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A new analysis by researchers at UCLA Health found that mortality rates of middle-aged Black Americans caused by the “deaths of despair” -- suicide, drug overdose and alcoholic liver disease – surpassed the rate of white Americans in 2022.

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A mutation in a protein regulating natural killer (NK) cells’ function is at the root of immune deficiency in some people with a rare genetic condition characterized by cognitive and developmental delay, seizures, and other manifestations. The findings also have broader implications for immunity and cell therapies.

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A pilot study led by UCLA Health Jonsson Comprehensive Cancer Center investigators suggests that for people with borderline resectable pancreatic cancer, administrating an immunotherapy drug in combination with chemotherapy before surgery is safe and may improve long-term outcomes.

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Study finds that lonely women experienced increased activation in regions of the brain associated with food cravings.

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Women with serious mental illness (SMI) who are pregnant or planning a pregnancy face gaps in information, support and resources in mental health services. The findings highlight the need to integrate pregnancy and parenting interventions, education, and other resources for women with SMI.

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Dr. Rhonda Voskuhl, a professor of neurology at UCLA Health, has been awarded the 2024 John Dystel Prize for Multiple Sclerosis Research in recognition of her outstanding contributions to multiple sclerosis research and treatment.

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HERSTORY is focused on understanding genetic, environmental, socio-economic, and other determinants of cancer in women with a family history of the disease.

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The results of a UCLA study suggest that using CXCL9 and CXCL10-producing dendritic cells alongside immunotherapy can be a promising strategy to overcome treatment resistance and improve clinical outcomes for patients with non-small cell lung cancer.

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The annual meeting will feature more than 40 regular, late-breaking and clinical trial abstracts from UCLA physicians and scientists, who will present their latest work in key areas of translational and basic scientific research, including new compounds and drug targets, combination immunotherapy approaches, updated organoid models, survivorship research and more.

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A vaccine against the bacterium that causes melioidosis was highly protective against the disease, which is endemic in many tropical areas, causing approximately 165,000 cases with 89,000 fatalities around the world each year. It is so dangerous that it is categorized as a Tier 1 Select Agent of bioterrorism.

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A new treatment approach that combines a targeted therapy drug with hormone therapy significantly increased the amount of time a person with stage 2 or 3 HR-positive, HER2-negative early breast cancer lives without the cancer returning, according to a new study co-led by UCLA Health Jonsson Comprehensive Cancer Center investigators.

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Text nudges encouraging people to get the COVID-19 vaccine, which had proven effective in prior real-world field tests, are also effective at prompting people to get a booster. The key in both cases is to include in the text a sense of ownership in the dose awaiting them.

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A team of UCLA Health Jonsson Comprehensive Cancer Center investigators has shown the combination of a short course of powerful and intense hormonal therapy with targeted radiation is safe and effective in treating people with prostate cancer that has come back and has spread to other parts of the body.

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The UCLA Department of Medicine is pleased to announce that Priscilla Hsue, MD will be joining us as the chief of the Division of Cardiology at UCLA, effective July 1, 2024.

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A new UCLA-led study suggests that some people living with long COVID may be able to alleviate certain symptoms by using short-term, self-regulating therapies.

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A team of investigators from the UCLA Health Jonsson Comprehensive Cancer and the University of Arkansas for Medical Sciences (UAMS) Winthrop P. Rockefeller Cancer Institute was awarded a $3.2 million grant from the National Institutes of Health to identify new ways to prevent and overcome treatment resistance to targeted therapy in patients with all sub-types of cutaneous melanoma, an aggressive form of skin cancer.

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A new training protocol to assist first responders in recognizing and responding to symptoms of heart events in women is being rolled out.

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UCLA Health researchers have discovered a group of specialized support cells in the brain that can regulate behaviors associated with human neuropsychiatric disorders.

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Researchers from the UCLA Health Jonsson Comprehensive Cancer Center show for the first time that a gene usually linked to giant axonal neuropathy, a rare and severe neurological condition, also plays a role in inhibiting aggressive tumor cell growth in head and neck cancers.

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A new UCLA Health study found Kundalini yoga provided several benefits to cognition and memory for older women at risk of developing Alzheimer’s disease including restoring neural pathways, preventing brain matter decline and reversing aging and inflammation-associated biomarkers – improvements not seen in a group who received standard memory training exercises.

