2-May-2005 4:35 PM EDT
Scripps Research Scientists Identify Infertility Molecule
Scripps Research Institute

Scientists at The Scripps Research Institute are reporting that mice created to lack a certain type of molecule known as an LPA receptor have fertility problems, which suggests that these receptors play a major role in conception.

11-May-2005 2:35 PM EDT
Scripps Scientists Describe Drug-Resistance Protein
Scripps Research Institute

Scientists at The Scripps Research Institute have solved the structure of a protein called MsbA that is involved in resisting antibiotics and chemotherapy. The structure of this membrane transporter protein is described in the current issue of the journal Science.

Released: 16-Jun-2005 1:45 PM EDT
NIH Awards $10.4 Million to Scripps Research/Scripps Florida
Scripps Research Institute

Researchers have been awarded a $10.4 million dollar grant from the NIH to establish The Scripps Research Institute Molecular Screening Center, a pilot program to discover small molecule tools for quickly translating basic biomedical discoveries into medically relevant applications.

Released: 1-Jul-2005 2:10 PM EDT
NIH Awards More than $50 Million to Solve Protein Structures
Scripps Research Institute

A consortium of scientists at The Scripps Research Institute and several other California institutions has been awarded a $52.7 million grant by the National Institute of General Medical Sciences, part of the National Institutes of Health.

Released: 26-Jul-2005 11:00 AM EDT
Scripps Summer Interns Leaving Lab to Return to Classroom
Scripps Research Institute

This marks the 6th week of an 8-week internship for twenty one students and three teachers. Over the summer, each intern becomes a member of a basic biomedical lab at Scripps, contributes to one or more research projects, and attends specially designed events including lunch seminars and a biotech company tour.

Released: 9-Aug-2005 8:35 AM EDT
NIH Awards $4.2 Million to Scripps Research
Scripps Research Institute

A team of scientists have been awarded a $4.2 million five-year grant to conduct basic science aimed at speeding the rate at which the next generation of DNA sequencing technologies will become available to scientists and clinicians.

30-Aug-2005 8:40 AM EDT
Mammalian Transcriptome Mapped
Scripps Research Institute

The FANTOM Consortium for Genome Exploration Research Group, a large international collection of scientists that includes researchers at The Scripps Research Institute's Florida campus, is reporting the results of a massive multi-year project to map the mammalian "transcriptome."

30-Aug-2005 8:45 AM EDT
Mysterious Molecules Begin to Yield Their Secrets
Scripps Research Institute

A team of investigators at The Scripps Research Institute and the Genomics Institute of the Novartis Research Foundation have discovered a way to screen hundreds and potentially thousands of "noncoding" RNA molecules to discover their functions within cells.

Released: 23-Sep-2005 2:30 PM EDT
Scripps Research Breaks Ground for Scripps Florida Campus
Scripps Research Institute

The Scripps Research Institute breaks ground today in Palm Beach County for construction of its 100-acre Scripps Florida campus, dedicated to advanced biomedical research and the application of the latest technologies in drug discovery.

Released: 23-Sep-2005 2:30 PM EDT
L. J. and F. A. De George Give $5 Million to Scripps Florida
Scripps Research Institute

Mr. and Mrs. Lawrence J. De George of Jupiter, Florida, have donated $5 million to The Scripps Research Institute to support biomedical science at the Institute's new campus in Palm Beach County.

Released: 27-Sep-2005 8:50 AM EDT
John J. Moores Donates $4 Million to Scripps Research Institute
Scripps Research Institute

San Diego business leader and philanthropist John J. Moores has contributed $4 million to The Scripps Research Institute to establish the Worm Institute for Research and Medicine to combat the painful, disfiguring, and debilitating diseases borne by worms that afflict hundreds of millions of people in much of the world.

Released: 28-Sep-2005 1:55 PM EDT
“Memory” of Nicotine Lingers in the Brain
Scripps Research Institute

Scientists at The Scripps Research Institute and Scripps Florida are reporting the results of one of the first studies looking at the long-term neurological effects of nicotine addiction on the brain's reward system. Their findings may have significant implications for people who are trying to quit smoking.

Released: 5-Oct-2005 12:00 PM EDT
Chemical Extracted from Soy Beans Inhibits Amyloidogenesis
Scripps Research Institute

Scientists at The Scripps Research Institute have discovered that a compound extracted from soy beans is a natural and potent inhibitor of a pathological process involved in a number of "amyloid" diseases, including a cluster of ailments called the familial amyloidoses.

