Heart failure patients may one day be able to restore cardiac function with medications that revive the body’s ability to regenerate heart muscle, a novel study at UT Southwestern Medical Center suggests.
Women who take oral contraceptives may be significantly less likely to experience certain musculoskeletal injuries than women who do not take the drugs or men, according to a study by UT Southwestern Medical Center.
Caring for someone with dementia or Alzheimer’s disease is challenging. In addition to the financial and physical demands, many caregivers are unprepared for the stress of trying to effectively communicate with a loved one who may be prone to agitation, verbal aggression, and hallucinations.
Humans aren’t the only living beings who find a singing voice attractive in the opposite sex – songbirds do too. For about a third of the approximately 4,000 songbird species that sing only one song, the features that make these tunes alluring to a potential mate have been a long-standing mystery.
Proteins known as oligomeric chaperones help suppress the formation of misshaped proteins that cause a variety of degenerative and neurodegenerative diseases, such as Alzheimer’s, Huntington’s, and Parkinson’s. In a new study, UT Southwestern Medical Center researchers identified a key feature necessary for one of these oligomeric chaperones, known as DNAJB8, to assemble from disparate parts and showed that the parts alone can reshape misfolded proteins. The findings, published in Structure, could lead to better ways to diagnose and treat these conditions.
Labor induction with vaginal misoprostol during childbirth achieves vaginal delivery rates similar to the oral alternative while significantly reducing the need for oxytocin, the most commonly used labor-inducing drug, UT Southwestern Medical Center researchers report.
A lump under the arm. Coughing that won’t go away. These can be the first signs of cancer – and a wake-up call that early detection and screening could save your life.
By focusing on a poxvirus protein, a team led by UT Southwestern Medical Center scientists has discovered an antiviral immune pathway that broadly fights a wide variety of viruses. Their findings, reported in Nature Microbiology, could eventually lead to new ways to prevent or treat viral infections or thwart autoimmune diseases.
Roundup of recent research involving UT Southwestern faculty members: Antibody treatment lowers risk for food allergies; Weight-loss surgery support offered for teens; Racial disparities found among pregnant patients with multiple sclerosis; Gestational age increased at start of COVID-19 pandemic
A gene therapy developed by researchers at UT Southwestern Medical Center for a rare disease called giant axonal neuropathy (GAN) was well tolerated in pediatric patients and showed clear benefits, a new study reports. Findings from the phase one clinical trial, published in the New England Journal of Medicine, could offer hope for patients with this rare condition and a host of other neurological diseases.
The composition of the gut microbiomes in a group of rectal cancer patients reveals distinct signatures by race, ethnicity, and age of onset, with white Hispanics showing significant presence of one specific type of bacteria, UT Southwestern Medical Center researchers report.
UT Southwestern Medical Center has joined more than a dozen leading medical centers and Microsoft to form the Trustworthy & Responsible AI Network (TRAIN), a national group designed to set standards and safely explore applications of artificial intelligence (AI) in health care.
Surgical nerve decompression, used to treat conditions such as carpal tunnel syndrome and sciatica, could play a role in relieving the pain of diabetic neuropathy patients, researchers at UT Southwestern Medical Center found.
Moncrief Cancer Institute debuted its new Mobile Screening Clinic prior to the Tarrant County Commissioners Court meeting today. The $1 million, 36-foot cancer screening clinic was funded by Tarrant County through a three-year, $9 million grant awarded to Moncrief Cancer Institute in 2022. Part of the federal funding Tarrant County received through the American Rescue Plan Act (ARPA), the grant enabled Moncrief to expand its comprehensive cancer screening program to more underserved residents in Tarrant County.
Future physicians persevere through pandemic to reach milestone moment
Delivering genetic material tagged with a cellular "ZIP code" prompted cells to secrete proteins or drugs into the bloodstream that successfully treated psoriasis and cancer in mouse models, UT Southwestern Medical Center scientists report in a new study.
The risk of dying while waiting for a liver transplant or having a transplant fail for patients with alcohol-associated liver diseases is higher among racial and ethnic minorities, according to UT Southwestern Medical Center researchers.
