Role of TGFβ1 Receptor Antagonist in Mice; Genes for AHR Receptor-Dependent Induction of CYP1A1; and More Featured in August 2019 Toxicological Sciences

Newswise — The August 2019 issue of Toxicological Sciences features contemporary reviews on cancer chemoprevention and predicting human infection risk. Tox Spotlight articles include identifying genes required for AHR receptor-dependent induction of CYP1A1 using a CRISPR/Cas9 whole-genome screen (an Open Access article); assessing drug-induced long QT and proarrhythmic risk using human stem cell-derived cardiomyocytes; measuring sensitivity to in vitro inhibition of CYP19 activity in freshwater fishes; and examining the role of TGFβ1 receptor antagonist GW788388 in mice. There also are Open Access articles on a new web portal for integrating mechanistic and toxicogenomic study results; the validation of GARD™skin Assay for chemical skin sensitizer assessment; and the role of quizalofop-p-ethyl in 3T3-L1 adipocytes.

Highlights of Toxicological Sciences Volume 170, Issue 2:

• CONTEMPORARY REVIEW: “Cancer Chemoprevention: Preclinical In Vivo Alternate Dosing Strategies to Reduce Drug Toxicities” (Free to Read)
• CONTEMPORARY REVIEW “Predicting Human Infection Risk: Do Rodent Host Resistance Models Add Value?” (Free to Read)
• TOX SPOTLIGHT “A CRISPR/Cas9 Whole-Genome Screen Identifies Genes Required for Aryl Hydrocarbon Receptor-Dependent Induction of Functional CYP1A1” (Open Access)
• TOX SPOTLIGHT “Assessing Drug-Induced Long QT and Proarrhythmic Risk Using Human Stem-Cell-Derived Cardiomyocytes in a Ca²⁺Imaging Assay: Evaluation of 28 CiPA Compounds at Three Test Sites”
• TOX SPOTLIGHT “Differential Sensitivity to In Vitro Inhibition of Cytochrome P450 Aromatase (CYP19) Activity Among 18 Freshwater Fishes”
• TOX SPOTLIGHT “The TGFβ1 Receptor Antagonist GW788388 Reduces JNK Activation and Protects Against Acetaminophen Hepatotoxicity in Mice”
• OPEN ACCESS “A Novel Open Access Web Portal for Integrating Mechanistic and Toxicogenomic Study Results”
• OPEN ACCESS “Validation of the GARD™skin Assay for Assessment of Chemical Skin Sensitizers: Ring Trial Results of Predictive Performance and Reproducibility”
• OPEN ACCESS “Quizalofop-p-Ethyl Induces Adipogenesis in 3T3-L1 Adipocytes”

Toxicological Sciences is the official journal of the Society of Toxicology (SOT), a professional and scholarly organization of more than 7,800 scientists from academic institutions, government, and industry representing the great variety of individuals who practice toxicology in the United States and other countries.