a nonprofit corporation dedicated to creating gene therapies for ultra-rare genetic conditions causing blindness.
Entrepreneurship: The Practice and Mindset, coauthored by Babson College Professor Heidi Neck, is winner of a 2018 TAA Most Promising New Textbook Award by the Textbook & Academic Authors Association (TAA).
Through a partnership with John Hancock Financial Services, Massachusetts Eye and Ear is preparing a team of runners for the 2018 Boston Marathon.® “Team Eye and Ear” comprises 67 members fundraising in support of Mass. Eye and Ear’s research programs to fight disorders of the eyes, ears, nose, throat, head and neck.
Babson College’s Women Innovating Now (WIN) Lab®Miami - a venture accelerator specifically for women entrepreneurs - welcomes a new director, Michelle Abbs. The accelerator is looking forward to an exciting spring of programming and the second annual finale event.
In the last eight years, the field of ancient DNA research has expanded from just one ancient human genome to more than 1,300. The latest 625 of those genomes debut Feb. 21 in two papers published simultaneously in Nature, including the largest study of ancient DNA to date.
To help catalyze the development of genetic therapies, Harvard Medical School is launching a new program aimed at educating pharma and biotech leaders on the latest advances in genetics and how to optimize them for drug discovery and other therapeutic innovations.
David A. Solá-Del Valle, M.D., a board-certified ophthalmologist and fellowship-trained glaucoma specialist, has recently joined the Glaucoma Service at Mass. Eye and Ear.
Janey L. Wiggs, M.D., Ph.D., FARVO, Associate Chief of Ophthalmology Clinical Research and Associate Director of the Howe Laboratory at Massachusetts Eye and Ear, is the 2018 recipient of the Dr. David L. Epstein Award
Tufts University today named Sarah Booth, Ph.D., the new director of the Jean Mayer USDA Human Nutrition Center for Research on Aging (HNRCA) at Tufts.
Research in mice pinpoints immune mechanism behind tissue damage and complications of chlamydia infection, the most common sexually transmitted disease in the United States. Separate immune mechanisms drive bacterial clearance versus immune-mediated tissue damage and subsequent disease. Therapies are needed to avert irreversible reproductive organ damage that can arise as a result of silent infections that go untreated.
Antibodies made by camels, llamas and alpacas allow scientists to study the structure and function of proteins in disease and health. While valuable, the approach is time-consuming, costly and often unsuccessful. Overcoming this barrier, scientists have devised a faster, cheaper and more reliable way to create these critical antibodies using yeast in a test tube.
Is it nature or nurture that ultimately shapes an organism? A new study reveals a dramatic landscape of gene expression changes across all cell types in the mouse visual cortex after a sensory experience, many linked to neural connectivity and the brain’s ability to rewire itself to learn and adapt.
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