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Released: 2-May-2022 12:05 PM EDT
Mapping Study Yields Novel Insights into DNA-Protein Connection, Paving Way for Researchers to Target New Treatments
 Johns Hopkins Bloomberg School of Public Health

DNA-to-protein mapping could help researchers understand some health disparities.

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Released: 2-May-2022 12:00 PM EDT
A novel ALDH1A1 Inhibitor Blocks Platinum-Induced Senescence and Stemness in Ovarian Cancer
 Preprints

Ovarian cancer is a deadly disease attributed to late-stage detection as well as recurrence and development of chemoresistance. Ovarian cancer stem cells (OCSCs) are hypothesized to be largely responsible for emergence of chemoresistant tumors.

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Released: 2-May-2022 12:00 PM EDT
Hypoxia-induced reprogramming of glucose-dependent metabolic pathways maintains the stemness of human bone marrow-derived endothelial progenitor cells
 Preprints

Dongni Lin, Kaihao Yan, Lingyun Chen, Junxiong Chen, Jianing Xu, Zhijing Xie, Zhujun Li, Shuo Lin, Jinghuan Li, Zhenzhou Chen

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Newswise: Hospitals Can Reduce Antibiotic Overuse by Avoiding Unnecessary Blood Draws in Critically Ill Children, Study Shows
Released: 2-May-2022 11:05 AM EDT
Hospitals Can Reduce Antibiotic Overuse by Avoiding Unnecessary Blood Draws in Critically Ill Children, Study Shows
 Johns Hopkins Medicine

A Johns Hopkins Children’s Center-led national quality improvement collaborative highlights a “less is more” method that may prevent antibiotic overprescribing

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Newswise: Lighting the tunnel of plant evolution: Scientists explore importance of two-pore channels in plants
Released: 2-May-2022 10:05 AM EDT
Lighting the tunnel of plant evolution: Scientists explore importance of two-pore channels in plants
 Tokyo University of Science

Two-pore channels (TPCs) are ancient ion channels present in the cells of both animals and plants.

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Newswise: Scientists Detail Brain Dynamics Implicated in Neurological Conditions
Released: 2-May-2022 10:05 AM EDT
Scientists Detail Brain Dynamics Implicated in Neurological Conditions
 University of North Carolina School of Medicine

This research in mice provides evidence for how dynamics in the default mode network of the brain are altered by activating the locus coeruleus region – a small nucleus in the brainstem that releases norepinephrine. It also suggests new targets for treatment to restore DMN function.

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Newswise: Study Explains Why Sense of Touch Varies Among Individuals
Released: 2-May-2022 10:05 AM EDT
Study Explains Why Sense of Touch Varies Among Individuals
New York Institute of Technology, New York Tech

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Released: 2-May-2022 10:05 AM EDT
Mayo Clinic research finds AI-enabled ECGs may identify patients at greater risk of stroke, cognitive decline
Mayo Clinic

Atrial fibrillation, the most common cardiac rhythm abnormality, has been linked to one-third of ischemic strokes, the most common type of stroke. But atrial fibrillation is underdiagnosed, partly because many patients are asymptomatic.

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Newswise: New Research Supports Combining Two Clinical Cancer Drugs to Treat Specific Type of Colorectal Cancers
Released: 2-May-2022 10:05 AM EDT
New Research Supports Combining Two Clinical Cancer Drugs to Treat Specific Type of Colorectal Cancers
 Case Western Reserve University

Researchers at the Case Western Reserve University School Medicine have found that combining two cancer drugs can be effective in treating a specific type of colorectal cancer, according to a new study published in Nature Communications.

