Study Explores Metabolism of Insulin-stimulating Hormone in Liver, Raises Questions about Conventional Endocrine Models

Article title: Rapid hepatic metabolism blunts the endocrine action of portally infused GLP-1 in male rats

Authors: Benedikt A. Aulinger, Marta Perabo, Randy J. Seeley, Klaus G. Parhofer, David A. D'Alessio

From the authors: "[R]esults support rapid inactivation of enterally released [glucagon-like peptide-1] in the liver as limiting endocrine actions on the b-cell, and raise questions about the conventional endocrine model of pharmacologic effects of [dipeptidylpeptidase 4] inhibitors."

This study is highlighted as one of January's "best of the best" as part of the American Physiological Society's APSselect program.