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For Colon Cancer Awareness Month, experts from the UCLA Health will educate members of the community on the importance of starting colorectal cancer screening early and continuing to have it done regularly throughout their lives to prevent the development of cancer.

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Samara Rahman, 74, enrolled in a clinical trial at UCLA Health that was evaluating an “off-the-shelf” vaccine that is given after surgery to prevent or delay the cancer from coming back in high-risk patients.

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Folasade May, MD, PhD, UCLA Health cancer prevention researcher and gastroenterologist, is available for interview on a variety of topics during colorectal cancer awareness month.

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A UCLA Health-led study found a combination of interventions of one-on-one telehealth coaching, peer support forums, and automated text messages more than doubled the use of the HIV prevention strategy, called PrEP, among younger, at-risk Americans, a group that historically has had low use of the medication.

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Scientists at the UCLA Health Jonsson Comprehensive Cancer Center have built and demonstrated the potential efficacy of a new chimeric antigen receptor (CAR) T-cell-based immunotherapy specifically designed to treat patients with cutaneous and rare subtypes of melanoma.

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A four-drug chemotherapy regimen of irinotecan liposome (Onivyde) in combination with oxaliplatin, leucovorin, and fluorouracil has been approved by the FDA for the first-line treatment of metastatic pancreatic adenocarcinoma.

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UCLA Therapy dogs dressed in costumes deliver Valentines to pediatric patients on the unit.

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A new study, co-led by UCLA Health and the University of Glasgow, found that young teenagers who develop a strong distrust of other people as a result of childhood bullying are substantially more likely to have significant mental health problems as they enter adulthood compared to those who do not develop interpersonal trust issues.

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Therapy dogs dressed in costumes deliver Valentines to pediatric patients on the unit.

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The UCLA team played a pivotal role in a clinical trial that led to the FDA granting accelerated approval of the first antibody drug conjugate (ADC), mirvetuximab soravtansine, for the treatment of platinum-resistant ovarian cancer.

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Genicular artery embolization is a non-invasive alternative to knee replacement.

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New prostate screening guidelines organized by the Prostate Cancer Foundation aim to address the longstanding health disparity in prostate cancer: Black men are diagnosed with and die from prostate cancer at a much higher rate than white men.

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A UCLA Health-led evaluation of Los Angeles County’s pilot program aimed at bolstering aid to gravely disabled homeless residents found the initiative could offer a promising framework to improve housing and health outcomes for this vulnerable population while also relieving overburdened psychiatric hospitals.

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Black, indigenous, and people of color (BIPOC) who were infected with COVID-19 experienced greater negative aftereffects in health and work loss than did similarly infected white participants, new research finds.

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A new study led by researchers at UCLA may change the way clinicians and scientists understand, diagnose and treat placenta accreta spectrum disorder, a serious condition in which the placenta fails to separate from the uterus at birth, jeopardizing the life and health of both mother and baby.

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UCLA-led research shows targeting the protein UCHL1 could lead to a new therapeutic approach for managing these cancers

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Surgeons and scientists at UCLA Health will present data on the latest basic science, translational and health services research that has the potential to improve patient care at the 19th annual Academic Surgical (ASC) Congress in Washington, D.C., Feb. 6 to 8.

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Infants born full term to mothers who were infected with COVID-19 during pregnancy had three times the risk of having respiratory distress compared with unexposed infants. In-utero exposure increased their risk of the disorder that most often strikes premature infants.

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You may have heard about the gut microbiome and its influence on a person’s overall health and well-being.

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UCLA Health has appointed leading breast surgical oncologist Dr. Mediget Teshome as the new chief of breast surgery and director of breast health.

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A team of researchers from UCLA and UC Irvine have created a unique repository of electronic health record data and high-fidelity physiological waveform data from tens of thousands of surgeries that will integrate artificial intelligence to improve patient outcomes. 

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A new study sheds light on how autophagy, the body’s process for removing damaged cell parts, when impaired, can play a role in causing heart failure

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A new study led by researchers from the UCLA Health Jonsson Comprehensive Cancer Center shows that using high doses of radiation while integrating an ablative radiotherapy technique called stereotactic ablative radiotherapy (SABR) concurrently with chemotherapy is safe and effective in treating people with locally advanced non-small cell lung cancer that is not suitable for surgery.