Hypoxia can get more ability to inhibit inflammation. But how it impact on survival time of mesenchymal stem cells (MSCs) is confusing and how preconditioned MSCs inhibiting inflammation are partially known. Those issues decided the value o
BACKGROUNDOsteoporosis (OP) has become a major public health problem worldwide. Most OP treatments are based on the inhibition of bone resorption, and it is necessary to identify additional treatments aimed at enhancing osteogenesis. In the
Knee osteoarthritis is a degenerative condition with a significant disease burden and no disease-modifying therapy. Definitive treatment ultimately requires joint replacement. Therapies capable of regenerating cartilage could significantly
A newly developed nanomaterial that mimics the behavior of proteins could be an effective tool for treating Alzheimer’s and other neurodegenerative diseases. The nanomaterial alters the interaction between two key proteins in brain cells — with a potentially powerful therapeutic effect.
A research team has provided an overview for understanding the genetic basis of ornamental and cold resistance traits in Mei (Prunus mume), a tree valued both for its ornamental and cultural significance in China.
Factor Bioscience Inc., a Cambridge-based biotechnology company focused on developing mRNA and cell-engineering technologies, announced its participation in the American Society of Gene & Cell Therapy (ASGCT) 27th Annual Meeting to be held in Baltimore, MD from May 7-11, 2024.
University of Maryland School of Medicine (UMSOM) Dean Mark T. Gladwin, MD, announced today that Martine Rothblatt PhD, JD, MBA, Chairperson and CEO of United Therapeutics, and inventor of SiriusXM Satellite Radio, will deliver the keynote address for this year’s graduating medical student class. The UMSOM MD graduation ceremony will take place at the Hippodrome Theatre on Thursday, May 16, 2024.
BACKGROUNDThe bone remodeling during orthodontic treatment for malocclusion often requires a long duration of around two to three years, which also may lead to some complications such as alveolar bone resorption or tooth root resorption. Lo
Cumulative evidence suggests that O-linked β-N-acetylglucosaminylation (O-GlcNAcylation) plays an important regulatory role in pathophysiological processes. Although the regulatory mechanisms of O-GlcNAcylation in tumors have been graduall
BACKGROUNDMesenchymal stem cells (MSCs) modulated by various exogenous signals have been applied extensively in regenerative medicine research. Notably, nanosecond pulsed electric fields (nsPEFs), characterized by short duration and high st
BACKGROUNDStem cell transplantation is a promising therapeutic option for curing perianal fistula in Crohn’s disease (CD). Anti-tumor necrotic factor (TNF) therapy combined with drainage procedure is effective as well. However, previous s
Mesenchymal stromal cells (MSCs) hold great promise for tissue regeneration in debilitating disorders. Despite reported improvements, the short-term outcomes of MSC transplantation, which is possibly linked to poor cell survival, demand ext
BACKGROUNDThe self-assembly of solid organs from stem cells has the potential to greatly expand the applicability of regenerative medicine. Stem cells can self-organise into microsized organ units, partially modelling tissue function and re
Mesenchymal stem cells (MSCs) are stem/progenitor cells capable of self-renewal and differentiation into osteoblasts, chondrocytes and adipocytes. The transformation of multipotent MSCs to adipocytes mainly involves two subsequent steps fro
High glucose (HG) culture conditions in vitro and persistent exposure to hyperglycemia in diabetes patients are detrimental to stem cells, analogous to any other cell type in our body. It interferes with diverse signaling pathways, i.e. mam
Psilera, a leading biotechnology company developing groundbreaking therapies for hard-to-treat neurological disorders, is pleased to announce the appointment of Magali Haas, M.D., Ph.D., to its esteemed Board of Directors.
Human artificial chromosomes (HACs) capable of working within human cells could power advanced gene therapies, including those addressing some cancers, along with many laboratory applications, though serious technical obstacles have hindered their development.
Kazia Therapeutics Limited (NASDAQ: KZIA), a biotechnology company specialising in oncology, is pleased to announce that it has entered into an exclusive licensing agreement with Sovargen Co., Ltd, a biotechnology company specializing in central nervous system (CNS) diseases, to develop, manufacture and commercialise paxalisib as a potential treatment of intractable epilepsy in focal cortical dysplasia type 2 (FCD T2) and tuberous sclerosis complex (TSC) disease.
Fungi naturally produce all the ingredients needed for a cruelty-free meat substitute. Our scientists are exploring how tuning the genomes of mushrooms and molds can transform these food sources into gourmet, nutrient-packed meals made with minimal processing and a light environmental footprint.
With the Leopoldina Prize for young scientists 2023, German National Academy of Sciences Leopoldina honors Dr. Jingyuan Xu, who researches novel heating and cooling technologies for the energy transition at Karlsruhe Institute of Technology (KIT). Currently, the young engineer can boast two more significant awards: the Hector RCD Award as well as admission to the Global Young Academy, an exclusive association of international young scientists.
An injectable hydrogel can mitigate damage to the right ventricle of the heart with chronic pressure overload, according to a new study published March 6 in Journals of the American College of Cardiology: Basic to Translational Science. The study, by a research team from the University of California San Diego, Georgia Institute of Technology and Emory University, was conducted in rodents.
In this new video, Eysenbach shares the origins of the Journal of Medical Internet Research and the driving forces that led him to establish an open access digital health journal. His passion for publishing, coupled with a background in medicine and information and computer science, fueled his vision to leverage the internet's transformative power in making medical information accessible to both professionals and consumers.
