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Insights on How SHARPIN Promotes Cancer Progression

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SBP and Technion Institute researchers have SHARPIN-ed their knowledge of how a malicious form of a protein drives the formation of melanoma through modulation of the PRMT5 pathway. The new research was published in The Journal of Clinical...
11-Dec-2017 4:00 PM EST Add to Favorites

Research Suggests New Pathways for Hyperaldosteronism

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Scientists have identified a mechanism that explains the development of hyperaldosteronism, a condition in which the adrenal glands produce too much aldosterone, The findings, published in JCI Insight, offer a path for drug discovery to treat the...
7-Dec-2017 9:05 AM EST Add to Favorites

D’Angelo Receives American Cancer Society Research Scholar Grant

Maximiliano D’Angelo, Ph.D., an assistant professor at Sanford Burnham Prebys Medical Discovery Institute (SBP), has received a four-year, $792,000 Research Scholar Grant from the American Cancer Society.
1-Dec-2017 5:00 AM EST Add to Favorites

Scientists Find Key to Regenerating Blood Vessels

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Florida researchers have identified a signaling pathway that is essential for angiogenesis, the growth of new blood vessels from pre-existing vessels. The findings, published in Nature Communications, may improve current strategies to improve blood...
20-Nov-2017 2:00 PM EST Add to Favorites

Preclinical Study Demonstrates Promising Treatment for Rare Bone Disease

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Researchers have demonstrated that the drug palovarotene suppresses the formation of bony tumors (osteochondromas) in models of multiple hereditary exostoses (MHE). The research, published in the Journal of Bone and Mineral Research, is an important...
21-Nov-2017 9:00 AM EST Add to Favorites

New Player in Alzheimer’s Disease Pathogenesis Identified

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Scientists have shown that a protein called membralin is critical for keeping Alzheimer’s disease pathology in check. The study, published in Nature Communications, shows that membralin regulates the cell’s machinery for producing beta-amyloid...
13-Nov-2017 5:00 PM EST Add to Favorites

Biomarker May Predict Early Alzheimer’s Disease

Researchers at SBP have identified a peptide that could lead to the early detection of Alzheimer’s disease (AD). The discovery, published in Nature Communications, may also provide a means of homing drugs to diseased areas of the brain to treat...
8-Nov-2017 10:00 AM EST Add to Favorites

How SORLA Protects Against Alzheimer’s Disease

Researchers have identified a new protective function for a brain protein genetically linked to Alzheimer’s. The findings, published in the Journal of Experimental Medicine, could inform novel treatment strategies to combat neurodegenerative...
7-Nov-2017 9:00 AM EST Add to Favorites

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