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Newswise: Story tips: Fueling up on savings, COVID’s behavior effect, cosmic collisions, seismic and sound, and space-to-ground comms
Released: 2-May-2022 9:40 AM EDT
Story tips: Fueling up on savings, COVID’s behavior effect, cosmic collisions, seismic and sound, and space-to-ground comms
 Oak Ridge National Laboratory

ORNL story tips: Fueling up on savings, COVID’s behavior effect, cosmic collisions, seismic and sound, and space-to-ground comms

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Newswise: Public Beware: Study Finds Potential for Massive Cancer Nutrition Misinformation on Pinterest
Released: 2-May-2022 9:25 AM EDT
Public Beware: Study Finds Potential for Massive Cancer Nutrition Misinformation on Pinterest
 Sylvester Comprehensive Cancer Center

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Newswise: Researchers Develop Smartphone-Powered Microchip for at-Home Medical Diagnostic Testing
Released: 2-May-2022 9:00 AM EDT
Researchers Develop Smartphone-Powered Microchip for at-Home Medical Diagnostic Testing
 University of Minnesota College of Science and Engineering

A University of Minnesota Twin Cities research team has developed a new microfluidic chip for diagnosing diseases that uses a minimal number of components and can be powered wirelessly by a smartphone. The innovation opens the door for faster and more affordable at-home medical testing.

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Released: 2-May-2022 8:30 AM EDT
‘Resetting’ the Injured Brain Offers Clues for Concussion Treatment
 Ohio State University

New research in mice raises the prospects for development of post-concussion therapies that could ward off cognitive decline and depression, two common conditions among people who have experienced a moderate traumatic brain injury.

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Released: 2-May-2022 8:00 AM EDT
Allogeneic hematopoietic stem cell transplantation: lessons learned by a molecular immunologist/transplant patient
 Trends in Immunology

Much has been learned about the genes and pathways that contribute to a diverse array of hematopoietic malignancies and other hematopoietic diseases. However, for many of these diseases, an allogeneic hematopoietic stem cell (HSC) transplant …

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Released: 2-May-2022 8:00 AM EDT
ILC1s control leukemia stem cell fate and limit development of AML
 Nature Immunology

… Here, we show that a high density of ILC1s induces leukemia stem cell (LSC) apoptosis in mice. At a lower density, ILC1s prevent LSCs from differentiating into leukemia progenitors and promote their differentiation into non-leukemic cells, thus …

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Released: 2-May-2022 8:00 AM EDT
Neighborhoods Most Affected by Racism, Inequities and COVID-19 Pandemic Stressors at a Greater Risk for Preterm Births, Study Finds
 Mount Sinai Health System

The cohort study follows women through pregnancy and birth to study if a SARS-CoV-2 infection, the virus that causes COVID-19, is associated with poor pregnancy outcomes.

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Released: 2-May-2022 8:00 AM EDT
Neuron-specific enolase promotes stem cell-like characteristics of small-cell lung cancer by downregulating NBL1 and activating the BMP2/Smad/ID1 pathway
 Oncogenesis

… In summary, our study demonstrated that NSE promoted stem cell-like characteristics of SCLC via NBL1 and the activation of the BMP2/… , which promotes stem cell-like characteristics [20, 21]. Thus, we aimed to determine …

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Released: 2-May-2022 8:00 AM EDT
Function of epithelial stem cell in the repair of alveolar injury
 Stem Cell Research & Therapy

… For example, in the repair phase after bacteria (Pseudomonas aeruginosa)-induced lung injury, 30–70% of the AT2s acquire the expression of a stem cell surface marker Sca-1 (stem cell antigen 1, or Ly6a) [15, 16]. The Sca-1 + AT2s are likely to …

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Released: 2-May-2022 8:00 AM EDT
Investigating the feasibility and ethical implications of phenotypic screening using stem cell-derived tissue models to detect and manage disease
 Stem Cell Reports

Stem-cell-derived tissue models generated from sick people are being used to understand human development and disease, drug development, and drug screening. However, it is possible to detect disease phenotypes before a patient …

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Released: 2-May-2022 8:00 AM EDT
ASCL1 activates neuronal stem cell-like lineage programming through remodeling of the chromatin landscape in prostate cancer
 Nature Communications

… ASCL1 is required to establish the neuronal and stem cell-like lineage … To determine whether ASCL1 is required for the development of neuronal and stem cell-like phenotype… neuronal and stem cell differentiation and functions to bias the cell fate …

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