Discover BMB, the annual meeting of the American Society for Biochemistry and Molecular Biology will be held March 23–26 in San Antonio. Secure your front-row seat to cutting-edge findings, approaches and technologies in the biological sciences by registering for a complimentary press pass to attend in person or to access press materials electronically.
A team of Iowa State University researchers developed protocols for growing organoids that mimic a turtle liver, the first organoids developed for a turtle and only the second for any reptile. The discovery will aid deeper study of turtle genetics, including the cause of traits with potential medical applications for humans such as the ability to survive weeks without oxygen.
The National Science Foundation has granted $15 million to the Integrative Movement Sciences Institute at the University of California, Irvine. This six-year funding, part of the NSF’s Biology Integration Institutes program, will support groundbreaking research led by Monica Daley, professor of ecology & evolutionary biology at the UCI School of Biological Sciences.
A greater understanding of how plants and microbes work together to store vast amounts of atmospheric carbon in the soil will help in the design of better bioenergy crops for the fight against climate change. Deciphering the mechanics of this mutually beneficial relationship is, however, challenging as conditions in nature are extremely difficult for scientists to replicate in the laboratory. To address this challenge, researchers created fabricated ecosystems or EcoFABs.
Bridging precision engineering and precision medicine to create personalized physiology avatars. Pursuing on-demand tissue and organ engineering for human health. Revolutionizing neuroscience by using AI to engineer advanced brain interface systems. Engineering the immune system for health and wellness. Designing and engineering genomes for organism repurposing and genomic perturbations.
Digital Science is pleased to announce that ReadCube, an award-winning leader in literature management and full-text document delivery, has launched a new solution for research-driven organizations – known simply as Literature Review by ReadCube.
Digital Science is pleased to announce that ReadCube, an award-winning leader in literature management and full-text document delivery, has launched a new solution for research-driven organizations – known simply as Literature Review by ReadCube.
Utilization of crude glycerol generated as a by-product from biodiesel production process, for the production of high value-added products, represents an opportunity to overcome the negative impact of low glycerol prices in the biodiesel industry. In the present investigation, alternative ways of valorization of crude glycerol have been provided, by using this renewable material as substrate by natural yeasts of the Generally Recognized As Safe (GRAS) species Yarrowia lipolytica.
The device, developed by researchers at the University of Illinois Urbana-Champaign, is silicon-based and takes advantage of techniques developed for microelectronics manufacturing.
From the invention of the wheel to the advent of the printing press to the splitting of the atom, history is replete with cautionary tales of new technologies emerging before humanity was ready to cope with them.
Dr. Phillip Ligrani, Eminent Scholar in Propulsion at The University of Alabama in Huntsville (UAH), has won the 2024 American Society of Mechanical Engineers (ASME) Henry R. Worthington Medal for developing innovative micro, millimeter and macro-scale pumping devices. Ligrani’s innovations are beneficial to a variety of applications, such as transporting biological samples without significant alteration or destruction of cells, and supplying coolant to maintain the temperatures of components subject to thermal loading, like lasers.
Membranes of vertically aligned carbon nanotubes (VaCNT) can be used to clean or desalinate water at high flow rate and low pressure. Recently, researchers of Karlsruhe Institute of Technology (KIT) and partners carried out steroid hormone adsorption experiments to study the interplay of forces in the small pores. They found that VaCNT of specific pore geometry and pore surface structure are suited for use as highly selective membranes. The researchers report in Nature Communications. (DOI: 10.1038/s41467-024-44883-2)
The recent approval of a CRISPR-Cas9 therapy for sickle cell disease demonstrates that gene editing tools can do a superb job knocking out genes to cure hereditary disease.
Any drug that is taken orally must pass through the lining of the digestive tract. Transporter proteins found on cells that line the GI tract help with this process, but for many drugs, it’s unknown which of those transporters they use to exit the digestive tract.
One of the most invasive Australian weeds is being touted as a potential economic crop, with benefits for the construction, mining and forestry industries, and potentially many First Nations communities.
Dustin Tyler, the Kent H. Smith II Professor of Biomedical Engineering at CWRU’s Case School of Engineering, co-founded a company that restores for people the sensation of touch—with help from a set of electrical rings that fit snugly on users’ fingers—from a distance.
The qualities of flowing blood, or hemodynamics, hold important insights into vascular diseases, but technological limitations have largely kept measurements of these properties out of reach in the clinic. Now, there may be a potential solution on the horizon.
Columbia Biomedical Engineer Ke Cheng has developed a technique that uses inhalation of exosomes, or nanobubbles, to directly deliver IL-12 mRNA to the lungs of mice.
In a study involving nearly 1,000 patients seen at the Baltimore Convention Center Field Hospital (BCCFH) during a five-month period in 2022 — researchers at Johns Hopkins Medicine, the University of Maryland School of Medicine and five other collaborators report that a rapid antigen test (RAT) for detecting SARS-CoV-2, the virus that causes COVID-19, can be used at home with accuracy comparable to the same test being administered by a health care professional.
Results from phase two clinical trials at UT Southwestern Medical Center showed that a suspension of gold nanocrystals taken daily by patients with multiple sclerosis (MS) and Parkinson's disease (PD) significantly reversed deficits of metabolites linked to energy activity in the brain and resulted in functional improvements.
Over 100,000 individuals in the United States are currently in need of organ transplants. The demand for organs, such as hearts, kidneys, and livers, far exceeds the available supply and people sometimes wait years to receive a donated organ.
Researchers at the Icahn School of Medicine at Mount Sinai have identified a new approach to controlling bacterial infections. The findings were described in the February 6 online issue of Nature Structural & Molecular Biology.