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A UCLA-led study suggests women who are 65 years old or older with high-risk breast cancer and are treated with chemotherapy are more likely to develop a substantial decline in physical function.

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Investigators at the UCLA Health Jonsson Comprehensive Cancer Center have pinpointed a combination immunotherapy treatment that enhances the immune response for people with malignant gliomas, an aggressive type of brain tumor that is fast growing and difficult to treat.

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UCLA Health researchers have discovered a mechanism that creates memories while reducing metabolic cost, even during sleep. This efficient memory occurs in a part of the brain that is crucial for learning and memory, and where Alzheimer’s disease begins.

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UCLA Health is set to host a unique symposium this week to explore the evolving research in psychedelic therapies and how combining it with reconnection to natural world could help to amplify their mental health benefits.

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A brief roundup of news and story ideas from the experts at UCLA Health.

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Four proposed state-of-the art image search engines for automating search and retrieval of digital histopathology slides were found to be of inadequate performance for routine clinical care. Some had less than 50% accuracy, which is not suitable for clinical practice.

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Researchers say a machine learning tool can identify many patients with rare, undiagnosed diseases years earlier, potentially improving outcomes and reducing cost and morbidity. The findings, led by researchers at UCLA Health, are described in Science Translational Medicine.

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A simple blood test could allow doctors to determine whether a person may be at higher risk for stroke or cognitive decline during their lifetime, according to a new UCLA Health study.

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Challenges remain in ensuring equitable access to screening and addressing gaps in evidence regarding supplemental screening modalities and the adoption of artificial intelligence (AI) technologies, notes Joann Elmore, MD, MPH, a professor of medicine at the David Geffen School of Medicine at UCLA in a newly published editorial in JAMA.

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UCLA Health is part of a multi-institution research team to receive a contract for up to $33 million from the federal Advanced Research Projects Agency for Health (ARPA-H) for the development of new treatments specifically focused on joint regeneration for osteoarthritis.

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For undocumented Latinx patients who sought care in the emergency room during the pandemic, the reported rate of having received the COVID-19 vaccine was found to be the same as U.S. citizens, a new UCLA Health study found.

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Faculty, scientists, and urologists from UCLA Health Urology will present research data on the latest discoveries and innovations in urology at the 2024 American Urological Association’s (AUA) Annual Meeting in San Antonio, Texas, May 3-6.

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A new UCLA Health study found certain genetic variants could help explain how long-term pesticide exposure could increase the risk of Parkinson’s disease.

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The FDA approval was based on results of the QUILT 3.032 clinical trial, which was led by Dr. Karim Chamie, associate professor urology at the David Geffen School of Medicine at UCLA and a researcher at the UCLA Health Jonsson Comprehensive Cancer Center.

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Patients have lower rates of mortality and hospital readmissions when treated by female physicians, with female patients benefitting more than their male counterparts.

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UCLA Health researchers will be co-principal investigators in the Untangling Addiction program launched this year by the nonprofit health research organization Wellcome Leap. The three-year, $50 million project includes 13 other partnering universities and organizations and is aimed at developing new ways to quantify addiction risk and progression through biomarkers.

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A new analysis by researchers at UCLA Health found that mortality rates of middle-aged Black Americans caused by the “deaths of despair” -- suicide, drug overdose and alcoholic liver disease – surpassed the rate of white Americans in 2022.

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A mutation in a protein regulating natural killer (NK) cells’ function is at the root of immune deficiency in some people with a rare genetic condition characterized by cognitive and developmental delay, seizures, and other manifestations. The findings also have broader implications for immunity and cell therapies.

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A pilot study led by UCLA Health Jonsson Comprehensive Cancer Center investigators suggests that for people with borderline resectable pancreatic cancer, administrating an immunotherapy drug in combination with chemotherapy before surgery is safe and may improve long-term outcomes.

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Study finds that lonely women experienced increased activation in regions of the brain associated with food cravings.

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Women with serious mental illness (SMI) who are pregnant or planning a pregnancy face gaps in information, support and resources in mental health services. The findings highlight the need to integrate pregnancy and parenting interventions, education, and other resources for women with SMI.

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Dr. Rhonda Voskuhl, a professor of neurology at UCLA Health, has been awarded the 2024 John Dystel Prize for Multiple Sclerosis Research in recognition of her outstanding contributions to multiple sclerosis research and treatment.

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HERSTORY is focused on understanding genetic, environmental, socio-economic, and other determinants of cancer in women with a family history of the disease.

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The results of a UCLA study suggest that using CXCL9 and CXCL10-producing dendritic cells alongside immunotherapy can be a promising strategy to overcome treatment resistance and improve clinical outcomes for patients with non-small cell lung cancer.

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The annual meeting will feature more than 40 regular, late-breaking and clinical trial abstracts from UCLA physicians and scientists, who will present their latest work in key areas of translational and basic scientific research, including new compounds and drug targets, combination immunotherapy approaches, updated organoid models, survivorship research and more.

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A vaccine against the bacterium that causes melioidosis was highly protective against the disease, which is endemic in many tropical areas, causing approximately 165,000 cases with 89,000 fatalities around the world each year. It is so dangerous that it is categorized as a Tier 1 Select Agent of bioterrorism.

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A new treatment approach that combines a targeted therapy drug with hormone therapy significantly increased the amount of time a person with stage 2 or 3 HR-positive, HER2-negative early breast cancer lives without the cancer returning, according to a new study co-led by UCLA Health Jonsson Comprehensive Cancer Center investigators.

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Text nudges encouraging people to get the COVID-19 vaccine, which had proven effective in prior real-world field tests, are also effective at prompting people to get a booster. The key in both cases is to include in the text a sense of ownership in the dose awaiting them.