Mayo Clinic's Todd and Karen Wanek Family Program for Hypoplastic Left Heart Syndrome (HLHS) and Children's of Alabama announce their collaboration within a consortium to provide solutions for patients with hypoplastic left heart syndrome, a rare and complex form of congenital heart disease in which the left side of the heart is severely underdeveloped.
Doctors need better ways to detect and monitor heart disease, the leading cause of death in industrialized countries. Researchers have developed an improved optical imaging technique that found differences between potentially life-threatening coronary plaques and those posing less imminent danger for patients with coronary artery disease. Their method may give cardiologists additional data to identify patients at higher risk of future heart attacks and help them improve medical therapy.
The inventors of a cancer immunotherapy developed at Roswell Park Comprehensive Cancer Center have announced a major step forward with that therapy, SurVaxM — a multimillion-dollar licensing deal that will help enable large, randomized clinical trials in both the U.S. and China.
A Mayo Clinic-led study involving 3,276 patients has found that people with inflammatory bowel disease, Type 1 diabetes or blood clots may be at increased risk of developing rheumatoid arthritis. The study, published in Mayo Clinic Proceedings, also found that people who have rheumatoid arthritis are at increased risk of developing heart disease, blood clots and sleep apnea.
Scientists at Sanford Burnham Prebys Medical Discovery Institute have identified a combination of two anti-cancer compounds that shrank pancreatic tumors in mice—supporting the immediate evaluation of the drugs in a clinical trial. U.S. Food and Drug Administration (FDA)–approved versions of the compounds are used today to treat certain leukemias and solid tumors, including melanoma. The study was published in Nature Cell Biology.
National Institutes of Health researchers found that a single, low-dose ketamine infusion was relatively free of side effects for patients with treatment-resistant depression. Elia Acevedo-Diaz, M.D., Carlos Zarate, M.D., and colleagues at the NIH's National Institute of Mental Health (NIMH) report their findings in the Journal of Affective Disorders.
The largest-ever clinical trial of a medication for pediatric cardiology patients found that an oral drug significantly improved exercise capacity in adolescent patients with severe, congenital single-ventricle heart defects. A study leader says the physiologic benefits represent a milestone in pediatric cardiology.
The Enhanced Lifestyles for Metabolic Syndrome (ELM) Trial, a multisite test of two lifestyle treatments for a dangerous cluster of sub-disease indicators called the metabolic syndrome, is now accepting applicants at five medical centers around the country.
University of North Carolina Lineberger Comprehensive Cancer Center researchers have discovered a promising method to identify aggressive breast cancer tumors that will respond to drugs that unleash the immune system against cancer.
According to new research findings presented this week at the 2019 ACR/ARP Annual Meeting, supportive laboratory assays to diagnose lupus, specifically the antinuclear antibody (ANA) test, are less often offered in developing nations due to a relative lack of resources.
According to new research findings presented at the 2019 ACR/ARP Annual Meeting, methotrexate did not demonstrate superior efficacy over placebo for pain relief and function evolution at three and 12 months in patients with erosive hand osteoarthritis, but did significantly reduce the progression of joint damage over placebo and seems to facilitate bone remodeling in these patients
The American College of Rheumatology (ACR) is previewing draft recommendations from an updated treatment guideline for managing patients with gout during the 2019 ACR/ARP Annual Meeting in Atlanta.
One of the many advertised benefits of vitamin D and fish oil supplements is that they reduce systemic inflammation, which in turn could help prevent certain chronic illnesses. However, a first-of-its-kind study published in AACC’s journal Clinical Chemistry has discovered that these two supplements do not actually reduce inflammation in healthy individuals, a finding that could help consumers make more informed choices about which supplements they decide to take.
As the winter months approach, nearly 100 Alaskan sled dogs between the ages of 8 and 13 – former athletes past their glory days – are participating in a $4.2 million study at Cornell University in a quest for one of the holy grails of medicine: how to slow aging.
Obesity increases a number of adverse health consequences including reduced health-related quality of life. But little is known about the relationship between weight loss and changes in quality of life.
The Human Immune Monitoring Center (HIMC) at the Icahn School of Medicine at Mount Sinai will apply cutting-edge high-throughput technologies to evaluate the therapeutic effects of Libtayo® (cemiplimab-rwlc), a PD-1 antibody blockade developed by biotechnology company Regeneron Pharmaceuticals, Inc and Sanofi.
