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Medicine

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ASH2017, ASH annual meeting, Ash, CAR T, DLBCL, Lymphoma, non-Hodgkin's lymphoma

Global CAR T Therapy Trial Shows High Rates of Durable Remission for Non-Hodgkin’s Lymphoma

In a pair of clinical trials stretching from Philadelphia to Tokyo, the chimeric antigen receptor (CAR) T cell therapy Kymriah™ (formerly known as CTL019) demonstrated long-lasting remissions in non-Hodgkin’s lymphoma (NHL) patients. Results from a global, multisite trial will be presented today at the 59th American Society of Hematology Annual Meeting and Exposition in Atlanta (Abstract #577). Results from the single-site study, with follow-up extending past two years, will be published today in the New England Journal of Medicine.

Medicine

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Multiple Myeloma, Hematologic Cancers

Sequencing Offers Clues to Progression Toward Multiple Myeloma

Researchers at Dana-Farber Cancer Institute have carried out the largest genomic analysis of patients with smoldering multiple myeloma (SMM), a precursor to full-blown blood cancer that doesn’t show outward symptoms.

Medicine

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CAR-T cell therapy, Lymphoma

Landmark CAR-T Cancer Study Published in the New England Journal of Medicine

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Loyola University Medical Center is the only Chicago center that participated in the pivotal clinical trial of a groundbreaking cancer treatment that genetically engineers a patient's immune system to attack cancer cells.

Medicine

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American Society Of Hematology, Medical Research, Myelofibrosis, genetic-based prediction model

International Research Team Identifies Genetic-Based Model for Predicting Outcomes in Primary Myelofibrosis

A group of investigators from Mayo Clinic and multiple academic research centers in Italy have identified a genetic model for predicting outcomes in patients with primary myelofibrosis who are 70 years or younger and candidates for stem cell transplant to treat their disease.

Medicine

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breast cancer, , DCE-MRI, dynamic contrast-enhanced magnetic resonance imaging , San Antonio Breast Cancer Symposium, finding small early lesions , psychosocial distress , Mammogram, pathogenic mutations

For Women with Genetic Risk, Bi-Annual MRI Beats Mammograms

Intensive surveillance including a dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) exam every six months was far more effective in detecting breast cancer in younger women with a high-risk genetic profile than an annual mammogram. DCE-MRI every six months performed well for early detection of invasive breast cancer in high-risk women.

Science

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RNA, rna analysis, Iowa State University, Big Data, big data analytics , Medicine, Genetics, Genome

New Online Database Brings the Genome Into Focus Using Molecular Structure

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An online database built by Iowa State University scientists provides a new tool with which researchers can study human biology. The database is freely accessible to anyone on the web, where it allows scientists to study the functions and structure of RNA with greater speed and ease than in the past.

Medicine

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MD Anderson Cancer Center, Breast Cancer, San Antonio Breast Cancer Symposium, PARP inhibitor, Brca Gene

PARP Inhibitor Improves Progression-Free Survival in Patients with Advanced Breast Cancers and BRCA Mutations

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In a randomized, Phase III trial led by researchers at The University of Texas MD Anderson Cancer Center, the PARP inhibitor talazoparib extended progression-free survival (PFS) and improved quality-of-life measures over available chemotherapies for patients with metastatic HER2-negative breast cancer and mutations in the BRCA1/2 genes.

Medicine

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Prostate Cancer, Genetics, Hereditary Cancer, Genetic Testing, Genetic Counseling

EMBARGOED

A reporter's PressPass is required to access this story until the embargo expires on 13-Dec-2017 4:00 PM EST

Science

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DNA, Dna Testing, S&T, DHS, Innovation

DHS S&T’s Rapid DNA Tech Completes DNA Testing in Minutes Instead of Months

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In late November 2017, the Massachusetts Office of Chief Medical Examiner (MAOCME) issued their first official identification of a deceased person based on the accredited use of Rapid DNA in their lab.

Medicine

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Neurology, Cell and Molecular Biology, ALS, Amyotrophic Lateral Sclerosis, Fragile X, Fragile X Syndrome, fragile X-associated tremor ataxia syndrome, Frontotemporal Dementia, Genetics, mutation causing protein

Study Finds Genetic Mutation Causes ‘Vicious Cycle’ in Most Common Form of ALS

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University of Michigan-led research brings scientists one step closer to understanding the development of neurodegenerative disorders such as ALS. A study published today in Nature Communications details what the researchers describe as a vicious cycle of toxic protein production set in motion by cell stress.







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