Released: 23-Nov-2005 4:40 PM EST
Chemical Chaperones Help Increase Deficient Enzyme Activity in Gaucher Disease
Scripps Research Institute

Scientists have discovered that certain chemical chaperones help increase the activity of various types of glucocerebrosidase, the enzyme lacking in patients with Gaucher (go-SHAY) disease.

Released: 30-Nov-2005 1:25 PM EST
"Unprecedented" Functional Amyloid Plays Beneficial Role in Human Cells
Scripps Research Institute

A group of scientists at The Scripps Research Institute have shown that the amyloid protein structure, which has been linked to neurodegeneration in diseases including Alzheimer's, Parkinson's, and Huntington's, carries out an important functional role in human physiology.

Released: 28-Mar-2006 9:20 AM EST
Enzyme Inhibitors Block Replication of SARS Virus
Scripps Research Institute

Scientists at The Scripps Research Institute have discovered a class of compounds that block the SARS virus from replicating, a finding that may open the door to new drug targets against the deadly disease.

Released: 19-Apr-2006 4:10 PM EDT
Gene Candidates for Predisposition to Alcohol Abuse
Scripps Research Institute

A collaborative study by scientists at The Scripps Research Institute as part of the Integrative Neuroscience Initiative on Alcoholism Consortium (INIA) have identified some 3,800 "unique genes" that may determine a predisposition for a high degree of alcohol intake.

Released: 26-Apr-2006 10:45 PM EDT
Immune Response to HIV in the Brain
Scripps Research Institute

A team of researchers at The Scripps Research Institute has shed new light on the molecular basis of problems with brain function in models chronically infected with an immune deficiency virus similar to human immunodeficiency virus (HIV), the cause of acquired immune deficiency syndrome (AIDS).

2-May-2006 9:40 AM EDT
Guidance in Treatment of Alcohol Dependence
Scripps Research Institute

A large-scale study of different treatment approaches for alcohol dependence underlines that medication can play a key role in treatment.

Released: 7-Jul-2006 7:40 PM EDT
Prion Disease Agent Causes Heart Damage
Scripps Research Institute

A team of researchers has shown for the first time that laboratory mice infected with the agent of scrapie -a brain-wasting disease of sheep-demonstrate high levels of the scrapie agent in their heart 300 days after being infected in the brain.

Released: 11-Jul-2006 9:00 AM EDT
Strategy for Creating Actively Programmed Anti-Cancer Molecules Unveiled
Scripps Research Institute

LA JOLLA, CA, July 10, 2006 -Scientists at The Scripps Research Institute and The Skaggs Institute for Chemical Biology have developed a unique assembly strategy to produce an anti-cancer targeting antibody, an approach that combines the merits of small molecule drug design with immunotherapy.

31-Jul-2006 3:00 PM EDT
Scientists Test Anti-Obesity Vaccine
Scripps Research Institute

In what may be the first published breakthrough of its kind in the global battle against obesity, scientists at The Scripps Research Institute have developed an anti-obesity vaccine that significantly slowed weight gain and reduced body fat in animal models.

Released: 14-Sep-2006 3:45 PM EDT
Scripps, McDonald’s Align to Fight Childhood Obesity and Type 2 Diabetes
Scripps Research Institute

The Scripps Research Institute and McDonald's today announced a collaboration regarding research and educational initiatives to drive progress toward a solution to childhood obesity and Type 2 diabetes. McDonald's will contribute $2 million to The Scripps Research Institute to address these critical health issues facing America's youth.

Released: 16-Jan-2008 1:30 PM EST
Florida Philanthropists Give $1 Million to Scripps Florida
Scripps Research Institute

Florida physician, businessman and philanthropist Phillip Frost and his wife, Patricia Frost, an ardent supporter of education and the arts, have donated $1 million to Scripps Florida, the biomedical research campus under construction in Jupiter, it was announced today.

25-Feb-2008 4:45 PM EST
Scientists Studying Sepsis in Mice Find Potential Drug Targets for Deadly Disease
Scripps Research Institute

Scientists at The Scripps Research Institute have uncovered a connection between blood coagulation and the immune system that may have important implications for people with sepsis, a severe and difficult to treat disease that kills tens of thousands of Americans a year.

Released: 27-Feb-2008 3:20 PM EST
Scientists Devise Approach that Stops HIV at Earliest Stage of Infection
Scripps Research Institute

Researchers at The Scripps Research Institute have developed a new two-punch strategy against HIV and they have already successfully tested aspects of it in the laboratory.