Physician and human rights activist Steven Miles, MD, Professor Emeritus of Medicine and Bioethics at the University of Minnesota, won the 2019 MacLean Center Prize in Clinical Ethics and Health Outcomes.
An international team of researchers has used nanoparticles to deliver a drug—one that previously failed in clinical trials for pain—into specific compartments of nerve cells, dramatically increasing its ability to treat pain in mice and rats. The findings are published Nov. 4 in Nature Nanotechnology.
A phase three clinical trial that UT Southwestern participated in determined that a three-drug combination improved lung function and reduced symptoms in cystic fibrosis (CF) patients who have a single copy of the most common genetic mutation for the disease.
Three researchers at the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA have received awards totaling more than $18 million from the California Institute for Regenerative Medicine, the state’s stem cell agency.
A federally funded study by Johns Hopkins Medicine researchers shows that wearable accelerometers — mechanical sensors worn like a watch, belt or bracelet to track movement — are a more reliable measure of physical activity and better than patient surveys and other methods used by physicians at assessing five-year risk of death in older adults.
November is national Pancreatic Cancer Awareness month. This year alone, more than 56,000 Americans will be diagnosed with pancreatic cancer. Pancreatic tumors are particularly aggressive and hard to treat "due to a mutational profile that makes it resistant to therapies that work better for other tumor types," explains Angela Alistar, MD, medical director of GI oncology at Morristown Medical Center. Dr. Alistar, an internationally known expert on pancreatic cancer, is now enrolling patients in five clinical trials aimed at pancreatic cancer.
A St. Jude Children’s Research Hospital study lowered the rate of relapse for patients with acute lymphoblastic leukemia.
A new study of 3,000 people in Wisconsin aged 21 and older with Down syndrome, published today [Monday, Oct. 28, 2019] in JAMA Neurology by researchers at the University of Wisconsin–Madison, shows that by age 55, three in five will be diagnosed with Alzheimer’s disease or a similar neurodegenerative condition. Meanwhile, people without Down syndrome are rarely diagnosed with dementia before age 65.
The National Comprehensive Cancer Network (NCCN®) Oncology Research Program (ORP) announces plans to support a phase II randomized trial for lung cancer patients with EGFR mutation or who have never smoked.
Seqster, the award-winning SaaS-based technology platform enabling consumer-centered health data management, today announced a 3-year licensing deal and partnership with La Jolla Institute of Immunology (LJI) to support the execution of a $6.9 million Asthma study funded by the National Institutes of Health/National Heart, Lung and Blood Institute (NIH NHLBI) that establishes one of only 10 PrecISE Network Clinical Centers nationwide.
Johns Hopkins Medicine has named Christina Tsien, M.D., the clinical director of the new Johns Hopkins National Proton Center at Sibley Memorial Hospital. Curtiland Deville, M.D., will serve as the associate proton director, while retaining his role as the clinical director for the radiation oncology clinic at Sibley Memorial Hospital.
In the first retrospective cohort study of the functional medicine model, Cleveland Clinic researchers found that functional medicine was associated with improvements in health-related quality of life. The study was published today in the Journal of the American Medical Association Network Open.
Atlantic Health System is treating patients in a new Phase 2 clinical trial of CAR T-cell therapy at Morristown Medical Center. A select number of sites across the U.S. are involved in this study, which is done on an outpatient basis. The study is sponsored by Juno Therapeutics, Inc. The study’s principal investigator, Mohamad Cherry, MD, medical director of hematology for Atlantic Health System Cancer Care, is a nationally known expert at treating and researching blood-related cancers such as lymphoma, leukemia and myeloma. Dr. Cherry is triple board-certified in internal medicine, hematology and medical oncology
Dr. Christopher E. Rudd has discovered a new cell therapy approach that boosts the immune response of T lymphocytes to malignant tumours.
NYU Langone Health and its Perlmutter Cancer Center have launched clinical whole genome DNA methylation profiling for patients with brain tumors. This leading-edge molecular assay utilizes DNA epigenetic signatures and artificial intelligence with machine learning to correctly identify and subtype brain tumors. NYU Langone Health is the first Clinical Laboratory Improvement Amendments (CLIA)-certified laboratory in the United States to receive state approval (New York State Department of Health) for whole genome DNA methylation for diagnosis and classification of brain tumors.