A molecule has demonstrated its ability to kill tumor cells and incite an immune response in preclinical models of small cell lung cancer (SCLC), according to UT Southwestern Medical Center researchers. The findings, published in Nature Communications, could lead to more successful treatments for SCLC, one of the leading causes of cancer-related deaths in the U.S.
Nine scientists and physicians in the Harold C. Simmons Comprehensive Cancer Center at UT Southwestern Medical Center have been awarded nearly $13 million in grants from the Cancer Prevention and Research Institute of Texas (CPRIT) to support research and prevention efforts on a wide range of cancer issues. UTSW received another $6 million for recruitment efforts.
UT Southwestern Medical Center researchers have developed an artificial intelligence (AI) method that writes its own algorithms and may one day operate as an "automated scientis" to extract the meaning behind complex datasets.
A drug in clinical trials as a treatment for metabolic dysfunction-associated steatotic liver disease (MASLD) works with a one-two punch that shuts down triglyceride production and fatty acid synthesis in liver cells, UT Southwestern Medical Center researchers show in a new study.
A subpopulation of gut bacteria given a commonly used antibiotic became "persisters" that were able to survive without developing true resistance, UT Southwestern Medical Center scientists discovered. Their findings, published in Cell Host & Microbe, could lead to better ways to fight bacterial infections.
Treating complex bacterial infections with customized therapies tailored to the infection and the patient is closer to reality, thanks to researchers at UT Southwestern Medical Center.
Glucagon, a hormone best known for promoting blood sugar production in the liver, also appears to play a key role in maintaining kidney health. When UT Southwestern Medical Center researchers removed receptors for this hormone from mouse kidneys, the animals developed symptoms akin to chronic kidney disease (CKD).
To call the connection James D. Griffin, M.D., has with UT Southwestern and Parkland Memorial Hospital lifelong is no exaggeration. Dr. Griffin was born at Parkland in 1958, when the labor and delivery ward was still segregated. More than six decades later, his colleagues at that hospital elected him President of the medical staff – the first Black physician to earn the honor.
Patients who are younger than about 40, male, or Black are among those most at risk for revision surgery after having had a total knee replacement, according to researchers at UT Southwestern Medical Center. The study, published in the Archives of Orthopaedic and Trauma Surgery, was the first to explore relationships among risk factors for revision after total knee arthroplasty (TKA).
UT Southwestern Medical Center researchers have identified a compound that selectively eliminates cancer cells while sparing immune cells in a form of cell death known as ferroptosis. The findings, published in Science Translational Medicine, could lead to new treatments for a wide variety of cancer types, the study authors say.
Jonathan W. Uhr, M.D., Professor Emeritus of Immunology at UT Southwestern Medical Center, who discovered how antibodies are made and developed a technique that led to the early detection of cancer cells, died Feb. 15. He was 96. Dr. Uhr was a member of the National Academy of Sciences and the American Academy of Arts and Sciences.
The same technology at work in induction cooktops cut the amount of bacteria present in a prosthetic joint infection when used in conjunction with antibiotics in a mouse model, UT Southwestern Medical Center researchers report in a new study.
Two hard-to-match transplant patients 250 miles apart are starting 2024 on a new path to healthy lives.
Results from phase two clinical trials at UT Southwestern Medical Center showed that a suspension of gold nanocrystals taken daily by patients with multiple sclerosis (MS) and Parkinson's disease (PD) significantly reversed deficits of metabolites linked to energy activity in the brain and resulted in functional improvements.
UT Southwestern Medical Center is partnering with Pfizer Inc. to develop RNA-enhanced delivery technologies for genetic medicine therapies through the Dallas-based medical center's Program in Genetic Drug Engineering.
Automated external defibrillators (AEDs) are underutilized during cardiac arrest episodes despite laws in some states requiring their availability in high-risk areas such as athletic facilities, researchers at UT Southwestern Medical Center found.
UT Southwestern Medical Center researchers have identified an experimental molecular compound that improved survival among cellular models and mouse models of amyotrophic lateral sclerosis (ALS), the fatal neurodegenerative disease.
Russell DeBose-Boyd, Ph.D., Professor of Molecular Genetics at UT Southwestern Medical Center, has been awarded the Hill Prize in Biological Sciences from the Texas Academy of Medicine, Engineering, Science and Technology (TAMEST) in recognition of his long-standing research into a key mechanism necessary for cholesterol control.
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