Released: 26-Mar-2008 2:50 PM EDT
Renowned Stem Cell Researcher Jeanne F. Loring Heads New Center at Scripps Research Institute
Scripps Research Institute

Professor Jeanne F. Loring, Ph.D., has been named founding director of the newly created Center for Regenerative Medicine at The Scripps Research Institute in La Jolla, California.

Released: 29-May-2008 1:40 PM EDT
NIH Awards $20 Million CTSA Grant to Scripps Translational Science Institute
Scripps Research Institute

The National Institutes of Health (NIH) announced today that Scripps Translational Science Institute (STSI) is one of 14 research centers to receive a highly competitive $20 million Clinical and Translational Science Award (CTSA) this year. STSI, led by Eric J. Topol, M.D., is a collaborative program between The Scripps Research Institute and Scripps Health, partnering with a number of institutions in San Diego.

Released: 15-Nov-2008 4:00 PM EST
San Diego Philanthropist John Moores Gives $2.1 Million to Scripps Research Institute
Scripps Research Institute

San Diego philanthropist, businessman, and community leader John J. Moores has contributed the first gift of $2.1 million to The Scripps Research Institute's new $50 million initiative to recruit new world-class researchers and sustain and expand the work of current scientists at the renowned La Jolla- and Florida-based biomedical organization, the Institute announced today.

Released: 3-Sep-2009 2:45 PM EDT
Two New Antibodies Found to Cripple HIV
Scripps Research Institute

Findings reveal an achilles heel on the virus for AIDS vaccine researchers to exploit.

Released: 16-Feb-2010 1:15 PM EST
Richard. A. Gephardt Elected to Lead Scripps Research Institute Board of Trustees
Scripps Research Institute

The Scripps Research Institute’s Board of Trustees today unanimously elected Richard A. Gephardt, president and CEO of Gephardt Government Affairs and a former U.S. Congressman and House Majority and Minority Leader, as its new chairman.

10-Mar-2010 1:15 PM EST
Light Activated “Warhead” Turns Modest Molecules Into Super Protein Killers
Scripps Research Institute

Using a novel light activation technique, Scripps Research Institute scientists have been able to turn molecules with only a modest ability to fight specific proteins into virtual protein destroyers.

Released: 22-Mar-2010 4:35 PM EDT
Richard and Helen Devos Gift Kicks Off Drive to Endow Scripps Florida Graduate School
Scripps Research Institute

The Richard and Helen DeVos Foundation has donated $100,000 to The Scripps Research Institute that will be used to jump start a new philanthropic drive to expand the graduate school program at Scripps Florida. The program, part of Scripps Research's Kellogg School of Science and Technology, offers a doctoral degree with an emphasis on chemistry, chemical biology, biophysics, or the biological sciences.

22-Mar-2010 4:15 PM EDT
Research Team Finds Structure of “Swine Flu” Virus
Scripps Research Institute

A team of scientists from The Scripps Research Institute and other institutions has solved the structure of a key protein from the virus that caused last year’s “swine flu” influenza epidemic. The structure reveals that the virus shares many features with influenza viruses common in the early 20th century, helping to explain why, in general, older individuals have been less severely affected by the recent outbreak than younger ones.

23-Mar-2010 3:00 PM EDT
Compulsive Eating Shares Same Addictive Biochemical Mechanism with Cocaine, Heroin Abuse
Scripps Research Institute

In a newly published study, scientists from The Scripps Research Institute have shown for the first time that the same molecular mechanisms that drive people into drug addiction are behind the compulsion to overeat, pushing people into obesity.

Released: 12-Apr-2010 4:45 PM EDT
Research Scientists Solve Mystery of Fragile Stem Cells
Scripps Research Institute

Scientists at The Scripps Research Institute have solved the decade-old mystery of why human embryonic stem cells are so difficult to culture in the laboratory, providing scientists with useful new techniques and moving the field closer to the day when stem cells can be used for therapeutic purposes.

19-Apr-2010 4:30 PM EDT
Scientists Reveal How Genetic Mutations May Cause Type 1 Diabetes
Scripps Research Institute

Scientists from The Scripps Research Institute have provided an answer to the 40-year-old mystery of how certain genetic mutations lead to Type 1 diabetes. This new molecular understanding could lead to novel therapies for Type 1 diabetes and other autoimmune diseases.