A universal influenza vaccine with the potential to be longer lasting and more effective than commercially available vaccines is destined for human clinical trials, thanks to a $17.9 million grant from the National Institute of Allergy and Infectious Diseases.
The 2018 federal Right to Try Act allows patients with a life-threatening illness to be treated with drugs that have not yet been approved by the Food and Drug Administration (FDA). Many in the oncology community say Right to Try strips away important regulatory protections and view the move as a risky step bound to create ethical dilemmas for physicians whose goal is to guide patients toward safe and appropriate treatment decisions. Oncology is one field at the forefront of requests for unapproved drugs. An interdisciplinary team of bioethicists, oncologists, and lawyers from Penn Medicine and other institutions penned a commentary published online this week in the Journal of Clinical Oncology to offer recommendations to help oncologists navigate this new “Right to Try” world, while maintaining their ethical obligations to patients.
New Precision Immunotherapy Therapy clinic at Moores Cancer Center at UC San Diego Health matches patients using genetic profiling to personalized cancer treatment plans.
A study published today in The New England Journal of Medicine found that in patients seen for heartburn unresponsive to treatment with Proton Pump Inhibitors (PPIs), an extensive, systematic workup revealed truly PPI-refractory and reflux-related heartburn in only a minority of cases. In other words, most patients with heartburn unrelieved by PPIs did not have gastroesophageal reflux disease (GERD) causing the symptom. Furthermore, for the selected subgroup identified as having reflux-related, PPI-refractory heartburn, surgery that corrects reflux was significantly superior (67% success rate) to continued medical therapy (28% success rate).
A multi-center randomized clinical trial evaluating a new artificial pancreas system — which automatically monitors and regulates blood glucose levels — has found that the new system was more effective than existing treatments at controlling blood glucose levels in people with type 1 diabetes.The study showed that the system improved participants’ blood glucose control throughout the day and overnight.
Study based at the Icahn School of Medicine at Mount Sinai and other centers finds new system has safety, efficacy benefits for people with type 1 diabetes
Researchers from Massachusetts Eye and Ear, Harvard Medical School and a team of EPFL researchers have developed a conformable electrode implant that will allow people with a dysfunctional inner ear to hear again. This new technology would improve existing auditory brainstem implants, which have a number of shortcomings.
Breast medical oncologist Ursa Brown-Glaberman, MD, wants to catch life-threatening breast cancers earlier, when these women have many more treatment choices and a much better chance of beating the disease. She leads the TMIST study at the UNM Cancer Cancer. The study compares tomosynthesis with 2-dimensional digital mammography for breast cancer screening.
This month, the UCLA Jonsson Cancer Center has launched a pioneering chimeric antigen receptor (CAR) T cell immunotherapy trial that will attack cancer cells by simultaneously recognizing two targets – CD19 and CD20 – that are expressed on B-cell lymphoma and leukemia.
UC San Diego Health has enrolled its first patient to evaluate a hand-held technology to fragment kidney stones. The clinical trial will assess the safety and effectiveness of breaking up kidney stones using acoustic energy.
In a media roundtable at 11 a.m. U.S. Central on Tuesday, October 15, leading neuroscientists will summarize key science being presented at the American Neurological Association’s 2019 Annual Meeting (ANA2019). Reporters may attend in person or dial in.
Psilocybin, a psychedelic drug believed to help rewire the brain, is now being studied to relieve treatment-resistant depression at The University of Texas Health Science Center at Houston (UTHealth) as part of a global Phase II clinical trial.
Georgetown University Medical Center, a Lewy Body Dementia (LBD) Association Research Center of Excellence, is now offering three clinical trials to study new treatments for LBD, a disease often confused with Parkinson’s and Alzheimer’s disease.
Researchers in WMG at the University of Warwick have developed a new method that could solve the problem of how to automate support of managing the complexities of care when applying multiple clinical practice guidelines, to patients with more than one medical issue.
A new nationwide clinical trial hopes to discover if patients that experience cardiac arrest survive more often and have a better recovery based on how long they have their body temperature cooled.
A new test to determine whether antibiotics will be effective against certain bacterial infections is helping physicians make faster and better prescription treatment choices.
Dr. McDonald has made seminal contributions as leader of the international CINRG (“Synergy”) Duchenne Natural History Study.
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