On the origin of congenital limb deficiency
SUNY Upstate Medical UniversityDavid R. Hootnick, M.D., reveals clinical evidence that most human congenital long bone deficiencies of lower limbs are the result of downstream effects of embryonic arterial dysgenesis, similar to that of thalidomide embryopathy; such limb deficiencies are, in fact, indistinguishable from those seen in the thalidomide epidemic of the ‘50s and ‘60s.