26-Apr-2010 2:30 PM EDT
Scientists Solve Protein Structure Revealing Secrets of Cell Membranes
Scripps Research Institute

A team of scientists at The Scripps Research Institute and the National Institutes of Health (NIH) has discovered the structure of a protein that pinches off tiny pouches from cells’ outer membranes. Cells use these pouches, or vesicles, to carry nutrients and other essential substances, but many medicines also hitch a ride inside them.

28-Apr-2010 2:00 PM EDT
Research Team Provides Groundbreaking New Understanding of Stem Cells
Scripps Research Institute

In findings that could one day lead to new therapies, researchers from The Scripps Research Institute have described some striking differences between the biochemistry of stem cells versus mature cells.

Released: 2-Dec-2010 12:00 PM EST
Research Scientists Home In on Chemicals Needed to Reprogram Cells
Scripps Research Institute

Groundbreaking discovery moves field closer to therapeutic applications.

25-Jan-2011 2:15 PM EST
Scientists Reveal Key Mechanism Governing Nicotine Addiction
Scripps Research Institute

New research could produce novel therapies that increase natural resistance to addiction to smoking.

Released: 31-Jan-2011 8:00 AM EST
Scientists Convert Skin Cells to Beating Heart Cells
Scripps Research Institute

Breakthrough discovery offers hope for new therapies for range of diseases.

Released: 21-Feb-2011 9:00 AM EST
Scripps Research Institute Names Michael Marletta as President
Scripps Research Institute

Renowned biochemist Michael A. Marletta, PhD, has been named by the Board of Trustees today as the next president of The Scripps Research Institute, effective January 1, 2012. He will succeed President Richard A. Lerner, MD, who has led the institution for 25 years.

Released: 3-Mar-2011 2:00 PM EST
Study Points to Liver, Not Brain, as Origin of Alzheimer’s Plaques
Scripps Research Institute

Unexpected results from a Scripps Research Institute and ModGene, LLC study could completely alter scientists’ ideas about Alzheimer’s disease—pointing to the liver instead of the brain as the source of the “amyloid” that deposits as brain plaques associated with this devastating condition. The findings could offer a relatively simple approach for Alzheimer’s prevention and treatment.

   
Released: 20-Mar-2013 3:30 PM EDT
John Moores Gives $2 Million to TSRI for River Blindness Test
Scripps Research Institute

Philanthropist, businessman and community leader John Moores has given The Scripps Research Institute (TSRI) approximately $2 million to fund the development of a new field test for Onchocerciasis, or river blindness, a parasitic infection that affects tens of millions of people in Africa, Latin America and other tropical regions.

   
21-Mar-2013 6:00 AM EDT
Study Reveals How Serotonin Receptors Can Shape Drug Effects
Scripps Research Institute

A team including scientists from The Scripps Research Institute, the University of North Carolina at Chapel Hill and the Chinese Academy of Sciences has determined and analyzed the high-resolution atomic structures of two kinds of human serotonin receptor.

   
Released: 25-Mar-2013 6:00 PM EDT
Scientists Find New Compounds, Approach to Breast Cancer
Scripps Research Institute

Using a broad spectrum of analytical tools, scientists from the Florida campus of The Scripps Research Institute have uncovered a class of novel compounds that can alter cell signaling activity, resulting in a variety of responses including a strong anti-inflammatory effect.

Released: 27-Mar-2013 11:15 AM EDT
Collaborative Grant Speeds Anti-Addiction Medication
Scripps Research Institute

As part of an unprecedented national effort to develop new drugs to treat neurological disorders, scientists from the Florida campus of The Scripps Research Institute have been awarded an innovative grant from the National Institute of Neurological Disorders and Stroke to help people break their addiction to nicotine.

   
Released: 28-Mar-2013 3:40 PM EDT
New Vaccine-Design Approach Targets Viruses Such as HIV
Scripps Research Institute

A team led by scientists from The Scripps Research Institute and the International AIDS Vaccine Initiative has unveiled a new technique for vaccine design that could be particularly useful against HIV and other fast-changing viruses.

   
1-Apr-2013 1:00 PM EDT
Revealed: Elusive Mechanism of Widely Used Click Reaction
Scripps Research Institute

Scientists at The Scripps Research Institute have illuminated the mechanism at the heart of one of the most useful processes in modern chemistry. A reaction that is robust and easy to perform, it is widely employed to synthesize new pharmaceuticals, biological probes, new materials and other products.


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